CN111671807A - External traditional Chinese medicine composition for children defervescence, gel plaster and preparation method thereof - Google Patents
External traditional Chinese medicine composition for children defervescence, gel plaster and preparation method thereof Download PDFInfo
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- CN111671807A CN111671807A CN202010697764.6A CN202010697764A CN111671807A CN 111671807 A CN111671807 A CN 111671807A CN 202010697764 A CN202010697764 A CN 202010697764A CN 111671807 A CN111671807 A CN 111671807A
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- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 6
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 241000510654 Bupleurum chinense Species 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Microbiology (AREA)
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- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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Abstract
The invention discloses an external traditional Chinese medicine composition for children defervescence, a gel plaster and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for children defervescence comprises radix bupleuri, cape jasmine and raw rhubarb. The preparation method of the external traditional Chinese medicine composition for children fever abatement comprises radix bupleuri aromatic water and extract. The gel plaster comprises bupleuri radix aromatic water, extract, sodium polyacrylate, aluminium glycollate, tartaric acid, polyvinylpyrrolidone, etc. The preparation method of the gel plaster comprises the steps of mixing, standing for swelling, mixing and stirring, and coating. The gel plaster prepared by the invention can simultaneously exert the efficacy of antipyresis of traditional Chinese medicine compatibility and the efficacy of physical cooling of the plaster; and the medicine has large medicine-carrying amount and convenient use, and provides a safe, effective and easily-accepted preparation for children with exogenous fever.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to an external traditional Chinese medicine composition for children to defervesce, a gel plaster and a preparation method thereof.
Background
Infantile fever is the most common symptom of pediatric infectious respiratory disease, has the characteristics of acute onset and rapid transmission, and is reported to occur 6 to 7 times per year on average, and in addition, about 10 to 15 percent of infants suffer from the disease more than 12 times per year. Complications such as convulsion and dehydration caused by high fever seriously harm the health and life safety of children.
At present, western medicines mostly adopt antipyretic analgesics and non-steroidal anti-inflammatory drugs for treatment, and although the antipyretic medicines have certain antipyretic curative effects, the problems of first-pass effect, short half-life period, large adverse reaction and the like exist, for example, aspirin can cause gastrointestinal irritation symptoms, asthma or rash and the like, so that the application range of the aspirin is limited.
In recent years, the traditional Chinese medicine for treating infantile exogenous fever is popular with people due to treatment of both symptoms and root causes and definite curative effect, but most of the traditional Chinese medicine is oral dosage form, the curative effect of children is affected clinically due to poor compliance of the medicine for patients, in addition, the functions of liver, kidney and other viscera of children are not perfect, the metabolism and excretion functions of oral medicines in vivo are poor, and various side effects are easy to generate.
Therefore, it is necessary to develop effective and safe Chinese medicine treatment methods and medicines which are easily accepted by children patients.
Disclosure of Invention
The invention aims at the problems in the prior art, provides an external traditional Chinese medicine composition for defervescing for children, a gel plaster containing the traditional Chinese medicine composition and a preparation method thereof, and the traditional Chinese medicine composition has the double effects of defervescing by compatibility of traditional Chinese medicines and physically cooling the gel.
In order to realize the purpose of the invention, the method is realized by the following technical scheme:
a topical Chinese medicinal composition for treating infantile fever comprises bupleuri radix, fructus Gardeniae and radix et rhizoma Rhei; the mass ratio of the radix bupleuri, the cape jasmine and the raw rhubarb is 5-4:2-3: 1.
The preparation method of the children defervescence external traditional Chinese medicine composition comprises the following two parts:
preparation of radix bupleuri aromatic water: soaking bupleuri radix in water, distilling, collecting distillate, and adding propylene glycol to obtain bupleuri radix aromatic water; distilling bupleuri radix residue;
preparing an extract: reflux-extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei in ethanol, and concentrating the filtrate under reduced pressure to obtain extract.
Preferably, in the preparation step of the bupleurum aromatic water:
the amount of the water is 6-10 times of the mass of the bupleurum; the dipping condition is dipping for 3-12h at 40-60 ℃; then distilling and collecting distillate with the mass at least two times of that of the radix bupleuri; 2 to 5 mass percent of propylene glycol is added into the distillate.
Preferably, in the preparation step of the extract:
reflux-extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei in 8-12 times of 60-80% volume fraction ethanol for 0.5-1.5 hr to obtain filtrate, and concentrating the filtrate under reduced pressure until the contents of bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei are 2g/ml to obtain extract.
A gel plaster containing an external traditional Chinese medicine composition for reducing fever of children comprises the following components in parts by mass:
the extract is obtained by extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei to obtain filtrate, and concentrating.
