CN112022980A - Traditional Chinese medicine formula for preventing African swine fever virus and preparation process of traditional Chinese medicine formula - Google Patents
Traditional Chinese medicine formula for preventing African swine fever virus and preparation process of traditional Chinese medicine formula Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine formula for preventing African swine fever virus and a preparation process of a medicament thereof, belonging to the technical field of medicaments for preventing African swine fever, and comprising the following raw materials in percentage by weight: 110-130 parts of gypsum, 22-38 parts of rhizoma anemarrhenae, 40-60 parts of radix rehmanniae, 85-115 parts of buffalo horn, 12-28 parts of coptis chinensis, 22-38 parts of cape jasmine, 19-32 parts of platycodon grandiflorum, 25-35 parts of scutellaria baicalensis, 22-40 parts of red paeony root, 25-35 parts of radix scrophulariae, 22-37 parts of cortex moutan, 18-33 parts of fructus forsythiae, 20-38 parts of lophatherum gracile, 8-12 parts of liquorice, 34-50 parts of common andrographis herb, 25-35 parts of polygonum cuspidatum, 25-35 parts of rheum officinale, 15-25 parts of mirabilite and 20-40 parts of folium isatidis. The invention has the function of turning off the African swine fever/swine fever, and can block the onset of diseases or cause mild onset of diseases in the uninfected or latent infection period, so that the swinery is turned into safety.
Description
Technical Field
The invention belongs to the technical field of medicaments for preventing African swine fever, and particularly relates to a traditional Chinese medicine formula for preventing African swine fever viruses and a preparation process of the medicament.
Background
African swine fever virus is an important member of the genus African swine fever virus of the family African swine fever, and the virus has some characteristics similar to those of the families iridoviridae and poxviridae. The diameter of the virus particle is 175-215 nm, and the virus particle is in 20-face symmetry and is provided with a capsule membrane. The genome is double stranded DNA with a size of 170-190 kb. In pigs, african swine fever virus replicates in several types of cytoplasm, especially reticuloendothelial cells and mononuclear macrophages.
China is a big country for raising pigs and pork consumption, the marketing amount, the stocking amount and the pork consumption amount of live pigs are all in the top of the world, the total import amount of the pigs and pork products is huge every year, the trade with a plurality of countries is frequent, and the number of commodities carried by passengers is large and the types are mixed. Therefore, the risk of transferring the African swine fever into China is increased, and once the African swine fever is transferred, the direct and indirect loss caused by the African swine fever is immeasurable. Therefore, how to effectively prevent and control African swine fever is a key problem to be urgently solved in the current pig industry.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine formula for preventing African swine fever virus and a preparation process of a medicament thereof, which are used for preventing African swine fever and swine fever.
In order to achieve the purpose, the invention adopts the following technical scheme: a traditional Chinese medicine formula for preventing African swine fever virus comprises the following raw materials in percentage by weight: 110-130 parts of gypsum, 22-38 parts of rhizoma anemarrhenae, 40-60 parts of radix rehmanniae, 85-115 parts of buffalo horn, 12-28 parts of coptis chinensis, 22-38 parts of cape jasmine, 19-32 parts of platycodon grandiflorum, 25-35 parts of scutellaria baicalensis, 22-40 parts of red paeony root, 25-35 parts of radix scrophulariae, 22-37 parts of cortex moutan, 18-33 parts of fructus forsythiae, 20-38 parts of lophatherum gracile, 8-12 parts of liquorice, 34-50 parts of common andrographis herb, 25-35 parts of polygonum cuspidatum, 25-35 parts of rheum officinale, 15-25 parts of mirabilite and 20-40 parts of folium isatidis.
Further, the material comprises the following raw materials in percentage by weight: 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of buffalo horn, 20 parts of coptis chinensis, 30 parts of cape jasmine, 25 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of red paeony root, 30 parts of figwort root, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 30 parts of lophatherum gracile, 10 parts of liquorice, 40 parts of common andrographis herb, 30 parts of giant knotweed rhizome, 30 parts of rheum officinale, 20 parts of mirabilite and 30 parts of folium isati.
