CN106539023A - A kind of Bee Pollen lyophilized biological and its preparation technology - Google Patents
A kind of Bee Pollen lyophilized biological and its preparation technology Download PDFInfo
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- CN106539023A CN106539023A CN201611061637.7A CN201611061637A CN106539023A CN 106539023 A CN106539023 A CN 106539023A CN 201611061637 A CN201611061637 A CN 201611061637A CN 106539023 A CN106539023 A CN 106539023A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of Bee Pollen lyophilized biological and its preparation technology, belong to biological products processing technique field.A kind of Bee Pollen lyophilized biological of the present invention, a kind of Bee Pollen lyophilized biological, including Bee Pollen, royal jelly, Chinese honey locust ground rice, each component parts by weight are：30～50 parts of Bee Pollen, 10～20 parts of royal jelly, 10～20 parts of Chinese honey locust ground rice, 1～2 part of forming agent, 1～2 part of adhesive, 1～2 part of acid, appropriate alcohol are (after follow-up baking step, content is nothing, the purpose for adding alcohol is to mix and be molded granulation), the Bee Pollen of this ratio and saponins contained by Chinese honey locust ground rice have synergy, the effect of surface the played lubricated larger for queen bee slurry viscosity is maximized, and prevents Chinese honey locust ground rice from affecting the taste and effectiveness of royal jelly products.Obtained Bee Pollen lyophilized biological is easily carried, instant edible or medicinal purpose, and compressing tablet is easily, high yield rate.
Description
Technical field
The invention belongs to biological products processing technique field, specifically, be related to a kind of Bee Pollen lyophilized biological and
Its preparation technology.
Background technology
Bee Pollen refers to the pollen load taken back during honeybee producting honey, the pollen formed after storage and fermentation in honeycomb.
Bee Pollen is the male sex-cell in flowering plant stamen, and it not only carries the hereditary information of life, and includes pregnant
Complete nutrients matter necessary to new life is educated, is basic, the source of heat energy that plant is produced a male heir to continue the family line.Honeybee is taken in gathering honey
Powder can collect pollen enough, form pollen load, and after into honeycomb, pollen load can be stored.Its main dietotherapy composition is：Egg
White matter, amino acid, vitamin, Bee Pollen element, trace element, organized enzyme, flavone compound, lipid, nucleic acid, brassin, plant
Acid etc..Wherein amino acid content and ratio are closest to the amino acid pattern that FAO (Food and Agriculture Organization of the United Nation) (FAO) is recommended, and this is natural
It is extremely rare in food.Bee Pollen is the concentrate constituted by the nutritious material with drug effect value, and it contains protein, carbon
Hydrate, mineral matter, vitamin and other active materials.Bee Pollen is both fabulous natural nutrient food, while and one
Preferable invigorant is planted, and with certain medical function.Bee Pollen derives from the Nature, is honeybee from phanerogam (nectar source
Plant and plant of pollen) the interior pollen grain for gathering of pistil, and add special glandular secretion thing (nectar and saliva) mixing
A kind of irregular discoid shape thing is formed.Bee Pollen has unique natural health effect and medical treatment and its cosmetic values, is got over
Recognized come more people, be kind of a high protein and low fat nutritional health food, be described as " all-round nutraceutical " " day of concentration
Right Drug Storage " " cosmetics for oral administration " etc., is the rarity in mankind's wholefood.Exposore is the hard shell of layer, with it is antiacid,
The characteristic of alkaline-resisting, Resistance to microbes, without the Bee Pollen of broken wall, slowly can only discharge content from its germinal aperature.It is fresh
Bee Pollen has special pungent fragrance taste, but taste is also had nothing in common with each other, and most of slightly bitter is puckery, directly takes, and easily causes vomiting.
Royal jelly also known as royal jelly, are the secretion of worker bee lingual gland, are specifically used to feed queen bee and worker bee larvae, are also natural
Tonic food.Royal jelly is the super nutritive food of the high active ingredient for being uniquely available for the mankind directly to take in the world, not only
Can beautifying face and moistering lotion, be also have very big benefit to our body.Fresh royal jelly is milky or flaxen sticky breast
Shape thing, with obvious sour and astringent acid, aftertaste is slightly sweet.Due to the composition of royal jelly it is extremely complex, containing extremely abundant life
Active substances, therefore, it is very sensitive to temperature, stable under low temperature, fails under high temperature, goes bad under normal temperature.Meanwhile, royal jelly
It is oxidized easily in atmosphere.
In view of royal jelly keeps in dark place, To Be Protected from Heat, it is oxidizable rotten the characteristics of, the Pure Royal Jeuy product for occurring in the market is main
There are following several forms.
1st, fresh royal jelly this be the simplest application process of most original, adopt from beehive come fresh royal jelly carry out in time
Filter, remove the impurity brought into during collection, then dispensed on demand, the fresh royal jelly for having dispensed is put into into refrigerator cold-storage,
Ready access upon use.This instructions of taking is very simple, is taken out according to consumption with appropriate tableware and directly take when eating.Due to without plus
Work process, is not affected by change of external conditions such as temperature, pressure, chemical substances, therefore its freshness and nutrition can be kept to live
Property material is difficult to be destroyed.Its weak point is eater it is necessary to have refrigerator, not easy to maintain when going on business or leaving home, agent when taking
Amount is difficult to grasp.
2nd, royal jelly freeze-dried powder, it is that fresh royal jelly is carried out freeze-drying processing, removes its about 65% moisture content, is only protected
Stay the dry product of 2～3% moisture content.This technology maintains the nutrient substance of the fresh royal jelly overwhelming majority, overcomes fresh queen bee
Slurry is difficult the shortcoming taken, carry and preserve, and is welcome by consumer.Its weak point is that dry powder is easily bonded in packaging bag
Layer, throat of easily choking when taking, and also it is unclean.
3rd, queen bee milk capsule this be China's production formulation earlier, including two kinds of hard shell capsules and soft capsule.Hard shell capsules
Built-in pulvis, the grease of the built-in fresh royal jelly of soft capsule are domestic at present to be mainly hard shell capsules.Hard shell capsules are that royal jelly is freezed
Powder loading capsule.The operation of this formulation is less complicated, carries and takes and all facilitates.Which has the disadvantage stomach of the hard shell capsules to human body
There is stimulation in portion, and after some people for having stomach trouble have eaten hard shell capsules, stomach has the reaction of discomfort.
Jing is retrieved, China Patent Publication No.：CN1273785A, publication date：2010.11.22 patent document disclose one
Process for preparing freeze-dried royal jelly tablets is planted, be it is characterized in that distilled water is added in fresh royal jelly first, royal jelly is carried out
Dilution process after, be put in vacuum freeze drier, subsequently -35～-45 degree under the conditions of freeze rapidly, vacuum be 5～
15 μ (micrometer of mercury), vapour pressure are to make under the conditions of 80～110 μ the hydrone for freezing directly rise Huawei's steam effusion, it is possible to
To royal jelly freeze-dried powder；Then Powdered royal jelly will be processed to knock down in rotary tablet machine, external operating environment control
System starts tablet press machine under 25～32 DEG C and 22%～30% damp condition, you can produce the lyophilized lozenge of royal jelly.But the work
The compressing tablet of skill production, as royal jelly freeze-dried powder viscosity is larger, in tableting processes, is very unlikely to the demoulding and causes yield rate not
It is high.
