CN111714402A - Mild cleansing composition and preparation method thereof - Google Patents

Abstract

The invention discloses a mild cleansing composition and a preparation method thereof, belonging to the technical field of daily cosmetics. The cleansing composition comprises an amino acid surfactant N-acyl amino acid surfactant and a biosurfactant mannitol erythritol ester, and the two have synergistic effects, so that the cleansing composition has a good cleaning effect, can also keep moisture and moisten, provides antibacterial and antibacterial properties, and is mild and non-irritant to skin; in addition, the preparation method of the cleansing composition is simple and is suitable for industrial mass production.

Description

Mild cleansing composition and preparation method thereof

Technical Field

The invention belongs to the technical field of daily cosmetics, and particularly relates to a mild cleansing composition and a preparation method thereof.

Background

The cleansing composition is a facial cosmetic for the purpose of cleansing the skin, and its cleansing mechanism is to reduce the surface tension of dirt by a surfactant and to remove the dirt by dispersion, foaming, emulsification, or the like. Different surfactants vary in foaming power, detergency and irritancy. Although the common surfactant has good decontamination capability, the common surfactant has strong irritation to the skin, and can destroy the sebum of the skin if being used for a long time, so that the skin is easily damaged by the outside, and adverse reactions such as dermatitis or allergy are caused; in addition, the face cleaning agent can take away moisture of the skin at the same time, so that the skin becomes dry and tight.

Disclosure of Invention

The present invention aims to overcome the disadvantages of the prior art and provide a mild cleansing composition.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a mild cleansing composition comprising an amino acid based surfactant and a biosurfactant.

The components of the facial cleanser interact with each other, so that a good synergistic effect can be achieved, the irritation to the skin can be reduced while the face is cleaned, and the moisturizing and bacteriostatic abilities are improved.

The amino acid surfactant provided by the invention is an amino acid derivative of natural source, has excellent surface activity, can effectively clean the face, has rich and fine foam, is mild and low in stimulation, and has good wetting effect and antibacterial capability.

The biosurfactant provided by the invention is a biosurfactant which has strong emulsifying capacity, good stability and no irritation by utilizing enzymes or microorganisms through biological catalysis and biosynthesis.

Preferably, the mild cleansing composition comprises the following components in parts by weight: 10-30 parts of amino acid surfactant and 1-10 parts of biosurfactant.

If the addition amount of the surfactant is too much, the cleaning is excessive, and adverse reactions such as dermatitis or allergy are easily caused; if too little, the cleaning effect will be poor; in addition, the amino acid surfactant and the biosurfactant have synergistic effect, and the components need to be kept in proper proportion to effectively act on the skin.

Preferably, in the mild cleansing composition, the amino acid type surfactant is an N-acyl amino acid type surfactant; the amino acid of the N-acyl amino acid type surfactant contains at least one of acidity, neutrality, and basicity.

The N-acyl amino acid type surfactant is generally prepared by condensing amino acid and long-chain fatty acid, and has good hard water resistance, emulsification and foaming properties.

Preferably, the N-acyl amino acid type surfactant comprises at least one of sodium lauroyl sarcosinate, sodium lauroyl glutamate, disodium lauroyl glutamate, potassium lauroyl glutamate, sodium cocoyl amido propionate, sodium cocoyl methyl taurate, sodium cocoyl glycinate, and potassium cocoyl glycinate.

Preferably, the N-acyl amino acid type surfactant comprises sodium lauroyl sarcosinate.

Preferably, in the mild cleansing composition, the biosurfactant comprises at least one of rhamnolipid, sophorolipid, mannosylerythritol lipid and trehalose glycolipid.

Preferably, the biosurfactant comprises a mannosylerythritol lipid.

The biosurfactant mannosylerythritol lipid provided by the invention is obtained by biological fermentation, not only has cleaning capability, but also has a structure similar to ceramide, can enter stratum corneum, improves moisturizing capability and reduces skin tightness; in addition, the composition can also resist and inhibit bacteria and repair the damage of other components in the composition to the skin.

Preferably, the mild cleansing composition further comprises the following components in parts by weight: 1-3 parts of thickening agent, 0.1-2 parts of emulsifier, 0.2-1.5 parts of neutralizer and 0.5-1.0 part of preservative.

Preferably, the thickening agent is one or two of acrylate copolymer and acrylic acid/C10-30 alkanol acrylate cross-linked polymer; the emulsifier comprises one or two of polysorbate-20 or PEG-7 glyceryl cocoate; the neutralizing agent comprises one or more of sodium hydroxide, potassium hydroxide and triethanolamine; the preservative comprises one or more of p-hydroxyacetophenone, 1,2 hexanediol, phenoxyethanol, ethylhexyl glycerol and pentanediol.

Meanwhile, the invention also discloses a preparation method of the mild cleansing composition, which comprises the following steps:

1) adding the thickening agent into cold water in a main pot, uniformly dispersing, heating to 80-85 ℃, and homogenizing and stirring until particles are completely dissolved;

2) after the step (1) is finished, adding an amino acid surfactant, uniformly stirring and preserving heat for 20-30 minutes;

3) after the step (2) is finished, cooling to 50-60 ℃, adding a neutralizer, and uniformly stirring;

4) after the step (3) is finished, cooling to 35-45 ℃, sequentially adding an emulsifier and a biosurfactant, and uniformly stirring;

5) and (4) after the step (4) is finished, adding a preservative, and uniformly stirring to obtain the face cleaning composition.

Compared with the prior art, the invention has the beneficial effects that:

the mild cleansing composition provided by the invention contains the amino acid surfactant and the biosurfactant, and the two surfactants act synergistically, so that the irritation and damage of chemical substances to the skin are reduced while the skin is cleaned, and the mild cleansing composition has the effects of moisturizing and inhibiting bacteria and is suitable for long-term use. In addition, the invention provides a preparation method of the mild cleansing composition, which has simple process and no need of excessive equipment and is suitable for industrial production.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Specific formulations of examples 1 to 17 and comparative examples 1 to 4 are shown in table 1, wherein the amino acid surfactant in examples 1 to 5 is sodium lauroyl sarcosinate, and the biosurfactant is mannosylerythritol lipid; the amino acid surfactants in embodiments 6 to 14 are sodium lauroyl glutamate, disodium lauroyl glutamate, potassium lauroyl glutamate, sodium cocoyl amidopropionate, sodium cocoyl methyl taurate, sodium cocoyl glycine, and potassium cocoyl glycine in this order, and the biosurfactant is mannosylerythritol; in examples 15 to 17, the amino acid surfactant is sodium lauroyl sarcosinate, and the biosurfactant is rhamnolipid, sophorolipid and trehalose glycolipid in this order; the amino acid surfactants in the comparative examples 1 to 4 are sodium lauroyl sarcosinate, and the biosurfactants are mannitol esters.

Table 1 sample recipe (wt.%)

The preparation methods of the above examples 1 to 17 and comparative examples 1 to 4 are as follows:

1) slowly adding the thickening agent into cold water in a main pot, uniformly dispersing, heating to 80-85 ℃, and homogenizing and stirring until no particles are dissolved completely;

2) after the step (1) is finished, adding an amino acid surfactant, uniformly stirring and preserving heat for 20-30 minutes (the step is omitted in the comparative example 2);

3) after the step (2) is finished, cooling to 50-60 ℃, adding a neutralizer, and uniformly stirring;

4) after the step (3) is finished, cooling to 35-45 ℃, sequentially adding an emulsifier and a biosurfactant, and uniformly stirring;

5) and (4) after the step (4) is finished, adding a preservative, and uniformly stirring to obtain the face cleaning composition.

Wherein, when the face cleaning composition of the embodiment 1 is prepared, the temperature is increased to 80 ℃ in the step (1), the mixture is stirred for 30 minutes in the step (2), the temperature is reduced to 50 ℃ in the step (3), and the temperature is reduced to 40 ℃ in the step (4); when the cleansing composition of example 2 was prepared, the temperature in step (1) was raised to 83 ℃, the mixture was stirred for 25 minutes in step (2), the temperature in step (3) was lowered to 55 ℃, and the temperature in step (4) was lowered to 35 ℃; when the cleansing composition described in example 3 was prepared, the temperature was raised to 85 ℃ in step (1), the mixture was stirred for 20 minutes in step (2), the temperature was lowered to 60 ℃ in step (3), and the temperature was lowered to 45 ℃ in step (4). The preparation conditions for the remaining experimental groups remained the same as in example 1.

1. Safety test (human body patch test)

The test samples are prepared in examples 1-17 and comparative examples 1-4, the number of the test persons is 210, the test persons are half of the number of the test persons, the test persons are 18-35 years old, the skin of the test persons is healthy, no allergic history of skin diseases exists, and the test persons meet the selection standard of volunteers; subjects were divided into 21 groups of 10 people each.

