CN112021695A - Medical mask of compound Chinese medicinal aromatherapy essential oil for resisting virus and influenza - Google Patents

Medical mask of compound Chinese medicinal aromatherapy essential oil for resisting virus and influenza Download PDF

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CN112021695A
CN112021695A CN202010937196.2A CN202010937196A CN112021695A CN 112021695 A CN112021695 A CN 112021695A CN 202010937196 A CN202010937196 A CN 202010937196A CN 112021695 A CN112021695 A CN 112021695A
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essential oil
chinese medicine
traditional chinese
oil
medical mask
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代兰松
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Dongguan Huayou Medical Technology Co ltd
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Dongguan Huayou Medical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A41D13/1107—Protective face masks, e.g. for surgical use, or for use in foul atmospheres characterised by their shape
    • A41D13/1115—Protective face masks, e.g. for surgical use, or for use in foul atmospheres characterised by their shape with a horizontal pleated pocket
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/06—Coniferophyta [gymnosperms], e.g. cypress
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A41D13/1192—Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/02—Layered materials
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/30—Antimicrobial, e.g. antibacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/02—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air by heating or combustion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
    • A61L9/145—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes air-liquid contact processes, e.g. scrubbing
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D2500/00—Materials for garments
    • A41D2500/30—Non-woven

Abstract

The invention discloses an antiviral and anti-influenza traditional Chinese medicine aromatherapy essential oil compound medical mask, which comprises outer-layer non-woven fabric, a traditional Chinese medicine aromatherapy essential oil carrier layer and inner-layer non-woven fabric, wherein the outer-layer non-woven fabric, the traditional Chinese medicine aromatherapy essential oil carrier layer and the inner-layer non-woven fabric are sequentially overlapped and sewn from outside to inside.

Description

Medical mask of compound Chinese medicinal aromatherapy essential oil for resisting virus and influenza
Technical Field
The invention relates to the technical field of medical masks, in particular to a medical mask of an antiviral and anti-influenza traditional Chinese medicine aromatherapy essential oil compound.
Background
The environment is increasingly worsened, harmful substances in the air are increased, and the emotion, health and working efficiency of people are affected by peculiar smell and air pollution. In recent years, influenza is frequently produced, and is mainly spread through droplets and air cross infection, so that cross infection can be effectively prevented and controlled by disinfecting air in public places, and large-scale spread of viruses is inhibited. Most of the air freshening disinfectants sold on the market at present contain artificially synthesized chemical sterilizing agents, and the air freshening disinfectants are often exposed in the air containing the chemical sterilizing agents and can cause harm to human health. Therefore, the development of safe and effective medical mask products of natural anti-influenza, anti-virus and anti-influenza traditional Chinese medicine aromatherapy essential oil compounds is particularly important for purifying indoor and outdoor air.
Disclosure of Invention
The invention aims to provide an antiviral and anti-influenza traditional Chinese medicine aromatherapy essential oil compound medical mask which is a pure traditional Chinese medicine essential oil formula, has the characteristics of bacteriostasis, antivirus, lasting fragrance and economy and applicability, and can solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
antiviral, anti influenza traditional chinese medicine champignon essential oil compound's medical gauze mask, including outer non-woven fabrics, traditional chinese medicine champignon essential oil carrier layer, inlayer non-woven fabrics, outer non-woven fabrics, traditional chinese medicine champignon essential oil carrier layer, inlayer non-woven fabrics stack from the outside inwards in proper order and sew up.
Further, the traditional Chinese medicine aromatherapy essential oil carrier layer is formed by dip-dyeing traditional Chinese medicine aromatherapy essential oil by melt-blown cloth, and the traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by weight:
5-10 parts of juniper essential oil, 2-10 parts of patchouli essential oil, 2-10 parts of clove essential oil, 5-10 parts of cinnamon essential oil and 5-10 parts of forsythia essential oil.
Further, the traditional Chinese medicine essential oil formula is mixed according to a certain proportion and then added into the substrate.
Further, the matrix is one or more than 2 of olive oil, tea tree essential oil, glyceryl monocaprylate and glycerol.
Further, the traditional Chinese medicine formula mixture accounts for 1.0-99%, and the matrix accounts for 1-99%.
Further, the production process of the medical mask comprises the following steps: soaking the melt-blown cloth produced by a melt-blowing machine in the essential oil of the traditional Chinese medicine for more than 24 hours, drying to obtain a carrier layer of the essential oil of the traditional Chinese medicine, and then sewing the outer non-woven fabric, the carrier layer of the essential oil of the traditional Chinese medicine and the inner non-woven fabric together in sequence to produce the medical mask of the virus and traditional Chinese medicine essential oil compound.
Further, the production process of the medical mask comprises the following steps: attaching a carrier layer containing Chinese medicinal aromatherapy essential oil on the inner non-woven fabric layer, wherein the carrier layer comprises a medical diaphragm layer, a bead-blasting capsule layer, and a medical absorbent cotton layer, and the bead-blasting capsule layer is broken by pinching to release essential oil to naturally volatilize into air.
Further, the production process of the medical mask comprises the following steps: the method comprises the steps of spraying components to 4 corners of a mask finished product by using a full-automatic Chinese medicinal aromatherapy essential oil spraying machine, then hermetically packaging, and naturally volatilizing into air after opening the package.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine aromatherapy essential oil carrier layer contains the traditional Chinese medicine aromatherapy essential oil, and the traditional Chinese medicine aromatherapy essential oil can be diffused into the air in modes of heating, spraying, natural volatilization and the like, or the traditional Chinese medicine aromatherapy essential oil is used for filtering and washing the air to achieve the purpose of refreshing and disinfecting the air, and has the characteristics of bacteriostasis, antivirus, lasting fragrance, economy and applicability.
Drawings
Fig. 1 is an overall structure diagram of the medical mask of the compound of the anti-virus anti-influenza traditional Chinese medicine aromatherapy essential oil of the invention.
In the figure: 1. outer layer non-woven fabric; 2. a traditional Chinese medicine aromatherapy essential oil carrier layer; 3. the inner layer is non-woven fabric.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1, the medical mask with antiviral and anti-influenza traditional Chinese medicine aromatherapy essential oil compound comprises an outer layer of non-woven fabric 1, a traditional Chinese medicine aromatherapy essential oil carrier layer 2 and an inner layer of non-woven fabric 3, wherein the outer layer of non-woven fabric 1, the traditional Chinese medicine aromatherapy essential oil carrier layer 2 and the inner layer of non-woven fabric 3 are sequentially overlapped and sewn from outside to inside, and the outer layer of non-woven fabric 1 and the inner layer of non-woven fabric 3 can ensure.
The traditional Chinese medicine aromatherapy essential oil carrier layer 2 is formed by dip-dyeing traditional Chinese medicine aromatherapy essential oil by melt-blown cloth, and the traditional Chinese medicine aromatherapy essential oil carrier layer 2 is provided with the traditional Chinese medicine aromatherapy essential oil, so that the medical mask has the characteristics of bacteriostasis, antivirus, lasting fragrance, economy and applicability.
Example 2
Antiviral, anti influenza traditional chinese medicine champignon essential oil compound's medical gauze mask, including outer non-woven fabrics 1, traditional chinese medicine champignon essential oil carrier layer 2, inlayer non-woven fabrics 3, outer non-woven fabrics 1, traditional chinese medicine champignon essential oil carrier layer 2, inlayer non-woven fabrics 3 stack from the outside in proper order and sew up, and this medical gauze mask dampproofing ventilative can be guaranteed to outer non-woven fabrics 1 and inlayer non-woven fabrics 3.
A carrier layer with traditional Chinese medicine aromatherapy essential oil is attached to the inner layer non-woven fabric 3 and comprises a medical diaphragm layer, an explosive capsule layer and a medical absorbent cotton layer, the explosive capsule layer is broken by pinching, and the essential oil is released to naturally volatilize into the air.
Example 3
Antiviral, anti influenza traditional chinese medicine champignon essential oil compound's medical gauze mask, including outer non-woven fabrics 1, traditional chinese medicine champignon essential oil carrier layer 2, inlayer non-woven fabrics 3, outer non-woven fabrics 1, traditional chinese medicine champignon essential oil carrier layer 2, inlayer non-woven fabrics 3 stack from the outside in proper order and sew up, and this medical gauze mask dampproofing ventilative can be guaranteed to outer non-woven fabrics 1 and inlayer non-woven fabrics 3.
The method comprises the steps of spraying components to 4 corners of a mask finished product by using a full-automatic Chinese medicinal aromatherapy essential oil spraying machine, then hermetically packaging, and naturally volatilizing into air after opening the package.
Example 4
The traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by mass:
8 parts of juniper essential oil, 6 parts of pogostemon cablin essential oil, 6 parts of clove essential oil, 7 parts of cinnamon essential oil and 7 parts of forsythia essential oil.
The Chinese medicinal essential oil is mixed according to a certain proportion and then added into the substrate. The matrix is mixture of oleum Olivarum and tea tree essential oil.
1% of a traditional Chinese medicine formula mixture and 99% of a substrate.
Example 5
The traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by mass:
5 parts of juniper essential oil, 4 parts of pogostemon cablin essential oil, 10 parts of clove essential oil, 5 parts of cinnamon essential oil and 10 parts of forsythia essential oil.
The Chinese medicinal essential oil is mixed according to a certain proportion and then added into the substrate. The matrix is mixture of tea tree essential oil and glyceryl monocaprylate.
5% of a traditional Chinese medicine formula mixture and 95% of a substrate.
Example 6
The traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by mass:
6 parts of juniper essential oil, 2 parts of pogostemon cablin essential oil, 10 parts of clove essential oil, 10 parts of cinnamon essential oil and 6 parts of forsythia essential oil.
The Chinese medicinal essential oil is mixed according to a certain proportion and then added into the substrate. The matrix is a mixture of glyceryl monocaprylate and glycerol.
50% of a traditional Chinese medicine formula mixture and 50% of a substrate.
Example 7
The traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by mass:
10 parts of juniper essential oil, 9 parts of pogostemon cablin essential oil, 2 parts of clove essential oil, 8 parts of cinnamon essential oil and 5 parts of forsythia essential oil.
The Chinese medicinal essential oil is mixed according to a certain proportion and then added into the substrate. The matrix is mixture of oleum Olivarum, tea tree essential oil, glyceryl monocaprylate, and glycerol.
99% of the traditional Chinese medicine formula mixture and 1% of the matrix.
The invention performs experiments (bacteriostasis ring method) on the bacteriostasis of the single and compound traditional Chinese medicine volatile oils of the traditional Chinese medicine aromatherapy essential oil of the 4 embodiments, and the experimental materials comprise:
sample preparation:
sample 1: juniper essential oil
Sample 2: patchouli essential oil
Sample 3: clove essential oil
Sample 4: cinnamon essential oil
Sample 5: forsythia essential oil
Sample 6: the mixture consists of juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil according to the proportion of 7.5:2:2:5: 5.
Experimental strains:
staphylococcus aureus (26112), escherichia coli (44113), staphylococcus albus (26069).
Respectively and uniformly coating the liquid culture of the three bacteria for 16-18 hours on the surface of a common plate by using sterile cotton swabs, slightly drying, clamping drug sensitive paper sheets absorbed with quantitative sample liquid medicine by using sterile tweezers, flatly paving the drug sensitive paper sheets on the surface of the plate inoculated with the bacteria, placing 3 drug sensitive paper sheets on one plate, culturing at 37 ℃, and observing the result the next day.
Table 1 test results of bacteriostatic effect of single herb essential oil (bacteriostatic ring diameter, mm, n 2 ~ 5, X ± SD)
Figure BDA0002672374020000051
Figure BDA0002672374020000061
Note: the antibacterial index, D ═ a × 0.3+ B × 0.2+ C × 0.5, the same below.
n represents the number of experimental repetitions (the same applies below).
The invention performs experiments (bacteriostasis ring method) on the bacteriostasis of the compound traditional Chinese medicine volatile oil with different proportions of the traditional Chinese medicine aromatherapy essential oil of the 4 embodiments, and the experimental materials comprise:
sample preparation:
sample 7, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 10:8:8:10: 10.
Sample 8, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 10:8:8:5: 5.
Sample 9, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:5:5:8: 8.
The sample 10 comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 10:2:2:5: 5.
Sample 11, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 10:2:5:8: 5.
Sample 12, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 5:8:8:10: 10.
Sample 13, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 5:2:2:5: 5.
Sample 14, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 5:2:2:8: 8.
Sample 15, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:5:5:8: 8.
Experimental strains: the same as the experimental strains.
TABLE 2 bacteriostatic effect test results of Chinese medicinal compound volatile oil with different proportions
(diameter of bacteriostatic ring, mm, n is 2-5,
Figure BDA0002672374020000071
)
Figure BDA0002672374020000072
the experiment is the result obtained by orthogonal design according to different proportions of the volatile oil, and the 9 formulas have bacteriostatic effects, which shows that the compatibility of medicines produces synergistic effect in bacteriostatic aspect.
The invention performs experiments (test tube dilution method) on the bacteriostasis of the compound traditional Chinese medicine volatile oil with different proportions of the traditional Chinese medicine aromatherapy essential oil of the 4 embodiments, and the experimental materials comprise:
sample preparation:
sample 6, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:2:2:5: 5.
The sample 10 comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 10:2:2:5: 5.
Sample 16, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:5:5:10: 10.
Experimental strains: the same as the experimental strains.
3mL of each of samples 6, 9 and 16 was dissolved in 1mL of Tween 80, and the nutrient broth was added to prepare diluted samples having 9 drug concentrations of 0.30mL, 0.15mL, 0.075mL, 0.0375mL, 0.01875mL, 0.009375mL, 0.004688mL, 0.002344mL and 0.001172mL, respectively, in total of 1mL per tube, and heat sterilized.
And (4) control: the strain control is culture medium without drug and test bacteria, and the drug control is liquid medicine without test bacteria.
The concentration of each concentration tube and strain control tube of each row of liquid medicine is 106cfc·ml-10.1mL of the test bacterial solution (8-hour culture) of (4), cultured at 37 ℃ for 24 hoursThen, one ring of each concentration was streaked out with an inoculating loop and inoculated on a solid nutrient agar plate, and the plate was incubated at 37 ℃ for 24 hours to observe the results. Observing each tube with naked eyes by taking turbidity as an index to observe whether each tube grows aseptically; the plates were visually observed for colony growth.
The Minimum Inhibitory Concentration (MIC) is determined and refers to the minimum drug concentration contained in the test strain which is completely inhibited from growing.
The Minimum Bactericidal Concentration (MBC) is determined and refers to the minimum drug concentration that completely kills the growth of the test species.
TABLE 3 MIC and MBC determination results (μ L. mL) of compound Chinese medicinal volatile oil at different ratios for 3 bacteria-1)
Figure BDA0002672374020000081
MIC and MBC are two important indexes of bacteriostasis and sterilization of the medicine, and the smaller the value is, the better the antibacterial effect of the medicine is. The comprehensive sterilization effect of the samples 9 and 16 is better.
The invention performs experiments on the antiviral effect of the compound Chinese medicinal volatile oil with different proportions of the Chinese medicinal aromatherapy essential oil of the 4 embodiments, and the experimental materials comprise:
sample preparation:
sample 6, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:2:2:5: 5.
The sample 10 comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 10:2:2:5: 5.
Sample 16, juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil, and forsythia essential oil in a ratio of 7.5:5:5:10: 10.
The positive control drug ribavirin, batch number 1901016.
And (3) poisoning seeds: influenza A virus H5N9 strain was passaged to MDCK Canine Kidney cells (Mad in-Darby Canine Kidney cell, Ma-Dou's Canine Kidney cells) and its titer was judged by lesion and hemagglutination of chicken erythrocytes at 37 ℃ with 5% CO2And culturing in an incubator.
The virus test was carried out on 96-well microtiter plates with 0.1mL per well, according to the guidelines for the research of new drugs in Chinese medicine (the administration of drug administration of the Ministry of public health of the people's republic of China, 1994 version). Cell number 1X105After each mL of the cells grow into a single layer, diluting the traditional Chinese medicine into 4 different concentrations by using a maintenance solution, discarding the original culture solution, adding the traditional Chinese medicine samples with different concentrations into cell holes, wherein each hole is 0.1mL, and the minimum dilution at which the cells do not have pathological changes is taken as the non-toxic limit of the liquid medicine to the cells. Simultaneous assay of TCID for challenge virus on MDCK cells50(50% tissue culture infectious dose). The test was performed with a virus control, a cell control, a drug toxicity control and a positive drug control (ribavirin). Standing at 37 deg.C for 5% CO2And culturing in an incubator. Lesions were observed under an inverted microscope and recorded daily. The observation was continued for 7 days and terminated when the cells in the virus control wells showed +++ lesions. The extent of lesion appearance of the cells was recorded according to the 6 th scale: -: the cells grow normally and no disease is generated; "+/-": cytopathic effects are less than 10% of the whole monolayer of cells; "+": cytopathic effects are less than 25% of the whole monolayer of cells; '++": cytopathic effects are less than 50% of the whole monolayer of cells; "+++": cytopathic effects are less than 75% of the whole monolayer of cells; "++++": cytopathic effects account for more than 75% of the entire monolayer of cells.
TABLE 4 inhibition of influenza A virus H5N9 by different mixture ratio of Chinese medicinal volatile oil
Figure BDA0002672374020000091
Figure BDA0002672374020000101
Note: "+" completely inhibits the virus "-" has no inhibitory effect on the virus.
The results show that the virus TCID is infected50At 100 doses, ribavirin is 100. mu.g/mL-1Has obvious inhibiting effect on H5N9, and sample No. 9 has 150 mu at the sub-toxic concentrationL·mL-1Has certain inhibiting effect on H5N 9. It is shown that sample 9 also has the effect of inhibiting common viruses in the air, and has the effect of air sterilization.
The experimental materials for simulating the field experiment comprise:
sample preparation:
traditional Chinese medicine essential oil aromatherapy 1: the composition comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 7.5:5:5:10: 10. The traditional Chinese medicine essential oil and the substrate are prepared according to the ratio of 1: 9.
Test strains: staphylococcus albus 8032, supplied by the military medical academy of sciences. And (4) preparing bacterial suspension by using common broth, wherein the generation number of the bacterial is 6-8.
More than 90% of particles phi of the aerosol generator are less than or equal to 5 mu m.
The volume of the aerosol chamber is 10m3。
A sampler: an FA-1 type impact air microorganism sampler.
The test temperature is 23-24 ℃, and the relative humidity is 50-58%.
The flow rate of the bacteria-contaminated sprayer is 21.7L/min, the spraying time is 5min, the stirring is carried out for 5min, and the standing is carried out for 5 min.
The disinfection method comprises the following steps: at 2mL/m for the test3In the amount of (1), using a QPQ-2300 model electric aerosol atomizer pair
Spraying in laboratory, sterilizing for 60min, and sampling. The control group used deionized water instead of disinfectant,
other operations were performed in the same experimental group. The experiment was repeated 3 times.
An FA-1 impact type air microorganism sampler is adopted, the sampling flow is 28.3L/min, and a point is arranged at the center of the chamber 1.0m away from the ground for sampling. Sampling is carried out when the disinfection action time is 0min and 60min, the sampling time of a control group sampler is 5s and 5s respectively, the sampling time of a test group sampler is 5s and 1min respectively, the number of live bacteria stored at different times is measured after sampling, and the killing rate is calculated according to the following formula:
Figure BDA0002672374020000111
Figure BDA0002672374020000112
Nt: the natural rate of bacterial death in the air;
V0' and Vt: air bacteria content before the start of the control group test and in different time in the test process are respectively;
Kt: the sterilization treatment has the effect of killing bacteria in the air;
V0' and Vt': the air bacterial contents before the sterilization treatment and in the sterilization process of the test groups at different times are respectively shown.
TABLE 5 killing effect of Chinese medicinal air-freshening disinfectant 1 on staphylococcus albus
Figure BDA0002672374020000113
Negative control: both the diluent and the medium grow aseptically.
The traditional Chinese medicine air freshening disinfectant 1 can kill common bacteria in the air and has an air sterilization effect.
The field experiment experimental material comprises:
sample preparation:
chinese medicine essential oil aromatherapy 2: the composition comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 7.5:5:5:10: 10. The traditional Chinese medicine essential oil and the substrate are prepared according to the ratio of 1: 9.
Traditional Chinese medicine essential oil aroma 3: the composition comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 7.5:5:5:10: 10. The traditional Chinese medicine essential oil and the substrate are prepared according to the ratio of 1: 49.
Test environment and instrumentation: room volume: 70m3
Temperature and humidity: room temperature: 31 ℃, room relative humidity: 85 percent of
Spraying equipment: electric aerosol atomizer, model: DQP-600.
Disinfecting and sampling:
the sampling is carried out for 2 times in total, and the sampling time points are 0h and 2h respectively.
The sampling method comprises the following steps: two plates with a diameter of 9cm were placed at each of the 5 sampling points, the sampling height was 1.0m, the petri dish was opened, after exposure for 10 minutes, the lid was closed, the sample was incubated at 37 ℃ for 24 hours, the number of colonies was counted and the mortality was calculated according to the following formula.
Figure BDA0002672374020000121
And (3) disinfection operation: uniformly spraying the mixture into a room by using an electric aerosol sprayer according to the dosage of 1mL per cubic meter, and disinfecting for 2h after spraying.
TABLE 6 disinfectant effect of Chinese medicinal air-freshening disinfectant 2 in closed state on site
Figure BDA0002672374020000122
TABLE 7 disinfectant effect of Chinese medicinal air-freshening disinfectant 3 in closed state on site
Figure BDA0002672374020000123
The acute oral toxicity test of the invention comprises the following materials:
sample preparation:
traditional Chinese medicine essential oil aroma 3: the composition comprises juniper essential oil, zedoary turmeric oil, patchouli oil, clove oil, cinnamon essential oil and forsythia essential oil in a ratio of 7.5:5:5:10: 10. The traditional Chinese medicine essential oil and the substrate are prepared according to the ratio of 1: 49.
Peanut oil is used for dilution.
Test animals: the NIH (national Institute of health) line white mouse (certification number: 0027327) has a weight of 18-22 g for each half of male and female.
20 NIH mice are selected, half of each mouse is male and female, and the weight is 18-22 g. Animals were acclimatized for 2 d. Animals were fasted overnight prior to dosingAnd free drinking water. During test, a proper amount of peanut oil is taken to dilute 5.0287g of traditional Chinese medicine air-refreshing disinfectant by 2-20 mL, the mixture is subjected to intragastric administration once according to 20mL/kg of body weight, namely the dose of 5000mg/kg of body weight, the animal reaction is immediately observed, the continuous observation is carried out for two weeks, the toxic reaction condition and death distribution of the animal are recorded, meanwhile, the dead animal is subjected to autopsy, the pathological change condition is recorded, and LD is judged50Whether or not it is greater than 5000mg/kg body weight.
The test result shows that: the traditional Chinese medicine air freshening disinfectant 2 is used for intragastric administration once according to the dose of 5000mg/kg body weight, and no obvious toxic reaction occurs to animals. After administration, the animal reaction is mainly manifested by reduced activity, and excitation and jumping of a few animals; the animal activity returned to normal at 2 hours after dosing; no animals died.
Therefore, it determines its LD50Greater than 5000mg/kg body weight.