Vacuum Freezing ＆ Drying Technology is under vacuum, to carry out the skill of lyophilization to the material under freezing state
Art, typically in the cellular of internal porous, compared to the material of drying, its rehydration effect is fabulous, is applied to for dried material
After food and medicine processing, the state before the original nutrient content of reservation of the food energy maximum possible after rehydration and drying, but by
The difference of quality, density, moisture content, common condensation point, eutectic point in every kind of food and medicine etc., its drying curve also will not be consistent,
Technical staff is needed to carry out corresponding curve adjustment with reference to the characteristic of food and medicine raw material.
The content of the invention
1. technical problem to be solved
Directly eat for Bee Pollen in prior art and royal jelly or medicinal inconvenience, the lyophilized tablet of existing royal jelly into
The low problem of product rate, the invention provides a kind of Bee Pollen lyophilized biological and its preparation technology.It can realize obtained
Bee Pollen lyophilized biological is easily carried, instant edible or medicinal purpose, and compressing tablet is easily, high yield rate.
2. technical scheme
Used in a kind of Bee Pollen lyophilized biological of the present invention, the know-why of Chinese honey locust ground rice is：
Contain a kind of saponin in saponin rice, saponin belongs to a kind of biosurfactant, and inventor is had found through test：Soap
Glucoside can play a part of lubricated for the surface of the particle thing in microcosmos, so as to play viscosity larger queen bee
The effect that slurry freeze-dried powder is processed through surface lubrication；And, in Bee Pollen also containing micro saponin constituents (content 10～
18.9mg/g, mainly in outer wall), both can produce the action effect of collaboration after being well mixed；Therefore, Chinese honey locust ground rice and queen bee
Freezed after slurry, Bee Pollen three mixing again, tablet is made very big facilitation.
To reach above-mentioned purpose, the technical scheme is that：
A kind of Bee Pollen lyophilized biological, including Bee Pollen, royal jelly, Chinese honey locust ground rice, each component parts by weight are：Honeybee
30～50 parts of pollen, 10～20 parts of royal jelly, 10～20 parts of Chinese honey locust ground rice, 1～2 part of forming agent, 1～2 part of adhesive, acid
1～2 part, appropriate alcohol (after follow-up baking step, content is nothing, and the purpose for adding alcohol is to be molded granulation),
The Bee Pollen of this ratio and saponins contained by Chinese honey locust ground rice have synergy, the surface larger for queen bee slurry viscosity
The effect of played lubricated is maximized, and prevents Chinese honey locust ground rice from affecting the taste and effectiveness of royal jelly products.
Preferably, forming agent is magnesium stearate；Adhesive is polyvinylpyrrolidone；Acid is that citric acid is (appropriate
Flavor adjustment, to adapt to different take crowd)；The yield rate of follow-up compressing tablet can be improved, and facilitates seasoning and shaping.By institute
State Bee Pollen, royal jelly and Chinese honey locust ground rice and be processed into lyophilized Bee Pollen mixed powder, the royal jelly of freeze-dried making, biologically active are protected
Holdup is high；And, obtained lyophilized Bee Pollen mixed powder belongs to vesicular texture, is easily crushed to thinner fineness, in order to
Follow-up granulation and compressing tablet.
Preferably, the making step of lyophilized Bee Pollen mixed powder is：
A, mixing：After the distilled water that Bee Pollen is dissolved in equivalent is mixed, then with royal jelly, Chinese honey locust ground rice, 20～40 parts
Distilled water uniformly mixes；Bee Pollen complicated component, needs Bee Pollen is passed through water dissolves respectively twice, ability uniform dissolution, with
Reach and royal jelly, the mixed uniformly purpose of Chinese honey locust ground rice；
B, paving disk：Disk is spread after mixing position, about 5mm are slightly descended to from material disc edge；
It is C, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -50 DEG C,
3 to 5 hours quick-frozen time；Due to being one layer of hard outer wall outside Bee Pollen pollen grain, pollen wall is, inside is containing each
The inclusion of nutriment and reproduction cell is planted, is separated by a membranoid substance between inclusion and pollen wall, and quick-frozen generation is thin
Little ice crystal can puncture the membranoid substance, after follow-up frozen dried, in order to content is discharged from germinal aperature, to promote human body to inhale
Receive；
D, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry Bee Pollen compound；
E, beat powder：Block lyophilized Bee Pollen compound powder is broken to into 80～100 mesh.
Preferably, the vacuum freeze drying curve of the lyophilized Bee Pollen mixed powder is：
A, temperature raising period：Inner panel temperature is warming up to 55～60 DEG C within 10～15 minutes, is evacuated to below 100Pa, condenser temperature control
Make below -50 DEG C, below -20 DEG C of temperature of charge；
B, distillation peak period：55～60 DEG C of plate temperature, 8～10h of holding, vacuum keep below 50Pa, condenser temperature control-
Less than 50 DEG C, below 0 DEG C of temperature of charge, more than when, stop heating；
C, middle temperature phase：Plate warm water is cold to be down to 40～45 DEG C of 6～8h of holding, and vacuum keeps below 30Pa, condenser temperature control
Below -50 DEG C, below 40 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is down to 25～30 DEG C of 1～2h of holding naturally, and vacuum keeps below 20Pa, condenser temperature
Control less than -50 DEG C, 30 DEG C of temperature of charge below, more than when, stopping heat；
E, hypothermic phase：25 DEG C of 1～2h of holding of plate temperature, vacuum keep below 20Pa.
Preferably, the vacuum freeze drying curve of lyophilized Bee Pollen mixed powder is：
A, temperature raising period：Inner panel temperature is warming up to 25 DEG C within 10～15 minutes, is evacuated to below 100Pa, condenser temperature control-
Less than 50 DEG C, below -20 DEG C of temperature of charge；
B, distillation phase：25 DEG C of 8～10h of holding of plate temperature, vacuum keep below 50Pa, condenser temperature to control below -50 DEG C,
Below 0 DEG C of temperature of charge, more than when, stop heating；
C, middle temperature phase：Plate temperature be warming up to 40～45 DEG C holding 6～8h, vacuum keep below 30Pa, condenser temperature control-
Less than 50 DEG C, below 30 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is warming up to 55～60 DEG C of 3～4h of holding, and vacuum keeps below 20Pa, condenser temperature control
System less than -50 DEG C, 40 DEG C of temperature of charge below, more than when, stopping heat；
E, hypothermic phase：Plate temperature drop keeps below 20Pa to 40 DEG C of 1～2h of holding, vacuum；
F, export：Temperature of charge line and plate temperature line keeping parallelism are without export after fluctuation half an hour.
The curve is inverse curve form, and the hole of obtained lyophilized Bee Pollen compound is uniform, is more suitable for beating powder.
A kind of manufacture craft of Bee Pollen lyophilized biological, step is：
Step one, raw material prepare：The lyophilized Bee Pollen mixed powder for selecting physical and chemical index and microbiological indicator qualified is main former
Material, magnesium stearate, polyvinylpyrrolidone and citric acid are auxiliary material；
Step 2, sieve powder：Various supplementary materials are crossed into the screen cloth of regulation mesh number, is beneficial to mixing；
Step 3, dispensing：The supplementary material for sieving is prepared by requirement ratio；
Step 4, mixing：After the completion of preparation, alcohol mixing, alcohol addition is added to be defined to be well mixed；
Step 5, granulation：The change of feed powder is noted in mixed process, until material granulates；
Step 6, drying：Material after granulation is entered into oven for drying；
Step 7, screening：After drying, with mesh screen by stock grading；
Step 8, compressing tablet：After classification, by material tabletting machine；
Step 9, packaging：Tablet after compressing tablet is packed with Aluminium-coating Packer.
Preferably, the Chinese honey locust ground rice is lyophilized Chinese honey locust ground rice, and its making step is：
A, cleaning：Draining is stood after saponin rice is cleaned；
B, immersion：Saponin rice after draining carries out immersion 4 to 5 in proceeding to the drinking water of 12～15 times of saponin rice gross weight little
When；
C, boiling are boiled：Soaking timing after boiling is heated in add after terminating jacketed pan and stopping heating after 16～20 minutes；
D, insulation：Temperature natural cooling is down to 80～84 DEG C, is incubated 40～50 minutes；
E, boiling are boiled：It is brought rapidly up to boiling, boiling boils 10～15 minutes；
F, cooling：20～25 DEG C are cooled to water-cooled cooling；
G, paving disk：Disk is spread after cooling position is slightly descended to from material disc edge；
It is H, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -40 DEG C,
3 to 3.5 hours quick-frozen time；
I, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry saponin rice；
J, beat powder：Block-type freeze-dried saponin rice is crushed to into 80～100 mesh.
Preferably, the mesh number of step 2 screen cloth is 80～100, reaches Chinese honey locust ground rice and Bee Pollen collaboration is made after being easy to mixing
Effect；It is nothing that step 6 is dried to alcohol content, and oven temperature is not more than 40 DEG C, it is to avoid temperature is too high to affect life to live
Property；The mesh number of step 7 screen cloth is 10, convenient to pelletize.
Preferably, the extraction step of the royal jelly is：
(1) royal jelly frame is taken out from beehive：Propose slurry frame is adopted to royal cell 65～75 hours from worm is moved, honeybee being trembled gently
Fall original position or nest in front of the door, swept only with the remaining group honeybee on honeybee brush handle frame, then interior is transported back adopting slurry frame and being put in fortune frame case；
(2) ceding of Taiwan：Make to adopt before the ceding of Taiwan slurry grid beam downwards, royal cell mouth upward, shake on leg it is several under, allow queen bee nit not from
Royal jelly is opened, then the wax part of stylobate Elevated section is prescinded with sharp blade；During the ceding of Taiwan, blade is firmly brisk uniform,
Make royal cell mouth smooth, it is impossible to cut larva；
(4) press from both sides worm：After the ceding of Taiwan, larva is pressed from both sides out for one with not leaking with tweezers, it is impossible to clip broken larva；It was found that during the ceding of Taiwan
The larva cut, the royal jelly of this stylobate is dug out and is put in the container for containing larva；
(5) take slurry：Taken with clean slurry pen of adopting, or drawn with slurry extracting machine；The royal jelly of taking-up loads to be contained in the devices such as slurry bottle,
Quick-frozen to less than -50 DEG C directly carry out freezing the making of Bee Pollen mixed powder.
Preferably, the vacuum freeze drying curve of the lyophilized Chinese honey locust ground rice is：
A, temperature raising period：Inner panel temperature is warming up to 90～100 DEG C within 10～15 minutes, is evacuated to 150～180Pa；
B, distillation peak period：90～100 DEG C of 4～5h of holding of plate temperature, vacuum keep 100～150Pa；
C, middle temperature phase：Plate warm water is cold to be down to 75～85 DEG C of 6～8h of holding, and vacuum keeps 60～80Pa；
D, parsing-desiccation phase：Plate temperature is down to 65～70 DEG C of 1～2h of holding naturally, and vacuum keeps 40～60Pa；
E, hypothermic phase：55～60 DEG C of 1～2h of holding of plate temperature, vacuum keep 40～50Pa；
F, short-term warming phase：Plate temperature is rapidly heated to 70～75 DEG C, after keeping 15～30min, export.
