CN111493302A - Propolis pollen royal jelly tablet and preparation method thereof - Google Patents
Propolis pollen royal jelly tablet and preparation method thereof Download PDFInfo
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- CN111493302A CN111493302A CN202010242461.5A CN202010242461A CN111493302A CN 111493302 A CN111493302 A CN 111493302A CN 202010242461 A CN202010242461 A CN 202010242461A CN 111493302 A CN111493302 A CN 111493302A
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- propolis
- royal jelly
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- 241000241413 Propolis Species 0.000 title claims abstract description 82
- 229940069949 propolis Drugs 0.000 title claims abstract description 82
- 229940109850 royal jelly Drugs 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title description 6
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 38
- -1 polysaccharide compounds Chemical class 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 30
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 24
- 239000005017 polysaccharide Substances 0.000 claims abstract description 24
- 229960003080 taurine Drugs 0.000 claims abstract description 21
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960001948 caffeine Drugs 0.000 claims abstract description 19
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 18
- 244000068988 Glycine max Species 0.000 claims abstract description 17
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 12
- 244000046052 Phaseolus vulgaris Species 0.000 claims abstract description 7
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims abstract description 7
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 5
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 14
- NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 claims description 12
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims description 12
- 235000008714 apigenin Nutrition 0.000 claims description 12
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims description 12
- 229940117893 apigenin Drugs 0.000 claims description 12
- 235000015838 chrysin Nutrition 0.000 claims description 12
- 229940043370 chrysin Drugs 0.000 claims description 12
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 11
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 11
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 11
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 235000012239 silicon dioxide Nutrition 0.000 claims description 11
- 229960001866 silicon dioxide Drugs 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 10
- 229930016911 cinnamic acid Natural products 0.000 claims description 10
- 235000013985 cinnamic acid Nutrition 0.000 claims description 10
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000007888 film coating Substances 0.000 claims description 8
- 238000009501 film coating Methods 0.000 claims description 8
- 229930003935 flavonoid Natural products 0.000 claims description 8
- 235000017173 flavonoids Nutrition 0.000 claims description 8
- 229940057948 magnesium stearate Drugs 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- 235000013312 flour Nutrition 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 159000000032 aromatic acids Chemical class 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 239000003208 petroleum Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000005238 degreasing Methods 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000011874 heated mixture Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 239000003826 tablet Substances 0.000 description 35
- 230000000694 effects Effects 0.000 description 16
- 239000000243 solution Substances 0.000 description 10
- 206010041349 Somnolence Diseases 0.000 description 8
- 230000036039 immunity Effects 0.000 description 7
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- 238000012360 testing method Methods 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 3
- 239000011344 liquid material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
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- 230000002829 reductive effect Effects 0.000 description 3
- 238000009210 therapy by ultrasound Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 241000256837 Apidae Species 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 241000256843 Apis mellifera ligustica Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
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- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
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- 230000002085 persistent effect Effects 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004854 plant resin Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
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- 230000009323 psychological health Effects 0.000 description 1
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- 238000002791 soaking Methods 0.000 description 1
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- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Agronomy & Crop Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Jellies, Jams, And Syrups (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a propolis pollen royal jelly tablet which comprises, by mass, 2-6 parts of pollen, 10-15 parts of royal jelly freeze-dried powder, 0.2-0.4 part of taurine, 0.04-0.08 part of caffeine, 0.1-0.3 part of bean powder, 0.5-1.5 parts of propolis alcohol extract with polysaccharide compounds filtered out, 0.2-0.5 part of antioxidant and auxiliary materials. The propolis pollen royal jelly tablet retains the original efficacy of the original propolis pollen royal jelly tablet, and taurine, caffeine and soybean powder substances are added on the original basis, so that fatigue of people can be driven away transiently and energy can be restored, the propolis pollen royal jelly tablet is beneficial to people with excessive working pressure, and people who need to be refreshed temporarily in time can eat the propolis pollen royal jelly tablet.
Description
Technical Field
The invention relates to a health product, in particular to a propolis pollen royal jelly tablet and a preparation method thereof.
Background
The propolis is one of traditional Chinese medicinal materials, and is a sticky solid jelly formed by mixing plant resin collected by Italian bee and industrial bee of Apidae and secretions such as jawbone and cerifera thereon according to Chinese medicinal pharmacopoeia. The wine-processed propolis is a soaked product of propolis, and is generally prepared by pulverizing propolis, soaking in ethanol for dissolution, filtering, recovering ethanol from filtrate, and drying. Propolis and wine-processed propolis have effects of tonifying deficiency, and relieving diabetes; the external use has the effects of detoxifying, relieving swelling, astringing and promoting granulation; it is used clinically in treating asthenia, senilism, hyperlipemia, etc.
Therefore, many products with propolis, such as propolis decoction pieces, propolis pollen royal jelly tablets, etc., appear on the market.
Fatigue is a comprehensive physiological process involving many physiological and biochemical factors, and is a normal physiological phenomenon that inevitably occurs when the human brain or physical activity reaches a certain stage, which marks a temporary decline in the original working capacity of the body and may be a precursor to the development of the body into an injured state. When a human body is in a fatigue state for a long time, premature senility and fatigue syndrome can be generated, and physical and psychological health is harmed.
Therefore, a propolis product with refreshing and anti-fatigue effects is urgently needed.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the propolis pollen royal jelly tablet which has the functions of refreshing and resisting fatigue and can effectively relieve fatigue for people with high working pressure.
The invention also discloses a preparation method of the propolis pollen royal jelly tablet, which can extract higher content of flavonoid compounds and aromatic acid compounds from propolis to prepare the propolis pollen royal jelly tablet and is beneficial to small-scale factory production.
In order to solve the technical problem, the invention is solved by the following technical scheme: the propolis pollen royal jelly tablet comprises, by mass, 2-6 parts of pollen, 10-15 parts of royal jelly freeze-dried powder, 0.2-0.4 part of taurine, 0.04-0.08 part of caffeine, 0.1-0.3 part of bean powder, 0.5-1.5 parts of propolis alcohol extract with polysaccharide compounds filtered out, 0.2-0.5 part of antioxidant and auxiliary materials.
Further optimizing, the auxiliary materials comprise one or more of low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and gastric-soluble film coating premix.
Preferably, the antioxidant comprises one or two of vitamin C and vitamin E.
Preferably, the propolis alcohol extract comprises flavonoid compounds and aromatic acid compounds.
Further optimized, the flavonoid compounds comprise chrysin and apigenin.
Preferably, the aromatic acid compound comprises cinnamic acid.
The propolis pollen royal jelly tablet prepared by the invention is prepared by mixing a plurality of substances, and polysaccharide compounds are filtered from propolis, so that most of effects of propolis alcohol extracts are kept.
Taurine is a special amino acid and is an essential nutrient element for human body. The most obvious effect of the taurine is to enhance immunity and resist fatigue, the taurine can combine hypochlorous acid in leucocytes to generate non-toxic substances, and the damage of the hypochlorous acid to the leucocytes is reduced, so that the immunity of a human body is improved. As the human body in a fatigue state can generate fatigue and the immunity is reduced, a little taurine is added into the pulp sheet for resisting fatigue and improving the immunity temporarily.
Caffeine is a stimulant which temporarily drives drowsiness and restores energy, but is not suitable for large-dose consumption, so a small amount of caffeine is added to the tablet to temporarily drive drowsiness and restore energy for tired people.
Typical examples of the flavonoid compounds include chrysin and apigenin. The chrysin and apigenin have certain antibacterial, anticancer and anti-inflammatory effects, can reduce the breeding of viruses, also reduce the generation of harmful bacteria in the oral cavity, and play a role in promoting the oral cavity health.
The aromatic acid compound is typically cinnamic acid, the cinnamic acid has the effects of killing or inhibiting various bacteria, fungi, pathogens, nematodes and the like, and also has the anti-inflammatory effect, so that people with high long-term working pressure generally have the phenomenon of immunity reduction, and are easy to have cold, fever and the like. The lauric acid can better respond to the phenomena of cold, fever and the like of the human body, and has better inhibiting effect when the unhealthy phenomenon of the human body occurs.
The bean pulp sheet contains proper amount of iron, which is the main medium for generating human body energy and is responsible for the important task of conveying oxygen to human organs and muscles.
Compared with the prior art, the propolis pollen royal jelly tablet retains the original efficacy of the original propolis pollen royal jelly tablet, and taurine, caffeine and soybean powder substances are added on the original basis, so that fatigue of people can be removed and energy can be restored momentarily, the propolis pollen royal jelly tablet is beneficial to people with excessive working pressure, and people who need to be refreshed temporarily in time can eat the propolis pollen royal jelly tablet.
The chrysin and the apigenin are both flavonoid compounds, and the combination of the chrysin and the apigenin has an additive effect, so that the anti-inflammation effect is more facilitated, the immunity is reduced due to long-term fatigue work, and the phenomena of cold, fever and the like are caused due to the reduction of the immunity, so that the phenomena are relieved.