Further, the invention also provides a process for preparing a powder medicament by using the traditional Chinese medicine formula for preventing the African swine fever virus, which comprises the following steps:
s1, crushing: pulverizing Gypsum Fibrosum, rhizoma anemarrhenae, radix rehmanniae, cornu Bubali, Coptidis rhizoma, fructus Gardeniae, radix Platycodi, Scutellariae radix, radix Paeoniae Rubra, radix scrophulariae, cortex moutan, fructus forsythiae, folium Bambusae, Glycyrrhrizae radix, herba Andrographitis, rhizoma Polygoni Cuspidati, radix et rhizoma Rhei, Natrii sulfas, and folium Isatidis respectively;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount, and mixing for later use;
s3, strain breeding: fermenting single strain for later use, fermenting composite strain for later use,
s4: aerobic fermentation: compounding the single fermentation strain and the composite fermentation strain prepared in the step S3, adding the mixture into the traditional Chinese medicine mixture obtained in the step S2, introducing oxygen, and performing aerobic fermentation for 72-96 hours to obtain an aerobic fermentation product; the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0;
s5, anaerobic fermentation: and (4) carrying out anaerobic fermentation on the aerobic fermentation product prepared in the step (S4), wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is carried out for 48-72 h, and the pH value of the finished product is controlled at 4.0-5.0, so that the finished product of the powder for preventing African swine fever viruses is obtained.
Preferably, in step S3, the single bacterium is bacillus subtilis for synthesizing antibacterial peptide; the composite strains in the step S3 are two or three of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum.
Preferably, the composite bacterial species in the step S3 are three bacterial species of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum.
Further, the invention also provides a process for preparing a liquid medicament by using the traditional Chinese medicine formula for preventing the African swine fever virus, which comprises the following steps:
s1, crushing: pulverizing Gypsum Fibrosum, rhizoma anemarrhenae, radix rehmanniae, cornu Bubali, Coptidis rhizoma, fructus Gardeniae, radix Platycodi, Scutellariae radix, radix Paeoniae Rubra, radix scrophulariae, cortex moutan, fructus forsythiae, folium Bambusae, Glycyrrhrizae radix, herba Andrographitis, rhizoma Polygoni Cuspidati, radix et rhizoma Rhei, Natrii sulfas, and folium Isatidis respectively;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount and mixing;
s3, extracting traditional Chinese medicines: putting the mixed medicine in the step S2 into liquid fermentation equipment for heat preservation treatment at 75-85 ℃ for 60 minutes to obtain liquid medicine;
s4, strain breeding: fermenting a single strain for later use, and fermenting a composite strain for later use;
s5, aerobic fermentation: adding the fermented single strain prepared in the step S4 into the liquid medicine obtained in the step S3, introducing oxygen, and performing aerobic fermentation for 60-72 h to obtain an aerobic fermentation product, wherein the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0;
s6, anaerobic fermentation: and (4) adding the fermented compound strain into the aerobic fermentation product obtained in the step (S5), and then performing anaerobic fermentation, wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is performed for 24-48 h, and the pH value after fermentation is 4.0-5.0, so that the finished product of the liquid medicament for preventing the African swine fever virus is obtained.
Preferably, in step S4, the single bacterium is Bacillus subtilis for synthesizing antibacterial peptide.
Preferably, the composite bacterial species in step S4 are two or three species of lactobacillus plantarum, saccharomyces cerevisiae, and clostridium butyricum.
Preferably, the composite bacterial species in the step S4 are three bacterial species of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum.
Compared with the prior art, the invention has the beneficial effects that:
1. the formula of the invention is mainly designed for preventing the dual blaze of qi and nutrient and the dual blaze of qi and blood of the pestilence disease, and the formula has heat-clearing medicines such as scutellaria baicalensis for promoting the decoction and stopping boiling; and fire-purging herbs such as Da Huang for firewood sucking from the bottom of the kettle; it can clear qi, purge fire, remove heat, cool blood, dissipate blood and prevent blood from binding heat. The whole formula can disperse lung qi, relieve heat toxin from upper energizer, clear pathogenic heat and reach skin, and promote three energizers to discharge pestilence toxin from urine. The medicine is infused in nutrient and blood of viscera and infiltrated into skin, muscles and bones, so that the pestilent toxicities are not remained.
