CN111971384A - 一种仿生肠-肝器官芯片及其制备方法和应用 - Google Patents

一种仿生肠-肝器官芯片及其制备方法和应用 Download PDF

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CN111971384A
CN111971384A CN201880092380.2A CN201880092380A CN111971384A CN 111971384 A CN111971384 A CN 111971384A CN 201880092380 A CN201880092380 A CN 201880092380A CN 111971384 A CN111971384 A CN 111971384A
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fluid channel
chip
photoresist
porous membrane
bionic
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CN111971384B (zh
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魏文博
陈娟娟
邹远强
肖亮
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BGI Shenzhen Co Ltd
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Abstract

一种基于微流控技术的仿生肠‑肝器官芯片及其制备方法和应用，该仿生肠‑肝器官芯片具有流体通道，在流体通道内设有多孔膜(130)，多孔膜(130)将流体通道分隔成上层流体通道(111)和下层流体通道(121)，下层流体通道(121)的底部设有若干个凹槽结构(122)。肠细胞接种于上层通道(111)内，并在多孔膜(130)上形成具有代谢与吸收功能的肠道上皮组织。肝细胞接种于下层通道(121)内，由于在下层流体通道(121)的底部设有若干个凹槽结构(122)，接种肝细胞后，肝细胞会聚集在凹槽结构(122)内形成肝细胞球，通过三维动态培育出的肝细胞与人体肝细胞更为接近，具有更完善的肝功能。利用该芯片可更准确的模拟肠道与肝脏的循环体系，有利于药代动力学、药物筛选、食品安全等研究领域的研究工作。

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PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
CN201880092380.2A 2018-05-21 2018-05-21 一种仿生肠-肝器官芯片及其制备方法和应用 Active CN111971384B (zh)

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CN114350594A (zh) * 2022-01-07 2022-04-15 中国疾病预防控制中心营养与健康所 一种模拟人体组织代谢流程的细胞仿生共培养方法

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CN110951676A (zh) * 2019-12-24 2020-04-03 江苏信安佳医疗科技有限公司 仿生肝类器官培养模型及其应用
CN113637580A (zh) * 2020-04-27 2021-11-12 复旦大学 一种多力场耦合的细胞组织培养芯片
CN113447548A (zh) * 2021-06-09 2021-09-28 华东师范大学 一种检测器官芯片生理病理参数的生物传感系统的构建方法
CN114317272B (zh) * 2021-12-07 2024-01-12 上海前瞻创新研究院有限公司 一种多细胞共培养的培养装置及细胞培养方法

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