The preparation method of the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition comprises the following steps:
(1) dissolving tartaric acid in a mixed solution of deionized water and bupleuri radix aromatic water, adding polyvinylpyrrolidone K90, carbomer 934 and carbomer 941, and standing to obtain a first mixture;
(2) mixing sodium polyacrylate NP700, dihydroxyaluminum glycolate, glycerol, propylene glycol and sorbitol, and adding the extract and the mixture I; stirring, mixing, and coating to obtain topical Chinese medicinal composition gel plaster for treating infantile fever.
Preferably, the standing in the step (1) is 12-24 h.
Preferably, in the step (2): and (3) stirring and mixing the sodium polyacrylate NP700, the dihydroxyaluminum glycinate, the glycerol, the propylene glycol and the sorbitol, wherein the stirring speed is more than or equal to 120rpm, the stirring time is more than or equal to 15min, the extractum is added, the mixture is stirred again after the first time, the stirring speed is more than or equal to 240pm, and the stirring time is more than or equal to 20 min.
Preferably, in the step (2): the thickness of the coating was 1 mm.
Preferably, in the step (2): after coating, the coating solution should be left standing at 25 ℃ and 60% RH for at least 12 hours.
The Chinese medicinal composition consists of radix bupleuri, gardenia and raw rhubarb. The medicines in the formula are harmonized, and have the effects of clearing away heat and toxic materials and purging pathogenic fire. Meanwhile, the gel plaster contains 30-60% of water, so that the medicine can be persistently promoted to be released to the skin, and the heat on the skin can be taken away by the evaporation of the water, thereby playing the role of physical cooling. Clinical verification shows that the medicine has better effect of treating the infantile fever.
The gel plaster prepared by the invention can simultaneously exert the efficacy of antipyresis of traditional Chinese medicine compatibility and the efficacy of physical cooling of the plaster; and the medicine has large medicine-carrying amount and convenient use, and provides a safe, effective and easily-accepted preparation for children with exogenous fever.
Detailed Description
The following specific examples are provided to further illustrate the present invention so that those skilled in the art may better understand the invention and practice it, but the examples are not intended to limit the invention. Other various modifications, substitutions and alterations of the above-described structures of the present invention will occur to those skilled in the art without departing from the basic technical spirit of the invention as described herein.
The Chinese medicinal herbs of the invention are bupleurum, gardenia and rhubarb. The crude drug refers to natural plant, animal and mineral crude drugs which are not processed or simply processed. In the present invention, the crude drugs particularly refer to three Chinese medicinal materials of bupleurum, gardenia and raw rhubarb.
Unless otherwise specified, the parts are parts by mass.
The pediatric antipyretic external traditional Chinese medicine composition is weighed according to the proportion in the following table 1.
TABLE 1
| Serial number | Radix bupleuri | Gardenia jasminoides ellis | Radix Et rhizoma Rhei |
| Combination 1 | 5 | 3 | 1 |
| Combination 2 | 4 | 2 | 1 |
| Combination 3 | 5 | 2 | 1 |
The preparation of the traditional Chinese medicine composition comprises two parts of radix bupleuri aromatic water and extract: the preparation method of the composition 1 and the composition 3 in the table 1 comprises the following steps:
(1) preparation of radix bupleuri aromatic water: taking Bupleurum chinense of combination 1 or combination 3 in Table 1, adding 6 times deionized water, soaking at 40 deg.C for 12 hr, distilling, and collecting distillate twice the weight of Bupleurum chinense; after the distillate is cooled to room temperature, adding pure propylene glycol with the mass percent of 2% of the distillate, and uniformly mixing to obtain radix bupleuri aromatic water; the distilled bupleurum dregs are reserved.
(2) Preparing an extract: filtering the radix bupleuri dregs in the step (1) at normal temperature and normal pressure, taking filter residues, and adding gardenia and raw rhubarb with the amount of combination 1 or combination 3 in the table 1; adding 80% ethanol with volume percentage 8 times of the total mass of the crude drugs; reflux extraction is carried out for 0.5h, and condensed water is continuously dripped when the reflux temperature is higher than the boiling point of ethanol to obtain filtrate; concentrating the filtrate under reduced pressure to concentration of 2g crude drug/mL under vacuum degree of-0.09 to-0.1 Mpa; thus obtaining the extract.
The preparation method of the composition 2 in the table 1 comprises the following steps:
(1) preparation of radix bupleuri aromatic water: taking 2 mass of radix bupleuri in the composition in Table 1, adding 6 times of deionized water, soaking at 60 ℃ for 3h, then distilling, and collecting distillate twice the mass of the radix bupleuri; after the distillate is cooled to room temperature, adding pure propylene glycol with 5% of the mass of the distillate, and uniformly mixing to obtain radix bupleuri aromatic water; the distilled bupleurum dregs are reserved.
