CN111529420A - Mild cleansing mousse suitable for sensitive muscles - Google Patents

Mild cleansing mousse suitable for sensitive muscles Download PDF

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CN111529420A
CN111529420A CN202010379770.7A CN202010379770A CN111529420A CN 111529420 A CN111529420 A CN 111529420A CN 202010379770 A CN202010379770 A CN 202010379770A CN 111529420 A CN111529420 A CN 111529420A
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percent
mousse
cocoyl
madecassoside
mild
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钟玉容
张娇
韩志东
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Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
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Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/046Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14Preparations for removing make-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract

The invention provides a mild cleansing mousse suitable for sensitive muscles, which comprises a moisturizing conditioning component, a surfactant component, an anti-sensitivity relieving component and a pH adjusting component; the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3 to 6 percent of cocoyl glutamic acid TEA salt, 1.5 to 3 percent of cocoyl disodium glutamate, 0.6 to 3 percent of lauryl hydroxy sulfobetaine and 0.3 to 1.8 percent of cocoyl methyl taurine sodium taurate; the anti-allergy relieving component comprises the following components in percentage by weight of the mild cleansing mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate and 0.1 to 0.2 percent of madecassoside. The moisturizing conditioning component of the face cleaning mousse has the effects of moisturizing, film forming, corrosion prevention assisting and low-temperature stability improvement, and the anti-allergy relieving component has the effects of immediate allergy relieving, inflammation diminishing, moisturizing, conditioning and repairing.

Description

Mild cleansing mousse suitable for sensitive muscles
Technical Field
The invention relates to the field of cosmetics, in particular to a mild cleansing mousse suitable for sensitive muscles.
Background
In daily life, various grease and dirt can be left and accumulated on the facial skin, if the facial skin is not cleaned in time, the left glyceride and dirt are easy to be oxidized, and simultaneously, microorganisms are easy to breed to damage the skin health. Facial skin cleansing is the first step in skin care. Most consumers can select the glycerin soap base main body type face cleaning product, because the glycerin soap base main body type face cleaning product has abundant foam, is easy to wash and has strong cleaning force, but the glycerin soap base main body type face cleaning product can damage the inherent skin lipid layer of the epidermis and reduce the protective capability of the epidermis barrier when non-oily skin people use the glycerin soap base main body type face cleaning product for a long time. In recent years, the amino acid surfactant main body cleansing products are more popular with consumers, and various formulations of the amino acid surfactant main body cleansing products are gradually developed by brands. For example, surfactants used in patent CN 109453061 a (a facial mousse for sensitive muscles) include potassium cocoyl glycinate and sapindoside, the CMC concentration of potassium cocoyl glycinate is high, low-temperature stability is not good, crystals are easy to precipitate, so that the facial mousse obtained by compounding the components is easy to precipitate and crystallize due to low-temperature stability, the pH of the system is greater than 6, and test data is not used for detecting the irritation of the product; the proportion of the surfactant in the patent CN 109875907A (a foam type face cleaning composition) is more than 50%, and MIT preservative is selectively added in the patent formula, so that although a product with abundant foam and good makeup removing capability is obtained, the irritation of the foam type face cleaning composition is greatly improved; the formula system in patent CN110327235A (a kind of elastic, dense, soft and clean face mousse and its preparation method) is soap base main body, pH of the product is more than 8, and the product has strong irritation to skin.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a mild cleansing mousse suitable for sensitive muscles.
In order to achieve the purpose, the invention adopts the technical scheme that: a mild facial mousse suitable for sensitive muscles, comprising a moisturizing conditioning component, a surfactant component, an anti-allergy soothing component and a pH adjusting component;
the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3-6% of cocoyl glutamic acid TEA salt, 1.5-3% of cocoyl disodium glutamate, 0.6-3% of lauryl hydroxy sulphobetaine and 0.3-1.8% of sodium cocoyl methyl taurate, or the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3 to 6 percent of cocoyl glutamic acid TEA salt, 1.5 to 3 percent of cocoyl disodium glutamate, 0.6 to 3 percent of lauryl hydroxy sulfobetaine and 0.3 to 1.8 percent of cocoyl methyl sodium taurate;
the anti-allergy relieving component comprises the following components in percentage by weight of the mild cleansing mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate and 0.1 to 0.2 percent of madecassoside.
