JP7332245B2 - メソスケールおよび/またはナノスケールの凝縮装置および方法 - Google Patents

メソスケールおよび/またはナノスケールの凝縮装置および方法 Download PDF

Info

Publication number
JP7332245B2
JP7332245B2 JP2020538856A JP2020538856A JP7332245B2 JP 7332245 B2 JP7332245 B2 JP 7332245B2 JP 2020538856 A JP2020538856 A JP 2020538856A JP 2020538856 A JP2020538856 A JP 2020538856A JP 7332245 B2 JP7332245 B2 JP 7332245B2
Authority
JP
Japan
Prior art keywords
array
fluid
microchannel
struts
strut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020538856A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021511203A (ja
JP2021511203A5 (enExample
Inventor
ブンシュ、ベンジャミン
スミス、ジョシュア
キム、ソン-チョル
ギフォード、ステイシー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
Original Assignee
International Business Machines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of JP2021511203A publication Critical patent/JP2021511203A/ja
Publication of JP2021511203A5 publication Critical patent/JP2021511203A5/ja
Application granted granted Critical
Publication of JP7332245B2 publication Critical patent/JP7332245B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/44—Edge filtering elements, i.e. using contiguous impervious surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2020538856A 2018-01-19 2019-01-14 メソスケールおよび/またはナノスケールの凝縮装置および方法 Active JP7332245B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/875,862 US20190226953A1 (en) 2018-01-19 2018-01-19 Microscale and mesoscale condenser devices
US15/875,862 2018-01-19
PCT/IB2019/050271 WO2019142086A1 (en) 2018-01-19 2019-01-14 Microscale and mesoscale condenser devices

Publications (3)

Publication Number Publication Date
JP2021511203A JP2021511203A (ja) 2021-05-06
JP2021511203A5 JP2021511203A5 (enExample) 2021-08-05
JP7332245B2 true JP7332245B2 (ja) 2023-08-23

Family

ID=67298103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020538856A Active JP7332245B2 (ja) 2018-01-19 2019-01-14 メソスケールおよび/またはナノスケールの凝縮装置および方法

Country Status (6)

Country Link
US (3) US20190226953A1 (enExample)
JP (1) JP7332245B2 (enExample)
CN (1) CN111615748B (enExample)
DE (1) DE112019000163T5 (enExample)
GB (1) GB2583301B (enExample)
WO (1) WO2019142086A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458474B2 (en) 2018-01-19 2022-10-04 International Business Machines Corporation Microfluidic chips with one or more vias
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US11517873B2 (en) 2019-10-29 2022-12-06 International Business Machines Corporation Controlled chemical synthesis using polymer substrates and nanofluidic separation systems
US20230285966A1 (en) * 2020-07-29 2023-09-14 Board Of Regents, The University Of Texas System Nanofabrication of deterministic diagnostic devices
US20240082839A1 (en) * 2021-01-22 2024-03-14 Hewlett-Packard Development Company, L.P. Microfluidic device chamber pillars
US12186748B2 (en) 2022-06-24 2025-01-07 Hewlett-Packard Development Company, L.P. Self-priming microfluidic structures
US12236226B2 (en) 2022-08-11 2025-02-25 Ford Global Technologies, Llc Secure update and audit of electronic control units

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140154703A1 (en) 2011-01-06 2014-06-05 Alison Skelley Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size
WO2017221898A1 (ja) 2016-06-20 2017-12-28 凸版印刷株式会社 液体媒体の置換方法及び該方法のための流路デバイス

