CN108477351A - A kind of liver-nourishing tea of the extract containing Agricus blazei and preparation method thereof - Google Patents
A kind of liver-nourishing tea of the extract containing Agricus blazei and preparation method thereof Download PDFInfo
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- CN108477351A CN108477351A CN201810260530.8A CN201810260530A CN108477351A CN 108477351 A CN108477351 A CN 108477351A CN 201810260530 A CN201810260530 A CN 201810260530A CN 108477351 A CN108477351 A CN 108477351A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
It is that the liver-nourishing tea is made by being separately added into Agricus blazei extract, florists chrysanthemum seedling extracting solution during just rubbing and rubbing again using wolfberry leaf, South Africa leaf as primary raw material the invention discloses liver-nourishing tea of a kind of extract containing Agricus blazei and preparation method thereof.The tea product has effects that well to quench one's thirst, promote the production of body fluid, lipid-loweringing, toxin expelling, nourishing the liver, protect liver, market promotion prospect is huge.
Description
Technical field
The invention belongs to Medicines and Health Product technical fields, and in particular to a kind of liver-nourishing tea and its system of the extract containing Agricus blazei
Preparation Method.
Background technology
Liver is metabolic organ important in human body, and very important effect is played in human detoxification, meanwhile, liver is also
Internal choleresis, the adjusting of protein, fat and carbohydrate levels are participated in, therefore Chinese medicine thinks that way to keep in good health head is protected again
Liver.But today's society, since rhythm of life is fast, longevity of service, pressure are big and is stayed up late by for a long time, excessive drinking and smoking, lacks movement
Etc. factors influence, keep the patients with liver diseases such as fatty liver, alcoholic liver, chronic hepatitis more and more.And on the other hand, for liver
The prevention of dirty disease, modern medicine and pharmacology not yet develop suitable specific drug.Therefore, by taking health product or drinking health care
Tea is come the effect of reaching nourishing the liver liver protection, it has also become the important means of the daily prevention liver diseases of people.
Agricus blazei also known as Brazilian mushroom, little Song mushrooms originate in Brazil, Peru, are a kind of saprophytic bacterias growing in summer and autumn.Ji Song
Young pilose antler tool almond flavor, crisp in taste, the pure fresh perfume (or spice) of taste, and it contains 8 kinds of amino acid and multiple-microorganism needed by human, ergot steroids
The ingredients such as alcohol, edible value are quite high.Meanwhile modern research shows that Agricus blazei also have enhancing function of immune system, it is hypoglycemic,
Reducing blood lipid and other effects, and it inhibits the effect of tumour to occupy first of each medicinal fungi, is a kind of rare fungi of dietotherapeutic.
Invention content
The purpose of the present invention is to provide liver-nourishing tea of a kind of extract containing Agricus blazei and preparation method thereof, the nourishing the liver tea sets
Have well quench one's thirst, promote the production of body fluid, lipid-loweringing, toxin expelling, nourishing the liver, protect liver the effect of, market promotion prospect is huge.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of liver-nourishing tea of the extract containing Agricus blazei, it is raw materials used to be calculated as by weight：20-25 parts of wolfberry leaf, South Africa leaf 10-
15 parts, 6-8 parts of Agricus blazei extract, 5-6 parts of florists chrysanthemum seedling extracting solution.
The Agricus blazei extract is to crush Agricus blazei fructification, crosses 80-100 mesh sieve；Then solid-liquid ratio 1 is pressed:5-20
Water is added in gained Agricus blazei powder in g/mL, and the mixture of the cellulase and protease of Agricus blazei powder weight 2-3% is added,
With hydrochloric acid conditioning solution pH to 6.0 ~ 6.5, enzymolysis processing 30min；Gained enzymolysis liquid is used into ultrasonic wave extraction 20- later
30min, ultrafiltration；It after gained filtrate is concentrated to dryness, is dissolved in water, is evaporated again；It so repeats to dissolve, be evaporated 3-5 times to drying
After object is without tart flavour, by mass volume ratio 1:Dried object is dissolved in water by 8-12 g/mL again, and the nothing of water consumption 60-70% is added
Water-ethanol, mixing centrifuge after standing overnight, and take pellet frozen drying to get the Agricus blazei extract；It is fine in the mixture
The mass ratio of the plain enzyme of dimension and protease is 1:1.