According to the toxicity evaluation criteria in the "Disinfection technical Specification" (2002 edition) of the Ministry of public health of the people's republic of China:
LD50the people with the weight more than 5000mg/kg are actually nontoxic;
LD50the patients with 501 mg/kg-5000 mg/kg body weight belong to low toxicity;
LD50the body weight of 51 mg/kg-500 mg/kg belongs to moderate toxicity;
LD50the patients with 1 mg/kg-50 mg/kg body weight belong to high toxicity;
LD50those with the weight less than 1mg/kg are extremely toxic.
Because of LD of the traditional Chinese medicine air-refreshing disinfectant 250More than 5000mg/kg body weight, is considered to be a non-toxic product.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims (8)

1. The medical mask is characterized by comprising an outer layer non-woven fabric (1), a traditional Chinese medicine aromatherapy essential oil carrier layer (2) and an inner layer non-woven fabric (3), wherein the outer layer non-woven fabric (1), the traditional Chinese medicine aromatherapy essential oil carrier layer (2) and the inner layer non-woven fabric (3) are sequentially overlapped and sewn from outside to inside.
2. The medical mask with the compound anti-virus and anti-influenza traditional Chinese medicine aromatherapy essential oil as claimed in claim 1, wherein the carrier layer (2) of the traditional Chinese medicine aromatherapy essential oil is formed by impregnating the traditional Chinese medicine aromatherapy essential oil with melt-blown cloth, and the traditional Chinese medicine aromatherapy essential oil comprises the following raw materials in parts by mass:
5-10 parts of juniper essential oil, 2-10 parts of patchouli essential oil, 2-10 parts of clove essential oil, 5-10 parts of cinnamon essential oil and 5-10 parts of forsythia essential oil.
3. The medical mask of claim 2, wherein the essential oil of the traditional Chinese medicine is mixed according to a certain proportion and then added into the substrate.
4. The medical mask of claim 3, wherein the base material is one or more than 2 of olive oil, tea tree essential oil, glyceryl monocaprylate and glycerin.
5. The medical mask of the compound of the essential oil of the antiviral and anti-influenza traditional Chinese medicine according to claim 4, wherein the mixture of the traditional Chinese medicine formula is 1.0-99% and the matrix is 1-99%.
6. The medical mask of virus traditional Chinese medicine aromatherapy essential oil compound according to claim 1, which is produced by the following process: the virus and traditional Chinese medicine aromatherapy essential oil compound medical mask is produced only by the traditional medical mask production process that the outer non-woven fabric (1), the traditional Chinese medicine aromatherapy essential oil carrier layer (2) and the inner non-woven fabric (3) are sequentially sewn together.
7. The medical mask of virus traditional Chinese medicine aromatherapy essential oil compound according to claim 1, which is produced by the following process: a carrier layer with traditional Chinese medicine aromatherapy essential oil is attached to the inner layer non-woven fabric (3) and comprises a medical diaphragm layer, an explosive capsule layer and a medical absorbent cotton layer, the explosive capsule layer is broken by pinching, and the essential oil is released to naturally volatilize into the air.
8. The medical mask of virus traditional Chinese medicine aromatherapy essential oil compound according to claim 1, which is produced by the following process: the method comprises the steps of spraying components to 4 corners of a mask finished product by using a full-automatic Chinese medicinal aromatherapy essential oil spraying machine, then hermetically packaging, and naturally volatilizing into air after opening the package.
CN202010937196.2A 2020-09-08 2020-09-08 Medical mask of compound Chinese medicinal aromatherapy essential oil for resisting virus and influenza Pending CN112021695A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101455850A (en) * 2007-12-14 2009-06-17 永正顾问有限公司 Air disinfectant
CN102349991A (en) * 2011-05-29 2012-02-15 王红芳 Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition
CN111097007A (en) * 2020-03-06 2020-05-05 南京克冠生物技术有限公司 Multifunctional medicine core, mask and application

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101455850A (en) * 2007-12-14 2009-06-17 永正顾问有限公司 Air disinfectant
CN102349991A (en) * 2011-05-29 2012-02-15 王红芳 Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition
CN111097007A (en) * 2020-03-06 2020-05-05 南京克冠生物技术有限公司 Multifunctional medicine core, mask and application

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