CN105520964A - Preparation method and application of royal jelly and bee pollen composition - Google Patents
Preparation method and application of royal jelly and bee pollen composition Download PDFInfo
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- CN105520964A CN105520964A CN201610076129.XA CN201610076129A CN105520964A CN 105520964 A CN105520964 A CN 105520964A CN 201610076129 A CN201610076129 A CN 201610076129A CN 105520964 A CN105520964 A CN 105520964A
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- bee pollen
- lac regis
- regis apis
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- 229940038481 bee pollen Drugs 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 229940109850 royal jelly Drugs 0.000 title abstract description 13
- 230000000873 masking effect Effects 0.000 claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000004108 freeze drying Methods 0.000 claims abstract description 8
- 239000002671 adjuvant Substances 0.000 claims abstract description 5
- 239000008176 lyophilized powder Substances 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 13
- 229920000858 Cyclodextrin Polymers 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 10
- 230000002879 macerating effect Effects 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
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- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 2
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 2
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 2
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 2
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- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
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- QHBZHVUGQROELI-SOFGYWHQSA-N (E)-10-hydroxydec-2-enoic acid Chemical compound OCCCCCCC\C=C\C(O)=O QHBZHVUGQROELI-SOFGYWHQSA-N 0.000 description 3
- QHBZHVUGQROELI-UHFFFAOYSA-N Royal Jelly acid Natural products OCCCCCCCC=CC(O)=O QHBZHVUGQROELI-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
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- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000256844 Apis mellifera Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
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- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 206010043521 Throat irritation Diseases 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
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- 230000001093 anti-cancer Effects 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 238000005265 energy consumption Methods 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
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- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Husbandry (AREA)
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Abstract
The invention discloses a preparation method and application of a royal jelly and bee pollen composition, and relates to the technical fields of processes of masking and freeze-drying of royal jelly, and extracting and preparing of bee pollen. The invention discloses a preparation method of masking and freeze-drying the royal jelly and a process for extracting and preparing bee pollen for the first time; the composition consists of royal jelly masking freeze-dried powder, a bee pollen alcohol extract and a bee pollen aqueous extract, and the composition, added with a few of adjuvant materials, can be processed into various health care preparations. The composition disclosed by the invention is especially suitable for middle and old-aged people and people with low immunity; and the composition is low in side effects, good in taste, convenient to take and easy for carrying.
Description
Technical field
The present invention relates to technical field of health care food, particularly a kind of Lac regis apis, bee pollen preparation method of composition and application thereof.
Background technology
Along with society and economic progress, the raising of people's living standard, the development of science and technology, the change of disease pattern and the pursuit to good health and a long life, functional food dark people's popular feeling gradually of enhancing immunity, people have started heavily to prevent from heavily treating to turn to, and this will greatly promote the development of the functional food of enhancing immunity.21 century will be the century that functional food is exhibited one's skill to the full.China has the huge treasure-house of this functional food of Chinese herbal medicine and other characteristic resources, the impetus that we should develop in conjunction with the functional food development trend of enhancing immunity and China, make great efforts to excavate these precious resources, develop the functional food of enhancing immunity with Chinese characteristics, to obtain due status in the international competition of fierceness.
Lac regis apis is that 5-15 age in days Worker head nutrition gland (lingual gland and Hubei Province gland) is secreted, and the special Mag material of the one for feed honeybee work and larva, also known as Lac regis apis, royal jelly etc.It treasures famous and precious, complicated component, has stronger health care and unusual medical effect, is the pure large so health food between food and pharmaceutical.
Since analyzing the chemical composition of Lac regis apis first from 1852, it is found that Lac regis apis is a kind of very complicated large so product, it is almost containing all compositions human body and animal body to nutritive value.Component content in fresh royal jelly is roughly: moisture 62.5%-70%, dry 30.0%-37.5%, wherein maximum with protein content, mineral and various vitamin 1.0%.Lac regis apis contains 20 several amino acids, includes the aminoacid of whole needed by human.In Lac regis apis, contained free fatty reaches more than 26 kinds, the most important with 10-HAD (10-HDA), be also called Royal Jelly acid or E-10-hydroxy-2-decylenic acid, the amount of this composition accounts for the over half of total fatty acids, it is the fatty acid that in Lac regis apis, content is the highest, content in fresh royal jelly is about 1.4%-2.0%, has the multiple efficacies such as antibacterial, antiviral, anticancer growth.
