CN111954534A - 用于预防固定期间肌力丧失的植物性蜕皮素 - Google Patents

用于预防固定期间肌力丧失的植物性蜕皮素 Download PDF

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Publication number
CN111954534A
CN111954534A CN201980025318.6A CN201980025318A CN111954534A CN 111954534 A CN111954534 A CN 111954534A CN 201980025318 A CN201980025318 A CN 201980025318A CN 111954534 A CN111954534 A CN 111954534A
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China
Prior art keywords
muscle
immobilization
composition
days
phenanthren
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CN201980025318.6A
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English (en)
Chinese (zh)
Inventor
皮埃尔·迪尔达
玛蒂尔德·拉蒂伊
勒内·拉丰
斯坦尼斯拉斯·韦耶
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Sorbonne Universite
Biophytis SA
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Sorbonne Universite
Biophytis SA
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Publication of CN111954534A publication Critical patent/CN111954534A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980025318.6A 2018-02-28 2019-02-20 用于预防固定期间肌力丧失的植物性蜕皮素 Pending CN111954534A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1851778 2018-02-28
FR1851778A FR3078252B1 (fr) 2018-02-28 2018-02-28 Phytoecdysones pour leur utilisation dans la prevention de la perte de force musculaire lors d’une immobilisation
PCT/FR2019/050392 WO2019166717A1 (fr) 2018-02-28 2019-02-20 Phytoecdysones pour leur utilisation dans la prévention de la perte de force musculaire lors d'une immobilisation

Publications (1)

Publication Number Publication Date
CN111954534A true CN111954534A (zh) 2020-11-17

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CN201980025318.6A Pending CN111954534A (zh) 2018-02-28 2019-02-20 用于预防固定期间肌力丧失的植物性蜕皮素

Country Status (9)

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US (2) US20210369735A1 (https=)
EP (1) EP3758709B1 (https=)
JP (1) JP7386798B2 (https=)
KR (1) KR20200128058A (https=)
CN (1) CN111954534A (https=)
BR (1) BR112020017492A2 (https=)
ES (1) ES3039265T3 (https=)
FR (1) FR3078252B1 (https=)
WO (1) WO2019166717A1 (https=)

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CN107735082A (zh) * 2015-04-16 2018-02-23 蒙塔博瑞恩研究公司 用于治疗肌肉萎缩的衍生物
CN110753547A (zh) * 2017-04-28 2020-02-04 比奥菲蒂斯公司 药用级20-羟基蜕皮素提取物、其用途及其制备
CN113766920A (zh) * 2019-03-15 2021-12-07 比奥菲蒂斯公司 用于治疗神经肌肉疾病的植物蜕皮素及其衍生物

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AU2003902621A0 (en) * 2003-05-27 2003-06-12 Commonwealth Scientific And Industrial Research Organisation Ecdysone receiptor ligand-binding domain structure
CN102231986A (zh) * 2007-11-30 2011-11-02 比奥菲蒂斯研究所简单股份有限公司 植物蜕皮激素在制备对代谢综合征有效的组合物中的用途
CN102014626A (zh) * 2008-03-14 2011-04-13 英特瑞克斯顿股份有限公司 甾族配体及其在基因开关调控中的应用
RU2390270C1 (ru) * 2009-03-13 2010-05-27 Общество С Ограниченной Ответственностью "Парафарм" Биологически активная добавка к пище
US20120065176A1 (en) * 2009-05-18 2012-03-15 Lynn Megeney Treatment of muscle disease characterized by insulin resistance
CN103354717A (zh) * 2010-12-13 2013-10-16 罗格斯大学 产生和使用油菜素类固醇促进骨骼肌和皮肤生长、修复和维持的方法
CN103957727A (zh) * 2011-11-10 2014-07-30 比奥菲蒂斯研究所简单股份有限公司 用于体重减轻饮食之后的体重稳定的植物蜕皮激素
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CN107735082A (zh) * 2015-04-16 2018-02-23 蒙塔博瑞恩研究公司 用于治疗肌肉萎缩的衍生物
CN107708685A (zh) * 2015-04-30 2018-02-16 比奥菲蒂斯公司 含有降胭脂树素的、用于保护视网膜色素上皮细胞的组合物
CN105343466A (zh) * 2015-11-16 2016-02-24 南阳理工学院 一种治疗冠心病的中药组合物
CN110753547A (zh) * 2017-04-28 2020-02-04 比奥菲蒂斯公司 药用级20-羟基蜕皮素提取物、其用途及其制备
CN110769832A (zh) * 2017-04-28 2020-02-07 比奥菲蒂斯公司 20-羟基蜕皮素及其衍生物在肌病治疗中的用途
CN113766920A (zh) * 2019-03-15 2021-12-07 比奥菲蒂斯公司 用于治疗神经肌肉疾病的植物蜕皮素及其衍生物

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Also Published As

Publication number Publication date
US20210369735A1 (en) 2021-12-02
US20230158046A1 (en) 2023-05-25
WO2019166717A1 (fr) 2019-09-06
FR3078252B1 (fr) 2020-08-14
EP3758709A1 (fr) 2021-01-06
FR3078252A1 (fr) 2019-08-30
JP2021516228A (ja) 2021-07-01
KR20200128058A (ko) 2020-11-11
JP7386798B2 (ja) 2023-11-27
ES3039265T3 (en) 2025-10-20
EP3758709B1 (fr) 2025-07-09
BR112020017492A2 (pt) 2020-12-22
EP3758709C0 (fr) 2025-07-09

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Application publication date: 20201117