2. The preparation process of the medicament is simple and reasonable, and the prepared medicament has the following functions: firstly, various toxins in the intestines are cleaned, gastrointestinal mucosa injury is repaired, gastrointestinal mucosa upper layer cells play an immune function, and pathogens cannot adhere to the intestinal wall. Lactic acid and butyric acid generated by beneficial bacteria (composite strains of lactobacillus plantarum and clostridium butyricum) form a beneficial acid environment in intestinal tracts, so that pathogens can be inactivated and weakened, and are discharged out of the body through the functions of clearing intestines and expelling toxins. Secondly, the non-specific immune function of the body is activated through the stimulation of the effective ingredients of the traditional Chinese medicine, a large amount of macrophages, natural killer cells, neutrophils, lysozyme, defensins and immune globulin are generated, and pathogens are phagocytized, inactivated and weakened. Thirdly, the effective components of the traditional Chinese medicine activate immune cells to generate interferon, transfer factor and the like, and block pathogen particles from adhering or penetrating into host cells, thereby achieving the effect of defending against African swine fever. Fourthly, the compound action: the unique strain (bacillus subtilis capable of synthesizing antibacterial peptide by using single strain) is metabolized to produce antibacterial peptide substances, and the antibacterial peptide substances are matched with polysaccharides, alkaloids and glycosides (specifically, the polysaccharides comprise glycyrrhiza polysaccharide, anemarrhena disaccharide and galloyl glucose; the alkaloids comprise coptisine and choline, the glycosides comprise polygonin, geniposide, crude platycodin, timosaponin, liquiritin, flavonoid glycoside, paeoniflorin, beta-sitosterol, coumarin, and phillyrin) in the traditional Chinese medicine, so that the surface of the virus protein is perforated, the protein is decomposed to damage the protein shell, and the nucleic acid structure of the virus is combined to prevent the replication of the genetic gene of the virus, thereby killing the virus. And fifthly, after the traditional Chinese medicine formula is fermented, the traditional Chinese medicine formula has the effects of benefiting qi, generating blood, removing blood stasis, strengthening body resistance and eliminating pathogenic factors, and the virulence of pathogens is weakened and converted into weak toxicity under the action of non-specific immunity, so that the lymphocyte function can be favorably exerted, and a pig body can generate a specific immune antibody after being infected for 42 days, thereby achieving the effect of rehabilitation.
Detailed Description
In order that those skilled in the art will better understand the present invention, the following description will be made in conjunction with specific embodiments thereof:
example 1
A traditional Chinese medicine formula for preventing African swine fever virus comprises the following raw materials in percentage by weight: 110-130 parts of gypsum, 22-38 parts of rhizoma anemarrhenae, 40-60 parts of radix rehmanniae, 85-115 parts of buffalo horn, 12-28 parts of coptis chinensis, 22-38 parts of cape jasmine, 19-32 parts of platycodon grandiflorum, 25-35 parts of scutellaria baicalensis, 22-40 parts of red paeony root, 25-35 parts of radix scrophulariae, 22-37 parts of cortex moutan, 18-33 parts of fructus forsythiae, 20-38 parts of lophatherum gracile, 8-12 parts of liquorice, 34-50 parts of common andrographis herb, 25-35 parts of polygonum cuspidatum, 25-35 parts of rheum officinale, 15-25 parts of mirabilite and 20-40 parts of folium isatidis.
The formula of the invention is mainly designed for preventing the dual blaze of qi and nutrient and the dual blaze of qi and blood of the pestilence disease, and the formula has heat-clearing medicines such as scutellaria baicalensis for promoting the decoction and stopping boiling; and fire-purging herbs such as Da Huang for firewood sucking from the bottom of the kettle; it can clear qi, purge fire, remove heat, cool blood, dissipate blood and prevent blood from binding heat. The whole formula can disperse lung qi, relieve heat toxin from upper energizer, clear pathogenic heat and reach skin, and promote three energizers to discharge pestilence toxin from urine. The medicine is infused in nutrient and blood of viscera and infiltrated into skin, muscles and bones, so that the pestilent toxicities are not remained.
Specifically, in this embodiment, 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of cornu bubali, 20 parts of coptis chinensis, 30 parts of cape jasmine, 25 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of radix paeoniae rubra, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 30 parts of lophatherum gracile, 10 parts of liquorice, 40 parts of andrographis paniculata, 30 parts of polygonum cuspidatum, 30 parts of rheum officinale, 20 parts of mirabilite, and 30 parts.