The formula components of the mild cleansing mousse suitable for the sensitive muscles comprise a moisturizing conditioning group, a surfactant group, an anti-allergy relieving group and a pH adjusting group, wherein the moisturizing conditioning group plays a role in moisturizing and film forming, anticorrosion assistance and low-temperature stability improvement, the anti-allergy relieving group plays a role in immediate allergy relief, anti-inflammation, moisturizing, conditioning and repairing, the surfactant component is prepared by matching cocoyl glutamic acid TEA salt, disodium cocoyl glutamate, lauryl hydroxy sulfobetaine and sodium cocoyl methyl taurate to ensure that the high-low temperature stability of the cleansing mousse is good, surface active crystals are not precipitated at low temperature, the cleansing mousse does not turn yellow and turn into flavor at high temperature, foams are dense and lasting, the oil and fat removing capability is good, the cleansing mousse is easy to wash and has no residue, and the irritation of the cleansing mousse is low at the same time, and the irritation of the cleansing mousse is greatly reduced by limiting the components and the content in the surfactant component and the anti-allergy relieving component, the mildness of the face cleaning mousse is improved, and the face cleaning mousse is very suitable for sensitive skin.
Preferably, the anti-allergy soothing component comprises the following components in weight percent of the mild cleansing mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate, 0.1 to 0.2 percent of madecassoside, 0.6 to 1.2 percent of 1, 2-pentanediol and 0.4 to 0.8 percent of 4-tert-butylcyclohexanol.
The inventor finds that the anti-allergy relieving components of the mild face-cleaning mousse suitable for the sensitive muscles are mixed by panthenol, allantoin, dipotassium glycyrrhizinate, madecassoside, 1, 2-pentanediol and 4-tert-butylcyclohexanol, so that the irritation of the face-cleaning mousse is greatly reduced, and the mildness of the face-cleaning mousse is improved.
Preferably, the weight ratio of the panthenol, the allantoin, the dipotassium glycyrrhizinate and the madecassoside is as follows: panthenol: allantoin: dipotassium glycyrrhizinate: 0.5 to 0.75 percent of madecassoside, (0.15 to 0.2 percent of madecassoside) (0.1 to 0.15 percent of madecassoside).
The inventor finds that the anti-allergy relieving component of the mild face cleansing mousse suitable for the sensitive muscles reduces the irritation of the face cleansing mousse and improves the mildness of the face cleansing mousse after the proportion of the component is limited.
Preferably, the weight ratio of the panthenol, the allantoin, the dipotassium glycyrrhizinate, the madecassoside, the 1, 2-pentanediol and the 4-tert-butylcyclohexanol is as follows: panthenol: allantoin: dipotassium glycyrrhizinate: madecassoside: 1, 2-pentanediol: 4-tert-butylcyclohexanol: 0.5:0.2:0.1:0.1:0.6: 0.4.
The inventors have found through studies that milder cleansing mousses having a milder and less irritating composition meet the above requirements when the ratio of anti-allergy soothing components of the mild cleansing mousse suitable for sensitive muscles described above is met.
Preferably, the conditioning moisturizing component comprises the following components in weight percent of the mild facial mousse: 2 to 10 percent of dipropylene glycol, 2 to 10 percent of glycerol, 0.4 to 0.8 percent of p-hydroxyacetophenone, 0.1 to 0.2 percent of hydrolyzed collagen, 0.4 to 0.8 percent of 1, 2-hexanediol and the balance of water.