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2726018B2 (ja) * 1995-07-07 1998-03-11 株式会社サクション瓦斯機関製作所 多管式熱交換器
US7892681B2 (en) 2005-07-19 2011-02-22 Pelton Walter E System of distributed electrochemical cells integrated with microelectronic structures
DE60332046D1 (de) 2002-10-23 2010-05-20 Univ Princeton Verfahren zur kontinuierlichen teilchentrennung unter verwendungvon zu feldern asymmetrisch ausgerichteten hindernisarrays
US7281387B2 (en) * 2004-04-29 2007-10-16 Carrier Commercial Refrigeration Inc. Foul-resistant condenser using microchannel tubing
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB2427468B (en) 2005-04-05 2011-03-02 Cellpoint Diagnostics Cell separation device and method for the detection of EpCAM positive cells
WO2006124597A2 (en) 2005-05-12 2006-11-23 Foster Ron B Infinitely stackable interconnect device and method
US7863189B2 (en) 2007-01-05 2011-01-04 International Business Machines Corporation Methods for fabricating silicon carriers with conductive through-vias with low stress and low defect density
FR2931141B1 (fr) 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
ES2628181T3 (es) 2008-07-24 2017-08-02 The Trustees Of Princeton University Dispositivo de matriz de choque que tiene espacios de separación asimétricos para la segregación de partículas
US8093099B2 (en) 2008-09-26 2012-01-10 International Business Machines Corporation Lock and key through-via method for wafer level 3D integration and structures produced
WO2010124155A1 (en) 2009-04-23 2010-10-28 Logos Energy, Inc. Lateral displacement array for microfiltration
US9039996B2 (en) 2010-10-12 2015-05-26 Stmicroelectronics, Inc. Silicon substrate optimization for microarray technology
CN102052803B (zh) * 2010-12-13 2012-11-28 上海环球制冷设备有限公司 集成冷凝满液式蒸发器装置及使用方法
US20170271207A9 (en) 2011-01-29 2017-09-21 International Business Machines Corporation Novel 3D Integration Method Using SOI Substrates And Structures Produced Thereby
CN102856329B (zh) 2011-06-30 2015-02-11 中芯国际集成电路制造(上海)有限公司 一种硅通孔封装方法
EP2964390B1 (en) 2013-03-06 2018-12-26 President and Fellows of Harvard College Use of devices for forming relatively monodisperse droplets
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN113512522A (zh) 2013-03-15 2021-10-19 普林斯顿大学理事会 用于高通量纯化的方法和设备
WO2014166000A1 (en) 2013-04-11 2014-10-16 The Governing Council Of The University Of Toronto Device for capture of particles in a flow
EP3560591B1 (en) 2013-10-18 2021-02-17 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
CA2930430A1 (en) 2013-11-22 2015-05-28 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
JP6649377B2 (ja) 2014-11-03 2020-02-19 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置による粒子の複合式分類および濃縮
US10058895B2 (en) 2014-11-26 2018-08-28 International Business Machines Corporation Continuous flow, size-based separation of entities down to the nanometer scale using nanopillar arrays
US9636675B2 (en) 2014-11-26 2017-05-02 International Business Machines Corporation Pillar array structure with uniform and high aspect ratio nanometer gaps
US9835538B2 (en) 2014-11-26 2017-12-05 International Business Machines Corporation Biopolymer separation using nanostructured arrays
CN105161473A (zh) * 2015-07-09 2015-12-16 江苏中圣压力容器装备制造有限公司 硅基毛细泵回路微型冷却器
US10976232B2 (en) * 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
CN105293428B (zh) 2015-10-19 2017-04-19 北京航天控制仪器研究所 一种mems器件的全硅化圆片级真空封装方法及封装器件
US9700891B2 (en) 2015-11-13 2017-07-11 International Business Machines Corporation Integrated nanofluidic arrays for high capacity colloid separation
WO2017087940A1 (en) 2015-11-20 2017-05-26 University Of Kansas Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
US10507466B2 (en) 2016-04-27 2019-12-17 International Business Machines Corporation Metal assisted chemical etching for fabricating high aspect ratio and straight silicon nanopillar arrays for sorting applications
US10386276B2 (en) 2016-09-20 2019-08-20 International Business Machines Corporation Phosphoprotein detection using a chip-based pillar array
US10010883B2 (en) 2016-09-20 2018-07-03 International Business Machines Corporation Deterministic lateral displacement arrays
US10253350B2 (en) 2016-09-20 2019-04-09 International Business Machines Corporation Separation of molecules using nanopillar arrays
US20200038861A1 (en) 2016-10-07 2020-02-06 The Regents Of The University Of Michigan Systems and methods for high throughput screening
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US11033901B2 (en) 2018-10-23 2021-06-15 International Business Machines Corporation Biomarker detection using integrated purification-detection devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140154703A1 (en) 2011-01-06 2014-06-05 Alison Skelley Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size
WO2017221898A1 (ja) 2016-06-20 2017-12-28 凸版印刷株式会社 液体媒体の置換方法及び該方法のための流路デバイス

Also Published As

Publication number Publication date
US20210231543A1 (en) 2021-07-29
US11566982B2 (en) 2023-01-31
GB2583301B (en) 2022-11-16
CN111615748A (zh) 2020-09-01
WO2019142086A1 (en) 2019-07-25
GB202010161D0 (en) 2020-08-19
DE112019000163T5 (de) 2020-07-09
CN111615748B (zh) 2023-08-29
US20190226953A1 (en) 2019-07-25
US11754476B2 (en) 2023-09-12
GB2583301A (en) 2020-10-21
JP2021511203A (ja) 2021-05-06
US20230097357A1 (en) 2023-03-30

Similar Documents

Publication Publication Date Title
US11754476B2 (en) Microscale and mesoscale condenser devices
EP2304414B1 (en) Bump array device having asymmetric gaps for segregation of particles
US11872560B2 (en) Microfluidic chips for particle purification and fractionation
US9333510B2 (en) Devices and methods for shape-based particle separation
EP2040843B1 (en) Apparatus for continuous particle separation
Choi et al. Continuous blood cell separation by hydrophoretic filtration
US20140227777A1 (en) Cell sorting by 3d flow and adhesive rolling
Shiri et al. Passive and active microfluidic separation methods
CN105848782B (zh) 流体过滤装置和组件
US12403470B2 (en) Microfluidic devices with multiple inlets and outlets
US20210283611A1 (en) Continous band-pass filter size separation using a negative angle dld array
KR102283604B1 (ko) 파티클 분리 장치
EP3870367A1 (en) Fluid refining device
KR101997742B1 (ko) 삼각형 미세 채널을 이용한 미세 입자 분리 장치
HK1129211B (en) Apparatus for continuous particle separation
HK1129211A (en) Apparatus for continuous particle separation
KR20050010245A (ko) 미소 기둥형 구조물과 교차 전기장을 이용한 생물학적분석 기기 및 그 방법

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210614

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210623

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220317

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20220502

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220510

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220808

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20220808

RD12 Notification of acceptance of power of sub attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7432

Effective date: 20220808

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230410

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230725

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20230727

RD14 Notification of resignation of power of sub attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7434

Effective date: 20230727

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230807

R150 Certificate of patent or registration of utility model

Ref document number: 7332245

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150