The spot pasting method comprises the following steps: a proper spot tester is selected, 0.02g of test object is dripped into the spot tester in a closed spot-patch experimental mode, a special adhesive tape is externally applied to cover the back of a test object, the test object is removed after 24 hours, skin reactions are observed after 0.5 hour, 6 hour, 12 hour, 24 hour and 48 hour after removal respectively, and the results are recorded according to the skin reaction grading standard in the cosmetic hygiene Specification. Table 2 shows the skin adverse reaction grading standard, and Table 3 shows the test results.

TABLE 2 grading Standard of adverse skin reactions

TABLE 3 safety test results

As can be seen from Table 3, the subjects did not have any adverse reaction, indicating that a small amount of the cleansing compositions of examples 1 to 17 and comparative examples 1 to 4 was safe to human body.

2. Irritation test-chick embryo chorioallantoic membrane blood vessel test (CAMVA)

According to SN/T2329-2009, the chick embryo chorioallantoic membrane blood vessel experiment is an in vitro method of an eye stimulation test, and is used for evaluating the eye stimulation degree of a tested body and evaluating the stimulation and safety degree of a product.

The experimental method comprises the following steps: using fertilized chicken embryos incubated for 10-12 days as experimental samples, marking the positions of air chambers on the surfaces of the eggshells, and stripping off the marked eggshells by using dental sawtooth bending forceps to expose white eggshell membranes; sucking a proper amount of sodium chloride solution with the mass fraction of 0.9% by using a suction pipe to wet the egg membrane, and pouring out the redundant solution; then carefully remove the intima with forceps to ensure the vascular membrane is not damaged. A Teflon ring (test ring) was placed on the intact chick embryo chorioallantoic membrane as the test area for the test sample. By utilizing the characteristics of completeness, clearness and transparency of chorioallantoic vessels of fertilized chick embryos, 0.3mL of each of the samples of examples 1 to 17 and comparative examples 1 to 4 was taken, the samples were diluted with 0.9 wt.% of sodium chloride solution until the concentration was 3 wt.%, 0.9 wt.% of sodium chloride solution as a negative control group, and 0.3 wt.% of sodium hydroxide solution as a positive control group, and the diluted samples were dropped onto the test area of the chick embryos, covered with a wet preservative film on an air chamber, and then placed in a 37 ℃ incubator for 30 min. The cultured chick embryos were irradiated with a lamp tube and the degree of damage to the blood vessels was observed and scored. 10 chick embryos are made for each sample, the irritation value is recorded, experimental data are screened by a Q value inspection method, and a weighted average value, namely an NC value, is calculated. The evaluation reference criteria are shown in table 4, and the test results are shown in table 6.

TABLE 4 irritation evaluation criteria

3. Cleansing effect

The cleansing effect tests of examples 1-17 and comparative examples 1-4 are carried out, the number of tested people is 210, all the tested people are healthy subjects who participate voluntarily, the skin of the implemented person is healthy and has no allergic history of skin diseases between the ages of 30-60, and the test criteria of the subjects are met; the experiment was performed in 21 groups of 10 people each.

The test method comprises the following steps: each volunteer is used for one week continuously, once in the morning and evening, and the sample is applied, massaged for 2-3 minutes and washed clean, and then the cleaning effect, the tight feeling and the foam richness of the product are evaluated. The scores are divided into 5 grades, and the better the effect, the higher the score. Table 5 shows the evaluation criteria, and the test results are shown in Table 6.

TABLE 5 evaluation criteria for cleansing effect

4. Moisture and oil content of skin

The test is carried out by using a multifunctional skin tester (model: MPA580) of German CK company, the test environment temperature is 22 +/-1 ℃, and the humidity is 50 +/-5%; the subjects were divided into 21 groups of 210 persons, aged between 16 and 60 years (except pregnant or lactating women), and were unable to use any product (cosmetic or topical) for 2-3 days on the test site. The subjects enter a constant temperature and humidity evaluation room to stand for 30 minutes and then the initial oil content and water content and the oil content and water content of the skin after cleaning the face are tested.

Test method, marking the inner side of the left arm and the right arm with 3 × 3cm in the experiment²In the test area, the same arm can mark a plurality of areas, and the areas are spaced by 1 cm. Both the test product and the placebo group were randomly distributed on the left and right arms. The measurement was carried out using a skin oil content test probe (Sebumeter) and a skin moisture content test probe (Corneometer). Each area was assayed 3 times in parallel. The initial content of each test area was measured and then measured at 2.0. + -. 0.1mg sample/cm²The dosage of the composition is that a latex finger stall is used for uniformly coating a sample in a test area, massaging for 2-3min, then cleaning with clear water and wiping clean, measuring the content of clean faces of a tested area and a blank control area, and testing the same volunteerIs done by the same measuring staff. The test results are shown in Table 6.

Skin oil reduction rate (initial oil content-oil content after cleansing)/initial oil content 100%

Skin moisture loss rate (initial moisture content-after-cleansing moisture content)/initial moisture content 100%

Table 6 results of performance testing

As can be seen from table 6, although the cleansing effect, the foam richness and the oil and fat reduction effect of comparative examples 1 and 3 were good, the tightening feeling, NC value (irritation) and water loss test results were poor, indicating that the cleansing composition containing only a single amino acid-based surfactant was highly irritating to the skin while cleansing the face, and damaged the skin with long-term use. The results of the tests on the tightness, NC value (irritation) and water loss of comparative examples 2 and 4 are relatively good, but the cleaning effect and the foam richness are not enough, which shows that the biosurfactant mannosylerythritol lipid has the characteristics of mildness and no irritation, but the face cleaning effect is slightly insufficient. In addition, from the test results of the examples, it can be found that the optimal combination of the amino acid-based surfactant selected from sodium lauroyl sarcosinate and the biosurfactant selected from mannosylerythritol lipid has.

The amino acid surfactant and the biosurfactant are contained in the examples 1-17, so that the cleansing composition is obviously superior to the comparative examples 1-4 in terms of comprehensive results of cleansing effect, tight feeling, foam richness, NC (irritation), water loss rate and grease reduction rate, and the synergistic effect of the two surfactants is demonstrated, so that the cleansing composition has the cleansing effect of the amino acid surfactant, has the characteristics of moisture retention, mildness and safety of the biosurfactant, and can relieve dry and tight skin after cleansing.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. A mild cleansing composition characterized in that said cleansing composition comprises an amino acid based surfactant and a biosurfactant.

2. The mild facial cleansing composition according to claim 1, wherein said facial cleansing composition comprises the following ingredients in parts by weight: 10-30 parts of amino acid surfactant and 1-10 parts of biosurfactant.

3. The mild cleansing composition according to claim 1, wherein said amino acid based surfactant is an N-acyl amino acid based surfactant; the amino acid of the N-acyl amino acid type surfactant contains at least one of acidity, neutrality, and basicity.

4. The mild cleansing composition according to claim 3 wherein said N-acyl amino acid based surfactant comprises at least one of sodium lauroyl sarcosinate, sodium lauroyl glutamate, disodium lauroyl glutamate, potassium lauroyl glutamate, sodium cocoyl amido propionate, sodium cocoyl methyl taurate, sodium cocoyl glycinate, and potassium cocoyl glycinate.

5. The mild cleansing composition according to claim 4 wherein said N-acyl amino acid type surfactant comprises sodium lauroyl sarcosinate.

6. The mild cleansing composition according to claim 1, wherein said biosurfactant comprises at least one of rhamnolipids, sophorolipids, mannosylerythritol lipids and trehalose glycolipids.

7. The mild cleansing composition according to claim 6 wherein said biosurfactant comprises mannosylerythritol lipids.

8. The mild facial cleansing composition according to any one of claims 1 to 7 further comprising the following components in parts by weight: 1-3 parts of thickening agent, 0.1-2 parts of emulsifier, 0.2-1.5 parts of neutralizer and 0.5-1.0 part of preservative.

9. The mild facial cleansing composition according to claim 8, wherein said thickening agent is one or both of an acrylate copolymer and an acrylic/C10-30 alkanol acrylate crosspolymer; the emulsifier comprises one or two of polysorbate-20 or PEG-7 glyceryl cocoate; the neutralizing agent comprises one or more of sodium hydroxide, potassium hydroxide and triethanolamine; the preservative comprises one or more of p-hydroxyacetophenone, 1,2 hexanediol, phenoxyethanol, ethylhexyl glycerol and pentanediol.

10. A method of preparing a mild facial cleansing composition according to any one of claims 1 to 9 comprising the steps of:

1) adding the thickening agent into cold water in a main pot, uniformly dispersing, heating to 80-85 ℃, and homogenizing and stirring until particles are completely dissolved;

2) after the step (1) is finished, adding an amino acid surfactant, uniformly stirring and preserving heat for 20-30 minutes;

3) after the step (2) is finished, cooling to 50-60 ℃, adding a neutralizer, and uniformly stirring;

4) after the step (3) is finished, cooling to 35-45 ℃, sequentially adding an emulsifier and a biosurfactant, and uniformly stirring;

5) and (4) after the step (4) is finished, adding a preservative, and uniformly stirring to obtain the face cleaning composition.