The inventor finds that the moisturizing conditioning component comprises dipropylene glycol, glycerol, hydrolyzed collagen, p-hydroxyacetophenone, 1, 2-hexanediol and water, so that the face mousse has good moisturizing effect and good antiseptic effect, and the low-temperature stability of the face mousse is improved.
Preferably, the pH adjusting component comprises the following components in weight percent of the mild facial mousse: 0.08 to 0.12 percent of EDTA disodium and 0.1 to 0.15 percent of citric acid.
The inventor discovers that the pH adjusting component content of the face cleansing mousse enables the pH of the face cleansing mousse to be 5.0-6.0, is basically consistent with the pH value of normal human skin, and improves the mildness of the face cleansing mousse through research.
Preferably, the surfactant component comprises the following components in weight percent of the mild facial mousse: 4.2 to 5.4 percent of cocoyl glutamic acid TEA salt, 2.1 to 2.7 percent of cocoyl glutamic acid disodium, 1.2 to 1.8 percent of lauryl hydroxy sulfobetaine and 0.6 to 1.8 percent of cocoyl methyl taurine sodium taurate.
The inventor finds that the cleansing mousse simultaneously improves the oil and grease removing capability and the mildness of the cleansing mousse through the limitation of the content of the surfactant component.
Preferably, the weight ratio of the cocoyl glutamic acid TEA salt to the cocoyl glutamic acid disodium salt to the lauryl hydroxy sulfobetaine to the cocoyl methyl taurate sodium taurate is as follows: cocoyl glutamate TEA salt: cocoyl disodium glutamate: lauryl hydroxy sulfobetaine: sodium cocoyl methyl taurate (7-9): (3.5-4.5): (2-3): 1.
the inventor finds that the cleansing mousse simultaneously improves the oil and grease removing capability and the mildness of the cleansing mousse through the limitation of the proportion of the surfactant components.
Preferably, the weight ratio of the cocoyl glutamic acid TEA salt to the cocoyl glutamic acid disodium salt to the lauryl hydroxy sulfobetaine to the cocoyl methyl taurate sodium taurate is as follows: cocoyl glutamate TEA salt: cocoyl disodium glutamate: lauryl hydroxy sulfobetaine: cocoyl methyl taurate sodium taurate ═ 7: 3.5: 2: 1.
preferably, the mild facial mousse comprises the following components in percentage by weight: 4.2% of TEA salt of cocoyl glutamic acid, 2.1% of disodium cocoyl glutamate, 1.2% of lauryl hydroxysulfobetaine, 0.6% of sodium cocoyl methyl taurate, 0.5% of panthenol, 0.2% of allantoin, 0.1% of dipotassium glycyrrhizinate, 0.1% of madecassoside, 1% of symstitive 1609, 0.1% of disodium EDTA, 0.1% of citric acid, 6% of dipropylene glycol, 6% of glycerol, 0.6% of p-hydroxyacetophenone, 0.1% of hydrolyzed collagen, 0.6% of 1, 2-hexanediol and the balance of water.
The cleansing mousse with the weight components has the best high-low temperature stability, foaming performance, oil and grease removing performance and better mildness.
The invention has the beneficial effects that: the invention provides a face cleaning mousse, which has the following advantages:
(1) the pH value is 5.0-6.0, the skin is weakly acidic and is close to the pH value of normal human skin;
(2) the stability at high and low temperature is good, surfactant crystals are not precipitated at low temperature, and yellowing and odor change are avoided at high temperature;
(3) the foam is dense and lasting, and the pump is good when matched with a pump head bottle with good air tightness to pump out the foam;
(4) the oil and fat removing capability is moderate, the washing is easy, no residue is left, and the washing liquid is suitable for various skin crowds;
(5) essence is not added, and surface preservative is not additionally added, so that the coconut has special fragrance and good mildness;
(6) the makeup removing capability is good, the makeup base and the makeup on the eyes and the lips can be easily removed, and the makeup remover has no stimulation when being used in the eyes;
(7) the film is comfortable after washing, no residue and no stickiness are left, and the skin is soft and smooth.
