CN111615748B - 微尺度和中尺度冷凝器装置 - Google Patents
微尺度和中尺度冷凝器装置 Download PDFInfo
- Publication number
- CN111615748B CN111615748B CN201980008769.9A CN201980008769A CN111615748B CN 111615748 B CN111615748 B CN 111615748B CN 201980008769 A CN201980008769 A CN 201980008769A CN 111615748 B CN111615748 B CN 111615748B
- Authority
- CN
- China
- Prior art keywords
- array
- microchannel
- fluid
- lattice
- pillars
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/44—Edge filtering elements, i.e. using contiguous impervious surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Fluid Mechanics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/875,862 US20190226953A1 (en) | 2018-01-19 | 2018-01-19 | Microscale and mesoscale condenser devices |
| US15/875,862 | 2018-01-19 | ||
| PCT/IB2019/050271 WO2019142086A1 (en) | 2018-01-19 | 2019-01-14 | Microscale and mesoscale condenser devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111615748A CN111615748A (zh) | 2020-09-01 |
| CN111615748B true CN111615748B (zh) | 2023-08-29 |
Family
ID=67298103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980008769.9A Active CN111615748B (zh) | 2018-01-19 | 2019-01-14 | 微尺度和中尺度冷凝器装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20190226953A1 (enExample) |
| JP (1) | JP7332245B2 (enExample) |
| CN (1) | CN111615748B (enExample) |
| DE (1) | DE112019000163T5 (enExample) |
| GB (1) | GB2583301B (enExample) |
| WO (1) | WO2019142086A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11458474B2 (en) | 2018-01-19 | 2022-10-04 | International Business Machines Corporation | Microfluidic chips with one or more vias |
| US20190226953A1 (en) | 2018-01-19 | 2019-07-25 | International Business Machines Corporation | Microscale and mesoscale condenser devices |
| US10946380B2 (en) | 2018-01-19 | 2021-03-16 | International Business Machines Corporation | Microfluidic chips for particle purification and fractionation |
| US11517873B2 (en) | 2019-10-29 | 2022-12-06 | International Business Machines Corporation | Controlled chemical synthesis using polymer substrates and nanofluidic separation systems |
| EP4281534A4 (en) * | 2021-01-22 | 2024-03-13 | Hewlett-Packard Development Company, L.P. | MICROFLUIDIC DEVICE CHAMBER PILLARS |
| US12186748B2 (en) | 2022-06-24 | 2025-01-07 | Hewlett-Packard Development Company, L.P. | Self-priming microfluidic structures |
| US12236226B2 (en) | 2022-08-11 | 2025-02-25 | Ford Global Technologies, Llc | Secure update and audit of electronic control units |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0926283A (ja) * | 1995-07-07 | 1997-01-28 | Sakushiyon Gas Kikan Seisakusho:Kk | 多管式熱交換器 |
| CN101340836A (zh) * | 2005-10-21 | 2009-01-07 | 开利商业冷藏公司 | 使用微通道管道的抗结垢冷凝器 |
| CN102052803A (zh) * | 2010-12-13 | 2011-05-11 | 上海环球制冷设备有限公司 | 集成冷凝满液式蒸发器装置及使用方法 |
| CN105161473A (zh) * | 2015-07-09 | 2015-12-16 | 江苏中圣压力容器装备制造有限公司 | 硅基毛细泵回路微型冷却器 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7892681B2 (en) | 2005-07-19 | 2011-02-22 | Pelton Walter E | System of distributed electrochemical cells integrated with microelectronic structures |
| ES2341103T3 (es) | 2002-10-23 | 2010-06-15 | The Trustees Of Princeton University | Procedimiento de separacion continua de particulas usando reticulados de obstaculos alineados asimetricamente respecto a campos. |
| JP2008538282A (ja) | 2005-04-05 | 2008-10-23 | セルポイント ダイアグノスティクス, インコーポレイテッド | 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法 |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| WO2006124597A2 (en) | 2005-05-12 | 2006-11-23 | Foster Ron B | Infinitely stackable interconnect device and method |
| US7863189B2 (en) | 2007-01-05 | 2011-01-04 | International Business Machines Corporation | Methods for fabricating silicon carriers with conductive through-vias with low stress and low defect density |
| FR2931141B1 (fr) | 2008-05-13 | 2011-07-01 | Commissariat Energie Atomique | Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri |
| EP2304414B1 (en) | 2008-07-24 | 2017-03-15 | The Trustees of Princeton University | Bump array device having asymmetric gaps for segregation of particles |
| US8093099B2 (en) | 2008-09-26 | 2012-01-10 | International Business Machines Corporation | Lock and key through-via method for wafer level 3D integration and structures produced |
| WO2010124155A1 (en) | 2009-04-23 | 2010-10-28 | Logos Energy, Inc. | Lateral displacement array for microfiltration |
| US9039996B2 (en) | 2010-10-12 | 2015-05-26 | Stmicroelectronics, Inc. | Silicon substrate optimization for microarray technology |
| WO2012094642A2 (en) * | 2011-01-06 | 2012-07-12 | On-Q-ity | Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size |
| US20170271207A9 (en) | 2011-01-29 | 2017-09-21 | International Business Machines Corporation | Novel 3D Integration Method Using SOI Substrates And Structures Produced Thereby |
| CN102856329B (zh) | 2011-06-30 | 2015-02-11 | 中芯国际集成电路制造(上海)有限公司 | 一种硅通孔封装方法 |
| CN108212237B (zh) | 2013-03-06 | 2020-12-08 | 哈佛学院院长及董事 | 形成相对单分散液滴的装置和方法 |
| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
| WO2014166000A1 (en) | 2013-04-11 | 2014-10-16 | The Governing Council Of The University Of Toronto | Device for capture of particles in a flow |
| US10202577B2 (en) | 2013-10-18 | 2019-02-12 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| JP6604945B2 (ja) | 2013-11-22 | 2019-11-13 | ザ ジェネラル ホスピタル コーポレイション | 粒子クラスタを単離するためのマイクロ流体方法およびシステム |
| CA2966623C (en) | 2014-11-03 | 2024-02-20 | The General Hospital Corporation | Concentrating particles in a microfluidic device |
| US9636675B2 (en) | 2014-11-26 | 2017-05-02 | International Business Machines Corporation | Pillar array structure with uniform and high aspect ratio nanometer gaps |
| US9835538B2 (en) | 2014-11-26 | 2017-12-05 | International Business Machines Corporation | Biopolymer separation using nanostructured arrays |
| US10058895B2 (en) | 2014-11-26 | 2018-08-28 | International Business Machines Corporation | Continuous flow, size-based separation of entities down to the nanometer scale using nanopillar arrays |
| US10976232B2 (en) * | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| CN105293428B (zh) | 2015-10-19 | 2017-04-19 | 北京航天控制仪器研究所 | 一种mems器件的全硅化圆片级真空封装方法及封装器件 |
| US9700891B2 (en) | 2015-11-13 | 2017-07-11 | International Business Machines Corporation | Integrated nanofluidic arrays for high capacity colloid separation |
| WO2017087940A1 (en) | 2015-11-20 | 2017-05-26 | University Of Kansas | Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles |
| US10507466B2 (en) | 2016-04-27 | 2019-12-17 | International Business Machines Corporation | Metal assisted chemical etching for fabricating high aspect ratio and straight silicon nanopillar arrays for sorting applications |
| CN109328098A (zh) * | 2016-06-20 | 2019-02-12 | 凸版印刷株式会社 | 液体介质的置换方法及用于该方法的流路设备 |
| US10010883B2 (en) | 2016-09-20 | 2018-07-03 | International Business Machines Corporation | Deterministic lateral displacement arrays |
| US10386276B2 (en) | 2016-09-20 | 2019-08-20 | International Business Machines Corporation | Phosphoprotein detection using a chip-based pillar array |
| US10253350B2 (en) | 2016-09-20 | 2019-04-09 | International Business Machines Corporation | Separation of molecules using nanopillar arrays |
| US20200038861A1 (en) | 2016-10-07 | 2020-02-06 | The Regents Of The University Of Michigan | Systems and methods for high throughput screening |
| US10946380B2 (en) | 2018-01-19 | 2021-03-16 | International Business Machines Corporation | Microfluidic chips for particle purification and fractionation |
| US20190226953A1 (en) * | 2018-01-19 | 2019-07-25 | International Business Machines Corporation | Microscale and mesoscale condenser devices |
| US11033901B2 (en) | 2018-10-23 | 2021-06-15 | International Business Machines Corporation | Biomarker detection using integrated purification-detection devices |
-
2018
- 2018-01-19 US US15/875,862 patent/US20190226953A1/en not_active Abandoned
-
2019
- 2019-01-14 DE DE112019000163.9T patent/DE112019000163T5/de active Pending
- 2019-01-14 CN CN201980008769.9A patent/CN111615748B/zh active Active
- 2019-01-14 GB GB2010161.4A patent/GB2583301B/en active Active
- 2019-01-14 JP JP2020538856A patent/JP7332245B2/ja active Active
- 2019-01-14 WO PCT/IB2019/050271 patent/WO2019142086A1/en not_active Ceased
-
2021
- 2021-04-12 US US17/227,522 patent/US11566982B2/en active Active
-
2022
- 2022-12-05 US US18/061,635 patent/US11754476B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0926283A (ja) * | 1995-07-07 | 1997-01-28 | Sakushiyon Gas Kikan Seisakusho:Kk | 多管式熱交換器 |
| CN101340836A (zh) * | 2005-10-21 | 2009-01-07 | 开利商业冷藏公司 | 使用微通道管道的抗结垢冷凝器 |
| CN102052803A (zh) * | 2010-12-13 | 2011-05-11 | 上海环球制冷设备有限公司 | 集成冷凝满液式蒸发器装置及使用方法 |
| CN105161473A (zh) * | 2015-07-09 | 2015-12-16 | 江苏中圣压力容器装备制造有限公司 | 硅基毛细泵回路微型冷却器 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7332245B2 (ja) | 2023-08-23 |
| JP2021511203A (ja) | 2021-05-06 |
| US11566982B2 (en) | 2023-01-31 |
| GB202010161D0 (en) | 2020-08-19 |
| US20210231543A1 (en) | 2021-07-29 |
| GB2583301A (en) | 2020-10-21 |
| US11754476B2 (en) | 2023-09-12 |
| US20230097357A1 (en) | 2023-03-30 |
| WO2019142086A1 (en) | 2019-07-25 |
| DE112019000163T5 (de) | 2020-07-09 |
| CN111615748A (zh) | 2020-09-01 |
| GB2583301B (en) | 2022-11-16 |
| US20190226953A1 (en) | 2019-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111615748B (zh) | 微尺度和中尺度冷凝器装置 | |
| EP2304414B1 (en) | Bump array device having asymmetric gaps for segregation of particles | |
| CN111615552B (zh) | 用于颗粒纯化和分馏的微流体芯片 | |
| US8563325B1 (en) | Coaxial microreactor for particle synthesis | |
| EP2378266B1 (en) | Particle separation and concentration system | |
| Wunsch et al. | Gel-on-a-chip: Continuous, velocity-dependent DNA separation using nanoscale lateral displacement | |
| US10710072B2 (en) | Particle separation apparatus and particle separation method | |
| KR20140084075A (ko) | 형상 기반 입자 분리를 위한 기기들 및 방법들 | |
| US20080290037A1 (en) | Methods and Apparatuses for Separating Biological Particles | |
| EP3631415B1 (en) | Oscillatory focusing of particles in channels | |
| CN105848782B (zh) | 流体过滤装置和组件 | |
| JP2017534840A (ja) | 微細構造分離フィルタ | |
| CN111330660A (zh) | 离心式高通量微滴制备芯片 | |
| JP7607267B2 (ja) | エマルション製造マイクロ流体デバイス | |
| KR101929930B1 (ko) | 미세유체소자 | |
| US12403470B2 (en) | Microfluidic devices with multiple inlets and outlets | |
| CN100503422C (zh) | 微结构错流式分离芯片 | |
| Rasna et al. | Tunable single-column deterministic lateral displacement device by adjustable crossflow | |
| CN112867566A (zh) | 流体提纯装置 | |
| Bhagat et al. | Spiral microfluidic nanoparticle separators | |
| Torino et al. | A parallel microfluidic device for hydrodynamic focusing of acute lymphoid Leukemia cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |