CN111905038A - Coconut oil-based antibacterial oil hydrogel and preparation method thereof - Google Patents
Coconut oil-based antibacterial oil hydrogel and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a coconut oil-based antibacterial oil hydrogel and a preparation method thereof, wherein the coconut oil-based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 25-30 parts of coconut essential oil, 15-20 parts of agilawood essential oil, 10-20 parts of folium artemisiae argyi essential oil, 8-12 parts of rosemary extract and 15-18 parts of dragon fruit stem extract. The oil-water gel prepared by the invention has good antibacterial effect on escherichia coli, staphylococcus aureus and streptococcus pneumoniae and has obvious effect on improving allergic rhinitis. The oil-water gel is applied to the edge of the nostril, so that air pathogens are captured and killed before the nasal cavity is replicated, harmful pathogens in the air are prevented from entering the body to the maximum extent, the free proliferation quantity in the nasal cavity is reduced, and the natural filtering performance of the nose is enhanced.
Description
Technical Field
The invention relates to the technical field of oil-water gels, and particularly relates to a coconut oil-based antibacterial oil-water gel and a preparation method thereof.
Background
With the development of society, more densely populated locations have emerged, leading to an increase in the number of pathogenic microorganisms and mutations. While the onset of respiratory illness is primarily the causative agent in the air inhaled through the nose and mouth. The oral cavity often kills airborne pathogens before they enter and infect the body. However, the nasal passages are less effective at trapping and killing pathogens. Pathogens are particularly vulnerable to allergic rhinitis in people. Pathogens in the air inhaled through the nose often enter the lungs, which can cause respiratory or other types of infections once they enter the blood. The inventor develops an oil-water gel which can better resist bacteria and can be applied to the near end of a nostril to reduce pathogens from entering a body through the nose.
Disclosure of Invention
In view of the above, the invention provides a coconut oil based antibacterial oil hydrogel and a preparation method thereof, which solve the technical problems.
The technical scheme of the invention is realized as follows:
the coconut oil based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 25-30 parts of coconut essential oil, 15-20 parts of agilawood essential oil, 10-20 parts of folium artemisiae argyi essential oil, 8-12 parts of rosemary extract and 15-18 parts of dragon fruit stem extract.
Preferably, the oil-water gel composition further comprises the following raw materials in parts by weight: 302-4 parts of povidone K, 1-3 parts of carbomer and 5-8 parts of glyceryl monocaprylate or glyceryl monocaprate.
Preferably, the coconut oil is coconut oil containing medium carbon chain fatty acid C8, wherein C10 is more than 80%.
Preferably, the dragon fruit stem extract is prepared by subcritical water extraction of dragon fruit stems, and specifically comprises the following steps: cleaning the dragon fruit stems, crushing, sieving to obtain dragon fruit stem powder, putting the dragon fruit stem powder into a subcritical water extraction device, extracting for 60-90 min at 2-3 MPa, extracting for 30-45 min at 4-5 MPa, combining the extracting solutions, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
Preferably, the coconut oil-based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 28 parts of coconut essential oil, 17 parts of agilawood essential oil, 15 parts of folium artemisiae argyi essential oil, 10 parts of rosemary extract, 16 parts of dragon fruit stem extract, 303 parts of povidone K, 2 parts of carbomer and 7 parts of glyceryl monocaprylate.
A preparation method of coconut oil-based antibacterial oil hydrogel comprises the following steps: preparing raw materials according to the parts by weight, adding rosemary extract and dragon fruit stem extract into 8-12 parts by weight of ultrapure water, and stirring to prepare a solution A; adding the coconut essential oil into the solution A under the stirring of 1200-1500 rpm and 40-50 ℃, and stirring for 10-20 min; then adding agilawood essential oil and folium artemisiae argyi essential oil under stirring at 500-800 rpm and 20-25 ℃, and stirring for 30-45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 1800-2200 rpm for 1-2 h, standing for 20-40 min, washing, freeze-drying and sterilizing to obtain the oil-water gel.
Preferably, the preparation method of the coconut oil-based antibacterial oil hydrogel comprises the following steps: preparing raw materials according to the parts by weight, adding rosemary extract and dragon fruit stem extract into 8-12 parts by weight of ultrapure water, and stirring to prepare a solution A; adding coconut essential oil into the solution A under stirring at 1300rpm and 48 deg.C, and stirring for 15 min; adding lignum Aquilariae Resinatum essential oil and folium Artemisiae Argyi essential oil under stirring at 600rpm and 20 deg.C, and stirring for 45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 2000rpm for 1.5h, standing for 30min, washing, freeze-drying, and sterilizing to obtain the oil-water gel.
Compared with the prior art, the invention has the beneficial effects that:
(1) the oil-water gel prepared by the invention has better antibacterial effect on escherichia coli, staphylococcus aureus and streptococcus pneumoniae.
(2) The oil-water gel prepared by the invention is clinically applied, has obvious effect on improving allergic rhinitis, has the total effective rate of more than 92.5 percent, and improves the resistance to pathogens.
(3) The oil-water gel is applied to the edge of the nostril, so that air pathogens are captured and killed before the nasal cavity is replicated, harmful pathogens in the air are prevented from entering the body to the maximum extent, the free proliferation quantity in the nasal cavity is reduced, and the natural filtering performance of the nose is enhanced.
(4) The oil-water gel of the present invention has been shown to help alleviate the body's immune response to many allergens, including dust mites, pollen, hay fever, animal dander, dust, particulate contamination, ozone, sulfur dioxide, and nitrogen oxides, etc., effectively trapping these allergens and alleviating the body's reaction to their presence.
(5) In addition, the oil-water gel can be applied to the vagina or the face to prevent the invasion of foreign pathogens and can be used as an effective antibacterial and antiviral barrier.
(6) The oil-water gel has pleasant smell, convenient use, safety and high efficiency.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
The coconut oil based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 25 parts of coconut essential oil, 20 parts of agilawood essential oil, 10 parts of folium artemisiae argyi essential oil, 12 parts of rosemary extract, 15 parts of dragon fruit stem extract, 302 parts of povidone K, 3 parts of carbomer and 5 parts of glyceryl monocaprylate; the coconut oil contains C8 medium-chain fatty acid, and coconut oil with C10 content of more than 80%.
Example 2
The coconut oil based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 30 parts of coconut essential oil, 15 parts of agilawood essential oil, 20 parts of folium artemisiae argyi essential oil, 8 parts of rosemary extract, 18 parts of dragon fruit stem extract, 304 parts of povidone K, 1 part of carbomer and 8 parts of glyceryl monocaprylate; the coconut oil contains C8 medium-chain fatty acid, and coconut oil with C10 content of more than 80%.
Example 3
The coconut oil based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 28 parts of coconut essential oil, 17 parts of agilawood essential oil, 15 parts of folium artemisiae argyi essential oil, 10 parts of rosemary extract, 16 parts of dragon fruit stem extract, 303 parts of povidone K, 2 parts of carbomer and 7 parts of glyceryl monocaprylate; the coconut oil contains C8 medium-chain fatty acid, and coconut oil with C10 content of more than 80%.
The preparation method of the coconut oil based antibacterial oil hydrogel in the above embodiments 1 to 3 comprises the following steps:
(1) preparing a dragon fruit stem extract: cleaning dragon fruit stems, drying, crushing, sieving with a 100-mesh sieve to obtain dragon fruit stem powder, loading the dragon fruit stem powder into a subcritical water extraction device, extracting for 80min at 2.3MPa, extracting for 40min at 4.8MPa, combining extracting solutions, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
(2) Preparing the raw materials according to the parts by weight, adding the rosemary extract and the dragon fruit stem extract into 10 parts by weight of ultrapure water, and uniformly stirring at normal temperature to prepare a solution A; adding coconut essential oil into the solution A under stirring at 1300rpm and 48 deg.C, and stirring for 15 min; adding lignum Aquilariae Resinatum essential oil and folium Artemisiae Argyi essential oil under stirring at 600rpm and 20 deg.C, and stirring for 45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 2000rpm for 1.5h, standing for 30min, washing, freeze-drying, and sterilizing to obtain the oil-water gel.
Example 4
The difference between the embodiment and the embodiment 3 is that the preparation method of the coconut oil-based antibacterial oil hydrogel comprises the following steps:
(1) preparing a dragon fruit stem extract: cleaning dragon fruit stems, drying, crushing, sieving with a 100-mesh sieve to obtain dragon fruit stem powder, loading the dragon fruit stem powder into a subcritical water extraction device, extracting for 90min at 2MPa, extracting for 45min at 4MPa, combining extracting solutions, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
(2) Preparing the raw materials according to the parts by weight, adding the rosemary extract and the dragon fruit stem extract into 8 parts by weight of ultrapure water, and uniformly stirring at normal temperature to prepare a solution A; adding coconut essential oil into the solution A under stirring at 1200rpm and 40 deg.C, and stirring for 20 min; adding lignum Aquilariae Resinatum essential oil and folium Artemisiae Argyi essential oil under stirring at 500rpm and 20 deg.C, and stirring for 45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 1800rpm for 1.8h, standing for 20min, washing, freeze-drying, and sterilizing to obtain the oil-water gel.
