DE112019000163T5 - Mikroskalige und mesoskalige verdichtungseinheiten - Google Patents

Mikroskalige und mesoskalige verdichtungseinheiten Download PDF

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Publication number
DE112019000163T5
DE112019000163T5 DE112019000163.9T DE112019000163T DE112019000163T5 DE 112019000163 T5 DE112019000163 T5 DE 112019000163T5 DE 112019000163 T DE112019000163 T DE 112019000163T DE 112019000163 T5 DE112019000163 T5 DE 112019000163T5
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DE
Germany
Prior art keywords
array
columns
fluid
microchannel
column
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Pending
Application number
DE112019000163.9T
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German (de)
English (en)
Inventor
Benjamin Wunsch
Joshua Smith
Sung-cheol Kim
Stacey Gifford
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International Business Machines Corp
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International Business Machines Corp
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Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of DE112019000163T5 publication Critical patent/DE112019000163T5/de
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/44Edge filtering elements, i.e. using contiguous impervious surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4077Concentrating samples by other techniques involving separation of suspended solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0858Side walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Fluid Mechanics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
DE112019000163.9T 2018-01-19 2019-01-14 Mikroskalige und mesoskalige verdichtungseinheiten Pending DE112019000163T5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/875,862 US20190226953A1 (en) 2018-01-19 2018-01-19 Microscale and mesoscale condenser devices
US15/875,862 2018-01-19
PCT/IB2019/050271 WO2019142086A1 (en) 2018-01-19 2019-01-14 Microscale and mesoscale condenser devices

Publications (1)

Publication Number Publication Date
DE112019000163T5 true DE112019000163T5 (de) 2020-07-09

Family

ID=67298103

Family Applications (1)

Application Number Title Priority Date Filing Date
DE112019000163.9T Pending DE112019000163T5 (de) 2018-01-19 2019-01-14 Mikroskalige und mesoskalige verdichtungseinheiten

Country Status (6)

Country Link
US (3) US20190226953A1 (enExample)
JP (1) JP7332245B2 (enExample)
CN (1) CN111615748B (enExample)
DE (1) DE112019000163T5 (enExample)
GB (1) GB2583301B (enExample)
WO (1) WO2019142086A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458474B2 (en) 2018-01-19 2022-10-04 International Business Machines Corporation Microfluidic chips with one or more vias
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US11517873B2 (en) 2019-10-29 2022-12-06 International Business Machines Corporation Controlled chemical synthesis using polymer substrates and nanofluidic separation systems
EP4281534A4 (en) * 2021-01-22 2024-03-13 Hewlett-Packard Development Company, L.P. MICROFLUIDIC DEVICE CHAMBER PILLARS
US12186748B2 (en) 2022-06-24 2025-01-07 Hewlett-Packard Development Company, L.P. Self-priming microfluidic structures
US12236226B2 (en) 2022-08-11 2025-02-25 Ford Global Technologies, Llc Secure update and audit of electronic control units

