CN111647000B - 吡嗪类衍生物及其在抑制shp2中的应用 - Google Patents

吡嗪类衍生物及其在抑制shp2中的应用 Download PDF

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Publication number
CN111647000B
CN111647000B CN201910160960.7A CN201910160960A CN111647000B CN 111647000 B CN111647000 B CN 111647000B CN 201910160960 A CN201910160960 A CN 201910160960A CN 111647000 B CN111647000 B CN 111647000B
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compound
radical
formula
halogen atom
membered
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CN201910160960.7A
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Chinese (zh)
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CN111647000A (zh
Inventor
孙海丰
王奎锋
李坤
汪波
戴诚
张涛
丁福云
马梦楠
陆金昌
李瑶
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Qinhao Pharmaceutical Suzhou Co Ltd
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Suzhou Genhouse Pharmaceutical Co ltd
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Priority to CN201910160960.7A priority Critical patent/CN111647000B/zh
Application filed by Suzhou Genhouse Pharmaceutical Co ltd filed Critical Suzhou Genhouse Pharmaceutical Co ltd
Priority to SG11202109603S priority patent/SG11202109603SA/en
Priority to AU2020233038A priority patent/AU2020233038B2/en
Priority to EP20766519.1A priority patent/EP3936502A4/en
Priority to CA3132395A priority patent/CA3132395A1/en
Priority to JP2021551865A priority patent/JP2022523786A/ja
Priority to US17/436,223 priority patent/US12338246B2/en
Priority to NZ780509A priority patent/NZ780509B2/en
Priority to KR1020217031808A priority patent/KR20210135561A/ko
Priority to IL286069A priority patent/IL286069B2/en
Priority to PCT/CN2020/077391 priority patent/WO2020177653A1/zh
Priority to MX2021010625A priority patent/MX2021010625A/es
Priority to CN202080014053.2A priority patent/CN113474338B/zh
Priority to BR112021017495A priority patent/BR112021017495A2/pt
Priority to PH1/2021/552134A priority patent/PH12021552134A1/en
Publication of CN111647000A publication Critical patent/CN111647000A/zh
Priority to CL2021002308A priority patent/CL2021002308A1/es
Priority to CONC2021/0013140A priority patent/CO2021013140A2/es
Application granted granted Critical
Publication of CN111647000B publication Critical patent/CN111647000B/zh
Priority to US18/101,511 priority patent/US11827644B2/en
Priority to US19/219,936 priority patent/US20250282791A1/en
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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CN201910160960.7A 2019-03-04 2019-03-04 吡嗪类衍生物及其在抑制shp2中的应用 Active CN111647000B (zh)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CN201910160960.7A CN111647000B (zh) 2019-03-04 2019-03-04 吡嗪类衍生物及其在抑制shp2中的应用
MX2021010625A MX2021010625A (es) 2019-03-04 2020-03-02 Derivado de pirazina y aplicacion del mismo en la inhibicion de shp2.
EP20766519.1A EP3936502A4 (en) 2019-03-04 2020-03-02 PYRAZINE DERIVATIVES AND THEIR USE TO INHIBIT SHP2
CA3132395A CA3132395A1 (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting shp2
JP2021551865A JP2022523786A (ja) 2019-03-04 2020-03-02 ピラジン誘導体およびｓｈｐ２の阻害の際のその適用
US17/436,223 US12338246B2 (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting SHP2
NZ780509A NZ780509B2 (en) 2020-03-02 Pyrazine derivative and application thereof in inhibiting shp2
BR112021017495A BR112021017495A2 (pt) 2019-03-04 2020-03-02 Derivado de pirazina e sua aplicação na inibição de shp2
AU2020233038A AU2020233038B2 (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting SHP2
PCT/CN2020/077391 WO2020177653A1 (zh) 2019-03-04 2020-03-02 吡嗪类衍生物及其在抑制shp2中的应用
SG11202109603S SG11202109603SA (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting shp2
IL286069A IL286069B2 (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting shp2
KR1020217031808A KR20210135561A (ko) 2019-03-04 2020-03-02 피라진 유도체 및 shp2 억제에서의 그의 적용
PH1/2021/552134A PH12021552134A1 (en) 2019-03-04 2020-03-02 Pyrazine derivative and application thereof in inhibiting shp2
CN202080014053.2A CN113474338B (zh) 2019-03-04 2020-03-02 吡嗪类衍生物及其在抑制shp2中的应用
CL2021002308A CL2021002308A1 (es) 2019-03-04 2021-09-03 Derivado de pirazina y aplicación del mismo en la inhibición de shp2
CONC2021/0013140A CO2021013140A2 (es) 2019-03-04 2021-09-30 Derivado de pirazina y aplicación del mismo en la inhibición de shp2
US18/101,511 US11827644B2 (en) 2019-03-04 2023-01-25 Pyrazine derivative and application thereof in inhibiting SHP2
US19/219,936 US20250282791A1 (en) 2019-03-04 2025-05-27 Pyrazine derivative and application thereof in inhibiting shp2

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Application Number Priority Date Filing Date Title
CN201910160960.7A CN111647000B (zh) 2019-03-04 2019-03-04 吡嗪类衍生物及其在抑制shp2中的应用

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CN111647000B true CN111647000B (zh) 2021-10-12

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CN202080014053.2A Active CN113474338B (zh) 2019-03-04 2020-03-02 吡嗪类衍生物及其在抑制shp2中的应用

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US (3) US12338246B2 (https=)
EP (1) EP3936502A4 (https=)
JP (1) JP2022523786A (https=)
KR (1) KR20210135561A (https=)
CN (2) CN111647000B (https=)
AU (1) AU2020233038B2 (https=)
BR (1) BR112021017495A2 (https=)
CA (1) CA3132395A1 (https=)
CL (1) CL2021002308A1 (https=)
CO (1) CO2021013140A2 (https=)
IL (1) IL286069B2 (https=)
MX (1) MX2021010625A (https=)
PH (1) PH12021552134A1 (https=)
SG (1) SG11202109603SA (https=)
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US12030875B2 (en) 2018-09-07 2024-07-09 PIC Therapeutics, Inc. EIF4E inhibitors and uses thereof
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