Example 5
The difference between the embodiment and the embodiment 3 is that the preparation method of the coconut oil-based antibacterial oil hydrogel comprises the following steps:
(1) preparing a dragon fruit stem extract: cleaning dragon fruit stems, drying, crushing, sieving with a 100-mesh sieve to obtain dragon fruit stem powder, loading the dragon fruit stem powder into a subcritical water extraction device, extracting for 60min at first 3MPa, extracting for 30min at second 5MPa, combining extracting solutions, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
(2) Preparing the raw materials according to the parts by weight, adding the rosemary extract and the dragon fruit stem extract into 12 parts by weight of ultrapure water, and uniformly stirring at normal temperature to prepare a solution A; adding coconut essential oil into the solution A under stirring at 1500rpm and 50 deg.C, and stirring for 10 min; adding lignum Aquilariae Resinatum essential oil and folium Artemisiae Argyi essential oil under stirring at 800rpm and 25 deg.C, and stirring for 30 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 2200rpm for 1.2h, standing for 40min, washing, freeze-drying, and sterilizing to obtain the oil-water gel.
Comparative example 1
The comparative example differs from example 3 in that the coconut oil based antibacterial oil hydrogel comprises the following raw materials in parts by weight: 10 parts of coconut essential oil, 25 parts of agilawood essential oil, 25 parts of folium artemisiae argyi essential oil, 15 parts of rosemary extract, 20 parts of dragon fruit stem extract, 303 parts of povidone K, 2 parts of carbomer and 7 parts of glyceryl monocaprylate.
Comparative example 2
The comparative example differs from example 3 in that the preparation method of the dragon fruit stem extract comprises the following steps: cleaning dragon fruit stems, drying, crushing, sieving with a 100-mesh sieve to obtain dragon fruit stem powder, loading the dragon fruit stem powder into a subcritical water extraction device, extracting for 120min at the pressure of 3.5MPa to obtain an extracting solution, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
Comparative example 3
The comparative example is different from example 3 in that the raw materials are prepared according to the parts by weight, rosemary extract and dragon fruit stem extract are added into 10 parts by weight of ultrapure water, and the mixture is stirred to prepare a solution A; adding coconut essential oil, agilawood essential oil, argy wormwood leaf essential oil, povidone K30, carbomer and glyceryl monocaprylate into the solution A at 1000rpm and 30 ℃ under stirring, and stirring for 3 h; standing for 30min, washing, freeze drying, and sterilizing to obtain oil-water gel.
First, bacteriostasis test
Respectively culturing Escherichia coli, Staphylococcus aureus and Streptococcus pneumoniae to logarithmic phase, inoculating 100 μ L of suspension with bacteria turbidity of 0.5mcf to corresponding agar plates, uniformly spreading, respectively adding 1g of oil-water gel prepared in examples 1-5 and comparative examples 1-3, repeating three plates for each bacteria, culturing at 37 deg.C for 24h, and observing the result. And measuring the diameter of the antibacterial circle, and repeating the step for 3 times to obtain an average value. The results are as follows:
the results show that compared with the comparative proportion of 1-3, the oil-water gel prepared in the embodiments 1-5 of the invention has better antibacterial effect on escherichia coli, staphylococcus aureus and streptococcus pneumoniae.
Second, clinical trial
1. Basic data: 160 allergic rhinitis volunteers, 18-50 years old, 76 men and 84 women were collected and randomly divided into 4 groups of 40 cases.
2. Major diagnostic criteria
(1) Symptoms are: sneezing, watery nasal discharge, nasal obstruction, and rhinocnesmus;
(2) physical signs: pale nasal mucosa, edema of the double lower nails, clear or sticky nasal discharge in the general nasal passages and nasal floor;
(3) serum specific IgE detection: the allergen of allergic rhinitis is determined, and the clinical manifestation history, skin prick test and serum specific IgE detection result are comprehensively considered.