But Lac regis apis has obvious acid, puckery, pungent and sweet feel, has obvious stimulation sense to palate and throat.After swallowing or spuing, throat irritation sense still can retain some times.Fresh royal jelly is unstable simultaneously, needs refrigerated storage; Take, carry inconvenience.
Bee pollen is that Apis gathers in the process of pollen from plant flower and adds some nectar and saliva, to make pollen stick integrated group, namely forms pollen load.Measure according to scientist, it is containing 20 several amino acids, 15 kinds of vitamin, 30 kinds of mineral elements, unsaturated fatty acid, organic acid, protein, lipid, carbohydrates, Polyphenols and Flavonoid substances, polysaccharide, enzyme, nucleic acid, hormone isoreactivity material.Because it contains abundant nutritional labeling, be more and more subject to people's attention.Modern study proves, bee pollen can improve quantity and the function of body T lymphocyte and macrophage, improves seroimmunity Protein G level, enhancing human body immunity function.Bee pollen is the elite of plant, is described as " nutraceutical the most completely ", " concentrated nutrition library ".How complete reservation bee pollen nutrition, is conducive to absorption of human body again, has become and has needed the urgent problem solved most.
The technical problem to be solved in the present invention is: the shortcoming existed for prior art, with not enough, the invention discloses a kind of technique simple, with short production cycle, obviously can reduce the preparation method of royal jelly acid, the disagreeable taste lyophilized powder such as puckery, pungent; Provide simultaneously and can retain bee pollen nutrition to greatest extent, be beneficial to again the extract of absorption of human body, then be prepared into various taking convenience by rational proportion, be beneficial to the health product carrying, increase stability.
Summary of the invention
Technical problem to be solved by this invention obviously reduces acid, the disagreeable taste such as puckery, pungent, improves compliance;
Technical problem to be solved by this invention retains bee pollen nutrition to greatest extent, is beneficial to absorption of human body again;
Another technical problem to be solved by this invention is to provide the health-care preparation of described Lac regis apis, bee pollen compositions.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
A kind of Lac regis apis of the present invention, bee pollen preparation method of composition and application thereof, is characterized in that, comprise following component: the various preparations that Lac regis apis taste masking lyophilized powder, bee pollen extract and a small amount of adjuvant are made.
A kind of Lac regis apis of the present invention, bee pollen preparation method of composition and application thereof, it is characterized in that, the preparation process of Lac regis apis taste masking lyophilized powder is:
A, cyclodextrin is dissolved in purified water, under stirring condition, add Lac regis apis, after stirring evenly, continue stirring 24 hours;
B, by aforesaid liquid in freeze dryer, lyophilization is to moisture less than 2.0%;
C, by finished product take out, pulverize, sieve for subsequent use.
Wherein, described cyclodextrin be selected from alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, carboxymethyl-beta-cyclodextrin, HP-β-CD or sulfobutyl ether-beta-cyclodextrin any one or arbitrarily multiple according to arbitrary proportion composition mixture; Be preferably HP-β-CD, cyclodextrin and Lac regis apis weight ratio 1:20-2:1, preferred 1:3.
A kind of Lac regis apis of the present invention, bee pollen preparation method of composition and application thereof, it is characterized in that, the preparation process of bee pollen extract is:
A, bee pollen are pulverized, and cross 100 mesh sieves, by the mode of comminution by gas stream breaking cellular wall by broken wall of melissa pollen.
B, bee pollen is added ethanol water, stir lower warm macerating a few hours, centrifugal with tube centrifuge, filtrate decompression is recycled to without alcohol taste, is solution 1;
C, residue add purified water, stir lower warm macerating a few hours, centrifugal with tube centrifuge; Filtrate is solution 2;
D, solution 1, solution is also 2-in-1, lyophilization is to moisture less than 2.0%;
E, by finished product take out, pulverize, sieve for subsequent use.
Wherein, described bee pollen extract, is characterized in that concentration of alcohol is 40-95%, preferably 80%, and warm macerating temperature is 30-50 DEG C, preferably 40 DEG C.
The present invention a kind of Lac regis apis, bee pollen compositions, is characterized in that described preparation is with described Lac regis apis taste masking lyophilized powder, bee pollen extract for active ingredient, the tablet made after adding adjuvant, capsule, granule, oral liquid.
Lac regis apis taste masking lyophilized powder of the present invention, the kind of cyclodextrin and consumption have obvious impact to Lac regis apis.When cyclodextrin kind is HP-β-CD, prepared Lac regis apis taste masking lyophilized powder good mouthfeel, successful is better than other cyclodextrin, when HP-β-CD: during Lac regis apis weight ratio=1:3, almost there is no acid, puckery, pungent disagreeable taste such as grade, mouthfeel is best, purified water consumption also can directly affect taste masking effect, when purified water consumption is very few, royal jelly solution viscosity is large, not easily mix, mouthfeel is poor, when purified water consumption is too much, mouthfeel gap is little, but waste energy consumption during lyophilizing, when purified water: during Lac regis apis weight ratio=1:1, both energy efficient, substantially mouthfeel is not affected again.
Bee pollen extract of the present invention, first jet mill breaking cellular wall is adopted, be beneficial to solvent extraction, with ethanol extraction flavonoid and Polyphenols etc., concentration of alcohol has the greatest impact to flavonoid and Polyphenols extraction ratio, when concentration of alcohol is 80%, flavonoid and Polyphenols extraction ratio the highest, use purified water by polysaccharide, aminoacid etc. after alcohol extraction, whole process controls temperature, retains enzyme, nucleic acid, hormone isoreactivity composition.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
The Lac regis apis lyophilized powder of embodiment 1 cyclodextrin taste masking enclose
Consisting of of Lac regis apis taste masking lyophilized powder:
Lac regis apis 300g
HP-β-CD 100g
Purified water 300g
Preparation method is as follows:
(1), by 100g HP-β-CD dissolve in 300g purified water, under stirring condition, add 300g Lac regis apis powder, after stirring evenly, continue stirring 36 hours;
(2), by aforesaid liquid in freeze dryer, lyophilization is to moisture less than 2.0%;
(3), by finished product take out, pulverize, sieve for subsequent use.
This lyophilized powder good mouthfeel, does not have acid, the disagreeable taste such as puckery, pungent substantially.
Prepared by embodiment 2 bee pollen extract
Bee pollen extract preparation method is as follows:
(1) bee pollen is pulverized, and crosses 100 mesh sieves, by the mode of comminution by gas stream breaking cellular wall by broken wall of melissa pollen.
(2) bee pollen is added 10 times amount 80% alcoholic solution, 40 DEG C are stirred lower warm macerating 2 hours, and centrifugal with tube centrifuge, filtrate decompression is recycled to without alcohol taste, is solution 1;
(3) residue adds 10 times amount purified water, and 40 DEG C are stirred lower warm macerating number 1 hour, centrifugal with tube centrifuge; Filtrate is solution 2;
(4) solution 1, solution is also 2-in-1, lyophilization is to moisture less than 2.0%;
(5) finished product is taken out, pulverize, sieve for subsequent use.Total polyphenols class content 4.53% in this extract, general flavone content 4.28%, total polysaccharides content 15.9%.
Embodiment 3 Lac regis apis, bee pollen combination buccal tablet
Consisting of of Lac regis apis taste masking lyophilizing buccal tablet:
Preparation method is as follows:
(1), royal jelly extracting taste masking lyophilized powder 350g, bee pollen extract 150g, add 100g mannitol, mixing 20min.
(2), by the powder of mix homogeneously add 90% ethanol, mix 10 minutes, hands is pinched agglomerating, and light pressure is namely loose, makes soft material, granulates with 24 mesh sieves, 40 DEG C of dry 3h.
(3) by dried granule 24 mesh sieve granulate, then add magnesium stearate, mix 10 minutes, tabletting selects Φ 12*6mm scrobicula to rush capsule-type punch die tabletting, makes 1000.
(4) entirely examine, bottling, warehouse-in.
This legal system obtains lyophilizing buccal tablet delicate mouthfeel, smooth surface is attractive in appearance, color and luster is consistent, hygroscopicity is little, thawing speed is moderate in mouth.
Embodiment 4 Lac regis apis, bee pollen combination particle
Consisting of of Lac regis apis taste masking lyophilizing buccal tablet:
Lac regis apis taste masking lyophilized powder 630g
Bee pollen extract 270g
Cane sugar powder 100g
Preparation method is as follows:
(1), royal jelly extracting taste masking lyophilized powder 630g, bee pollen extract 270g, add 100g cane sugar powder, mixing 20min.
(2), by the powder of mix homogeneously add 95% ethanol, mix 10 minutes, granulate, 40 DEG C of dry 2h.