Drawings
Fig. 1 is a graph showing the result of the corrosion prevention performance test of the cleansing mousse according to the embodiment of the invention.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
A mild facial mousse suitable for sensitive muscles, comprising a moisturizing conditioning component, a surfactant component, an anti-allergy soothing component and a pH adjusting component;
the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3 to 6 percent of cocoyl glutamic acid TEA salt, 1.5 to 3 percent of cocoyl disodium glutamate, 0.6 to 3 percent of lauryl hydroxy sulfobetaine and 0.3 to 1.8 percent of cocoyl methyl taurine sodium taurate;
the anti-allergy relieving component comprises the following components in percentage by weight of the mild cleansing mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate, 0.1 to 0.2 percent of madecassoside and 1 to 2 percent of Symsitive 1609;
the pH adjusting component comprises the following components in percentage by weight of the mild cleansing mousse: 0.08 to 0.12 percent of EDTA disodium and 0.1 to 0.15 percent of citric acid;
the moisturizing conditioning component comprises the following components in percentage by weight of the mild cleansing mousse: 2 to 10 percent of dipropylene glycol, 2 to 10 percent of glycerol, 0.4 to 0.8 percent of p-hydroxyacetophenone, 0.1 to 0.2 percent of hydrolyzed collagen, 0.4 to 0.8 percent of 1, 2-hexanediol and the balance of water;
wherein SymStative 1609 is composed of 60 wt% of 1, 2-pentanediol and 40 wt% of 4-tert-butylcyclohexanol.
The preparation method of the mild cleansing mousse suitable for sensitive muscles comprises the following steps:
(1) mixing EDTA disodium, dipropylene glycol, glycerin, p-hydroxyacetophenone, hydrolyzed collagen and water at 75-80 ℃ to obtain phase A;
(2) mixing the TEA salt of cocoyl glutamic acid, disodium cocoyl glutamic acid, lauryl hydroxy sulfobetaine and sodium cocoyl methyl taurate, and then uniformly mixing the mixture with the A phase at the temperature of between 55 and 65 ℃;
(3) mixing 1, 2-hexanediol and SymStative 1609, adding into the mixed phase obtained in the step (2) at 45-55 ℃, and uniformly mixing;
(4) dissolving panthenol, allantoin, dipotassium glycyrrhizinate and madecassoside in water, adding into the mixed phase obtained in the step (3) at 45-55 ℃, and mixing uniformly;
(5) and (3) adding citric acid into water for dissolving, adding the citric acid into the mixed phase obtained in the step (3) at the temperature of between 45 and 55 ℃, and uniformly mixing.
The percentage formulations of the facial mousses of examples 1-2, comparative examples 1-4 are shown in table 1.
TABLE 1 percentage formula of face-cleaning mousse
Figure BDA0002481005950000061
Figure BDA0002481005950000071
Effect example 1
1. The ph and stability of the facial mousses of examples 1-2 and comparative examples 1-4 were measured by observing the ph and stability of the facial mousses after they were left at a specific temperature for a specific time, and the results are shown in table 2,
TABLE 2 mousse pH and stability for cleansing
Figure BDA0002481005950000072
Figure BDA0002481005950000081
2. Test of Corrosion protection
The detection method comprises the following steps: european pharmacopoeia EP9.0(5.1.3 microbial preservative efficacy test).
The test results of the preservation ability of example 2 are shown in fig. 1, which illustrates that the cleansing mousse of the present invention has excellent preservation performance.
3. Eye irritation-chick embryo chorioallantoic Membrane test
The irritation of examples 1-3, comparative examples 3-5, control 1(Curel Ke moist immersion moisturizing cleansing foam), and control 2(Dove moist cleansing mousse) was tested.