(2) Preparing an extract: filtering the radix bupleuri dregs obtained in the step (1) at normal temperature and normal pressure, taking filter residues, and adding 2 combined amounts of gardenia and raw rhubarb in the table 1; adding 60% ethanol with volume percentage 12 times of the total mass of the crude drugs; reflux extraction is carried out for 1.5h, and condensed water is continuously dripped when the reflux temperature is higher than the boiling point of ethanol to obtain filtrate; concentrating the filtrate under reduced pressure to concentration of 2g crude drug/mL under vacuum degree of-0.09 to-0.1 Mpa; thus obtaining the extract.
Preparation of external traditional Chinese medicine composition gel plaster for defervescing of children
Example one
Step (1): dissolving 70 parts of tartaric acid in mixed liquid of 3360 parts of deionized water and 1600 parts of radix bupleuri aromatic water, adding polyvinylpyrrolidone K90200 parts, carbomer 93450 parts and carbomer 94150 parts, and standing for 12 hours to fully swell the polyvinylpyrrolidone K90, the carbomer 934 and the carbomer 941; to obtain a first mixture.
Step (2): mixing 700800 parts of sodium polyacrylate NP, 70 parts of dihydroxyaluminum glycerol, 2500 parts of glycerol, 250 parts of propylene glycol and 250 parts of sorbitol, stirring at 120rpm for 15min, adding 800 parts of the extract and the mixture I, continuously stirring at 240rpm for 20min, and coating at room temperature to obtain a coating with a thickness of 1 mm. Standing at 25 deg.C and 60% RH for 12h, cutting into certain specification, packaging into aluminum foil bags, and sealing to obtain topical Chinese medicinal composition gel plaster for treating infantile fever.
This example uses the bupleurum aroma and extract prepared in combination 1.
Example two
Step (1): dissolving 50 parts of tartaric acid in a mixed solution of 4000 parts of deionized water and 1400 parts of radix bupleuri aromatic water, adding polyvinylpyrrolidone K90300 parts, carbomer 93425 parts and carbomer 94125 parts, and standing for 24 hours to fully swell the polyvinylpyrrolidone K90, the carbomer 934 and the carbomer 941; to obtain a first mixture.
Step (2): mixing sodium polyacrylate NP 700700 parts, aluminum glyceroxide 50 parts, glycerol 2000 parts, propylene glycol 250 parts and sorbitol 500 parts, stirring at 120rpm for 15min, adding 700 parts of the extract and the mixture I, stirring at 240rpm for 20min, and coating at room temperature to obtain a coating with a thickness of 1 mm. Standing at 25 deg.C and 60% RH for 12h, cutting into certain specification, packaging into aluminum foil bags, and sealing to obtain topical Chinese medicinal composition gel plaster for treating infantile fever.
This example uses the bupleurum aroma and extract prepared in combination 2.
EXAMPLE III
Step (1): dissolving 30 parts of tartaric acid in a mixed solution of 4120 parts of deionized water and 1200 parts of radix bupleuri aromatic water, adding polyvinylpyrrolidone K90400 parts, carbomer 93410 parts and carbomer 94110 parts, and standing for 12 hours to fully swell the polyvinylpyrrolidone K90, the carbomer 934 and the carbomer 941; to obtain a first mixture.
Step (2): mixing sodium polyacrylate NP 700600 parts, aluminum glyceroxide 30 parts, glycerol 2000 parts, propylene glycol 500 parts and sorbitol 500 parts, stirring at 120rpm for 15min, adding 600 parts of the extract and the mixture I, stirring at 240rpm for 20min, and coating at room temperature to obtain a coating with a thickness of 1 mm. Standing at 25 deg.C and 60% RH for 12h, cutting into certain specification, packaging into aluminum foil bags, and sealing to obtain topical Chinese medicinal composition gel plaster for treating infantile fever.
This example uses the bupleurum aroma and extract prepared in combination 3.
Application of clinical Effect test
Test subjects: 100 cases of infantile fever, among which: 60 men and 40 women, the oldest 12 years old and the youngest 2 years old.
The treatment method comprises the following steps:
the parallel control principle was used to divide 100 febrile children into 4 groups, of which the treatment groups were examples 1-3, and the positive control group was 1 group, with 25 patients each.
Treatment groups: the gel plasters of the embodiments 1 to 3 are respectively applied to the Dazhui acupoint of a patient for 1 time respectively in the morning and evening, each time is applied for 4 to 6 hours, and 3 days are a treatment course.