The florists chrysanthemum seedling extracting solution is to beat to be slurried after cleaning florists chrysanthemum seedling, then by weight 1:Sweet osmanthus flower distillate is added in 1-2,
Dipping through filtered through gauze and extracts moisture after 2-3 days, and the florists chrysanthemum seedling extracting solution is made.
The preparation method of the liver-nourishing tea of the extract containing Agricus blazei includes the following steps：
1）After wolfberry leaf, South Africa leaf are washed with water respectively, in shady and cool, ventilation airing 5-8h；
2）Wolfberry leaf is put into green-keeping machine, in 100-120 DEG C of water-removing processing 5-8min；
3）By the wolfberry leaf airing cooling after water-removing, then pours into rolling machine and mix jointly with South Africa leaf, Agricus blazei extract
Uniformly, then by pneumatics, light pressure, the principle of pneumatics 10-15min is rubbed, until tealeaves shapes substantially；
4）By the tealeaves after rubbing, airing cools down after dry 2-3h at 60-80 DEG C；
5）Tealeaves after drying is poured into rolling machine again, pneumatics uniformly sprays into florists chrysanthemum seedling extracting solution after rubbing 3min, then presses
Light pressure, middle pressure, the principle of pneumatics rub 30-50min, to form the tea item tightly locked；
6）By the freeze-dried rear packaging of gained tea item to get the liver-nourishing tea.
The present invention is particularly advantageous in that compared with the prior art：
（1）Obtain through refining that the standby prior art of extract is different, and the present invention carries out ultrasonic extraction again after enzymolysis, can make system from conventional water
Polyoses content is obviously improved in standby Agricus blazei extract.
（2）Florists chrysanthemum seedling extracting solution is prepared using sweet osmanthus dew retting in the present invention, it is bright using sweet osmanthus flower distillate dispersing stagnated hepatoqi, clearing lung-heat
Purpose effect improves the easypro liver clearing liver effect of florists chrysanthemum seedling.
（3）Agricus blazei extract is added in just rubbing step in the present invention, is not only to keep Agricus blazei extract effective
It is wrapped in inside tea item, and using the addition of powdered Agricus blazei extract, can further promote the destruction of leaf texture, to fast
Speed reaches good knead effect；Florists chrysanthemum seedling extracting solution is sprayed into rubbing step again, is the desiccation using tealeaves after drying
Promote the absorption of extracting solution；And the tea item after rubbing again is freeze-dried, and can be not only effectively retained various contained in product
Ingredient, and freeze-dried rear tea loose and porous inner surface, the dissolution of functional component when being conducive to brew.
（4）The present invention with the wolfberry leaf that has effects that liver-kidney tonifying, promote the production of body fluid to quench thirst with heat-clearing, cool blood, detoxicating functions
South Africa leaf be primary raw material, have in conjunction with liver-nourishing tea prepared by Agricus blazei extract and florists chrysanthemum seedling extracting solution and well quench one's thirst, give birth to
The effect of Tianjin, lipid-loweringing, toxin expelling, nourishing the liver, protect liver, market promotion prospect is huge.
Specific implementation mode
In order to make content of the present invention easily facilitate understanding, With reference to embodiment to of the present invention
Technical solution is described further, but the present invention is not limited only to this.
The preparation of Agricus blazei extract：Agricus blazei fructification is crushed, 80-100 mesh sieve is crossed；Then solid-liquid ratio 1 is pressed:10
Water is added in gained Agricus blazei powder in g/mL, and the mixture of the cellulase and protease of Agricus blazei powder weight 2% is added（It is fine
The mass ratio of the plain enzyme of dimension and protease is 1:1）, with hydrochloric acid conditioning solution pH to 6.0 ~ 6.5, enzymolysis processing 30min；Later by institute
It obtains enzymolysis liquid and uses ultrasonic wave extraction 20min, ultrafiltration；It after gained filtrate is concentrated to dryness, is dissolved in water, is evaporated again；So weight
Redissolve solution, be evaporated 3-5 times to dried object without tart flavour after, by mass volume ratio 1:Dried object is dissolved in water by 10 g/mL again, and
The absolute ethyl alcohol of water consumption 60% is added, mixing centrifuges after standing overnight, and takes pellet frozen drying to get Agricus blazei extract；
The yield of gained Agricus blazei extract is up to 4.1%, polyoses content up to 88%.
