CN106237205A

CN106237205A - A kind of medicine treating asthma and preparation method thereof

Info

Publication number: CN106237205A
Application number: CN201610713602.0A
Authority: CN
Inventors: 李永国
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-24
Filing date: 2016-08-24
Publication date: 2016-12-21

Abstract

The present invention provides a kind of medicine treating asthma, relates to the field of Chinese medicines.The primary raw material of described medicine is: herba meliloti, Herba Reineckeae Carneae, bad grass, Flos Sauropi changiani leaf, Dendrobium jenkinsii Wall ex Lindl．, Flos Gomphrenae, Herba Spilanthis Acmellae, Aster auriculatus Franch., Cortex Seu Radix Wikstroemiae Micranthae, dark blue thick stick, Herba Buddlejae Lindleyanae, Herba Droserae rotundifoliae, Radix Roscoeae Intermediae, Herba Dracocephali Integrifolii and Radix Glycyrrhizae.The each crude drug of the present invention, through scientific compatibility, synergism, has effect of nourishing the lung to arrest cough, lowering the adverse QI to relieve asthma and promoting flow of QI and blood, respond well for treating asthma, has specific aim high, and safety has no side effect, and is worth of widely use.

Description

A kind of medicine treating asthma and preparation method thereof

Technical field

The present invention relates to Chinese drug preparation technique field, be specifically related to a kind of medicine treating asthma and preparation method thereof.

Background technology

Asthma is a kind of common multiple diseases, is to be drenched by various kinds of cell particularly mastocyte, eosinophilic granulocyte and T The chronic airway inflammation that bar cell participates in.In the recent decade, the country such as the U.S., Britain, Australia, New Zealand asthma prevalence On the rise with mortality rate, the whole world there are about 100,000,000 asthmatic patients, it has also become the one of serious threat public health is main slow Property disease.Its clinical symptoms is: has premonitory symptom such as sneeze, watery nasal discharge before outbreak, coughs, uncomfortable in chest etc., as processed not in time, and can Asthma occur because bronchial obstruction increases the weight of, severe patient can be forced to take seat or in orthopnea, dry cough or cough up a large amount of white , even there is cyanosis etc. in frothy sputum.If bronchial asthma patient occurs that serious acute shows effect, treatment not in time may be fatal； Control the best asthmatic patient routine work and daily life all can be made a difference.

At present, use Chinese and Western combination, its medicine many employings aminophylline, ephedrine, diphenhydramine the treatment of asthma more With antibiotics etc., though these medicines can play mitigation for the moment, but great majority all can not enter for the pathogenic factor of asthma Row treatment, cures the symptoms, not the disease, easily recurs after drug withdrawal, and some medicine has bigger side effect, it is impossible to long-term taking；Therefore be badly in need of grinding Make a kind of effective treatment asthma and the medicament having no side effect.

Summary of the invention

It is an object of the invention to: for the problem of above-mentioned existence, it is provided that a kind of medicine treating asthma and preparation side thereof Method.Chinese medicine preparation of the present invention is formed by 15 taste Chinese herbal medicine reasonable preparations, complements each other, has nourishing the lung to arrest cough, lowering the adverse QI to relieve asthma and row Effect that gas is invigorated blood circulation, respond well for treating asthma, there is specific aim high, safety has no side effect, and is worth of widely use.

To achieve these goals, the technical solution used in the present invention is as follows: a kind of medicine treating asthma, described medicine Raw material composition and parts by weight be: herba meliloti 11-23 part, Herba Reineckeae Carneae 9-21 part, rely grass 8-24 part, Flos Sauropi changiani leaf 15-27 part, Dendrobium jenkinsii Wall ex Lindl． 6-18 part, Flos Gomphrenae 8-24 part, Herba Spilanthis Acmellae 5-25 part, Aster auriculatus Franch. 10-30 part, Cortex Seu Radix Wikstroemiae Micranthae 11-23 part, dark blue thick stick 12-24 Part, Herba Buddlejae Lindleyanae 9-21 part, Herba Droserae rotundifoliae 12-20 part, Radix Roscoeae Intermediae 8-16 part, Herba Dracocephali Integrifolii 15-27 part, Radix Glycyrrhizae 6-18 part.