3. beneficial effect
The technical scheme provided using the present invention, compared with existing known technology, is had the effect that：
(1) a kind of Bee Pollen lyophilized biological of the invention, the combination of Chinese honey locust ground rice and Bee Pollen solve royal jelly
A difficult problem for the bad control of the excessive compressing tablet of freeze-dried powder viscosity, for the making of royal jelly products will play very big facilitation；
(2) a kind of Bee Pollen lyophilized biological of the invention, lyophilized Bee Pollen mixed powder obtained in lyophilized technique, in which
Portion's structure is in cellular, easy rehydration, also can maximum possible holding its original biologically active, nutrient content therein can
Separate out through the effect of water from hole, royal jelly obtained in lyophilized technique and Bee Pollen, effectively prevent its biologically active because
Aoxidize for heating, so as to maintain its activity, the combination and synergistic action effect for nutrient content provides the possibility of maximum,
And dried open structure, it is easily broken, is to beat powder also to create condition；
(3) a kind of Bee Pollen lyophilized biological of the invention, Bee Pollen and Chinese honey locust ground rice, royal jelly, three about 3：
1：1 proportion relation, is inventor through test all the year round, summary and analyzes resulting, by Bee Pollen and Chinese honey locust ground rice
The effect of saponins surface the played lubricated larger for queen bee slurry viscosity is maximized, and prevents Chinese honey locust ground rice shadow
Ring the taste and effectiveness of royal jelly products；Royal jelly presses 1 with Chinese honey locust ground rice：1 ratio allotment, also can effectively extend queen bee
The holding time of slurry activity, therefore, the mixing of three can play synergistic effect, royal jelly can be kept as far as possible to give birth to
Tetramune process and machine the biologically active of rear storage period；
(4) a kind of Bee Pollen lyophilized biological of the invention, plus appropriate alcohol, after follow-up baking step, contains
Amount is nothing, add alcohol, the purpose of adhesive and forming agent be in order to mix and be molded granulation, to improve the yield rate of compressing tablet,
Acid can appropriate flavor adjustment, to adapt to different take crowd；
(5) manufacture craft of a kind of Bee Pollen lyophilized biological of the invention, obtained Bee Pollen lyophilized biological
High yield rate, Bee Pollen, the biologically active conservation rate height of royal jelly, is convenient for carrying, can take immediately, and taste also adapts to difference
Crowd；
(6) manufacture craft of a kind of Bee Pollen lyophilized biological of the invention, be inventor according to various materials not
The targetedly processing step carried out with characteristic, the measure of Jing inventor, the common condensation point of saponin rice at -32 DEG C or so, therefore, it is right
Its quick-frozen requirement is scheduled on less than -40 DEG C, to ensure that each composition of saponin rice can freeze；Boil → be incubated → boil from immersion → boiling
The four-part form that boils softens and cooks, be inventor according to the harder quality of saponin rice, first pass through the immersion infiltration passage of water, then pass through
Boiling is boiled, and insulation is played a part of to consolidate the passage of water, and last secondary boiling is boiled, and the passage of water is maximized
Get through, and specific technological parameter has been drawn through test → practice for many years → test again → summarize, be quick-frozen later by water
Subchannel solidification lays the first stone, then is freezed, so as to the saponin rice after freezing generates cellular lyophilized structure；
(7) manufacture craft of a kind of Bee Pollen lyophilized biological of the invention, royal jelly are total to condensation point at -30 DEG C or so,
Quick freezing repository temperature requires as less than -50 DEG C, increases temperature difference effect, to improve ratio shared by royal jelly zone of maximum ice crystal formation, and subtract
Little internal ice crystal, prevents ice crystal from puncturing royal jelly cell membrane and losing activity；
(8) manufacture craft of a kind of Bee Pollen lyophilized biological of the invention, the vacuum refrigeration for freezing Chinese honey locust ground rice are done
Dry curve, and inventor is through test all the year round, summary and analyzes gained, obtained lyophilized Chinese honey locust ground rice viscosity is reduced, and is fitted
Close the mixing with royal jelly and synergy；
(9) preparation method of a kind of Bee Pollen lyophilized biological of the invention, the vacuum for freezing Bee Pollen mixed powder are cold
It is that inventor is formulated according to the special quality of saponin rice and royal jelly to freeze drying curve, be inventor through test for many years →
Put into practice → test again → summarize, be the crystallization of creative work, taken into account lyophilized cost and lyophilized saponin rice, royal jelly, melissa
Powder maintains its biologically active without the lyophilized quality subsided, maximization；And, inventor Jing test find, temperature curve it is anti-
Formula temperature-raising method, the hole of obtained lyophilized Bee Pollen compound are uniform, are more suitable for beating powder；
(10) manufacture craft of a kind of Bee Pollen lyophilized biological of the invention, the royal jelly for being extracted go out rate height, return
Slurry rate is high, and larva survival rate is high, and royal jelly impurity is few.
Specific embodiment
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
A kind of Bee Pollen lyophilized biological of the present embodiment, each component parts by weight are：30 parts of Bee Pollen, royal jelly 10
Part, 10 parts of Chinese honey locust ground rice, 1 part of magnesium stearate, 1 part of polyvinylpyrrolidone, 1 part of citric acid, 90 parts of alcohol.
A kind of preparation method of Bee Pollen lyophilized biological of the present embodiment, which comprises the following steps that：
First, royal jelly is taken：
1st, fresh honeybee is extracted：
(1) produce the condition of royal jelly：, up to more than 8 sufficient frames, health is disease-free, has more little children in group for group's gesture of bee colony
Worm, the extraneous lowest temperature is more than 14 DEG C；Honeybee forage (honey, powder) is sufficient, and the external world starts by having certain nectar source and powder source
Production；
(2) instrument and equipment of royal jelly are produced：Adopt slurry frame (frame formula adopts slurry frame, or drawer type adopts slurry frame)；Stylobate (wax
Or plastics) or queen cell cup strip；Moving needle for bee-keeping：Royal jelly collector (bamboo chip or 2, No. 3 paintbrushes), sheet rubber, vavuum pump royal jelly collector, fortune frame case (from
System), tweezers, cut entablature blade, slurry filling container, refrigerator or refrigerator-freezer, other (alcohol, gauze, adhesive plasters etc.).
(3) adopt the preparation before slurry：Adopting slurry is carried out indoors, and work-yard cleans up；Work will by ground before starting
A little water are spilt, prevents from kicking up a dust；Operating personnel will wear work clothes, wear working cap, wear masks, and hand is cleaned up；All contacts
The apparatus of royal jelly is such as：Blade, tweezers, slurry, soymilk container tool etc. are taken, with 75% alcohol disinfecting and dried every time.
(4) royal jelly frame is taken out from beehive：Propose slurry frame is adopted to royal cell 70 hours from worm is moved, gently honeybee is shaken off to
In situ or nest in front of the door, is swept only with the remaining group honeybee on honeybee brush handle frame, then transports interior back adopting slurry frame and being put into transport in frame case；
(5) ceding of Taiwan：Make to adopt before the ceding of Taiwan slurry grid beam downwards, royal cell mouth upward, shake on leg it is several under, allow queen bee nit not from
Royal jelly is opened, then the wax part of stylobate Elevated section is prescinded with sharp blade；During the ceding of Taiwan, blade is firmly brisk uniform,
Make royal cell mouth smooth, it is impossible to cut larva；
(6) press from both sides worm：After the ceding of Taiwan, larva is pressed from both sides out for one with not leaking with tweezers, it is impossible to clip broken larva；It was found that during the ceding of Taiwan
The larva cut, the royal jelly of this stylobate is dug out and is put in the container for containing larva；
(7) take slurry：Taken with clean slurry pen of adopting, or drawn with slurry extracting machine；The royal jelly of taking-up loads to be contained in the devices such as slurry bottle,
Quick-frozen to less than -50 DEG C directly carry out freezing the making of Bee Pollen mixed powder.
2nd, Chinese honey locust ground rice is lyophilized Chinese honey locust ground rice, and its making step is：
A, cleaning：Draining is stood after saponin rice is cleaned；
B, immersion：Saponin rice after draining carries out immersion 4 hours in proceeding to the drinking water of 12 times of saponin rice gross weight；
C, boiling are boiled：Soaking timing after boiling is heated in add after terminating jacketed pan and stopping heating after 16 minutes；
D, insulation：Temperature natural cooling is down to 80 DEG C, is incubated 40 minutes；
E, boiling are boiled：It is brought rapidly up to boiling, boiling boils 10 minutes；
F, cooling：20 DEG C are cooled to water-cooled cooling；
G, paving disk：Disk is spread after cooling position is slightly descended to from material disc edge；
It is H, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -40 DEG C,
3 hours quick-frozen time；
I, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry saponin rice；Vacuum freeze drying curve is：
A, temperature raising period：Inner panel temperature is warming up to 90 DEG C within 10 minutes, is evacuated to 150Pa；
B, distillation peak period：Plate temperature 90 keeps 5h, vacuum to keep 100Pa；
C, middle temperature phase：Plate warm water is cold to be down to 75 DEG C of holding 8h, and vacuum keeps 60Pa；
D, parsing-desiccation phase：Plate temperature is down to 65 DEG C of holding 2h naturally, and vacuum keeps 40Pa；
E, hypothermic phase：55 DEG C of holding 2h of plate temperature, vacuum keep 40Pa；
F, short-term warming phase：Plate temperature is rapidly heated to 70 DEG C, and after keeping 30min, export is obtained block-type freeze-dried Chinese honey locust ground rice.
J, beat powder：Block-type freeze-dried saponin rice is crushed to into 80 mesh.
3rd, the making of Bee Pollen mixed powder is freezed, step is：
A, mixing：By the 30 parts of mixing of 30 parts of Bee Pollen and distilled water, at least up to half dissolved state；Take with step one again
10 parts of step 2 of fresh royal jelly obtained in freeze the 10 parts of mixing of Chinese honey locust ground rice after, the distilled water mixing for adding 20 parts is equal
It is even；
B, paving disk：Disk is spread after mixing extremely from material disc along the position of lower 5mm；
It is C, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -50 DEG C,
3 hours quick-frozen time；
D, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry Bee Pollen mixed powder；
E, beat powder：Block lyophilized Bee Pollen mixed powder is crushed to into 100 mesh.
4th, the making of Bee Pollen lyophilized biological tablet, step is：
Step one, raw material prepare：The lyophilized Bee Pollen mixed powder for selecting physical and chemical index and microbiological indicator qualified is main former
Material, magnesium stearate, polyvinylpyrrolidone and citric acid are auxiliary material；
Step 2, sieve powder：Various supplementary materials are crossed into the screen cloth of 100 mesh, is beneficial to mixing；
Step 3, dispensing：The supplementary material for sieving is freezed into 50 parts of Bee Pollen mixed powder, 1 part of magnesium stearate, polyvinyl pyrrole
1 part of alkanone, 1 part of citric acid (can plus can be not added with, need adjustment according to taste)；50 parts of high-purity medicinal alcohol；
Step 4, mixing：After the completion of preparation, 50 parts of high-purity medicinal alcohol is added；
Step 5, granulation：The change of feed powder is noted in mixed process, until material granulates；
Step 6, drying：Material after granulation is entered into oven for drying, oven temperature is not more than 30 DEG C；
Step 7, screening：After drying, with 10 mesh mesh screens by stock grading；
Step 8, compressing tablet：After classification, by material tabletting machine；
Step 9, packaging：Tablet after compressing tablet is packed with Aluminium-coating Packer, Bee Pollen lyophilized biological piece is obtained
Agent.
Lyophilized biological tablet obtained in the present embodiment, piece shape are clean and tidy, the demoulding easily, take with it is easy to carry, and most
It is possible greatly to maintain the original bioactivator of royal jelly.
Embodiment 2
A kind of Bee Pollen lyophilized biological of the present embodiment, including royal jelly, Bee Pollen, Chinese honey locust ground rice, each component weight
Measuring number is：50 parts of Bee Pollen, 20 parts of royal jelly, 20 parts of Chinese honey locust ground rice, 2 parts of magnesium stearate, 2 parts of polyvinylpyrrolidone.
A kind of preparation method of Bee Pollen lyophilized biological of the present embodiment, its basic step improve it with embodiment 1
Place is：
The vacuum freeze drying curve of lyophilized Bee Pollen mixed powder is：
A, temperature raising period：Inner panel temperature is warming up to 50～60 DEG C within 30～45 minutes, is evacuated to below 120Pa, condenser temperature control
Make below -50 DEG C, below -20 DEG C of temperature of charge；
B, distillation peak period：50～60 DEG C of plate temperature, 8～10h of holding, vacuum keep below 50Pa, condenser temperature control-
Less than 50 DEG C, below 0 DEG C of temperature of charge, more than when, stop heating；
C, middle temperature phase：Plate warm water is cold to be down to 40～45 DEG C of 6～8h of holding, and vacuum keeps below 30Pa, condenser temperature control
Below -50 DEG C, below 40 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is down to 25～30 DEG C of 1～2h of holding naturally, and vacuum keeps below 20Pa, condenser temperature
Control less than -50 DEG C, 30 DEG C of temperature of charge below, more than when, stopping heat；
E, hypothermic phase：25 DEG C of 1～2h of holding of plate temperature, vacuum keep below 20Pa.
The vacuum freeze drying curve of the lyophilized Bee Pollen mixed powder of the present embodiment is inventor according to Bee Pollen, saponin rice
The quality special with royal jelly and formulate, be inventor through test → practice for many years → test again → summarize, be creative
The crystallization of work, has taken into account lyophilized cost and lyophilized saponin rice, Bee Pollen, royal jelly without the lyophilized quality subsided, has maximized and protect
Its biologically active is held.
Embodiment 3
A kind of Bee Pollen lyophilized biological of the present embodiment, including royal jelly, Bee Pollen, Chinese honey locust ground rice, each component weight
Measuring number is：40 parts of Bee Pollen, 15 parts of royal jelly, 15 parts of Chinese honey locust ground rice, 1.5 parts of magnesium stearate, polyvinylpyrrolidone 1.5
Part.
A kind of preparation method of the Bee Pollen lyophilized biological of the present embodiment, its basic step with embodiment 1, difference
Place is：
The making step of Chinese honey locust ground rice is：
A, cleaning：Draining is stood after saponin rice is cleaned；
B, immersion：Saponin rice after draining carries out immersion 5 hours in proceeding to the drinking water of 15 times of saponin rice gross weight；
C, boiling are boiled：Soaking timing after boiling is heated in add after terminating jacketed pan and stopping heating after 20 minutes；
D, insulation：Temperature natural cooling is down to 84 DEG C, is incubated 50 minutes；
E, boiling are boiled：It is brought rapidly up to boiling, boiling boils 15 minutes；
F, cooling：25 DEG C are cooled to water-cooled cooling；
G, paving disk：Disk is spread after cooling position is slightly descended to from material disc edge；
It is H, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -40 DEG C,
3.5 hours quick-frozen time；
I, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry saponin rice；Vacuum freeze drying curve is：
A, temperature raising period：Inner panel temperature is warming up to 100 DEG C within 15 minutes, is evacuated to 180Pa；
B, distillation peak period：100 DEG C of holding 4h of plate temperature, vacuum keep 150Pa；
C, middle temperature phase：Plate warm water is cold to be down to 85 DEG C of holding 6h, and vacuum keeps 80Pa；
D, parsing-desiccation phase：Plate temperature is down to 70 DEG C of holding 1h naturally, and vacuum keeps 60Pa；
E, hypothermic phase：60 DEG C of holding 1h of plate temperature, vacuum keep 50Pa；
F, short-term warming phase：Plate temperature is rapidly heated to 75 DEG C, and after keeping 15min, export is obtained block-type freeze-dried Chinese honey locust ground rice.
J, beat powder：Block-type freeze-dried saponin rice is crushed to into 100 mesh.
The making step of lyophilized Bee Pollen mixed powder is：
A, mixing：By the 40 parts of mixing of 40 parts of Bee Pollen and distilled water, at least up to half dissolved state；Take with step one again
15 parts of step 2 of fresh royal jelly obtained in freeze the 15 parts of mixing of Chinese honey locust ground rice after, the distilled water mixing for adding 30 parts is equal
It is even；
B, paving disk：Disk is spread after mixing position is slightly descended to from material disc edge；
It is C, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -50 DEG C,
5 hours quick-frozen time；
D, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry Bee Pollen mixed powder；
The vacuum freeze drying curve of lyophilized Bee Pollen mixed powder is：
A, temperature raising period：Inner panel temperature is warming up to 25 DEG C within 10～15 minutes, is evacuated to below 100Pa, condenser temperature control-
Less than 50 DEG C, below -20 DEG C of temperature of charge；
B, distillation phase：25 DEG C of 8～10h of holding of plate temperature, vacuum keep below 50Pa, condenser temperature to control below -50 DEG C,
Below 0 DEG C of temperature of charge, more than when, stop heating；
C, middle temperature phase：Plate temperature be warming up to 40～45 DEG C holding 6～8h, vacuum keep below 30Pa, condenser temperature control-
Less than 50 DEG C, below 30 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is warming up to 55～60 DEG C of 3～4h of holding, and vacuum keeps below 20Pa, condenser temperature control
System less than -50 DEG C, 40 DEG C of temperature of charge below, more than when, stopping heat；
E, hypothermic phase：Plate temperature drop keeps below 20Pa to 40 DEG C of 1～2h of holding, vacuum；
F, export：Temperature of charge line and plate temperature line keeping parallelism are obtained block jelly without export after fluctuation half an hour and freeze melissa
Powder.
J, beat powder：Block lyophilized Bee Pollen mixed powder is crushed to into 100 mesh.
It is finally the making of Bee Pollen lyophilized biological tablet, step is：
Step one, raw material prepare：The lyophilized Bee Pollen mixed powder for selecting physical and chemical index and microbiological indicator qualified is main former
Material, magnesium stearate, polyvinylpyrrolidone and citric acid are auxiliary material；
Step 2, sieve powder：Various supplementary materials are crossed into the screen cloth of 100 mesh, is beneficial to mixing；
Step 3, dispensing：The supplementary material for sieving is freezed into 85 parts of Bee Pollen mixed powder, 1.5 parts of magnesium stearate, polyethylene pyrrole
1.5 parts of pyrrolidone, 1.5 parts of citric acid (can plus can be not added with, need adjustment according to taste)；85 parts of high-purity medicinal alcohol；
Step 4, mixing：After the completion of preparation, 85 parts of high-purity medicinal alcohol is added；
Step 5, granulation：The change of feed powder is noted in mixed process, until material granulates；
Step 6, drying：Material after granulation is entered into oven for drying, oven temperature is not more than 30 DEG C；
Step 7, screening：After drying, with 10 mesh mesh screens by stock grading；
Step 8, compressing tablet：After classification, by material tabletting machine；
Step 9, packaging：Tablet after compressing tablet is packed with Aluminium-coating Packer, Bee Pollen lyophilized biological piece is obtained
Agent.
Embodiment 4
A kind of Bee Pollen lyophilized biological of the present embodiment, including royal jelly, Bee Pollen, Chinese honey locust ground rice, each component weight
Measuring number is：30 parts of Bee Pollen, 15 parts of royal jelly, 15 parts of Chinese honey locust ground rice, 10 parts of Bee Pollen, 1.5 parts of magnesium stearate, polyethylene pyrrole
1.5 parts of pyrrolidone.
A kind of preparation method of the Bee Pollen lyophilized biological of the present embodiment, its basic step with embodiment 1, difference
Place is：
The making step of Chinese honey locust ground rice is：
A, cleaning：Draining is stood after saponin rice is cleaned；
B, immersion：Saponin rice after draining carries out immersion 4 hours in proceeding to the drinking water of 13 times of saponin rice gross weight；
C, boiling are boiled：Soaking timing after boiling is heated in add after terminating jacketed pan and stopping heating after 18 minutes；
D, insulation：Temperature natural cooling is down to 80 DEG C, is incubated 60 minutes；
E, boiling are boiled：It is brought rapidly up to boiling, boiling boils 15 minutes；
F, cooling：Temperature fall is cooled to 25 DEG C；
G, paving disk：Disk is spread after cooling position, about 5mm are slightly descended to from material disc edge；
It is H, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -40 DEG C,
4 hours quick-frozen time；
I, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry saponin rice；Vacuum freeze drying curve is：
A, temperature raising period：Inner panel temperature is warming up to 100 DEG C within 20 minutes, is evacuated to 180Pa；
B, distillation peak period：100 DEG C of holding 3h of plate temperature, vacuum keep 150Pa；
C, middle temperature phase：Plate warm water is cold to be down to 90 DEG C of holding 7h, and vacuum keeps 80Pa；
D, parsing-desiccation phase：Plate temperature is down to 70 DEG C of holding 1h naturally, and vacuum keeps 60Pa；
E, hypothermic phase：60 DEG C of plate temperature, vacuum keep 50Pa, wait that the gentle temperature of charge line of plate is parallel to continue 40 points without fluctuation
Clock, export are obtained block-type freeze-dried Chinese honey locust ground rice.
J, beat powder：Block-type freeze-dried saponin rice is crushed to into 100 mesh.
The making step of lyophilized Bee Pollen mixed powder is：
A, mixing：By the 30 parts of mixing of 30 parts of Bee Pollen and distilled water, at least up to half dissolved state；Take with step one again
15 parts of step 2 of fresh royal jelly obtained in freeze 15 parts of Chinese honey locust ground rice and 10 parts of propolis (propolis is first dissolved in alcohol) is mixed
After conjunction, the distilled water for adding 40 parts is well mixed；
B, paving disk：Disk is spread after mixing position, about 5mm are slightly descended to from material disc edge；
It is C, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -50 DEG C,
5 hours quick-frozen time；
D, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block jelly after being dried in proceeding to vacuum freeze drying cabin
Dry Bee Pollen mixed powder；
The vacuum freeze drying curve of lyophilized Bee Pollen mixed powder is：
A, temperature raising period：Inner panel temperature is warming up to 25 DEG C within 15 minutes, is evacuated to below 100Pa, and condenser temperature is controlled at -50 DEG C
Hereinafter, below -20 DEG C of temperature of charge；
B, distillation phase：25 DEG C of holding 10h of plate temperature, vacuum keep below 50Pa, condenser temperature to control below -50 DEG C, thing
Below 0 DEG C of material temperature degree, more than when, stop heating；
C, middle temperature phase：Plate temperature be warming up to 40 DEG C holding 8h, vacuum keep below 30Pa, condenser temperature control -50 DEG C with
Under, below 30 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is warming up to 60 DEG C of holding 3h, and vacuum keeps below 20Pa, condenser temperature to control -50
Below DEG C, below 40 DEG C of temperature of charge, more than when, stop heating；
E, middle temperature phase：Plate temperature drop keeps below 20Pa to 30 DEG C of holding 2h, vacuum；
F, export：Temperature of charge line and plate temperature line keeping parallelism are obtained block jelly without export after fluctuation half an hour and freeze melissa
Powder.
J, beat powder：Block lyophilized Bee Pollen mixed powder is crushed to into 100 mesh.
It is finally the making of Bee Pollen lyophilized biological tablet, step is：
Step one, raw material prepare：The lyophilized Bee Pollen mixed powder for selecting physical and chemical index and microbiological indicator qualified is main former
Material, magnesium stearate, polyvinylpyrrolidone and citric acid are auxiliary material；
Step 2, sieve powder：Various supplementary materials are crossed into the screen cloth of 100 mesh, is beneficial to mixing；
Step 3, dispensing：The supplementary material for sieving is freezed into 85 parts of Bee Pollen mixed powder, 1.5 parts of magnesium stearate, polyethylene pyrrole
1.5 parts of pyrrolidone, 1.5 parts of citric acid (can plus can be not added with, need adjustment according to taste)；85 parts of high-purity medicinal alcohol；
Step 4, mixing：After the completion of preparation, 85 parts of high-purity medicinal alcohol is added；
Step 5, granulation：The change of feed powder is noted in mixed process, until material granulates；
Step 6, drying：Material after granulation is entered into oven for drying, oven temperature is not more than 30 DEG C；
Step 7, screening：After drying, with 10 mesh mesh screens by stock grading；
Step 8, compressing tablet：After classification, by material tabletting machine；
Step 9, packaging：Tablet after compressing tablet is packed with Aluminium-coating Packer, Bee Pollen lyophilized biological piece is obtained
Agent.
Inventor had once carried out pharmacological testing with big white mouse：150 big white mouse are performed the operation, is then existed with chemical substance
The coat of the stomach of big white mouse causes ulcer.4 hours of Post operation start to feed royal jelly lyophilized biological tablet.1 group 25 are tested, often
The tablet of embodiment 1 is fed every 4 hours；2 groups 25 are tested, and the tablet of embodiment 2 are fed every 4 hours；3 groups 25 are tested,
The tablet of embodiment 3 is fed every 4 hours；4 groups 25 are tested, and the tablet of embodiment 4 are fed every 4 hours；Test 5 group 25
Only, the royal jelly with dosage is fed every 4 hours.Control group 25, feeds physiological saline daily.By the 10th day, will be all big
White mouse is performed the operation, and observes the situation of gastric ulcer.
As a result：
The gastric ulcer healing rate for testing 1 group of big white mouse is that 82.5%, the gastric ulcer healing rate of 2 groups of big white mouse of experiment is
88.1%th, the gastric ulcer healing rate for testing 3 groups of big white mouse is that 91.3%, the gastric ulcer healing rate of 4 groups of big white mouse of experiment is
96.7%th, the gastric ulcer healing rate for testing 5 groups of big white mouse is that the gastric ulcer healing rate of 86.2%, control group big white mouse is
17.5%.Not only apparently higher than control group, 2 to 4 groups of experiment also greater than test 2 groups to the healing rate of 1 to 4 group of experiment, and ulcer
Area reduces, shoals.
Analysis result, royal jelly and propolis, Bee Pollen are respectively provided with the pharmacological effect of antibacterial, anti-inflammatory, after freeze-dried film-making, three
Person or the two can produce the effect of cooperating type, can speed up the gastric ulcer healing of big white mouse.
Below schematically the invention and embodiments thereof are described, the description is not restricted.So,
If one of ordinary skill in the art is enlightened by which, in the case of without departing from this creation objective, without creative design
Go out the frame mode similar to the technical scheme and embodiment, the protection domain of this patent all should be belonged to.
Claims (10)
1. a kind of Bee Pollen lyophilized biological, including Bee Pollen, royal jelly, Chinese honey locust ground rice, it is characterised in that each component weight
Number is：30～50 parts of Bee Pollen, 10～20 parts of royal jelly, 10～20 parts of Chinese honey locust ground rice, 1～2 part of forming agent, adhesive 1～2
Part, 1～2 part of acid, appropriate alcohol.
2. a kind of Bee Pollen lyophilized biological according to claim 1, it is characterised in that：The forming agent is stearic acid
Magnesium；Adhesive is polyvinylpyrrolidone；Acid is citric acid；The Bee Pollen, royal jelly and Chinese honey locust ground rice are processed into
Lyophilized Bee Pollen mixed powder.
3. a kind of Bee Pollen lyophilized biological according to claim 2, it is characterised in that：The lyophilized Bee Pollen mixing
The making step of powder is：
A, mixing：After the distilled water that Bee Pollen is dissolved in equivalent is mixed, then with royal jelly, Chinese honey locust ground rice, 20～40 parts of distillation
Water uniformly mixes；
B, paving disk：Disk is spread after mixing position is slightly descended to from material disc edge；
It is C, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -50 DEG C, it is quick-frozen
3 to 5 hours time；
D, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block-type freeze-dried honeybee after being dried in proceeding to vacuum freeze drying cabin
Pollen compound；
E, beat powder：Block lyophilized Bee Pollen compound powder is broken to into 80～100 mesh.
4. a kind of Bee Pollen lyophilized biological according to claim 3, it is characterised in that：The lyophilized Bee Pollen mixing
The vacuum freeze drying curve of powder is：
A, temperature raising period：Inner panel temperature is warming up to 55～60 DEG C within 10～15 minutes, is evacuated to below 100Pa, condenser temperature control-
Less than 50 DEG C, below -20 DEG C of temperature of charge；
B, distillation peak period：55～60 DEG C of 8～10h of holding of plate temperature, vacuum keep below 50Pa, condenser temperature to control at -50 DEG C
Hereinafter, below 0 DEG C of temperature of charge, more than when, stop heating；
C, middle temperature phase：Plate warm water is cold to be down to 40～45 DEG C of 6～8h of holding, and vacuum keeps below 30Pa, condenser temperature to control -50
Below DEG C, below 40 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature is down to 25～30 DEG C of 1～2h of holding naturally, and vacuum keeps below 20Pa, condenser temperature control
Below -50 DEG C, below 30 DEG C of temperature of charge, more than when, stop heating；
E, hypothermic phase：25 DEG C of 1～2h of holding of plate temperature, vacuum keep below 20Pa.