(3) entirely examine, pack, warehouse-in.
This legal system obtains that lyophilizing particle appearance is consistent, ratio of briquetting is high, melting is good, good mouthfeel, sugariness are moderate.
Embodiment 5 Lac regis apis, bee pollen combination particle
Consisting of of Lac regis apis taste masking lyophilizing buccal tablet:
Lac regis apis taste masking lyophilized powder 450g
Bee pollen extract 450
Cane sugar powder 100g
Preparation method is as follows:
(1), royal jelly extracting taste masking lyophilized powder 450g, bee pollen extract 50g, add 100g cane sugar powder, mixing 20min.
(2), by the powder of mix homogeneously add 95% ethanol, mix 10 minutes, granulate, 40 DEG C of dry 2h.
(3) entirely examine, pack, warehouse-in.
This legal system obtains that lyophilizing particle appearance is consistent, ratio of briquetting is high, melting is good, good mouthfeel, sugariness are moderate.
Claims (6)
1. Lac regis apis, bee pollen preparation method of composition and an application thereof, is characterized in that, comprises following component: the various preparations that Lac regis apis taste masking lyophilized powder, bee pollen extract and a small amount of adjuvant are made.
2. according to Lac regis apis a kind of described in claim 1, bee pollen preparation method of composition and application thereof, it is characterized in that, the preparation process of Lac regis apis taste masking lyophilized powder is:
A, cyclodextrin is dissolved in purified water, under stirring condition, add Lac regis apis, after stirring evenly, continue stirring 24 hours.
B, by aforesaid liquid in freeze dryer, lyophilization is to moisture less than 2.0%.
C, by finished product take out, pulverize, sieve for subsequent use.
3. according to Lac regis apis a kind of described in claim 1, bee pollen preparation method of composition and application thereof, it is characterized in that, the preparation process of bee pollen extract is:
A, bee pollen are pulverized, and cross 100 mesh sieves, by the mode of comminution by gas stream breaking cellular wall by broken wall of melissa pollen.
B, bee pollen is added ethanol water, stir lower warm macerating a few hours, centrifugal with tube centrifuge, filtrate decompression is recycled to without alcohol taste, is solution 1;
C, residue add purified water, stir lower warm macerating a few hours, centrifugal with tube centrifuge; Filtrate is solution 2;
D, solution 1, solution is also 2-in-1, lyophilization is to moisture less than 2.0%;
E, by finished product take out, pulverize, sieve for subsequent use.
4. according to Lac regis apis taste masking lyophilized powder according to claim 2, it is characterized in that cyclodextrin be selected from alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, carboxymethyl-beta-cyclodextrin, HP-β-CD or sulfobutyl ether-beta-cyclodextrin any one or arbitrarily multiple according to arbitrary proportion composition mixture; Be preferably HP-β-CD, cyclodextrin and Lac regis apis weight ratio 1:20-2:1, preferred 1:3.
5. according to bee pollen extract according to claim 3, it is characterized in that concentration of alcohol is 40-95%, preferably 80%, warm macerating temperature is 30-50 DEG C, preferably 40 DEG C.
6., according to Lac regis apis a kind of described in claim 1-5, bee pollen compositions, it is characterized in that described preparation is with described Lac regis apis taste masking lyophilized powder, bee pollen extract for active ingredient, the tablet made after adding adjuvant, capsule, granule, oral liquid.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106539023A (en) * | 2016-11-28 | 2017-03-29 | 安徽博蜂生物科技有限公司 | A kind of Bee Pollen lyophilized biological and its preparation technology |
| CN106722611A (en) * | 2016-11-28 | 2017-05-31 | 安徽博蜂生物科技有限公司 | A kind of royal jelly lyophilized biological and its preparation technology |
| CN111493302A (en) * | 2020-03-31 | 2020-08-07 | 浙江金童生物科技有限公司 | Propolis pollen royal jelly tablet and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106539023A (en) * | 2016-11-28 | 2017-03-29 | 安徽博蜂生物科技有限公司 | A kind of Bee Pollen lyophilized biological and its preparation technology |
| CN106722611A (en) * | 2016-11-28 | 2017-05-31 | 安徽博蜂生物科技有限公司 | A kind of royal jelly lyophilized biological and its preparation technology |
| CN111493302A (en) * | 2020-03-31 | 2020-08-07 | 浙江金童生物科技有限公司 | Propolis pollen royal jelly tablet and preparation method thereof |
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