CN111615748B - 微尺度和中尺度冷凝器装置 - Google Patents

微尺度和中尺度冷凝器装置 Download PDF

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Publication number
CN111615748B
CN111615748B CN201980008769.9A CN201980008769A CN111615748B CN 111615748 B CN111615748 B CN 111615748B CN 201980008769 A CN201980008769 A CN 201980008769A CN 111615748 B CN111615748 B CN 111615748B
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array
microchannel
fluid
lattice
pillars
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CN111615748A (zh
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B·旺施
J·史密斯
金圣哲
S·吉福德
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International Business Machines Corp
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International Business Machines Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/44—Edge filtering elements, i.e. using contiguous impervious surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201980008769.9A 2018-01-19 2019-01-14 微尺度和中尺度冷凝器装置 Active CN111615748B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/875,862 US20190226953A1 (en) 2018-01-19 2018-01-19 Microscale and mesoscale condenser devices
US15/875,862 2018-01-19
PCT/IB2019/050271 WO2019142086A1 (en) 2018-01-19 2019-01-14 Microscale and mesoscale condenser devices

Publications (2)

Publication Number Publication Date
CN111615748A CN111615748A (zh) 2020-09-01
CN111615748B true CN111615748B (zh) 2023-08-29

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US (3) US20190226953A1 (enExample)
JP (1) JP7332245B2 (enExample)
CN (1) CN111615748B (enExample)
DE (1) DE112019000163T5 (enExample)
GB (1) GB2583301B (enExample)
WO (1) WO2019142086A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458474B2 (en) 2018-01-19 2022-10-04 International Business Machines Corporation Microfluidic chips with one or more vias
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US11517873B2 (en) 2019-10-29 2022-12-06 International Business Machines Corporation Controlled chemical synthesis using polymer substrates and nanofluidic separation systems
US20230285966A1 (en) * 2020-07-29 2023-09-14 Board Of Regents, The University Of Texas System Nanofabrication of deterministic diagnostic devices
US20240082839A1 (en) * 2021-01-22 2024-03-14 Hewlett-Packard Development Company, L.P. Microfluidic device chamber pillars
US12186748B2 (en) 2022-06-24 2025-01-07 Hewlett-Packard Development Company, L.P. Self-priming microfluidic structures
US12236226B2 (en) 2022-08-11 2025-02-25 Ford Global Technologies, Llc Secure update and audit of electronic control units

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0926283A (ja) * 1995-07-07 1997-01-28 Sakushiyon Gas Kikan Seisakusho:Kk 多管式熱交換器
CN101340836A (zh) * 2005-10-21 2009-01-07 开利商业冷藏公司 使用微通道管道的抗结垢冷凝器
CN102052803A (zh) * 2010-12-13 2011-05-11 上海环球制冷设备有限公司 集成冷凝满液式蒸发器装置及使用方法
CN105161473A (zh) * 2015-07-09 2015-12-16 江苏中圣压力容器装备制造有限公司 硅基毛细泵回路微型冷却器

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892681B2 (en) 2005-07-19 2011-02-22 Pelton Walter E System of distributed electrochemical cells integrated with microelectronic structures
DE60332046D1 (de) 2002-10-23 2010-05-20 Univ Princeton Verfahren zur kontinuierlichen teilchentrennung unter verwendungvon zu feldern asymmetrisch ausgerichteten hindernisarrays
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB2427468B (en) 2005-04-05 2011-03-02 Cellpoint Diagnostics Cell separation device and method for the detection of EpCAM positive cells
WO2006124597A2 (en) 2005-05-12 2006-11-23 Foster Ron B Infinitely stackable interconnect device and method
US7863189B2 (en) 2007-01-05 2011-01-04 International Business Machines Corporation Methods for fabricating silicon carriers with conductive through-vias with low stress and low defect density
FR2931141B1 (fr) 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
ES2628181T3 (es) 2008-07-24 2017-08-02 The Trustees Of Princeton University Dispositivo de matriz de choque que tiene espacios de separación asimétricos para la segregación de partículas
US8093099B2 (en) 2008-09-26 2012-01-10 International Business Machines Corporation Lock and key through-via method for wafer level 3D integration and structures produced
WO2010124155A1 (en) 2009-04-23 2010-10-28 Logos Energy, Inc. Lateral displacement array for microfiltration
US9039996B2 (en) 2010-10-12 2015-05-26 Stmicroelectronics, Inc. Silicon substrate optimization for microarray technology
CN103889556A (zh) * 2011-01-06 2014-06-25 Gpb科学有限责任公司 在引入亲和性和大小两者的微流体芯片上的循环肿瘤细胞捕获
US20170271207A9 (en) 2011-01-29 2017-09-21 International Business Machines Corporation Novel 3D Integration Method Using SOI Substrates And Structures Produced Thereby
CN102856329B (zh) 2011-06-30 2015-02-11 中芯国际集成电路制造(上海)有限公司 一种硅通孔封装方法
EP2964390B1 (en) 2013-03-06 2018-12-26 President and Fellows of Harvard College Use of devices for forming relatively monodisperse droplets
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN113512522A (zh) 2013-03-15 2021-10-19 普林斯顿大学理事会 用于高通量纯化的方法和设备
WO2014166000A1 (en) 2013-04-11 2014-10-16 The Governing Council Of The University Of Toronto Device for capture of particles in a flow
EP3560591B1 (en) 2013-10-18 2021-02-17 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
CA2930430A1 (en) 2013-11-22 2015-05-28 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
JP6649377B2 (ja) 2014-11-03 2020-02-19 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置による粒子の複合式分類および濃縮
US10058895B2 (en) 2014-11-26 2018-08-28 International Business Machines Corporation Continuous flow, size-based separation of entities down to the nanometer scale using nanopillar arrays
US9636675B2 (en) 2014-11-26 2017-05-02 International Business Machines Corporation Pillar array structure with uniform and high aspect ratio nanometer gaps
US9835538B2 (en) 2014-11-26 2017-12-05 International Business Machines Corporation Biopolymer separation using nanostructured arrays
US10976232B2 (en) * 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
CN105293428B (zh) 2015-10-19 2017-04-19 北京航天控制仪器研究所 一种mems器件的全硅化圆片级真空封装方法及封装器件
US9700891B2 (en) 2015-11-13 2017-07-11 International Business Machines Corporation Integrated nanofluidic arrays for high capacity colloid separation
WO2017087940A1 (en) 2015-11-20 2017-05-26 University Of Kansas Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
US10507466B2 (en) 2016-04-27 2019-12-17 International Business Machines Corporation Metal assisted chemical etching for fabricating high aspect ratio and straight silicon nanopillar arrays for sorting applications
JP6933212B2 (ja) * 2016-06-20 2021-09-08 凸版印刷株式会社 液体媒体の置換方法及び該方法のための流路デバイス
US10386276B2 (en) 2016-09-20 2019-08-20 International Business Machines Corporation Phosphoprotein detection using a chip-based pillar array
US10010883B2 (en) 2016-09-20 2018-07-03 International Business Machines Corporation Deterministic lateral displacement arrays
US10253350B2 (en) 2016-09-20 2019-04-09 International Business Machines Corporation Separation of molecules using nanopillar arrays
US20200038861A1 (en) 2016-10-07 2020-02-06 The Regents Of The University Of Michigan Systems and methods for high throughput screening
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US11033901B2 (en) 2018-10-23 2021-06-15 International Business Machines Corporation Biomarker detection using integrated purification-detection devices

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0926283A (ja) * 1995-07-07 1997-01-28 Sakushiyon Gas Kikan Seisakusho:Kk 多管式熱交換器
CN101340836A (zh) * 2005-10-21 2009-01-07 开利商业冷藏公司 使用微通道管道的抗结垢冷凝器
CN102052803A (zh) * 2010-12-13 2011-05-11 上海环球制冷设备有限公司 集成冷凝满液式蒸发器装置及使用方法
CN105161473A (zh) * 2015-07-09 2015-12-16 江苏中圣压力容器装备制造有限公司 硅基毛细泵回路微型冷却器

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JP7332245B2 (ja) 2023-08-23
US20210231543A1 (en) 2021-07-29
US11566982B2 (en) 2023-01-31
GB2583301B (en) 2022-11-16
CN111615748A (zh) 2020-09-01
WO2019142086A1 (en) 2019-07-25
GB202010161D0 (en) 2020-08-19
DE112019000163T5 (de) 2020-07-09
US20190226953A1 (en) 2019-07-25
US11754476B2 (en) 2023-09-12
GB2583301A (en) 2020-10-21
JP2021511203A (ja) 2021-05-06
US20230097357A1 (en) 2023-03-30

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