5. a kind of Bee Pollen lyophilized biological according to claim 3, it is characterised in that：The lyophilized Bee Pollen mixing
The vacuum freeze drying curve of powder is：
A, temperature raising period：Inner panel temperature is warming up to 25 DEG C within 10～15 minutes, is evacuated to below 100Pa, and condenser temperature is controlled at -50 DEG C
Hereinafter, below -20 DEG C of temperature of charge；
B, distillation phase：25 DEG C of 8～10h of holding of plate temperature, vacuum keep below 50Pa, condenser temperature to control below -50 DEG C, material
Below 0 DEG C of temperature, more than when, stop heating；
C, middle temperature phase：Plate temperature is warming up to 40～45 DEG C of 6～8h of holding, and vacuum keeps below 30Pa, condenser temperature to control at -50 DEG C
Hereinafter, below 30 DEG C of temperature of charge, more than when, stop heating；
D, parsing-desiccation phase：Plate temperature be warming up to 55～60 DEG C holding 3～4h, vacuum keep below 20Pa, condenser temperature control-
Less than 50 DEG C, below 40 DEG C of temperature of charge, more than when, stop heating；
E, hypothermic phase：Plate temperature drop keeps below 20Pa to 40 DEG C of 1～2h of holding, vacuum；
F, export：Temperature of charge line and plate temperature line keeping parallelism are without export after fluctuation half an hour.
6. the manufacture craft of the Bee Pollen lyophilized biological described in a kind of claim 4, it is characterised in that step is：
Step one, raw material prepare：The lyophilized Bee Pollen mixed powder for selecting physical and chemical index and microbiological indicator qualified is primary raw material, firmly
Fatty acid magnesium, polyvinylpyrrolidone and citric acid are auxiliary material；
Step 2, sieve powder：Various supplementary materials are sieved, is beneficial to mixing；
Step 3, dispensing：The supplementary material for sieving is prepared by requirement ratio；
Step 4, mixing：After the completion of preparation, alcohol mixing, alcohol addition is added to be defined to be well mixed；
Step 5, granulation：The change of feed powder is noted in mixed process, until material granulates；
Step 6, drying：Material after granulation is entered into oven for drying；
Step 7, screening：After drying, with mesh screen by stock grading；
Step 8, compressing tablet：After classification, by material tabletting machine；
Step 9, packaging：Tablet after compressing tablet is packed with Aluminium-coating Packer.
7. the manufacture craft of Bee Pollen lyophilized biological according to claim 6, it is characterised in that：The Chinese honey locust ground rice
To freeze Chinese honey locust ground rice, its making step is：
A, cleaning：Draining is stood after saponin rice is cleaned；
B, immersion：Saponin rice after draining carries out immersion 4 to 5 hours in proceeding to the drinking water of 12～15 times of saponin rice gross weight；
C, boiling are boiled：Soaking timing after boiling is heated in add after terminating jacketed pan and stopping heating after 16～20 minutes；
D, insulation：Temperature natural cooling is down to 80～84 DEG C, is incubated 40～50 minutes；
E, boiling are boiled：It is brought rapidly up to boiling, boiling boils 10～15 minutes；
F, cooling：20～25 DEG C are cooled to water-cooled cooling；
G, paving disk：Disk is spread after cooling position is slightly descended to from material disc edge；
It is H, quick-frozen：By paving disk after semi-finished product proceed to carry out in quick freezing repository it is quick-frozen, quick freezing repository temperature require be less than -40 DEG C, it is quick-frozen
3 to 3.5 hours time；
I, vacuum freeze drying：Semi-finished product after quick-frozen obtain final product block-type freeze-dried soap after being dried in proceeding to vacuum freeze drying cabin
Angle rice；
J, beat powder：Block-type freeze-dried saponin rice is crushed to into 80～100 mesh.
8. the manufacture craft of Bee Pollen lyophilized biological according to claim 6, it is characterised in that：The royal jelly
Extraction step is：
(1) royal jelly frame is taken out from beehive：Propose slurry frame is adopted to royal cell 65～75 hours from worm is moved, gently honeybee is shaken off to
In situ or nest in front of the door, is swept only with the remaining group honeybee on honeybee brush handle frame, then transports interior back adopting slurry frame and being put into transport in frame case；
(2) ceding of Taiwan：Make to adopt before the ceding of Taiwan slurry grid beam downwards, royal cell mouth upward, shake on leg it is several under, allow queen bee nit without departing from king
Then the wax part of stylobate Elevated section is prescinded by slurry with sharp blade；During the ceding of Taiwan, blade is firmly brisk uniform, makes king
Entablature is smooth, it is impossible to cut larva；
(4) press from both sides worm：After the ceding of Taiwan, larva is pressed from both sides out for one with not leaking with tweezers, it is impossible to clip broken larva；It was found that cutting during the ceding of Taiwan
Larva, the royal jelly of this stylobate is dug out put into contain larva container in；
(5) take slurry：Taken with clean slurry pen of adopting, or drawn with slurry extracting machine；The royal jelly of taking-up loads to be contained in the devices such as slurry bottle, quick-frozen
The making of lyophilized Bee Pollen mixed powder is carried out to less than -50 DEG C or directly.
9. the manufacture craft of Bee Pollen lyophilized biological according to claim 6, it is characterised in that：The lyophilized Chinese honey locust
The vacuum freeze drying curve of ground rice is：
A, temperature raising period：Inner panel temperature is warming up to 90～100 DEG C within 10～15 minutes, is evacuated to 150～180Pa；
B, distillation peak period：90～100 DEG C of 4～5h of holding of plate temperature, vacuum keep 100～150Pa；
C, middle temperature phase：Plate warm water is cold to be down to 75～85 DEG C of 6～8h of holding, and vacuum keeps 60～80Pa；
D, parsing-desiccation phase：Plate temperature is down to 65～70 DEG C of 1～2h of holding naturally, and vacuum keeps 40～60Pa；
E, hypothermic phase：55～60 DEG C of 1～2h of holding of plate temperature, vacuum keep 40～50Pa；
F, short-term warming phase：Plate temperature is rapidly heated to 70～75 DEG C, after keeping 15～30min, export.
10. the manufacture craft according to the arbitrary described Bee Pollen lyophilized biological of claim 6 to 10, it is characterised in that：Institute
The mesh number for stating step 2 screen cloth is 80～100；It is nothing that step 6 is dried to alcohol content, and oven temperature is not more than 40 DEG C；Step
The mesh number of seven screen clothes is 10.
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| CN109892609A (en) * | 2019-03-14 | 2019-06-18 | 温州声大蜂业专业合作社 | A kind of royal jelly-pollen sweet and preparation method thereof |
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Effective date of registration: 20191227 Address after: 243000 Anhui Province Economic and Technological Development Zone Ma'anshan Hongqi Road No. 88 Branch Center in A426 Applicant after: Anhui Jinfeng bee venom Biotechnology Development Co., Ltd Address before: 243000 Anhui city of Ma'anshan province Dangtu County Gu Shu Town Industrial Zone Ping Road No. 1 Applicant before: Anhui bee Biotechnology Co., Ltd. |