Positive control group: the sunflower medical antipyretic patch is coated with a conventional medicament and is used according to a method of a specification.
Treatment criteria were:
the effect is shown: the body temperature returns to normal within 4 hours after the medicine is taken;
the method has the following advantages: the body temperature drops to more than or equal to 1 ℃ on the original basis within 4 hours after the medicine is taken;
and (4) invalidation: the body temperature decreased <1 ℃ on the original basis or increased instead within 4 hours after administration.
The treatment results are shown in table 2.
TABLE 2
| Number of examples | Show effect | Is effective | Invalidation | Total effective rate (%) | |
| Example 1 | 25 | 16 | 8 | 1 | 96 |
| Example 2 | 25 | 15 | 8 | 2 | 92 |
| Example 3 | 25 | 13 | 10 | 2 | 92 |
| Positive control | 25 | 14 | 9 | 2 | 92 |
From the above results, the average total effective rate of examples 1-3 is 93%, which shows that the product of the present invention has a better therapeutic effect on infantile fever abatement.
Claims (10)
1. An external Chinese medicinal composition for treating infantile fever is characterized by comprising radix bupleuri, cape jasmine and raw rhubarb; the mass ratio of the radix bupleuri, the cape jasmine and the raw rhubarb is 5-4:2-3: 1.
2. The method for preparing the traditional Chinese medicine composition for external use for children to defervesce according to claim 1, wherein the traditional Chinese medicine composition for external use for children to defervesce comprises two parts of radix bupleuri aromatic water and extract:
preparation of radix bupleuri aromatic water: soaking bupleuri radix in water, distilling, collecting distillate, and adding propylene glycol to obtain bupleuri radix aromatic water; distilling bupleuri radix residue;
preparing an extract: reflux-extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei in ethanol, and concentrating the filtrate under reduced pressure to obtain extract.
3. The preparation method of the external traditional Chinese medicine composition for children defervescence according to claim 2, which is characterized in that in the preparation step of the bupleurum aromatic water:
the amount of the water is 6-10 times of the mass of the bupleurum; the dipping condition is dipping for 3-12h at 40-60 ℃; then distilling and collecting distillate with the mass at least two times of that of the radix bupleuri; 2 to 5 mass percent of propylene glycol is added into the distillate.
4. The preparation method of the external traditional Chinese medicine composition for children defervescence according to claim 2, which is characterized in that in the preparation step of the extract:
reflux-extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei in 8-12 times of 60-80% volume fraction ethanol for 0.5-1.5 hr to obtain filtrate, and concentrating the filtrate under reduced pressure until the contents of bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei are 2g/ml to obtain extract.
5. A gel plaster containing an external traditional Chinese medicine composition for reducing fever of children is characterized by comprising the following components in parts by mass:
the extract is obtained by extracting bupleuri radix residue, fructus Gardeniae and radix et rhizoma Rhei to obtain filtrate, and concentrating.
6. The preparation method of the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition according to claim 5, which is characterized by comprising the following steps:
(1) dissolving tartaric acid in a mixed solution of deionized water and bupleuri radix aromatic water, adding polyvinylpyrrolidone K90, carbomer 934 and carbomer 941, and standing to obtain a first mixture;
(2) mixing sodium polyacrylate NP700, dihydroxyaluminum glycolate, glycerol, propylene glycol and sorbitol, and adding the extract and the mixture I; stirring, mixing, and coating to obtain topical Chinese medicinal composition gel plaster for treating infantile fever.
7. The method for preparing the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition according to claim 6, wherein the step (1) is performed for 12-24 hours.
8. The method for preparing the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition according to claim 6, wherein in the step (2): mixing sodium polyacrylate NP700, dihydroxyaluminum glycolate, glycerol, propylene glycol and sorbitol under stirring at a speed of not less than 120rpm for not less than 15 min; adding the extract and the mixture, and stirring again under the conditions that the stirring speed is more than or equal to 240rpm and the stirring time is more than or equal to 20 min.
9. The method for preparing the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition according to claim 6, wherein in the step (2): the thickness of the coating was 1 mm.
10. The method for preparing the gel plaster containing the pediatric antipyretic external traditional Chinese medicine composition according to any one of claims 6 to 9, wherein in the step (2): after coating, the coating solution should be left standing at 25 ℃ and 60% RH for at least 12 hours.
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| CN109718286A (en) * | 2019-03-07 | 2019-05-07 | 张春梅 | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of fever |
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| CN101224244A (en) * | 2007-12-31 | 2008-07-23 | 浙江省中医院 | Children clearing heat suppository and preparing method thereof |
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Application publication date: 20200918 |