A process for preparing a powder medicament from a traditional Chinese medicine formula for preventing African swine fever virus comprises the following steps:
s1, crushing: respectively crushing gypsum, rhizoma anemarrhenae, radix rehmanniae, cornu bubali, coptis chinensis, gardenia, platycodon grandiflorum, scutellaria baicalensis, red paeony root, radix scrophulariae, cortex moutan, fructus forsythiae, lophatherum gracile, liquorice, common andrographis herb, giant knotweed rhizome, rheum officinale, mirabilite and folium isatidis (100 meshes and 200 meshes) for later use;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount, and mixing for later use;
s3, strain breeding: fermenting single strain for later use, fermenting composite strain for later use,
s4: aerobic fermentation: compounding the single fermentation strain prepared in the step S3 with the composite fermentation strain, adding the compound fermentation strain into the traditional Chinese medicine mixture obtained in the step S2, adding the single strain according to 2 percent, adding the composite strain according to 5 percent, introducing oxygen, and performing aerobic fermentation for 72-96 hours to obtain an aerobic fermentation product; the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0;
s5, anaerobic fermentation: and (4) carrying out anaerobic fermentation on the aerobic fermentation product prepared in the step (S4), wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is carried out for 48-72 h, and the pH value of the finished product is controlled at 4.0-5.0, so that the finished product of the powder for preventing African swine fever viruses is obtained.
The composite strains in the step S3 are two or three of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum. The composite strains in the embodiment are lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum according to the ratio of 1: 1: 1, and mixing.
The powder for preventing African swine fever virus prepared in the embodiment 1 is mixed with 1% -2% of materials, and a treatment course is 5-7 days after feeding; preferably, the weight ratio of the feed to the powder is 100: 1.5.
example 2
The embodiment 2 is basically the same as the embodiment 1 in technical scheme, and the difference is that: in example 2, 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of cornu bubali, 20 parts of coptis chinensis, 30 parts of cape jasmine, 19 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of radix paeoniae rubra, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 20 parts of lophatherum gracile, 10 parts of liquorice, 34 parts of common andrographis herb, 25 parts of polygonum cuspidatum, 25 parts of rheum officinale, 15 parts of mirabilite and 20 parts of folium isati.
Example 3
The embodiment 3 is basically the same as the embodiment 1, and the difference is that: in example 3, 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of cornu bubali, 20 parts of coptis chinensis, 30 parts of cape jasmine, 32 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of radix paeoniae rubra, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 38 parts of lophatherum gracile, 10 parts of liquorice, 50 parts of andrographis paniculata, 35 parts of polygonum cuspidatum, 35 parts of rheum officinale, 25 parts of mirabilite and 40 parts of folium.
Example 4
The embodiment 4 is basically the same as the embodiment 1, and the difference is that: embodiment 4 provides a process for preparing a liquid medicament from a traditional Chinese medicine formula for preventing african swine fever virus, which comprises the following steps:
s1, crushing: respectively crushing 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of buffalo horn, 20 parts of coptis chinensis, 30 parts of cape jasmine, 25 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of red paeony root, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 30 parts of lophatherum gracile, 10 parts of liquorice, 40 parts of common andrographis herb, 30 parts of polygonum cuspidatum, 30 parts of rheum officinale, 20 parts of mirabilite and 30 parts of folium isatidis (100 meshes and 200 meshes) for later;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount and mixing;
s3, extracting traditional Chinese medicines: putting the mixed medicine in the step S2 into liquid fermentation equipment for heat preservation treatment at 75-85 ℃ for 60 minutes to obtain liquid medicine;
s4, strain breeding: fermenting a single strain for later use, and fermenting a composite strain for later use;
s5, aerobic fermentation: adding the fermented single strain prepared in the step S4 into the liquid medicine obtained in the step S3, introducing oxygen, and performing aerobic fermentation for 60-72 h to obtain an aerobic fermentation product, wherein the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0; wherein, the single strain is bacillus subtilis for synthesizing antibacterial peptide, and the fermented single strain is inoculated according to 2 percent of the total weight of the traditional Chinese medicine components;
s6, anaerobic fermentation: and (4) adding the fermented compound strain into the aerobic fermentation product obtained in the step (S5), and then performing anaerobic fermentation, wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is performed for 24-48 h, and the pH value after fermentation is controlled at 4.0-5.0, so that the finished product of the liquid medicament for preventing the African swine fever virus is obtained.