Taurine, caffeine and bean flour which have independent functions and are not mutually influenced.
A preparation method of propolis pollen royal jelly tablets comprises the following steps:
s1, freezing the propolis raw material, crushing and sieving, degreasing for 12-24 h by using petroleum ether, drying, and refluxing by using 80% ethanol;
s2, adding the degreased propolis powder into an ethanol solution with the mass fraction of 40-80%, treating for 30-50 min by using ultrasonic waves, and placing in a water bath at 50-90 ℃ to filter out polysaccharide compounds, wherein the total filtering time is 2-4 h;
s3, cooling and filtering to obtain propolis alcohol extract solution with polysaccharide compound removed;
s4, selecting proper amount of soybeans to grind, so as to obtain soybean powder;
s5, mixing the propolis alcohol extract solution, the bean flour, the pollen, taurine and caffeine in proportion, adding sodium carboxymethyl starch, adding a proper amount of purified water, granulating by a wet method, and drying;
and S6, after finishing the granules, adding royal jelly freeze-dried powder, low-substituted hydroxypropyl cellulose, croscarmellose sodium and silicon dioxide in proportion, uniformly mixing, adding magnesium stearate, mixing for 5-8 minutes, tabletting, controlling the weight of the tablets to be 0.5-0.6 g, and coating to obtain the propolis pollen royal jelly tablets.
Further optimizing, wherein the mass fraction of the ethanol solution is 50-60%; the temperature of the heated mixture is 44-46 ℃.
Further optimization, the pollen sterilization adopts Co 60-gamma ray for sterilization.
In order to filter polysaccharide substances in the propolis alcohol extract, petroleum ether is adopted to carry out primary degreasing on a propolis raw material, 80% ethanol is used for refluxing, the degreased propolis raw material is added into an ethanol solution with the mass fraction of 40% -80%, ultrasonic treatment is carried out for 30-50 min, the mixture is placed in a water bath at 50-90 ℃ to filter the polysaccharide compounds, and four factors of temperature, ultrasonic treatment time, total leaching filtering time and liquid-material ratio in the leaching and filtering process are selected for testing, so that the polysaccharide compounds can be filtered as much as possible. Preventing excessive sugar intake and affecting oral health.
Detailed Description
The present invention will be described in further detail in order to make the objects, technical solutions and advantages thereof more apparent.
Example 1: the propolis pollen royal jelly tablet comprises, by mass, 2 parts of pollen, 10 parts of royal jelly freeze-dried powder, 0.2 part of taurine, 0.04 part of caffeine, 0.1 part of soybean powder, 0.15 part of chrysin, 0.35 part of apigenin, 1 part of cinnamic acid, 0.2 part of vitamin C and various mixtures of auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and a gastric-soluble film coating premixing agent.
Example 2: the propolis pollen royal jelly tablet comprises, by mass, 3 parts of pollen, 12 parts of royal jelly freeze-dried powder, 0.2 part of taurine, 0.04 part of caffeine, 0.15 part of soybean powder, 0.2 part of chrysin, 0.55 part of apigenin, 1 part of cinnamic acid, 0.3 part of vitamin C and various mixtures of auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and a gastric-soluble film coating premixing agent.
Example 3: the propolis pollen royal jelly tablet comprises, by mass, 4 parts of pollen, 12 parts of royal jelly freeze-dried powder, 0.25 part of taurine, 0.04 part of caffeine, 0.2 part of soybean powder, 0.2 part of chrysin, 0.75 part of apigenin, 1.2 parts of cinnamic acid, 0.5 part of vitamin C and various mixtures of auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and gastric-soluble film coating premix.
Example 4: the propolis pollen royal jelly tablet comprises, by mass, 5 parts of pollen, 13 parts of royal jelly freeze-dried powder, 0.3 part of taurine, 0.05 part of caffeine, 0.2 part of soybean powder, 0.2 part of chrysin, 0.95 part of apigenin, 1.5 parts of cinnamic acid, 0.2 part of vitamin E and various mixtures of auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and gastric-soluble film coating premix.
Example 5: the propolis pollen royal jelly tablet comprises, by mass, 5 parts of pollen, 13 parts of royal jelly freeze-dried powder, 0.4 part of taurine, 0.07 part of caffeine, 0.3 part of soybean powder, 0.23 part of chrysin, 1.15 parts of apigenin, 1.5 parts of cinnamic acid, 0.3 part of vitamin E and various mixtures of auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and gastric-soluble film coating premix.