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2726018B2 (ja) * 1995-07-07 1998-03-11 株式会社サクション瓦斯機関製作所 多管式熱交換器
US7892681B2 (en) 2005-07-19 2011-02-22 Pelton Walter E System of distributed electrochemical cells integrated with microelectronic structures
ES2341103T3 (es) 2002-10-23 2010-06-15 The Trustees Of Princeton University Procedimiento de separacion continua de particulas usando reticulados de obstaculos alineados asimetricamente respecto a campos.
US7281387B2 (en) * 2004-04-29 2007-10-16 Carrier Commercial Refrigeration Inc. Foul-resistant condenser using microchannel tubing
JP2008538282A (ja) 2005-04-05 2008-10-23 セルポイント ダイアグノスティクス, インコーポレイテッド 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
WO2006124597A2 (en) 2005-05-12 2006-11-23 Foster Ron B Infinitely stackable interconnect device and method
US7863189B2 (en) 2007-01-05 2011-01-04 International Business Machines Corporation Methods for fabricating silicon carriers with conductive through-vias with low stress and low defect density
FR2931141B1 (fr) 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
EP2304414B1 (en) 2008-07-24 2017-03-15 The Trustees of Princeton University Bump array device having asymmetric gaps for segregation of particles
US8093099B2 (en) 2008-09-26 2012-01-10 International Business Machines Corporation Lock and key through-via method for wafer level 3D integration and structures produced
WO2010124155A1 (en) 2009-04-23 2010-10-28 Logos Energy, Inc. Lateral displacement array for microfiltration
US9039996B2 (en) 2010-10-12 2015-05-26 Stmicroelectronics, Inc. Silicon substrate optimization for microarray technology
CN102052803B (zh) * 2010-12-13 2012-11-28 上海环球制冷设备有限公司 集成冷凝满液式蒸发器装置及使用方法
WO2012094642A2 (en) * 2011-01-06 2012-07-12 On-Q-ity Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size
US20170271207A9 (en) 2011-01-29 2017-09-21 International Business Machines Corporation Novel 3D Integration Method Using SOI Substrates And Structures Produced Thereby
CN102856329B (zh) 2011-06-30 2015-02-11 中芯国际集成电路制造(上海)有限公司 一种硅通孔封装方法
CN108212237B (zh) 2013-03-06 2020-12-08 哈佛学院院长及董事 形成相对单分散液滴的装置和方法
CN105247042B (zh) 2013-03-15 2021-06-11 普林斯顿大学理事会 用于高通量纯化的方法和设备
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN110186835B (zh) 2013-03-15 2022-05-31 Gpb科学有限公司 颗粒的片上微流体处理
WO2014166000A1 (en) 2013-04-11 2014-10-16 The Governing Council Of The University Of Toronto Device for capture of particles in a flow
US10202577B2 (en) 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
JP6604945B2 (ja) 2013-11-22 2019-11-13 ザ ジェネラル ホスピタル コーポレイション 粒子クラスタを単離するためのマイクロ流体方法およびシステム
CA2966623C (en) 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
US9636675B2 (en) 2014-11-26 2017-05-02 International Business Machines Corporation Pillar array structure with uniform and high aspect ratio nanometer gaps
US9835538B2 (en) 2014-11-26 2017-12-05 International Business Machines Corporation Biopolymer separation using nanostructured arrays
US10058895B2 (en) 2014-11-26 2018-08-28 International Business Machines Corporation Continuous flow, size-based separation of entities down to the nanometer scale using nanopillar arrays
CN105161473A (zh) * 2015-07-09 2015-12-16 江苏中圣压力容器装备制造有限公司 硅基毛细泵回路微型冷却器
US10976232B2 (en) * 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
CN105293428B (zh) 2015-10-19 2017-04-19 北京航天控制仪器研究所 一种mems器件的全硅化圆片级真空封装方法及封装器件
US9700891B2 (en) 2015-11-13 2017-07-11 International Business Machines Corporation Integrated nanofluidic arrays for high capacity colloid separation
WO2017087940A1 (en) 2015-11-20 2017-05-26 University Of Kansas Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
US10507466B2 (en) 2016-04-27 2019-12-17 International Business Machines Corporation Metal assisted chemical etching for fabricating high aspect ratio and straight silicon nanopillar arrays for sorting applications
CN109328098A (zh) * 2016-06-20 2019-02-12 凸版印刷株式会社 液体介质的置换方法及用于该方法的流路设备
US10010883B2 (en) 2016-09-20 2018-07-03 International Business Machines Corporation Deterministic lateral displacement arrays
US10386276B2 (en) 2016-09-20 2019-08-20 International Business Machines Corporation Phosphoprotein detection using a chip-based pillar array
US10253350B2 (en) 2016-09-20 2019-04-09 International Business Machines Corporation Separation of molecules using nanopillar arrays
US20200038861A1 (en) 2016-10-07 2020-02-06 The Regents Of The University Of Michigan Systems and methods for high throughput screening
US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US20190226953A1 (en) * 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US11033901B2 (en) 2018-10-23 2021-06-15 International Business Machines Corporation Biomarker detection using integrated purification-detection devices

Also Published As

Publication number Publication date
JP7332245B2 (ja) 2023-08-23
JP2021511203A (ja) 2021-05-06
US11566982B2 (en) 2023-01-31
GB202010161D0 (en) 2020-08-19
US20210231543A1 (en) 2021-07-29
GB2583301A (en) 2020-10-21
CN111615748B (zh) 2023-08-29
US11754476B2 (en) 2023-09-12
US20230097357A1 (en) 2023-03-30
WO2019142086A1 (en) 2019-07-25
CN111615748A (zh) 2020-09-01
GB2583301B (en) 2022-11-16
US20190226953A1 (en) 2019-07-25

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