CN112004937A - β-丙氨酸、β-丙氨酸盐以及泛酸盐的制备方法 - Google Patents

β-丙氨酸、β-丙氨酸盐以及泛酸盐的制备方法 Download PDF

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CN112004937A
CN112004937A CN202080002127.0A CN202080002127A CN112004937A CN 112004937 A CN112004937 A CN 112004937A CN 202080002127 A CN202080002127 A CN 202080002127A CN 112004937 A CN112004937 A CN 112004937A
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alanine
beta
fumaric acid
reaction
pantothenate
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刘文杰
陈彦
邱贵森
陆成梁
曾聪明
苏金环
陆伟华
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Guang'an Mojia Biotechnology Co ltd
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
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    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
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Abstract

本发明提供了一种β‑丙氨酸的制备方法，包括：将含有富马酸和氨水的反应物在催化剂存在下制备得到β‑丙氨酸产物，其中所述催化剂包含含有天冬氨酸酶和L‑天冬氨酸‑α‑脱羧酶的催化组合物，并且在反应过程中加入富马酸，而且加入的富马酸的摩尔总量等于所述反应物中的氨水的初始摩尔量减去所述反应物中的富马酸的初始摩尔量。本发明还提供了β‑丙氨酸盐(特别是β‑丙氨酸钙、β‑丙氨酸钠、β‑丙氨酸钾)和泛酸盐(特别是泛酸钙、泛酸钠、泛酸钾)的制备方法。

Description

PCT国内申请，说明书已公开。

Claims (34)

  1. PCT国内申请，权利要求书已公开。
CN202080002127.0A 2019-03-20 2020-03-18 β-丙氨酸、β-丙氨酸盐以及泛酸盐的制备方法 Pending CN112004937A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2019102126350 2019-03-20
CN201910212635.0A CN111718969A (zh) 2019-03-20 2019-03-20 β-丙氨酸的制备方法
CN202010075180 2020-01-22
CN2020100751805 2020-01-22
PCT/CN2020/079957 WO2020187256A1 (zh) 2019-03-20 2020-03-18 β-丙氨酸、β-丙氨酸盐以及泛酸盐的制备方法

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CN112004937A true CN112004937A (zh) 2020-11-27

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EP (1) EP3943606A4 (zh)
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386476A1 (en) * 1989-02-06 1990-09-12 Mitsubishi Petrochemical Co., Ltd. Process for producing L-alanine
CN102851333A (zh) * 2012-03-21 2013-01-02 蒋光玉 一种生物催化合成β-丙氨酸的方法
CN103320480A (zh) * 2013-06-25 2013-09-25 南京大学 一种双酶偶联制备β-丙氨酸的方法
CN108191688A (zh) * 2017-12-28 2018-06-22 大连韦德生化科技有限公司 一种合成及结晶d-泛酸钙的方法
CN108440325A (zh) * 2018-03-30 2018-08-24 安徽省恒锐新技术开发有限责任公司 D-泛酸钙的合成方法

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
JPH1042886A (ja) 1996-07-30 1998-02-17 Mitsui Petrochem Ind Ltd 微生物によるβ−アラニンの製造法
EG21758A (en) 1997-11-14 2002-02-27 Procter & Gamble Absorbent article having improved viscous fluid bodily waste mangement properties
DE602005015692D1 (de) * 2004-04-26 2009-09-10 Dsm Ip Assets Bv Verfahren zur herstellung von calcium-d-panthothenat
CN105018405A (zh) * 2015-07-27 2015-11-04 中国食品发酵工业研究院 一株组成型表达基因工程菌及其生产l-丙氨酸的应用
CN106755155A (zh) * 2016-12-07 2017-05-31 江南大学 一种用双酶串联制备β‑丙氨酸的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386476A1 (en) * 1989-02-06 1990-09-12 Mitsubishi Petrochemical Co., Ltd. Process for producing L-alanine
CN102851333A (zh) * 2012-03-21 2013-01-02 蒋光玉 一种生物催化合成β-丙氨酸的方法
CN103320480A (zh) * 2013-06-25 2013-09-25 南京大学 一种双酶偶联制备β-丙氨酸的方法
CN108191688A (zh) * 2017-12-28 2018-06-22 大连韦德生化科技有限公司 一种合成及结晶d-泛酸钙的方法
CN108440325A (zh) * 2018-03-30 2018-08-24 安徽省恒锐新技术开发有限责任公司 D-泛酸钙的合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高宇 等: "双酶偶联转化富马酸制备β-丙氨酸的工艺的建立与优化", 《生物工程学报》 *

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