Example 6: the propolis pollen royal jelly tablet comprises, by mass, 6 parts of pollen, 15 parts of royal jelly freeze-dried powder, 0.4 part of taurine, 0.08 part of caffeine, 0.3 part of soybean powder, 0.25 part of chrysin, 1.25 parts of apigenin, 1.5 parts of cinnamic acid and 0.5 part of vitamin E, and auxiliary materials including low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and a gastric-soluble film coating premix.
The mouthwashes in the above examples were all prepared by the following preparation method:
s1, freezing propolis raw materials, pulverizing, sieving, defatting with petroleum ether for 12h, drying, and refluxing with 80% ethanol;
s2, adding the degreased propolis powder into an ethanol solution with the mass fraction of 80%, treating for 45min by using ultrasonic waves, and placing in a water bath at 80 ℃ to filter out polysaccharide compounds, wherein the total filtering time is 3.5 h;
s3, cooling and filtering to obtain propolis alcohol extract solution with polysaccharide compound removed;
s4, selecting proper amount of soybeans to grind, so as to obtain soybean powder;
s5, mixing the propolis alcohol extract solution, the bean flour, the pollen, taurine and caffeine in proportion, adding sodium carboxymethyl starch, adding a proper amount of purified water, granulating by a wet method, and drying;
s6, after finishing the granules, adding royal jelly freeze-dried powder, low-substituted hydroxypropyl cellulose, croscarmellose sodium and silicon dioxide according to a proportion, uniformly mixing, adding magnesium stearate, mixing for 5 minutes, tabletting, controlling the tablet weight to be 0.5g, and coating to obtain the propolis pollen royal jelly tablets.
The effect of the propolis pollen royal jelly tablet in the above embodiment is illustrated by the following experiment:
a group of persons with over-working pressure or working overnight, such as programmers and sales, is selected, wherein the number of the persons is 120, the number of the persons is 90 for males, the number of the persons is 30 for females, and the persons are randomly divided into 6 groups, and each group comprises 20 persons. The contents of each propolis pollen royal jelly tablet prepared in the embodiments 1-6 are respectively 0.5g, and the effective rate (%) of the test is counted immediately when one tablet is taken at 22-24 o' clock at night. (1) Obviously improve the following steps: to a great extent, the fatigue is relieved and the drowsiness is removed. (2) And (3) relieving: the fatigue is relieved to a certain degree, but the effect is not obvious because the user still feels sleepy. (3) And (4) invalidation: or slight or no reduction in drowsiness. (4) The worsening is that the drowsiness is stronger.
TABLE 1 test effect of propolis pollen royal jelly tablets of examples 1 to 6 after 20 to 30min of test population
| Obviously improve | Mitigation | Invalidation | Deterioration of | High efficiency | |
| Example 1 | Male 10, female 3 | Male 4, female 1 | Male 1, female 1 | 0 | 90% |
| Example 2 | Male 9, female 5 | Male 6, female 0 | 0 | 0 | 100% |
| Example 3 | Male 10, female 4 | Male 4, female 1 | Male 1, female 0 | 0 | 95% |
| Example 4 | Male 9, female 4 | Male 6, female 0 | Male 0, female 1 | 0 | 95% |
| Example 5 | Male 11, female 4 | Male 4, female 1 | 0 | 0 | 100% |
| Example 6 | Male 9, female 4 | Male 6, female 1 | 0 | 0 | 100% |
The results in table 1 show that after people with the symptoms of high working pressure, excessive stay up and the like eat the propolis pollen royal jelly tablet, the propolis pollen royal jelly tablet has the effects of temporarily recovering energy and removing drowsiness, and the effects of examples 2, 5 and 6 are better, wherein the effect of example 5 is the best.
Then, in order to detect how long the propolis pollen royal jelly tablet can temporarily restore energy, obviously improved and relieved people are continuously tracked, and the people are counted when the next drowsiness comes.
TABLE 2 persistent effects in the effectiveness test in examples 1 to 6 above
| Average temporary recovery time | |
| Example 1 | 1.6h |
| Example 2 | 1.8h |
| Example 3 | 1.9h |
| Example 4 | 2.0h |
| Example 5 | 2.3h |
| Example 6 | 2.1h |
As can be seen from Table 2, example 5 exhibited a relatively good effect with an average temporary recovery time of 2.3 hours.
In conclusion, the propolis pollen royal jelly tablet retains the original effect of the original propolis pollen royal jelly tablet, the polysaccharide compounds are filtered, and the taurine, the caffeine and the soybean flour substances are added on the original basis, so that the propolis pollen royal jelly tablet can transiently remove fatigue feeling and refreshment of people, is beneficial to people with excessive working pressure and is eaten by people needing to be refreshed temporarily.
In order to ensure that the polysaccharide compounds in the propolis alcohol extract are filtered out as much as possible, four factors of temperature, ultrasonic treatment time, total leaching and filtering time and liquid-material ratio in the leaching and filtering process are selected for testing, so that the polysaccharide compounds can be filtered out as much as possible.
TABLE 3 Effect of four factors on polysaccharide Compound filtration results
And (3) parallelly measuring the absorbance A = abc of the sample at the wavelength of 620nm by using a UV-2501PC ultraviolet-visible spectrophotometer, wherein (a is an absorption coefficient which is a fixed value, b is the thickness of a cuvette and is known) and c is the mass concentration of the polysaccharide, so that the polysaccharide content is calculated, and finally the polysaccharide extraction rate is calculated. Therefore, the liquid-material ratio of 40:1 is treated by ultrasonic for 45min and placed in a water bath at 80 ℃ to filter out the polysaccharide compounds, the process with the total filtering time of 3.5h can filter out the polysaccharide compounds as much as possible, and the method has good application prospect.
In conclusion, the propolis pollen royal jelly tablet retains partial substances of the propolis extract in the buccal tablet, such as flavonoid compounds and aromatic acid compounds, but filters out polysaccharide compounds in the propolis alcohol extract to prevent excessive sugar intake from influencing oral health. And taurine, caffeine and soybean powder are added, so that people who have excessive sugar intake especially for people with excessive working pressure can be driven away, and the fatigue feeling and the energy recovery of people can be facilitated.
S3, cooling and filtering to obtain propolis alcohol extract solution with polysaccharide compound removed;
furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (9)
1. A propolis pollen royal jelly tablet is characterized in that: the propolis pollen royal jelly tablet comprises, by mass, 2-6 parts of pollen, 10-15 parts of royal jelly freeze-dried powder, 0.2-0.4 part of taurine, 0.04-0.08 part of caffeine, 0.1-0.3 part of soybean powder, 0.5-1.5 parts of propolis alcohol extract with polysaccharide compounds filtered out, 0.2-0.5 part of antioxidant and auxiliary materials.
2. The propolis pollen royal jelly tablet as claimed in claim 1, characterized in that: the auxiliary materials comprise one or more of low-substituted hydroxypropyl cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate and gastric-soluble film coating premix.
3. The propolis pollen royal jelly tablet as claimed in claim 1, characterized in that: the antioxidant comprises one or two of vitamin C and vitamin E.
4. The propolis pollen royal jelly tablet as claimed in claim 1, characterized in that: the propolis alcohol extract comprises flavonoid compounds and aromatic acid compounds.
5. The propolis pollen royal jelly tablet according to claim 4, characterized in that: the flavonoid compounds comprise chrysin and apigenin.
6. The propolis pollen royal jelly tablet according to claim 4, characterized in that: the aromatic acid compound comprises cinnamic acid.
7. A method for preparing propolis pollen royal jelly tablet as claimed in any one of claims 1 to 6, characterized in that: the method comprises the following steps:
s1, freezing the propolis raw material, crushing and sieving, degreasing for 12-24 h by using petroleum ether, drying, and refluxing by using 80% ethanol;
s2, adding the degreased propolis powder into an ethanol solution with the mass fraction of 40-80%, treating for 30-50 min by using ultrasonic waves, and placing in a water bath at 50-90 ℃ to filter out polysaccharide compounds, wherein the total filtering time is 2-4 h;
s3, cooling and filtering to obtain propolis alcohol extract solution with polysaccharide compound removed;
s4, selecting proper amount of soybeans to grind, so as to obtain soybean powder;
s5, mixing the propolis alcohol extract solution, the bean flour, the pollen, taurine and caffeine in proportion, adding sodium carboxymethyl starch, adding a proper amount of purified water, granulating by a wet method, and drying;
and S6, after finishing the granules, adding royal jelly freeze-dried powder, low-substituted hydroxypropyl cellulose, croscarmellose sodium and silicon dioxide in proportion, uniformly mixing, adding magnesium stearate, mixing for 5-8 minutes, tabletting, controlling the weight of the tablets to be 0.5-0.6 g, and coating to obtain the propolis pollen royal jelly tablets.
8. The method for preparing propolis-pollen-royal jelly tablets according to claim 6, characterized in that: the mass fraction of the ethanol solution is 50% -60%; the temperature of the heated mixture is 44-46 ℃.
9. The method for preparing propolis-pollen-royal jelly tablets according to claim 6, characterized in that: the pollen sterilization adopts Co 60-gamma ray for sterilization.
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