The detection basis is as follows: SN/T2329-2009 cosmetic eye irritation/corrosiveness chick embryo chorioallantoic Membrane test, 10% sample concentration, HET-CAM stimulation evaluation
(1) Experimental materials: chicken embryo: SPF-grade White lewyng chickens (White Leghorn chicken) purchased from xinxing dahua farm eggs ltd, production license number: SCXK (Yue) 2018-.
(2) The culture conditions are as follows: the temperature of the incubator is 37.5 +/-0.5 ℃, and the relative humidity is 55-70%.
(3) Reagents and controls: positive Control (PC): 0.1mol/L NaOH solution; negative Control (NC): 0.9% NaCl solution; test sample (TA): 0.3040g of the test substance was weighed and purified water was added to the test substance to give a solution having a concentration of 10% (w/w).
(4) The experimental method comprises the following steps:
preparation of CAM: 0 d-old chick embryos are purchased and incubated to 9 d-old chick embryos, and defective chick embryos are inspected and discarded. Marking the position of an air chamber on the surface of a normal chick embryo egg shell, peeling off the egg shell part, and exposing a white egg membrane; the intima is carefully removed with forceps to ensure that the vascular membrane is not damaged.
Official test
Stimulation scoring method: each group of 6 chick embryos, 0.3mL of the original test substance was directly dropped on the CAM surface, the CAM reaction was observed, and the time to the onset of each toxic effect within 5min of action was recorded to the second, including 3 reactions of bleeding, coagulation and vessel thawing, and the extent of the reaction was recorded.
End point scoring method: and (3) directly dripping 0.3mL of prepared test substance on the surface of the CAM of each group of 6 chicken embryos, observing the reaction condition of the CAM, after 3min of action, slightly washing the test substance by using normal saline, removing the test substance, and observing 3 reactions and degrees of bleeding, blood coagulation and vessel thawing within about 30s after washing. If observations indicate that at least 1 response scored more than moderately (total score ≧ 12) in all 6 embryos, the test should be repeated once.
The positive control and the negative control were operated by the stimulation scoring method.
Data analysis
Stimulation scoring method (IS): recording the time of appearance and the degree of response of each detection endpoint, calculating the stimulation score (IS) using the following formula, and retaining the last two decimal points as a result:
Figure BDA0002481005950000091
sec H, sec L and sec C represent the average time (seconds) at which bleeding, vessel thawing and clotting were observed on the CAM membrane, respectively.
TABLE 3 evaluation of stimulation scoring results
Stimulation score IS Prediction classification
IS<1 Nonirritating Non-irritant (NI)
1≤IS<5 Mild irritancy Slightly Irritant (SI)
5≤IS<9 Moderate irritancy Modern Irritant (MI)
IS≥10 Strong irritant/corrosive Strong irritant/Corrosive (Co)
The results are shown in Table 4.
TABLE 4 irritation of face mousse
Test example Stimulation score IS
Example 1 2.82
Example 2 3.01
Example 3 2.95
Comparative example 3 3.43
Comparative example 4 2.88
Reference 1 3.52
Control 2 6.54
As can be seen from Table 1, the facial mousses of examples 1-3 all had lower IS irritation scores than the commercial Thermus amino acid facial mousse product "Curel Ke moisten soak skin care foam", while the "Curel Ke moisten soak skin care foam" IS well known for mildness of sensitive muscle application, which may indicate that the mildness of the facial mousses of examples IS better than the mildness of the control 1 "Curel Ke moisten soak skin care foam". The reference 2, "Dove moist cleansing mousse", IS also a cleansing mousse product that was hot-sold and discharged first three, and since it IS a system of amino acid surface active complex soap base and preservative ingredient embodying MIT, the reference has an IS irritation score of greater than 5, which IS moderate irritation.
Example 1 compared to example 2, the total surfactant component content of example 2 was greater than the total surfactant content of example 1, whereas the IS irritation score of example 1 was less than that of example 2, indicating that a reduction in total surfactant content IS beneficial for improving mildness of the facial mousse.
Comparative example 3 lacks the anti-sensitivity soothing component compared to example 2, the IS irritation score of comparative example 3 IS higher than that of example 2 (3.43 > 3.01), indicating that the addition of ingredients of the anti-sensitivity soothing component effectively improves the overall mildness of the facial mousse, and by comparing example 1 with comparative example 4, indicating that the addition of allantoin, hydroxyasiaticoside with panthenol, dipotassium glycyrrhizinate, 0.1% to 0.2% hydroxyasiaticoside, 1, 2-pentanediol and 4-tert-butylcyclohexanol as anti-sensitivity soothing components in the facial mousse provides a synergistic effect, reducing the irritation of the facial mousse.
4. Erythrocyte hemolysis test (refer to Liu Su, He Hua hong, Li Jie, preliminary study of erythrocyte hemolysis test for detecting eye irritation of cosmetics [ J ] Chinese medicine science 2015,5(16):188-
(1) Experimental methods
Erythrocyte hemolysis test preparation of erythrocyte suspension: taking 7mL of blood from the heart of a healthy rabbit, adding 1mL of 2% potassium oxalate solution to prepare fresh anticoagulated rabbit blood, adding 10mL of PBS to dilute the anticoagulated rabbit blood, and storing the anticoagulated rabbit blood in a refrigerator at 4 ℃ for later use.
Preparation of sample suspension: and selecting proper concentration to prepare a sample series solution. For each sample, 5 test doses were established, PBS as solvent, and 100mg/L Sodium Dodecyl Sulfate (SDS) as positive control.
Hemolysis and protein denaturation assays: each concentration 3 brace of the sample group is plugged into a test tube, and 10mL of sample solution is added into each tube; the negative control group 3 is provided with a brace and a test tube, and 10mL of PBS is added into each tube; a positive control group 3 is inserted into the test tube, 10mL of Sodium Dodecyl Sulfate (SDS) with the concentration of 100mg/L is added into each tube; blank control group 3 tubes with stoppers were added to each tube with 10mL of distilled water. 0.2mL of diluted rabbit blood was added to each tube, gently mixed, and incubated at 37 ℃ for 30 min. After the completion of the reaction, the reaction mixture is centrifuged for 10min at 2000r/min, and the supernatant is absorbed and transferred into a cuvette and subjected to absorbance (A) values at 540nm, 560nm and 575nm of a spectrophotometer. The hemolysis rate (%) and the protein Denaturation Index (DI) were calculated according to the following formulas.
Figure BDA0002481005950000111
The results are shown in Table 5, HC50 represents the sample concentration at which 50% of erythrocytes were hemolyzed.
Figure BDA0002481005950000112
R1A blank control distilled water centrifugation supernatant A575/A540 value; r2Centrifuging the supernatant for the sample to obtain a value of A575/A540; r3The supernatant was centrifuged for positive control SDS A575/A540 values.
TABLE 5 haemolysis rate of face-cleaning mousse
Figure BDA0002481005950000113
Figure BDA0002481005950000121
As can be seen from Table 5, the irritation of the cleansing mousse was significantly less than that of the control in examples 1 and 2, and the addition of the ingredients of the anti-allergy soothing group was shown to effectively increase the overall mildness of the cleansing mousse by comparing examples 1-2 and comparative example 3, and the addition of allantoin, madecassoside with panthenol, dipotassium glycyrrhizinate, 0.1% to 0.2% madecassoside, 1, 2-pentanediol and 4-tert-butylcyclohexanol as anti-allergy soothing components in the cleansing mousse resulted in a synergistic effect, reducing the irritation of the cleansing mousse by comparing examples 1 and 4.
5. Human body trial evaluation
The test method comprises the following steps:
(1) the number of people: 20 persons
(2) Sex: 90% of women and 10% of men
(3) Age range: 25% of the total composition is 18-30 years old, 30% of the total composition is 31-40 years old, 40% of the total composition is 41-50 years old, and 5% of the total composition is over 50 years old
(4) The product is as follows: example 2, comparative example 3, comparative example 4
(5) The use times are as follows: the same pump head packaging material is used for blind test for 1 week in sequence, and the face is cleaned once a day
(6) Evaluation method: self-evaluation, the score is 5 points, 5 points are the best effect, and 1 point is the worst effect
(7) Evaluation dimension: the results of rich and fine foam, long-lasting foam, degree of easy rinsing, cleansing power, moisture retention after use, skin softness after use, and use temperature are shown in table 7.
TABLE 7 trial Scoring for face cleansing mousse
Figure BDA0002481005950000131
The evaluation of the example 2 is close to that of the comparison product 1, the evaluation of the example 2 is better than that of the comparison product 3 in terms of foam rich fineness and cleaning force, and the overall feedback of the example 2 is as follows: the foam is rich and lasting, the washing is easy, no residue is left, the cleaning force is good, the skin is soft and not tight after the use, and the using process is mild;
after trial, the evaluation of the moisture retention and the softness of the skin of the control 2 is obviously lower than that of the other two types, and the evaluation of the foam endurance is slightly better than that of the control 2 and the control, wherein 2 dry skin subjects feed back the control 2 to have stabbing pain in the using process, and other subjects feed back the skin to have strong tightness after use.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (9)

1. A mild facial mousse suitable for sensitive muscles, comprising a moisturizing conditioning component, a surfactant component, an anti-allergy soothing component and a pH adjusting component;
the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3-6% of cocoyl glutamic acid TEA salt, 1.5-3% of cocoyl disodium glutamate, 0.6-3% of lauryl hydroxy sulphobetaine and 0.3-1.8% of sodium cocoyl methyl taurate, or the surfactant component comprises the following components in percentage by weight of the mild cleansing mousse: 3 to 6 percent of cocoyl glutamic acid TEA salt, 1.5 to 3 percent of cocoyl disodium glutamate, 0.6 to 3 percent of lauryl hydroxy sulfobetaine and 0.3 to 1.8 percent of cocoyl methyl sodium taurate;
the anti-allergy relieving component comprises the following components in percentage by weight of the mild cleansing mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate and 0.1 to 0.2 percent of madecassoside.
2. The mild facial mousse according to claim 1, wherein the anti-allergy soothing composition comprises the following components in weight percent of the mild facial mousse: 0.5 to 1.0 percent of panthenol, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of dipotassium glycyrrhizinate, 0.1 to 0.2 percent of madecassoside, 0.6 to 1.2 percent of 1, 2-pentanediol and 0.4 to 0.8 percent of 4-tert-butylcyclohexanol.
3. The gentle facial mousse for sensitive muscles according to claim 2, wherein the weight ratio of panthenol, allantoin, dipotassium glycyrrhizinate and madecassoside is: panthenol: allantoin: dipotassium glycyrrhizinate: 0.5 to 0.75 percent of madecassoside, (0.15 to 0.2 percent of madecassoside) (0.1 to 0.15 percent of madecassoside).
4. The gentle facial mousse for sensitive muscles according to claim 2, wherein the weight ratio of panthenol, allantoin, dipotassium glycyrrhizinate, madecassoside, 1, 2-pentanediol, 4-tert-butylcyclohexanol is: panthenol: allantoin: dipotassium glycyrrhizinate: madecassoside: 1, 2-pentanediol: 4-tert-butylcyclohexanol: 0.5:0.2:0.1:0.1:0.6: 0.4.
5. The gentle mildness cleansing mousse suitable for sensitive muscles according to claim 1 or 2, wherein the moisturizing conditioning composition comprises the following components in weight percentage of the mild cleansing mousse: 2 to 10 percent of dipropylene glycol, 2 to 10 percent of glycerol, 0.4 to 0.8 percent of p-hydroxyacetophenone, 0.1 to 0.2 percent of hydrolyzed collagen, 0.4 to 0.8 percent of 1, 2-hexanediol and the balance of water.
6. The gentle facial mousse according to claim 5, wherein the pH adjusting component comprises the following components in weight percent of the gentle facial mousse: 0.08 to 0.12 percent of EDTA disodium and 0.1 to 0.15 percent of citric acid.
7. The gentle mildness cleansing mousse for sensitive muscles according to claim 1 or 2, wherein the surfactant composition comprises the following components in weight percentage of the mild cleansing mousse: 4.2 to 5.4 percent of cocoyl glutamic acid TEA salt, 2.1 to 2.7 percent of cocoyl glutamic acid disodium, 1.2 to 1.8 percent of lauryl hydroxy sulfobetaine and 0.6 to 1.8 percent of cocoyl methyl taurine sodium taurate.
8. The mild facial mousse suitable for sensitive muscles according to claim 7, wherein the weight ratio of the cocoyl glutamate TEA salt, the disodium cocoyl glutamate, the lauryl hydroxysultaine and the sodium cocoyl methyl taurate is: cocoyl glutamate TEA salt: cocoyl disodium glutamate: lauryl hydroxy sulfobetaine: sodium cocoyl methyl taurate (7-9): (3.5-4.5): (2-3): 1.
9. the gentle facial mousse according to claim 1, wherein the gentle facial mousse comprises the following components in weight percent: 4.2% of TEA salt of cocoyl glutamic acid, 2.1% of disodium cocoyl glutamate, 1.2% of lauryl hydroxysulfobetaine, 0.6% of sodium cocoyl methyl taurate, 0.5% of panthenol, 0.2% of allantoin, 0.1% of dipotassium glycyrrhizinate, 0.1% of madecassoside, 1% of symstitive 1609, 0.1% of disodium EDTA, 0.1% of citric acid, 6% of dipropylene glycol, 6% of glycerol, 0.6% of p-hydroxyacetophenone, 0.1% of hydrolyzed collagen, 0.6% of 1, 2-hexanediol and the balance of water.
CN202010379770.7A 2020-05-07 2020-05-07 Mild cleansing mousse suitable for sensitive muscles Pending CN111529420A (en)

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CN112263507A (en) * 2020-11-09 2021-01-26 无限极(中国)有限公司 Composition for reducing skin irritation caused by surfactant and application thereof
CN112545919A (en) * 2020-12-14 2021-03-26 广州市拉凯尔干细胞研究所 Dual hyaluronic acid face-cleaning mousse
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CN114796014A (en) * 2022-04-21 2022-07-29 顾远玥 Efficient acne-removing anti-allergy face-cleaning mousse and preparation method thereof
CN115054542A (en) * 2022-06-13 2022-09-16 浙江犀望生物科技有限公司 Double-layer amino acid cleansing mousse applicable to sensitive muscles and preparation method thereof
CN115624498A (en) * 2022-07-04 2023-01-20 广州丝芬化妆品有限公司 Composition applied to face cleaning products and preparation method thereof
CN114948822A (en) * 2022-07-07 2022-08-30 杭州孔凤春化妆品股份有限公司 Amino acid moisturizing cleansing foam and preparation method thereof
EP4311545A1 (en) * 2022-07-29 2024-01-31 Isdin, S. A. Compounds useful for the post-sting treatment from a cnidarian organism
EP4311544A1 (en) * 2022-07-29 2024-01-31 Isdin, S. A. Compounds useful against jellyfish stings
CN115227632A (en) * 2022-08-03 2022-10-25 广东馨柯生命科学有限公司 Anti-inflammatory and antibacterial mild cleansing mousse rich in peony extract Essenpure PRE and preparation method of mild cleansing mousse
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