3. The using method comprises the following steps: test groups 1-4 correspond to the application of the oil-water gels prepared in examples 1-3 and comparative example 1, respectively, and the oil-water gels are lightly and uniformly smeared on the edges of the nostrils of the volunteers, 1 time in the morning and at night, 7 days as a treatment course, and 2 treatment courses are used.
3 therapeutic results
3.1 therapeutic Effect score sheet
3.2 efficacy index (n) ═ [ (pre-treatment total score-post-treatment total score) ÷ pre-treatment total score ] × 100%
The effect is shown: the curative effect index is more than or equal to 66 percent.
The method has the following advantages: the curative effect index is more than or equal to 26 percent and less than 66 percent.
And (4) invalidation: the curative effect index is less than 26 percent.
3.3 therapeutic Effect
The above results indicate that the oil-water gels prepared in examples 1 to 3 of the present invention have significant effects on improving allergic rhinitis compared to comparative example 1, and the total effective rate is more than 92.5%.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. The coconut oil-based antibacterial oil hydrogel is characterized by comprising the following raw materials in parts by weight: 25-30 parts of coconut essential oil, 15-20 parts of agilawood essential oil, 10-20 parts of folium artemisiae argyi essential oil, 8-12 parts of rosemary extract and 15-18 parts of dragon fruit stem extract.
2. The coconut oil based antibacterial oil hydrogel as claimed in claim 1, wherein the oil hydrogel composition further comprises the following raw materials in parts by weight: 302-4 parts of povidone K, 1-3 parts of carbomer and 5-8 parts of glyceryl monocaprylate or glyceryl monocaprate.
3. The coconut oil based antibacterial oil hydrogel as claimed in claim 2, wherein the coconut oil is a medium carbon chain fatty acid C8, C10 is more than 80% coconut oil.
4. The coconut oil based antibacterial oil hydrogel as claimed in claim 2, wherein the dragon fruit stem extract is obtained by subjecting dragon fruit stem to subcritical water extraction.
5. The coconut oil based antibacterial oil hydrogel as claimed in claim 4, wherein the preparation method of the dragon fruit stem extract comprises the following steps: cleaning the dragon fruit stems, drying, crushing, sieving to obtain dragon fruit stem powder, putting the dragon fruit stem powder into a subcritical water extraction device, extracting for 60-90 min at 2-3 MPa, extracting for 30-45 min at 4-5 MPa, combining the extracting solutions, centrifuging, concentrating, and drying to obtain the dragon fruit stem extract.
6. The coconut oil based antibacterial oil hydrogel as claimed in claim 1, which comprises the following raw materials in parts by weight: 28 parts of coconut essential oil, 17 parts of agilawood essential oil, 15 parts of folium artemisiae argyi essential oil, 10 parts of rosemary extract, 16 parts of dragon fruit stem extract, 303 parts of povidone K, 2 parts of carbomer and 7 parts of glyceryl monocaprylate.
7. The method for preparing the coconut oil-based antibacterial oil hydrogel as claimed in claim 5, characterized by comprising the following steps: preparing the raw materials according to the parts by weight, adding the rosemary extract and the dragon fruit stem extract into 8-12 parts by weight of water, and stirring to obtain a solution A; adding the coconut essential oil into the solution A under the stirring of 1200-1500 rpm and 40-50 ℃, and stirring for 10-20 min; then adding agilawood essential oil and folium artemisiae argyi essential oil under stirring at 500-800 rpm and 20-25 ℃, and stirring for 30-45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 1800-2200 rpm for 1-2 h, standing for 20-40 min, washing, freeze-drying and sterilizing to obtain the oil-water gel.
8. The method for preparing the coconut oil-based antibacterial oil hydrogel as claimed in claim 7, characterized by comprising the following steps: preparing the raw materials according to the parts by weight, adding the rosemary extract and the dragon fruit stem extract into 8-12 parts by weight of water, and stirring to obtain a solution A; adding coconut essential oil into the solution A under stirring at 1300rpm and 48 deg.C, and stirring for 15 min; adding lignum Aquilariae Resinatum essential oil and folium Artemisiae Argyi essential oil under stirring at 600rpm and 20 deg.C, and stirring for 45 min; and finally adding povidone K30, carbomer, glyceryl monocaprylate or glyceryl monocaprate, stirring at 2000rpm for 1.5h, standing for 30min, washing, freeze-drying, and sterilizing to obtain the oil-water gel.
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| CN113583755A (en) * | 2021-08-17 | 2021-11-02 | 海口楠脂香业有限公司 | Extraction method of agilawood essential oil |
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