Preferably, a kind of medicine treating asthma, the raw material of described medicine forms and parts by weight are: herba meliloti 14- 20 parts, Herba Reineckeae Carneae 12-18 part, rely grass 12-20 part, Flos Sauropi changiani leaf 18-24 part, Dendrobium jenkinsii Wall ex Lindl． 9-15 part, Flos Gomphrenae 12-20 part, astronomy Grass 10-20 part, Aster auriculatus Franch. 15-25 part, Cortex Seu Radix Wikstroemiae Micranthae 14-20 part, dark blue thick stick 15-21 part, Herba Buddlejae Lindleyanae 12-18 part, Herba Droserae rotundifoliae 14- 18 parts, Radix Roscoeae Intermediae 10-14 part, Herba Dracocephali Integrifolii 18-24 part, Radix Glycyrrhizae 9-15 part.

Preferably, a kind of medicine treating asthma, the raw material of described medicine forms and parts by weight are: herba meliloti 17 Part, Herba Reineckeae Carneae 15 parts, bad grass 16 parts, Flos Sauropi changiani leaf 21 parts, Dendrobium jenkinsii Wall ex Lindl． 12 parts, Flos Gomphrenae 16 parts, Herba Spilanthis Acmellae 15 parts, Aster auriculatus Franch. 20 Part, Cortex Seu Radix Wikstroemiae Micranthae 17 parts, 18 parts of dark blue thick stick, Herba Buddlejae Lindleyanae 15 parts, Herba Droserae rotundifoliae 16 parts, Radix Roscoeae Intermediae 12 parts, Herba Dracocephali Integrifolii 21 parts, Radix Glycyrrhizae 12 parts.

Further, according to above-mentioned formula, present invention also offers the preparation method of said medicine, comprise the following steps:

(1) according to weight portion weigh herba meliloti, Herba Reineckeae Carneae, rely grass, Flos Sauropi changiani leaf, Dendrobium jenkinsii Wall ex Lindl．, Flos Gomphrenae, Herba Spilanthis Acmellae, Aster auriculatus Franch., Cortex Seu Radix Wikstroemiae Micranthae, dark blue thick stick, Herba Buddlejae Lindleyanae, Herba Droserae rotundifoliae, Radix Roscoeae Intermediae, Herba Dracocephali Integrifolii and Radix Glycyrrhizae；

(2) after raw material step (1) weighed is cleaned and dried, shred to length less than 1cm, then add raw material gross mass 6- 8 times and alcohol solution dipping 40-60min that volumetric concentration is 75-85%, reflux, extract, 2-3 time subsequently, extract 1-2h every time, close And extract gained liquid, decompression recycling ethanol every time, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；Alcohol extraction is remaining Remaining medicinal residues retain standby；

(3) in the remaining medicinal residues of step (2) gained alcohol extraction, add the water of raw material gross weight 6-8 times, heating and refluxing extraction 2-3 time, extract 1-2 hour every time, merge each extracting solution, then carry out concentrating, be dried, pulverize, obtain water extract dry powder；

(4) by uniform to step (2) gained alcohol extraction thing dry powder and step (3) gained water extract dry powder blend, add pharmaceutically The adjuvant that can receive, makes powder, granule, tablet, pill or capsule.

Further, in Chinese medicine preparation of the present invention, effect and effect of each primary raw material medicine are as follows: herba meliloti: its taste is micro- Sweet, property is put down.There is relieving spasm to stop pain effect.Being mainly used in asthma, bronchitis, intestinal colic, external controls wound, and lymph node swells and ache.

Herba Reineckeae Carneae: its sweet in the mouth, property is put down.There is nourishing the lung to arrest cough, synthetism effect of dispeling the wind.For pulmonary tuberculosis, cough is spat blood, chronic Bronchitis, asthma, rheumatic arthritis；Traumatic injury is controlled in external, fracture.

