CN111918858A - 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品 - Google Patents

化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品 Download PDF

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CN111918858A
CN111918858A CN201980023092.6A CN201980023092A CN111918858A CN 111918858 A CN111918858 A CN 111918858A CN 201980023092 A CN201980023092 A CN 201980023092A CN 111918858 A CN111918858 A CN 111918858A
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lipid
nucleic acid
straight chain
alkyl
combination
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CN111918858B (zh
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蒋澄宇
李晓芸
杜涧超
梁竹
王志清
王晨轩
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Institute of Basic Medical Sciences of CAMS
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Abstract

涉及从中药中提取多种能够促进核酸递送的化合物或合成的化合物，并利用所提取的化合物或多种组合促进核酸如sRNA吸收和进入靶细胞中，并能促进核酸进入有此需要的对象体内的靶部位；所述中药选自红景天、蒲公英、穿心莲和金银花中药饮片；所述核酸用于治疗疾病，例如心脏、脾、肾、胃、肺和/或肠疾病。

Description

PCT国内申请，说明书已公开。

Claims (66)

  1. PCT国内申请，权利要求书已公开。
CN201980023092.6A 2018-03-29 2019-03-28 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品 Active CN111918858B (zh)

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CNPCT/CN2018/081155 2018-03-29
PCT/CN2018/081155 WO2018177383A1 (zh) 2017-03-29 2018-03-29 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品
PCT/CN2019/080175 WO2019184991A1 (zh) 2018-03-29 2019-03-28 化合物或中药提取物在制备核酸递送试剂中的应用及其相关产品

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EP4056552A4 (en) * 2019-11-08 2023-11-29 Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences USE OF LIPID IN THE PREPARATION OF A NUCLEIC ACID DELIVERY REAGENT AND ASSOCIATED PRODUCT
CN115671025A (zh) * 2021-07-27 2023-02-03 中国医学科学院基础医学研究所 Fa类脂质化合物在制备核酸递送试剂中的应用及其相关产品
CN113755496B (zh) * 2021-09-18 2023-11-10 中国医学科学院基础医学研究所 小rna及其在糖尿病治疗中的用途
WO2024026466A2 (en) * 2022-07-29 2024-02-01 Kodikaz Therapeutic Solutions, Inc. Nucleic acid-based delivery systems and uses thereof
WO2024061211A1 (zh) * 2022-09-20 2024-03-28 中国医学科学院基础医学研究所 用于核酸递送的脂质化合物以及包含所述脂质化合物的相关应用及药物

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