The liquid preparation is used in a ratio of 0.2% by weight to water (the ratio of water intake to liquid weight is 100: 0.2).
The composite bacterial in S5 is two or three of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum.
The composite bacterial strain in the embodiment 2 is lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum according to the ratio of 1: 1: 1, inoculating the strain according to 5 percent of the total weight of the traditional Chinese medicine components.
The liquid preparation for preventing African swine fever virus prepared in example 4 is mixed with 1% -2% of feed, and a treatment course is 5-7 days after feeding.
Example 5
The embodiment 5 is basically the same as the embodiment 4 in technical scheme, and the difference is that: in example 5, 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of cornu bubali, 20 parts of coptis chinensis, 30 parts of cape jasmine, 19 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of radix paeoniae rubra, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 20 parts of lophatherum gracile, 10 parts of liquorice, 34 parts of andrographis paniculata, 25 parts of polygonum cuspidatum, 25 parts of rheum officinale, 15 parts of mirabilite and 20 parts of folium.
Example 6
The embodiment 6 is basically the same as the embodiment 4 in technical scheme, and the difference is that: in example 6, 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of cornu bubali, 20 parts of coptis chinensis, 30 parts of cape jasmine, 32 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of radix paeoniae rubra, 30 parts of radix scrophulariae, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 38 parts of lophatherum gracile, 10 parts of liquorice, 50 parts of andrographis paniculata, 35 parts of polygonum cuspidatum, 35 parts of rheum officinale, 25 parts of mirabilite and 40 parts of folium.
Control of cases of African swine fever excess: town, county, bobai, guangxi, 1100 sows:
the pig farm dies the sows and the fattened pigs with unknown reasons in 6-12 days in 2020, the African swine fever is positive after 20 sows and fattened samples are inspected, the large-area death of the pig herd is controlled after 20 days of use of the medicament (powder), and the pig herd is recovered to be stable after 17 days of use, so that the casualties are basically avoided. After 37 days of use, the production of the sow is basically recovered and stable, and the sow group does not have fever, purplish red plaque, pore bleeding, hematochezia, hematuria, abortion and other symptoms. 20 heads of blood samples of the sows are inspected by a veterinary laboratory with inspection qualification through secondary inspection, and no African swine fever positive cases are found. The above situations are real cases of the factory.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (9)
1. The traditional Chinese medicine formula for preventing African swine fever virus is characterized by comprising the following raw materials in percentage by weight: 110-130 parts of gypsum, 22-38 parts of rhizoma anemarrhenae, 40-60 parts of radix rehmanniae, 85-115 parts of buffalo horn, 12-28 parts of coptis chinensis, 22-38 parts of cape jasmine, 19-32 parts of platycodon grandiflorum, 25-35 parts of scutellaria baicalensis, 22-40 parts of red paeony root, 25-35 parts of radix scrophulariae, 22-37 parts of cortex moutan, 18-33 parts of fructus forsythiae, 20-38 parts of lophatherum gracile, 8-12 parts of liquorice, 34-50 parts of common andrographis herb, 25-35 parts of polygonum cuspidatum, 25-35 parts of rheum officinale, 15-25 parts of mirabilite and 20-40 parts of folium isatidis.
2. The traditional Chinese medicine formula for preventing African swine fever virus according to claim 1, which comprises the following raw materials in percentage by weight: 120 parts of gypsum, 30 parts of rhizoma anemarrhenae, 50 parts of radix rehmanniae, 100 parts of buffalo horn, 20 parts of coptis chinensis, 30 parts of cape jasmine, 25 parts of platycodon grandiflorum, 30 parts of scutellaria baicalensis, 30 parts of red paeony root, 30 parts of figwort root, 30 parts of cortex moutan, 25 parts of fructus forsythiae, 30 parts of lophatherum gracile, 10 parts of liquorice, 40 parts of common andrographis herb, 30 parts of giant knotweed rhizome, 30 parts of rheum officinale, 20 parts of mirabilite and 30 parts of folium isati.
3. A process for preparing a powder medicament from a traditional Chinese medicine formula for preventing african swine fever virus according to claim 1 or 2, which comprises the following steps:
s1, crushing: pulverizing Gypsum Fibrosum, rhizoma anemarrhenae, radix rehmanniae, cornu Bubali, Coptidis rhizoma, fructus Gardeniae, radix Platycodi, Scutellariae radix, radix Paeoniae Rubra, radix scrophulariae, cortex moutan, fructus forsythiae, folium Bambusae, Glycyrrhrizae radix, herba Andrographitis, rhizoma Polygoni Cuspidati, radix et rhizoma Rhei, Natrii sulfas, and folium Isatidis respectively;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount, and mixing for later use;
s3, strain breeding: fermenting single strain for later use, fermenting composite strain for later use,
s4: aerobic fermentation: compounding the single fermentation strain and the composite fermentation strain prepared in the step S3, adding the mixture into the traditional Chinese medicine mixture obtained in the step S2, introducing oxygen, and performing aerobic fermentation for 72-96 hours to obtain an aerobic fermentation product; the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0;
s5, anaerobic fermentation: and (4) carrying out anaerobic fermentation on the aerobic fermentation product prepared in the step (S4), wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is carried out for 48-72 h, and the pH value of the finished product is controlled at 4.0-5.0, so that the finished product of the powder for preventing African swine fever viruses is obtained.
4. The process for preparing powder preparation according to claim 3, wherein in step S3, the single bacterium is Bacillus subtilis for synthesizing antibacterial peptide; the composite strains in the step S3 are two or three of lactobacillus plantarum, saccharomyces cerevisiae and clostridium butyricum.
5. The process for preparing powder medicament according to claim 4, wherein the composite bacterial species in step S3 are Lactobacillus plantarum, Saccharomyces cerevisiae, Clostridium butyricum.
6. A process for preparing a liquid medicament by using the traditional Chinese medicine formula for preventing african swine fever virus according to claim 1 or 2, which comprises the following steps:
s1, crushing: pulverizing Gypsum Fibrosum, rhizoma anemarrhenae, radix rehmanniae, cornu Bubali, Coptidis rhizoma, fructus Gardeniae, radix Platycodi, Scutellariae radix, radix Paeoniae Rubra, radix scrophulariae, cortex moutan, fructus forsythiae, folium Bambusae, Glycyrrhrizae radix, herba Andrographitis, rhizoma Polygoni Cuspidati, radix et rhizoma Rhei, Natrii sulfas, and folium Isatidis respectively;
s2, mixing the traditional Chinese medicines: selecting the traditional Chinese medicines in the step S1 according to the amount and mixing;
s3, extracting traditional Chinese medicines: putting the mixed medicine in the step S2 into liquid fermentation equipment for heat preservation treatment at 75-85 ℃ for 60 minutes to obtain liquid medicine;
s4, strain breeding: fermenting a single strain for later use, and fermenting a composite strain for later use;
s5, aerobic fermentation: adding the fermented single strain prepared in the step S4 into the liquid medicine obtained in the step S3, introducing oxygen, and performing aerobic fermentation for 60-72 h to obtain an aerobic fermentation product, wherein the aerobic fermentation temperature is controlled at 37 ℃, and the pH value is controlled at 5.0-6.0;
s6, anaerobic fermentation: and (4) adding the fermented compound strain into the aerobic fermentation product obtained in the step (S5), and then performing anaerobic fermentation, wherein the temperature of the anaerobic fermentation environment is controlled at 37 ℃, the anaerobic fermentation is performed for 24-48 h, and the pH value after fermentation is controlled at 4.0-5.0, so that the finished product of the liquid medicament for preventing the African swine fever virus is obtained.
7. The process for preparing a liquid medicament according to claim 6, wherein in step S4, the single bacterium is Bacillus subtilis which synthesizes antibacterial peptide.
8. The process for preparing a liquid medicament according to claim 7, wherein the composite bacterial species in step S4 are two or three species selected from Lactobacillus plantarum, Saccharomyces cerevisiae, and Clostridium butyricum.
9. The process for preparing a liquid medicament according to claim 8, wherein the composite bacterial species in step S4 are lactobacillus plantarum, saccharomyces cerevisiae, clostridium butyricum.
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