Rely careless: its bitter in the mouth, cold nature.There is heat clearing away, dampness removing, hemostasia effect.Cure mainly gonorrhea, leucorrhea with red and white discharge, asthma, apoplexy due to phlegm Band blood.

Flos Sauropi changiani leaf: it is lightly seasoned, property is put down." Luchuan book on Chinese herbal medicine ": " cough due to lung-heat is controlled in lung heat clearing." Nanning City's medicine will ": " only phlegm-fire Cough, asthma.

Dendrobium jenkinsii Wall ex Lindl．: its sweet in the mouth, light, cool in nature.There is moistening the lung and resolving phlegm, cough and asthma relieving efficacy.It is mainly used in cough due to lung-heat, roars Breathe heavily.

Flos Gomphrenae: its sweet in the mouth, property is put down.There is relieving cough and asthma, suppressing the hyperactive liver improving eyesight effect.It is mainly used in bronchial asthma, anxious, slow Property bronchitis, pertussis, hemoptysis of pulmonary tuberculosis, dizzy, blurred vision, dysentery.

Herba Spilanthis Acmellae: its acrid in the mouth, warm in nature.There is detoxification and promoting urination, relieving cough and relieving asthma, reducing swelling and alleviating pain effect.It is mainly used in malaria, tooth Bitterly, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis.

Aster auriculatus Franch.: its acrid in the mouth, fiber crops, warm in nature.There is expelling wind and cold, cough and asthma relieving efficacy.Cure mainly flu, asthma, pulmonary tuberculosis Cough, chronic bronchitis.

Cortex Seu Radix Wikstroemiae Micranthae: it is lightly seasoned, property is put down.There is relieving cough and resolving phlegm effect.Cure mainly acute toothache, asthma, pertussis.

Dark blue thick stick: its bitter in the mouth, puckery, property is put down.There is heat-clearing toxin-expelling functions.Cure mainly intermingling cold and heat, dysentery, enteritis and asthma.

Herba Buddlejae Lindleyanae: its taste is micro-pungent, bitter, warm in nature.There is expelling wind and removing dampness, relieving cough and resolving phlegm, dissipating blood stasis disinsection efficiency.It is mainly used in propping up Tracheitis, cough, asthma, rheumatic arthritis, traumatic injury；Wound hemorrhage, burn and scald are controlled in external, and kill maggot and go out wriggler With.

Herba Droserae rotundifoliae: its acrid in the mouth, sweet；Property flat, return lung meridian.Have and eliminate the phlegm, antitussive, relieving asthma, dysentery-stopping efficacy.Cure mainly and cough Cough, asthma, pertussis, dysentery.

Radix Roscoeae Intermediae: its bitter in the mouth, cool in nature.There is lung-clearing asthma-relieving effect.Cure mainly cough, asthma.

Herba Dracocephali Integrifolii: its bitter in the mouth, warm in nature.Have cough-relieving, eliminate the phlegm, effect of relievining asthma.Be mainly used in cough, phlegm dyspnea, chronic Tracheitis.

Radix Glycyrrhizae: its sweet in the mouth, property is put down, is returned 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.? In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, to grow and cough lung moistening, emergency is detoxified, and is in harmonious proportion hundred medicines.Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, stomach Intestinal ulcer and solution poison of drug, alimentary toxicosis etc.；Processed with honey cures mainly spleen and stomach function and goes down, and big loose stool is thin, weak heating and coughing Cough, cardiopalmus etc..

In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:

Medicine of the present invention pathogeny based on asthma, the prescription developed, scientific and reasonable compatibility, it then follows " monarch, minister, assistant, Make " principle, ten five tastes Chinese herbal medicine complement each other, and play the pharmacological function effect of nourishing the lung to arrest cough, lowering the adverse QI to relieve asthma and promoting flow of QI and blood altogether, enter And asthma can be cured the most accurately and rapidly.This medicine is the medicine of a kind of dialectical treatment, have specific aim high, Therapeutic effect is good, effective percentage is high, advantage to human non-toxic's side effect.

Detailed description of the invention

Below by way of specific embodiment, the invention will be further described.