The preparation of florists chrysanthemum seedling extracting solution：It beats and is slurried after florists chrysanthemum seedling is cleaned, then by weight 1:1 is added sweet osmanthus flower distillate,
Dipping through filtered through gauze and extracts moisture after 2 days, and the florists chrysanthemum seedling extracting solution is made.
Embodiment 1
1）After 200 g wolfberry leaf, 150 South Africa g leaves are washed with water respectively, in shady and cool, ventilation airing 5h；
2）Wolfberry leaf is put into green-keeping machine, in 100 DEG C of water-removing processing 8min；
3）By the wolfberry leaf airing cooling after water-removing, then poured into rolling machine jointly with South Africa leaf, 65 g Agricus blazeis extracts
It is uniformly mixed, then 10min is rubbed by pneumatics, light pressure, the principle of pneumatics, until tealeaves shapes substantially；
4）By the tealeaves after rubbing, airing cools down after dry 3h at 60 DEG C；
5）Tealeaves after drying is poured into rolling machine again, pneumatics uniformly sprays into 60 g florists chrysanthemum seedling extracting solutions after rubbing 3min,
30min is rubbed by light pressure, middle pressure, the principle of pneumatics again, to form the tea item tightly locked；
6）By the freeze-dried rear packaging of gained tea item to get liver-nourishing tea.
Embodiment 2
1）After 220 g wolfberry leaf, 130 South Africa g leaves are washed with water respectively, in shady and cool, ventilation airing 6h；
2）Wolfberry leaf is put into green-keeping machine, in 110 DEG C of water-removing processing 5min；
3）By the wolfberry leaf airing cooling after water-removing, then poured into rolling machine jointly with South Africa leaf, 70 g Agricus blazeis extracts
It is uniformly mixed, then 12min is rubbed by pneumatics, light pressure, the principle of pneumatics, until tealeaves shapes substantially；
4）By the tealeaves after rubbing, airing cools down after dry 2h at 70 DEG C；
5）Tealeaves after drying is poured into rolling machine again, pneumatics uniformly sprays into 55 g florists chrysanthemum seedling extracting solutions after rubbing 3min,
40min is rubbed by light pressure, middle pressure, the principle of pneumatics again, to form the tea item tightly locked；
6）By the freeze-dried rear packaging of gained tea item to get liver-nourishing tea.
Embodiment 3
1）After 250 g wolfberry leaf, 100 South Africa g leaves are washed with water respectively, in shady and cool, ventilation airing 8h；
2）Wolfberry leaf is put into green-keeping machine, in 120 DEG C of water-removing processing 6min；
3）By the wolfberry leaf airing cooling after water-removing, then poured into rolling machine jointly with South Africa leaf, 75 g Agricus blazeis extracts
It is uniformly mixed, then 15min is rubbed by pneumatics, light pressure, the principle of pneumatics, until tealeaves shapes substantially；
4）By the tealeaves after rubbing, airing cools down after dry 2h at 80 DEG C；
5）Tealeaves after drying is poured into rolling machine again, pneumatics uniformly sprays into 50 g florists chrysanthemum seedling extracting solutions after rubbing 3min,
50min is rubbed by light pressure, middle pressure, the principle of pneumatics again, to form the tea item tightly locked；
6）By the freeze-dried rear packaging of gained tea item to get liver-nourishing tea.
Efficacy test
High lipid food：Basal feed 82%, lard 10%, cholesterol 2%, sodium taurocholate 0.6%, propylthiouracil (PTU) 0.4%, sucrose 5%.
Comparison 1：Under the conditions of embodiment 2, tea prepared by Agricus blazei extract is substituted using un-extracted Agricus blazei powder
Leaf sample.
Comparison 2：Under the conditions of embodiment 2, substitute prepared by the florists chrysanthemum seedling extracting solution that osmanthus honey dipping obtains using by water
Tea Samples.
Take SD rats 50, half male and half female, 180 ~ 220g of weight, adaptability raising is randomly divided into normal control after a week
Group, model group and 3 groups of experimental groups（Compare 1 group, comparison 2 groups, 2 groups of embodiment）, in addition to Normal group feeding basal feed,
Remaining each group feeding high lipid food, free water, experimental group is in daily morning gavage 2mL Aqua Folium Camelliae sinensis（5g tealeaves is taken, 50mL water is added to rush
It is filtered after bubble）, it is continuous to feed 3 weeks, after last time administration fasting, can't help water.It morning next day, will be numb after rat weight
Liquor-saturated, abdominal aorta is taken a blood sample for measuring blood fat（Triglycerides TG, total cholesterol TC, high-density lipoprotein HLD, low-density lipoprotein
White LDL, very low density lipoprotein VLDL）, and liver is taken to weigh liver weight in wet base, it is as a result shown in Table 1,2 respectively.
1 rat fat testing result of table
2 rat liver index testing result of table
By result in table as it can be seen that compared with Normal group, model group rats Triglycerides in Serum, total cholesterol, low-density
Lipoprotein and very low density lipoprotein content significantly increase, but serum middle-high density lipoprotein content increases unobvious；With model
Group is compared, triglycerides, total cholesterol, low-density lipoprotein bletilla extra-low density fat egg in 2 groups of contrast groups, embodiment rat blood serums
Bai Jun decreases, and hdl concentration is promoted, wherein it is with obvious effects with 2 groups of embodiment, and its liver index is closer to just
Ordinary water is flat, it was demonstrated that the tealeaves prepared using Agricus blazei extract and the florists chrysanthemum seedling extracting solution obtained using osmanthus honey dipping is had more
Lipid-loweringing well, liver-protecting efficacy.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification should all belong to the covering scope of the present invention.
Claims (4)
1. a kind of liver-nourishing tea of extract containing Agricus blazei, it is characterised in that：It is raw materials used to be calculated as by weight：Wolfberry leaf 20-25
Part, leaf 10-15 parts of South Africa, 6-8 parts of Agricus blazei extract, 5-6 parts of florists chrysanthemum seedling extracting solution.
2. liver-nourishing tea according to claim 1, it is characterised in that：The Agricus blazei extract is by Agricus blazei fructification
It crushes, sieving；Then solid-liquid ratio 1 is pressed:Water is added in gained Agricus blazei powder in 5-20 g/mL, and Agricus blazei powder weight 2- is added
3% cellulase and the mixture of protease, with hydrochloric acid conditioning solution pH to 6.0 ~ 6.5, enzymolysis processing 30min；Later by institute
It obtains enzymolysis liquid and uses ultrasonic wave extraction 20-30min, ultrafiltration；It after gained filtrate is concentrated to dryness, is dissolved in water, is evaporated again；So
Repeat to dissolve, be evaporated 3-5 times to dried object without tart flavour after, by mass volume ratio 1:8-12 g/mL add dried object water-soluble again
Solution, and the absolute ethyl alcohol of water consumption 60-70% is added, mixing centrifuges after standing overnight, and takes pellet frozen drying to get the Ji
Fructificatio Tricholomatis Matsutakis extract；
The mass ratio of the mixture cellulase and protease is 1:1.
3. liver-nourishing tea according to claim 1, it is characterised in that：The florists chrysanthemum seedling extracting solution is stirred after cleaning florists chrysanthemum seedling
Slurry is broken into, then by weight 1:Sweet osmanthus flower distillate is added in 1-2, and dipping through filtered through gauze and extracts moisture after 2-3 days, and the chrysanthemum is made
Flower seedling extracting solution.
4. a kind of preparation method of liver-nourishing tea as described in claim 1, it is characterised in that：Include the following steps：
1）After wolfberry leaf, South Africa leaf are washed with water respectively, in shady and cool, ventilation airing 5-8h；
2）Wolfberry leaf is put into green-keeping machine, in 100-120 DEG C of water-removing processing 5-8min；
3）By the wolfberry leaf airing cooling after water-removing, then pours into rolling machine and mix jointly with South Africa leaf, Agricus blazei extract
Uniformly, then by pneumatics, light pressure, the principle of pneumatics 10-15min is rubbed, until tealeaves shapes substantially；
4）By the tealeaves after rubbing, airing cools down after dry 2-3h at 60-80 DEG C；
5）Tealeaves after drying is poured into rolling machine again, pneumatics uniformly sprays into florists chrysanthemum seedling extracting solution after rubbing 3min, then presses
Light pressure, middle pressure, the principle of pneumatics rub 30-50min, to form the tea item tightly locked；
6）By the freeze-dried rear packaging of gained tea item to get the liver-nourishing tea.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111165629A (en) * | 2019-12-31 | 2020-05-19 | 浙江百兴食品有限公司 | Matsutake tea drink and preparation method thereof |
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| CN111165629A (en) * | 2019-12-31 | 2020-05-19 | 浙江百兴食品有限公司 | Matsutake tea drink and preparation method thereof |
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Application publication date: 20180904 |