Embodiment 1 one kinds treats the medicine of asthma, and the raw material of described medicine forms and parts by weight are: herba meliloti 23 Part, Herba Reineckeae Carneae 21 parts, bad grass 24 parts, Flos Sauropi changiani leaf 27 parts, Dendrobium jenkinsii Wall ex Lindl． 18 parts, Flos Gomphrenae 24 parts, Herba Spilanthis Acmellae 25 parts, Aster auriculatus Franch. 30 Part, Cortex Seu Radix Wikstroemiae Micranthae 23 parts, 24 parts of dark blue thick stick, Herba Buddlejae Lindleyanae 21 parts, Herba Droserae rotundifoliae 20 parts, Radix Roscoeae Intermediae 16 parts, Herba Dracocephali Integrifolii 27 parts, Radix Glycyrrhizae 18 parts.

Embodiment 2 one kinds treats the medicine of asthma, and the raw material of described medicine forms and parts by weight are: herba meliloti 17 Part, Herba Reineckeae Carneae 15 parts, bad grass 16 parts, Flos Sauropi changiani leaf 21 parts, Dendrobium jenkinsii Wall ex Lindl． 12 parts, Flos Gomphrenae 16 parts, Herba Spilanthis Acmellae 15 parts, Aster auriculatus Franch. 20 Part, Cortex Seu Radix Wikstroemiae Micranthae 17 parts, 18 parts of dark blue thick stick, Herba Buddlejae Lindleyanae 15 parts, Herba Droserae rotundifoliae 16 parts, Radix Roscoeae Intermediae 12 parts, Herba Dracocephali Integrifolii 21 parts, Radix Glycyrrhizae 12 parts.

Embodiment 3 one kinds treats the medicine of asthma, and the raw material of described medicine forms and parts by weight are: herba meliloti 11 Part, Herba Reineckeae Carneae 9 parts, bad grass 8 parts, Flos Sauropi changiani leaf 15 parts, Dendrobium jenkinsii Wall ex Lindl． 6 parts, Flos Gomphrenae 8 parts, Herba Spilanthis Acmellae 5 parts, 10 parts of Aster auriculatus Franch., Cortex Seu Radix Wikstroemiae Micranthae 11 parts, 12 parts of dark blue thick stick, Herba Buddlejae Lindleyanae 9 parts, Herba Droserae rotundifoliae 12 parts, Radix Roscoeae Intermediae 8 parts, Herba Dracocephali Integrifolii 15 parts, 6 parts of Radix Glycyrrhizae.

Embodiment 4 is prepared the method for the medicine of above-described embodiment 1-3 and can be followed the steps below:

(2) after raw material step (1) weighed is cleaned and dried, shred to length less than 1cm, then add raw material gross mass 6 Times and alcohol solution dipping 40min that volumetric concentration is 75%, reflux, extract, 2 times subsequently, extract 1h every time, merge and extract every time Gained liquid, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；The medicinal residues guarantor that alcohol extraction is remaining Stay standby；

(3) in the remaining medicinal residues of step (2) gained alcohol extraction, add the water of raw material gross weight 6 times, heating and refluxing extraction 2 Secondary, extract 1 hour every time, merge each extracting solution, then carry out concentrating, be dried, pulverize, obtain water extract dry powder；

(4) by uniform to step (2) gained alcohol extraction thing dry powder and step (3) gained water extract dry powder blend, add pharmaceutically Powder made by the adjuvant that can receive.

Embodiment 5 is prepared the method for the medicine of above-described embodiment 1-3 and can be followed the steps below:

(2) after raw material step (1) weighed is cleaned and dried, shred to length less than 1cm, then add raw material gross mass 7 Times and alcohol solution dipping 50min that volumetric concentration is 80%, reflux, extract, 3 times subsequently, extract 1.5h every time, merge and carry every time Take gained liquid, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；The medicinal residues that alcohol extraction is remaining Retain standby；

(3) in the remaining medicinal residues of step (2) gained alcohol extraction, add the water of raw material gross weight 7 times, heating and refluxing extraction 3 Secondary, extract 1.5 hours every time, merge each extracting solution, then carry out concentrating, be dried, pulverize, obtain water extract dry powder；

(4) by uniform to step (2) gained alcohol extraction thing dry powder and step (3) gained water extract dry powder blend, add pharmaceutically Granule made by the adjuvant that can receive.

Embodiment 6 is prepared the method for the medicine of above-described embodiment 1-3 and can be followed the steps below:

(2) after raw material step (1) weighed is cleaned and dried, shred to length less than 1cm, then add raw material gross mass 8 Times and alcohol solution dipping 60min that volumetric concentration is 85%, reflux, extract, 3 times subsequently, extract 2h every time, merge and extract every time Gained liquid, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；The medicinal residues guarantor that alcohol extraction is remaining Stay standby；

(3) in the remaining medicinal residues of step (2) gained alcohol extraction, add the water of raw material gross weight 8 times, heating and refluxing extraction 3 Secondary, extract 2 hours every time, merge each extracting solution, then carry out concentrating, be dried, pulverize, obtain water extract dry powder；

(4) by uniform to step (2) gained alcohol extraction thing dry powder and step (3) gained water extract dry powder blend, add pharmaceutically Pill made by the adjuvant that can receive.

Claims

1. the medicine treating asthma, it is characterised in that: the raw material of described medicine forms and parts by weight are: herba meliloti 11-23 part, Herba Reineckeae Carneae 9-21 part, bad grass 8-24 part, Flos Sauropi changiani leaf 15-27 part, Dendrobium jenkinsii Wall ex Lindl． 6-18 part, Flos Gomphrenae 8-24 part, astronomy Grass 5-25 part, Aster auriculatus Franch. 10-30 part, Cortex Seu Radix Wikstroemiae Micranthae 11-23 part, dark blue thick stick 12-24 part, Herba Buddlejae Lindleyanae 9-21 part, Herba Droserae rotundifoliae 12-20 Part, Radix Roscoeae Intermediae 8-16 part, Herba Dracocephali Integrifolii 15-27 part, Radix Glycyrrhizae 6-18 part.

A kind of medicine treating asthma the most according to claim 1, it is characterised in that: the raw material composition of described medicine and weight Amount number is:

Herba meliloti 14-20 part, Herba Reineckeae Carneae 12-18 part, rely grass 12-20 part, Flos Sauropi changiani leaf 18-24 part, Dendrobium jenkinsii Wall ex Lindl． 9-15 part, thousand days Red 12-20 part, Herba Spilanthis Acmellae 10-20 part, Aster auriculatus Franch. 15-25 part, Cortex Seu Radix Wikstroemiae Micranthae 14-20 part, dark blue thick stick 15-21 part, Herba Buddlejae Lindleyanae 12-18 Part, Herba Droserae rotundifoliae 14-18 part, Radix Roscoeae Intermediae 10-14 part, Herba Dracocephali Integrifolii 18-24 part, Radix Glycyrrhizae 9-15 part.

A kind of medicine treating asthma the most according to claim 1, it is characterised in that: the raw material composition of described medicine and weight Amount number is: herba meliloti 17 parts, Herba Reineckeae Carneae 15 parts, bad grass 16 parts, Flos Sauropi changiani leaf 21 parts, Dendrobium jenkinsii Wall ex Lindl． 12 parts, Flos Gomphrenae 16 part, day Literary composition grass 15 parts, 20 parts of Aster auriculatus Franch., Cortex Seu Radix Wikstroemiae Micranthae 17 parts, 18 parts of dark blue thick stick, Herba Buddlejae Lindleyanae 15 parts, Herba Droserae rotundifoliae 16 parts, Radix Roscoeae Intermediae 12 parts, Herba Dracocephali Integrifolii 21 parts, 12 parts of Radix Glycyrrhizae.

4. according to a kind of medicine treating asthma according to any one of claim 1-3, it is characterised in that: described medicine is scattered Agent, granule, tablet, pill or capsule.

5. according to the preparation method of a kind of medicine treating asthma according to any one of claim 1-4, it is characterised in that: bag Include following steps: