CN109999072A - A kind of preparation method of fresh ginseng active material - Google Patents
A kind of preparation method of fresh ginseng active material Download PDFInfo
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- CN109999072A CN109999072A CN201910410925.6A CN201910410925A CN109999072A CN 109999072 A CN109999072 A CN 109999072A CN 201910410925 A CN201910410925 A CN 201910410925A CN 109999072 A CN109999072 A CN 109999072A
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- ginseng
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention relates to a kind of preparation methods of fresh ginseng active material, belong to the prepared slices of Chinese crude drugs and food processing technology field.This preparation method includes: using fresh ginseng as raw material, and after water is cleaned, squeezing obtains extracting solution A and ginseng Rong A, ginseng Rong A is divided and is soaked in water for ginseng Rong B and ginseng Rong C, ginseng Rong B, is squeezed, is separated by solid-liquid separation, extracting solution B and ginseng Rong D, extracting solution B are transferred in ginseng Rong C, impregnate, squeezing is separated by solid-liquid separation, obtains extracting solution C and ginseng Rong E, it repeats the above process, merges gained extracting solution, sweetener is added after filtering, freeze again, crushes, obtain fresh ginseng activated freeze dried powder；Merge gained ginseng Rong, dry, pulverize, obtain ginseng Rong's powder.The present invention solves the problems such as conventional ginseng medicine materical crude slice and fresh ginseng carrying cost height, the transformation of concocting process loss of effective components, heating process active material, and use is more convenient, and process is simple, and amount of water is small, improves freeze-drying efficiency, can amplify production.
Description
Technical field
The present invention relates to a kind of preparation methods of fresh ginseng active material, belong to the prepared slices of Chinese crude drugs and foods processing technique neck
Domain.
Background technique
Ginseng (Panax Ginseng C.A.Meyer) is traditional rare traditional Chinese medicine, and the Ministry of Public Health's No. 17 text in 2012 is by 5
The ginseng of year and 5 years or less artificial growth is included in new resource food.Theory of traditional Chinese medical science thinks ginseng sweet, slight bitter, tepor, returns spleen, lung,
The heart, kidney channel, can replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforce the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.It to be taken off for physically weak, cold weak pulse of limb,
Spleen eating less, the deficiency syndrome of the lung are breathed with cough, injury thirst, Heat Diabetes, deficiency of qi and blood, and prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold.With people
Ginseng is that the product of primary raw material covers each fields such as drug, daily necessities, cosmetics, food, health food.
Ginseng effective component is ginsenoside, polysaccharide, polypeptide and microelement etc., and there is also multiple active enzymes in fresh ginseng
Class, such as peroxidase (POD), catalase (CAT), superoxide dismutase (SOD)[1], anti-oxidant, removing is freely
Base effect is significant.Malonyl ginsenoside (such as Rb1, Rb2, Rc) content is higher in fresh ginseng, have very strong reduction blood glucose,
The activity removed free radical, melanin is inhibited to be formed, such saponin constituent polarity is big, and hydrophily is strong, is highly soluble in water, but unstable
It is fixed, it can hydrolyze under the high temperature conditions[2-4]。
Fresh goods ginseng requires condition of storage harsh, not easy to maintain and transport.Traditional processing of Panax ginseng method is sun-dried ginseng
With steam resulting red ginseng, active constituent can occur centainly to change compared with fresh goods ginseng, and loss of effective components is more.And tradition
Ginseng medicine materical crude slice is easily mouldy to damage by worms, and storage cost is high, and edible way is to decoct to extract, inconvenient, is unfavorable for daily consumption.
Compared with common ginseng medicine materical crude slice, fresh ginseng dried frozen aquatic products are without dry property, user's mouth parched and tongue scorched and dry throat in clinical test
Symptom's ratio is greatly decreased[3].There is patent applications report[5、6]By fresh ginseng plus boiling boiling extraction, concentration or heated, high pressure
Technique obtains extracting solution, then extracting solution is lyophilized to prepare freeze-dried powder, but high temperature extraction can destroy in ginseng organized enzyme and the third two
Acyl group Ginsenosides, and fresh ginseng unique flavor, decoct or heating is larger to its flavor effect.
Summary of the invention
In order to solve the above-mentioned technical problem the present invention, provides a kind of without heating extraction preparation fresh ginseng freeze-drying activity
The method of substance.
The technical scheme to solve the above technical problems is that a kind of preparation method of fresh ginseng active material, packet
It includes:
1) using fresh ginseng as raw material, after water is cleaned, squeezing collects Ginseng extract and ginseng Rong, as extracting solution A respectively
With ginseng Rong A, ginseng Rong A is divided for ginseng Rong B and ginseng Rong C；
2) 1) gained ginseng Rong B and ginseng Rong C is further processed, 0.7~1.2 times of its weight is added in Xiang Rencan Rong B
40 DEG C of water below impregnate 5~10min, squeeze again, are separated by solid-liquid separation, obtain extracting solution B and ginseng Rong D；
3) 2) gained extracting solution B is transferred in ginseng Rong C, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution C
With ginseng Rong E；
4) step 2) and step 3) are an extraction process, and the process of repetition carries out 1-3 times altogether；
5) merge above-mentioned gained extracting solution, total extract is obtained, by total extract with 60~200 mesh filter-cloth filterings, to filtrate
Middle that the sweetener for accounting for fresh ginseng weight 0~5% is added, centrifugation cleans or without centrifugal treating, and filtrate is placed in -40~-10 DEG C of jellies
After knot 4~12 hours, it is lower than 10% in -30~40 DEG C of dryings to water content, obtains fresh ginseng activity extract, the fresh ginseng is living
Property extract according to subsequent preparation process need select crushed 8~80 meshes or do not pulverize and sieve to get fresh ginseng activity jelly
Dry powder；
6) merge above-mentioned gained ginseng Rong, obtain total ginseng Rong, dry, total ginseng Rong after drying is according to subsequent preparation process
It needs to select to crushed 8~80 meshes or do not pulverize and sieve to get ginseng Rong's powder.
Based on the above technical solution, the present invention can also be improved as follows.
Further, in 1), the ginseng Rong B accounts for the 1/3 to 1/2 of the ginseng Rong A weight.
Further, in 5), the sweetener includes the mixture of any one or two kinds in sucrose and glucose.Institute
It can not only be used for freeze-drying skeleton agent, and adjustable mouthfeel with sweetener.
Further, in 6), the drying includes drying, dry in the shade, dry or being lyophilized.
Further, with stirring during the immersion.
The technical scheme to solve the above technical problems is that a kind of preparation method of fresh ginseng active material, packet
It includes:
1) using fresh ginseng as raw material, after water is cleaned, squeezing collects Ginseng extract and ginseng Rong, as extracting solution A respectively
It is ginseng Rong B, ginseng Rong C and ginseng Rong D by ginseng Rong's A trisection with ginseng Rong A；
2) 1) gained ginseng Rong B, ginseng Rong C and ginseng Rong D are further processed, its weight 0.7 is added in Xiang Rencan Rong B
~1.2 times of 40 DEG C of water below impregnate 5~10min, squeeze again, are separated by solid-liquid separation, obtain extracting solution B and ginseng Rong E；
3) 2) gained extracting solution B is transferred in ginseng Rong C, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution C
With ginseng Rong F；
4) 3) gained extracting solution C is transferred in ginseng Rong D, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution D
With ginseng Rong G；
5) step 2), step 3 and step 4) are an extraction process, and the process of repetition carries out 1-3 times altogether；
6) merge said extracted liquid, obtain total extract, by total extract with 60~200 mesh filter-cloth filterings, add into filtrate
Enter to account for the sweetener of fresh ginseng weight 0~5%, centrifugation removal of impurities or without centrifugal treating, filtrate be placed in -40~-10 DEG C freeze 4~
After 12 hours, it is lower than 10% in -30~40 DEG C of dryings to water content, obtains fresh ginseng activity extract, the fresh ginseng activity mentions
Object is taken to need to select to crushed 8~80 meshes or not pulverize and sieve to get fresh ginseng activated freeze dried powder according to subsequent preparation process；
7) merge above-mentioned ginseng Rong, obtain total ginseng Rong, dry, total ginseng Rong after drying is according to subsequent preparation process needs
Selection crushed 8~80 meshes or not pulverize and sieve to get ginseng Rong's powder.
Based on the above technical solution, the present invention can also be improved as follows.
Further, in 6), the sweetener includes the mixture of any one or two kinds in sucrose and glucose.Institute
It can not only be used for freeze-drying skeleton agent, and adjustable mouthfeel with sweetener.
Further, in 7), the drying includes drying, dry in the shade, dry or being lyophilized.
Further, with stirring during the immersion.
The beneficial effects of the present invention are:
Fresh ginseng activity extract prepared by the present invention adds water to redissolve rapidly, can smell the peculiar fragrance of fresh ginseng after dissolution,
Fresh ginseng flavour is strong, both can directly take after mixing it with water, and can also directly enter pulvis, pill, powder, granule, capsule, tablet etc., also
It can be used as cosmetic material and the products such as facial mask, essence powder, toner be made.
Through detecting, content of ginsenoside and SOD enzyme activity are above the fresh people of unit mass in this fresh ginseng activated freeze dried powder
Join corresponding index.When taking as food, relative to fresh ginseng, the dose of product of the present invention is less, but effective component is taken in
Amount is suitable.
Ginseng solid matter after expression separation extracting solution is named as " ginseng Rong " by the present invention, and ginseng Rong is dry,
Other ginseng class products are prepared as, fresh ginseng raw material availability can be improved.Gained ginseng Rong's powder ginseng taste is strong, can further add
Work is food, cosmetics etc..
The present invention solves conventional ginseng medicine materical crude slice and fresh ginseng carrying cost height, concocting process loss of effective components, heating
The problems such as process active material transformation, use is more convenient, and process is simple, and amount of water is small, improves freeze-drying efficiency, can
Amplification production.
Detailed description of the invention
Fig. 1 is the assay figure of ginsenoside reference substance Rg1, Re and Rb1；
Fig. 2 is monomer saponin assay figure in ginseng Rong's powder of the preparation of the embodiment of the present invention 1；
Fig. 3 is monomer saponin assay figure in the fresh ginseng active material freeze-dried powder of the preparation of the embodiment of the present invention 1；
Fig. 4 is the DPPH free radical scavenging activity testing result figure of the embodiment of the present invention 1 and comparative example 1-3 products obtained therefrom；
Fig. 5 is total reducing power testing result figure of the embodiment of the present invention 1 and comparative example 1-3 products obtained therefrom.
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
Embodiment 1
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B and ginseng Rong C.1 times of 40 DEG C of water below of its weight are added into ginseng Rong B,
It impregnates 10 minutes, stirring in 5 minutes is primary, puts into juice extractor again, and ginseng Rong D and Ginseng extract B is collected in squeezing respectively.
Ginseng extract B is transferred in ginseng Rong C, is impregnated 10 minutes, squeezing, collects ginseng Rong E respectively and ginseng extracts
Liquid C.
1 times of 40 DEG C of water below of its weight are added into ginseng Rong E, impregnate 10 minutes, ginseng Rong F is collected in squeezing respectively
And Ginseng extract D.
Ginseng extract D is transferred in ginseng Rong D, is impregnated 10 minutes, squeezing, collects ginseng Rong G respectively and ginseng extracts
Liquid E.
Above-mentioned gained Ginseng extract A, Ginseng extract C and Ginseng extract E are merged, total extract is obtained.With 100 mesh
Filter-cloth filtering total extract mixes, and is centrifuged with 14000 revs/min, obtains centrifugate, be transferred in freeze dryer, freeze 4 with -30 DEG C
After hour, then freeze 6 hours at -20 DEG C, -20 DEG C~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove and be lyophilized
Machine, dried frozen aquatic products finally obtain fresh ginseng activated freeze dried powder by 8 meshes.The water content of fresh ginseng activated freeze dried powder is 9.4%,
Yield is 13.6%, and color is rice white, total saponin content 1.49g/100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1)
For 0.95g/100g, SOD vigor is 27527U/g, and opening places 24 hours and has no the obvious moisture absorption.By extracting solution and obtain powder rate ratio
Example, after freeze-dried powder is dissolved in water, aqueous solution is consistent with preceding Ginseng extract character, mouthfeel is lyophilized.
Above-mentioned gained ginseng Rong F and ginseng Rong G is merged, total ginseng Rong is obtained.It is freeze-dried, freezes by above-mentioned lyophilized technique
Dry product crushed 8 meshes, obtain ginseng Rong's powder.The yield of ginseng Rong's powder is 14.2%, total saponin content 0.75g/100g, three kinds
The sum of monomer saponin (Rg1+Re+Rb1) is 0.50g/100g, and SOD vigor is 1351U/g.
Embodiment 2
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B and ginseng Rong C.It is below that 0.7 times 40 DEG C of its weight is added into ginseng Rong B
Water is impregnated and is stirred 5 minutes, puts into juice extractor again, and ginseng Rong D and Ginseng extract B is collected in squeezing respectively.
Ginseng extract B is transferred in ginseng Rong C, is impregnated and is stirred 5 minutes, and ginseng Rong E and ginseng are collected in squeezing respectively
Extracting solution C.
0.7 times of 40 DEG C of water below of its weight are added into ginseng Rong E, impregnates and stirs 5 minutes, squeezes, collects respectively
Ginseng Rong F and Ginseng extract D.
Ginseng extract D is transferred in ginseng Rong D, is impregnated and is stirred 5 minutes, and ginseng Rong G and ginseng are collected in squeezing respectively
Extracting solution E.
Above-mentioned gained Ginseng extract A, Ginseng extract C and Ginseng extract E are merged, total extract is obtained.With 100 mesh
Filter-cloth filtering total extract mixes, and is centrifuged with 14000 revs/min, obtains centrifugate, be transferred in freeze dryer, is frozen with -30 DEG C
After knot 4 hours, then freeze 6 hours at -20 DEG C, -20 DEG C~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove and freeze
Dry machine, dried frozen aquatic products finally obtain fresh ginseng activated freeze dried powder by 30 meshes.Fresh ginseng activated freeze dried powder water content is 8.7%,
Yield is 13.2%, and color is rice white, total saponin content 1.39g/100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1)
For 0.87g/100g, SOD vigor is 25462U/g, and opening places 24 hours and has no the obvious moisture absorption.By extracting solution and obtain powder rate ratio
Example, after freeze-dried powder is dissolved in water, aqueous solution is consistent with preceding Ginseng extract character, mouthfeel is lyophilized, and fresh ginseng taste is strong.
Above-mentioned gained ginseng Rong F and ginseng Rong G are taken, flat dry until moisture is 10%, then crushed 30 meshes, obtain people
Join Rong's powder.The yield of ginseng Rong's powder is 15.1%, total saponin content 0.82g/100g, three kinds of monomer saponins (Rg1+Re+Rb1)
The sum of be 0.52g/100g, SOD vigor be 2076U/g.
Embodiment 3
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B and ginseng Rong C.It is below that 1.2 times 40 DEG C of its weight is added into ginseng Rong B
Water is impregnated and is stirred 5 minutes, puts into juice extractor again, and ginseng Rong D and Ginseng extract B is collected in squeezing respectively.
Ginseng extract B is transferred in ginseng Rong C, is impregnated and is stirred 5 minutes, and ginseng Rong E and ginseng are collected in squeezing respectively
Extracting solution C.
1.2 times of 40 DEG C of water below of its weight are added into ginseng Rong E, impregnates and stirs 5 minutes, squeezes, collects respectively
Ginseng Rong F and Ginseng extract D.
Ginseng extract D is transferred in ginseng Rong D, is impregnated and is stirred 5 minutes, and ginseng Rong G and ginseng are collected in squeezing respectively
Extracting solution E.
Above-mentioned gained Ginseng extract A, Ginseng extract C and Ginseng extract E are merged, total extract is obtained.With 100 mesh
Filter-cloth filtering total extract mixes, and the sucrose for accounting for the fresh ginseng weight 5% that feeds intake is added into filtrate, and dissolution mixes.With 14000
Rev/min centrifugation, obtain centrifugate, be transferred in freeze dryer, after freezing 4 hours with -30 DEG C, then freeze at -20 DEG C 6 hours, -
20 DEG C~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, dried frozen aquatic products are finally obtained fresh by 8 meshes
Ginseng activated freeze dried powder.The water content of fresh ginseng activated freeze dried powder is 8.4%, yield 16.1%, and total saponin content is
1.53g/100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 0.92g/100g, and SOD vigor is 25136U/g, and color is
Rice white, opening place 24 hours and have no the obvious moisture absorption.After taking 0.5g freeze-dried powder that 50mL water is added to dissolve, fresh ginseng taste is strong, mouthfeel
Slightly sweet tea.
Above-mentioned gained ginseng Rong F and ginseng Rong G are taken, tiling is dried in the shade, until moisture is 10%, then be crushed 30 meshes, is obtained people
Join Rong's powder.The yield of ginseng Rong's powder is 12.6%, total saponin content 0.67g/100g, three kinds of monomer saponins (Rg1+Re+Rb1)
The sum of be 0.45g/100g, SOD vigor be 2012U/g.
Embodiment 4
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B and ginseng Rong C.It is below that its 40 DEG C of 1.2 times of weight is added into ginseng Rong B
Water is impregnated and is stirred 5 minutes, puts into juice extractor again, and ginseng Rong D and Ginseng extract B is collected in squeezing respectively.
Ginseng extract B is transferred in ginseng Rong C, is impregnated and is stirred 5 minutes, and ginseng Rong E and ginseng are collected in squeezing respectively
Extracting solution C.
Above-mentioned gained Ginseng extract A and Ginseng extract C is merged, total extract is obtained.It is always mentioned with 100 mesh filter-cloth filterings
Liquid is taken, is mixed, the sucrose for accounting for the fresh ginseng weight 5% that feeds intake is added into filtrate, dissolution mixes.It is centrifuged with 14000 revs/min,
Centrifugate is obtained, is transferred in freeze dryer, after freezing 4 hours with -30 DEG C, then is freezed at -20 DEG C 6 hours, -20 DEG C~15 DEG C subtract
Press dry dry 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, it is active freeze-dried to finally obtain fresh ginseng by 8 meshes for dried frozen aquatic products
Powder.The water content of gained fresh ginseng activated freeze dried powder is 6.4%, yield 13.2%, total saponin content 1.45g/100g, three
The sum of kind monomer saponin (Rg1+Re+Rb1) is 0.84g/100g, and SOD vigor is 24193U/g, and color is rice white, and opening is put
It sets 24 hours and has no the obvious moisture absorption.After taking 0.5g freeze-dried powder that 50mL water is added to dissolve, fresh ginseng taste is strong, and mouthfeel omits sweet tea.
Above-mentioned gained ginseng Rong D and ginseng Rong E are taken, tiling is dried in the shade, until moisture is 10%, then be crushed 30 meshes, is obtained people
Join Rong's powder.The yield of ginseng Rong's powder is 13.2%, total saponin content 0.72g/100g, three kinds of monomer saponins (Rg1+Re+Rb1)
The sum of be 0.41g/100g, SOD vigor be 1418U/g.
Embodiment 5
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B, ginseng Rong C and ginseng Rong D.Its weight is added into ginseng Rong B 0.7 times 40
DEG C water below impregnates 10 minutes, and stirring in 5 minutes is primary, puts into juice extractor again, and ginseng Rong E and people are collected in squeezing respectively
Join extracting solution B.
Ginseng extract B is transferred in ginseng Rong C, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong F and Ginseng extract C respectively.
Ginseng extract C is transferred in ginseng Rong D, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong G and Ginseng extract D respectively.
0.7 times of 40 DEG C of water below of its weight are added into ginseng Rong E, impregnate 10 minutes, stirring in 5 minutes is primary, again
It puts into juice extractor, ginseng Rong H and Ginseng extract E is collected in squeezing respectively.
Ginseng extract E is transferred in ginseng Rong F, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong I and Ginseng extract F respectively.
Ginseng extract F is transferred in ginseng Rong G, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong J and Ginseng extract G respectively.
0.7 times of 40 DEG C of water below of its weight are added into ginseng Rong H, impregnate 10 minutes, stirring in 5 minutes is primary, again
It puts into juice extractor, ginseng Rong K and Ginseng extract H is collected in squeezing respectively.
Ginseng extract H is transferred in ginseng Rong I, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong L and Ginseng extract I respectively.
Ginseng extract I is transferred in ginseng Rong J, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong M and Ginseng extract J respectively.
Above-mentioned gained Ginseng extract A, Ginseng extract D, Ginseng extract G and Ginseng extract J are merged, obtains and always mentions
Take liquid.It with 200 mesh filter-cloth filtering total extracts, mixes, the glucose for accounting for the fresh ginseng weight 5% that feeds intake is added into filtrate, it is molten
Solution mixes.It is centrifuged with 14000 revs/min, obtains centrifugate, be transferred in freeze dryer, after freezing 4 hours with -30 DEG C, then -
20 DEG C are freezed 6 hours, and -20 DEG C~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, dried frozen aquatic products pass through
80 meshes finally obtain fresh ginseng activated freeze dried powder.The water content of gained fresh ginseng activated freeze dried powder is 9.6%.Obtained freeze-drying
Powder yield is 17.7%, and color is rice white, total saponin content 1.21g/100g, three kinds of monomer saponins (Rg1+Re+Rb1) it
With for 0.79g/100g, SOD vigor is 22126U/g, and opening places 24 hours and has no the obvious moisture absorption.This freeze-dried powder of 0.5g is taken to add
Water 100mL, rocks, it is seen that powder leaches rapidly, can smell the peculiar fragrance of fresh ginseng, and through tasting, fresh ginseng flavour is obvious, flavor
It is unique.
Above-mentioned gained ginseng Rong K, ginseng Rong L and ginseng Rong M are placed in air dry oven, are with 60 DEG C of drying to moisture
10%, then crushed 80 meshes, obtain ginseng Rong's powder.The yield of gained ginseng Rong's powder is 13.6%, total saponin content 0.81g/
100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 0.53g/100g, and SOD vigor is 2235U/g.
Embodiment 6
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B, ginseng Rong C and ginseng Rong D.Its 0.7 times of weight 40 is added into ginseng Rong B
DEG C water below impregnates 10 minutes, and stirring in 5 minutes is primary, puts into juice extractor again, and ginseng Rong E and people are collected in squeezing respectively
Join extracting solution B.
Ginseng extract B is transferred in ginseng Rong C, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong F and Ginseng extract C respectively.
Ginseng extract C is transferred in ginseng Rong D, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong G and Ginseng extract D respectively.
0.7 times of 40 DEG C of water below of its weight are added into ginseng Rong E, impregnate 10 minutes, stirring in 5 minutes is primary, again
It puts into juice extractor, ginseng Rong H and Ginseng extract E is collected in squeezing respectively.
Ginseng extract E is transferred in ginseng Rong F, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong I and Ginseng extract F respectively.
Ginseng extract F is transferred in ginseng Rong G, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong J and Ginseng extract G respectively.
Above-mentioned gained Ginseng extract A, Ginseng extract D and Ginseng extract G are merged, total extract is obtained.With 200 mesh
Filter-cloth filtering total extract mixes, and the glucose for accounting for the fresh ginseng weight 5% that feeds intake is added into filtrate, and dissolution mixes.With
14000 revs/min of centrifugations, obtain centrifugate, are transferred in freeze dryer, after freezing 4 hours with -30 DEG C, then at -20 DEG C freeze 6
Hour, -20 DEG C~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, dried frozen aquatic products pass through 80 meshes, most
Fresh ginseng activated freeze dried powder is obtained eventually.The water content of the fresh ginseng activated freeze dried powder is 7.1%, and freeze-dried powder yield is
15.7%, color is rice white, total saponin content 1.12g/100g, and the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are
0.65g/100g, SOD vigor are 17126U/g, and opening places 24 hours and has no the obvious moisture absorption.This freeze-dried powder of 0.5g is taken to add water
100mL rocks, it is seen that powder leaches rapidly, can smell the peculiar fragrance of fresh ginseng, and through tasting, fresh ginseng flavour is obvious, and flavor is only
It is special.
Above-mentioned gained ginseng Rong I, ginseng Rong H and ginseng Rong J are placed in air dry oven, are with 60 DEG C of drying to moisture
10%, then crushed 80 meshes, obtain ginseng Rong's powder.The yield of gained ginseng Rong's powder is 14.3%, total saponin content 0.92g/
100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 0.59g/100g, and SOD vigor is 3235U/g.
Embodiment 7
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong A and Ginseng extract A is collected in squeezing respectively.
Ginseng Rong A is divided into ginseng Rong B, ginseng Rong C and ginseng Rong D.Its weight is added into ginseng Rong B 0.7 times 40
DEG C water below impregnates 10 minutes, and stirring in 5 minutes is primary, puts into juice extractor again, and ginseng Rong E and people are collected in squeezing respectively
Join extracting solution B.
Ginseng extract B is transferred in ginseng Rong C, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong F and Ginseng extract C respectively.
Ginseng extract C is transferred in ginseng Rong D, is impregnated 10 minutes, stirring in 5 minutes is primary, puts into juice extractor, pressure
It squeezes, collects ginseng Rong G and Ginseng extract D respectively.
Above-mentioned gained Ginseng extract A and Ginseng extract D is merged, total extract is obtained.It is always mentioned with 200 mesh filter-cloth filterings
Liquid is taken, is mixed, the glucose for accounting for the fresh ginseng weight 5% that feeds intake is added into filtrate, dissolution mixes.With 14000 revs/min from
The heart obtains centrifugate, is transferred in freeze dryer, after freezing 4 hours with -30 DEG C, then freezes 6 hours at -20 DEG C, and -20 DEG C~15
DEG C be dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, it is living to finally obtain fresh ginseng by 80 meshes for dried frozen aquatic products
Property freeze-dried powder.The water content of gained fresh ginseng activated freeze dried powder is 6.1%, and yield 13.7%, color is rice white, total saposins
Content is 1.01g/100g, and the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 0.57g/100g, and SOD vigor is 15128U/g,
Opening places 24 hours and has no the obvious moisture absorption.It takes this freeze-dried powder of 0.5g to add water 100mL, rocks, it is seen that powder leaches rapidly, audible
To the peculiar fragrance of fresh ginseng, through tasting, fresh ginseng flavour is obvious, unique flavor.
Above-mentioned gained ginseng Rong G, ginseng Rong E and ginseng Rong F are placed in air dry oven, are with 60 DEG C of drying to moisture
10%, then crushed 80 meshes, obtain ginseng Rong's powder.The yield of gained ginseng Rong's powder is 15.7%, total saponin content 0.98g/
100g, the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 0.65g/100g, and SOD vigor is 7079U/g.
Comparative example 1
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, is laid in pallet,
After freezing 4 hours with -30 DEG C, then freeze at -20 DEG C 4 hours, -20 DEG C~15 DEG C are dried under reduced pressure 25 hours, and 35 DEG C of dryings 24 are small
When, freeze dryer is removed, dried frozen aquatic products finally obtain freeze-dried powder, water content 8.1% by 8 meshes.Gained fresh ginseng freeze-dried powder
Yield is 29.1%, and color is rice white.Total saponin content is the sum of 1.30g/100g, three kinds of monomer saponins (Rg1+Re+Rb1)
For 0.62g/100g, SOD vigor is 15870U/g.
Comparative example 2
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, is cut into 5mm sheet, direct plunges into juice extractor
In, ginseng Rong and Ginseng extract are collected in squeezing respectively.The water of 10 times of weight is added in ginseng Rong, decocts and extracts 10 minutes,
Filtering, remainder squeezing, collects ginseng Rong and Ginseng extract respectively.Merge gained Ginseng extract, 70 DEG C of reduced pressures
It is transferred in freeze dryer after being 1.12 to relative density, after freezing 4 hours with -30 DEG C, then freezes at -20 DEG C 4 hours, -20 DEG C
~15 DEG C are dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, dried frozen aquatic products finally obtain freeze-drying by 8 meshes
Powder, water content 7.6%.Obtained freeze-drying powder yield is 12.65%, and color is brown color, and opening occurs after placing 24 hours
Moisture absorption caking phenomenon.Total saponin content is 1.52g/100g, and the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are 1.08g/100g,
SOD vigor is 7231U/g.
Comparative example 3
After ginseng is harvested, impurity and dis-medicinal part are removed, is cleaned with water, crushes, 1 times of weight water is added, at 70 DEG C
6min is ground, is direct plungeed into juice extractor, is squeezed, Ginseng extract is collected, after freezing 4 hours with -30 DEG C, then in -20 DEG C of jellies
Knot 4 hours, -20 DEG C~15 DEG C were dried under reduced pressure 25 hours, 35 DEG C drying 24 hours, remove freeze dryer, dried frozen aquatic products by 8 meshes,
Finally obtain freeze-dried powder, water content 6.8%.Obtained freeze-drying powder yield is 14.20%, and color is ecru, and opening is placed
Have no the obvious moisture absorption within 24 hours.Total saponin content is 1.50g/100g, and the sum of three kinds of monomer saponins (Rg1+Re+Rb1) are
0.97g/100g, SOD vigor are 10232U/g.
Measure effect experiment
For clear saponin component recovery rate, compares active enzyme and retain and correspond to radicals scavenging effect, choose above-mentioned
More excellent scheme and comparative example gained sample, detection method shown according to the form below carry out total saposins, monomer saponin, SOD enzyme in embodiment
Activity and DPPH free radical scavenging activity and the detection of total reducing power.
Products obtained therefrom of the present invention is detected through detection project in following table, and the saponin extraction efficiency of present invention process route can be evaluated
And SOD enzyme activity retention.
1 detection project of table
DPPH free radical scavenging activity experimental method
Test solution preparation: each sample is taken to be extracted respectively with distilled water, then doubling dilution is at 25mg/mL, 12.5mg/
ML, 6.25mg/mL, 3.12mg/mL, 1.56mg/mL, 0.78mg/ml concentration.4 DEG C save for use.
Continuous mode: accurate 1.0mL various concentration (or different samples) sample liquid of drawing in 10mL test tube, adds
The DPPH free radical ethanol solution of 4.0mL 0.004% (w/v), makes total volume 5.0mL.It is placed at room temperature for after firmly shaking up
Absorbance value (ultraviolet specrophotometer) is surveyed at 524nm after 30min.It is repeated 3 times, is averaged.
The clearance rate R of DPPH is calculated as follows in sample liquid: R=[A0- (A1-A2)]/A0 × 100%
The absorbance value of A0=4mLDPPH solution+1mL ethanol solution；
The absorbance value of A1=4mLDPPH solution+1mL sample liquid；
The absorbance value of A2=4mL ethanol solution+1mL sample liquid.
Total reducing power experimental method
Test solution preparation: taking each sample to be extracted respectively with distilled water, then doubling dilution is at 50mg/mL, 25mg/mL,
12.5mg/mL, 6.25mg/mL concentration.
Continuous mode: accurate 1.0mL various concentration sample liquid of drawing sequentially adds 2.5mL0.2mol/L in test tube
1% potassium ferricyanide (K of pH6.6 phosphate buffer solution and 2.5mL3Fe(CN)6) solution, certainly quickly cooling after 50 DEG C of water-baths heat preservation 20min
But, 2.5mL10% trichloroacetic acid solution is added, 4000r/min is centrifuged 10min, takes supernatant 2.5mL.Into the supernatant
2.5mL distilled water is sequentially added, the oscillation of 0.1% liquor ferri trichloridi of 0.5mL shakes up, and stands 10min.Its extinction is surveyed under 700nm
Angle value (OD), absorbance is bigger, and total reducing power is stronger.
Experimental result
Sample detection the results are shown in Table shown in 2-4 and Fig. 1-5,1 active material freeze-dried powder saponin(e testing result of preferred embodiment
Suitable with comparative example, saponin extraction rate is suitable with comparative example, but enzyme SOD vigor and total reducing power are higher than comparative example, remove
DPPH free radical effect and total reducing power are also significantly better than other samples.Still contain saponin constituent in fresh ginseng Rong's powder, after having
Continuous processing and the value utilized.
2 testing result of table
Table 3DPPH radicals scavenging experimental result
The total reducing power experimental result of table 4
Above-mentioned testing result is it is found that present invention fresh ginseng freeze-drying active material (Ginseng extract freeze-drying obtained
Powder) in be rich in Ginsenosides, and the SOD enzyme activity of unit mass be higher than other samples, remove free radical (DPPH) and
Total reducing power is significantly higher than other samples, illustrates to retain very advantageous to active enzyme ingredient according to product produced by the present invention,
It is excellent in removing harmful free radicals and anti-oxidant aspect.
Still contain saponin(e active component in ginseng Rong's powder, illustrates the place of remaining ginseng Rong after extracting to fresh ginseng squeezing
Great meaning is managed, it is more abundant to ginseng utilization.
Meanwhile it being lyophilized compared to extracting solution is decocted, the production for being directly freeze-dried fresh goods ginseng without heating extraction liquid
Product, fresh ginseng flavor are stronger；The product of crushing is directly lyophilized compared to fresh ginseng, this extract freeze-drying powder can be quickly dissolved into water
In, solution is limpid, takes mouthfeel more preferably, and it is more preferably convenient that preparation deploys use；Compared to other conventional ginseng processing modes, the present invention
The fresh ginseng activity extract that technique obtains be more convenient for storage and transportation and preparation allotment.But consideration is not heated may be to saponin component
Extraction efficiency has certain influence, such as increases solvent usage, can increase accordingly energy consumption of freeze drying, therefore the present invention will be used to halve and take
Sample, the method for repeating extraction reduce solvent usage (solvent usage and patent[6]Report is suitable), guaranteeing functional component recovery rate
While, reduce energy consumption of freeze drying.
In conclusion the fresh ginseng without heating extraction is freeze-dried the great development significance of active material class product, can both solve
Certainly conventional ginseng carrying cost is high, takes inconvenient problem, further improves the status of active ingredient loss after heating.And the present invention
Preparation process is simple, and product property is stablized, and is able to maintain fresh goods flavor, has the good prospect of marketing.
[reference listing]
1, Qin Xiaoye, Li Yinqing, Tao Guibin wait vigour changes research [J] of 5 kinds of enzymes in ginseng under difference holding conditions
Chinese traditional Chinese medicine magazine, 2014,29 (8): 2621-2623.
2, Liu Zhi, Wang Lijuan, Zheng Yinan wait the content of malonyl ginsenoside in .RP-HPLC method measurement fresh ginseng
[J] Pharmaceutical Analysis magazine, 2007,27 (9): 1322-1324.
3, Zhao Baitao, Zhang Weiming, Qian Hua are ginseng freeze-dried and observe [C] the 8th to the composition influence of saponin(e and clinical pharmacological property
National Chinese medicine and the seminar of natural drug science and the 5th national medicinal plant and pharmacy,galenic scientific seminar collection of thesis
4, Primary Study [J] the Jilin Agriculture University of Song Wengang, Sun Liwei, Li Yu ginsenoside Rb1's white-skinned face function is learned
Report, 2010,3 (5): 498-499+504.
5, Xu Lu, ginseng is fresh to mention freeze-dried powder medicine materical crude slice [P], application number 201810733206.3.
6, the preparation method of oral instant preparation is lyophilized in Beijing Tongrentang health medicine company (Liaoning) Co., Ltd, fresh ginseng
[P], application number 201510205460.2.
7, Song Jiamin, Wang Hongfei, Sun Meng wait response phase method optimization golden cicada flower polysaccharide extracting process and antioxidant activity point
Analyse [J] Food Science, 2018,39 (4): 275-281.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of preparation method of fresh ginseng active material characterized by comprising
1) using fresh ginseng as raw material, after water is cleaned, squeezing collects Ginseng extract and ginseng Rong, as extracting solution A and people respectively
Join Rong A, ginseng Rong A is divided for ginseng Rong B and ginseng Rong C；
2) 1) gained ginseng Rong B and ginseng Rong C is further processed, 0.7~1.2 times 40 DEG C of its weight is added in Xiang Rencan Rong B
Water below impregnates 5~10min, squeezes again, is separated by solid-liquid separation, obtains extracting solution B and ginseng Rong D；
3) 2) gained extracting solution B is transferred in ginseng Rong C, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution C and people
Join Rong E；
4) step 2) and step 3) are an extraction process, and the process of repetition carries out 1-3 times altogether；
5) merge above-mentioned gained extracting solution, obtain total extract, by total extract with 60~200 mesh filter-cloth filterings, add into filtrate
Enter to account for the sweetener of fresh ginseng weight 0~5%, centrifugation removal of impurities or without centrifugal treating, filtrate be placed in -40~-10 DEG C freeze 4~
After 12 hours, it is lower than 10% in -30~40 DEG C of dryings to water content, obtains fresh ginseng activity extract, the fresh ginseng activity mentions
Object is taken to need to select to crushed 8~80 meshes or not pulverize and sieve to get fresh ginseng activated freeze dried powder according to subsequent preparation process；
6) merge above-mentioned gained ginseng Rong, obtain total ginseng Rong, dry, total ginseng Rong after drying is according to subsequent preparation process needs
Selection crushed 8~80 meshes or not pulverize and sieve to get ginseng Rong's powder.
2. preparation method according to claim 1, which is characterized in that in 1), the ginseng Rong B accounts for the ginseng Rong A
The 1/3 to 1/2 of weight.
3. preparation method according to claim 1, which is characterized in that in 5), the sweetener includes sucrose and grape
The mixture of any one or two kinds in sugar.
4. preparation method according to claim 1, which is characterized in that in 6), the drying includes drying, drying in the shade, drying
Dry or freeze-drying.
5. preparation method according to claim 1, which is characterized in that with stirring during the immersion.
6. a kind of preparation method of fresh ginseng active material characterized by comprising
1) using fresh ginseng as raw material, after water is cleaned, squeezing collects Ginseng extract and ginseng Rong, as extracting solution A and people respectively
Join Rong A, is ginseng Rong B, ginseng Rong C and ginseng Rong D by ginseng Rong's A trisection；
2) 1) gained ginseng Rong B, ginseng Rong C and ginseng Rong D are further processed, be added in Xiang Rencan Rong B its weight 0.7~
1.2 times of 40 DEG C of water below impregnate 5~10min, squeeze again, are separated by solid-liquid separation, obtain extracting solution B and ginseng Rong E；
3) 2) gained extracting solution B is transferred in ginseng Rong C, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution C and people
Join Rong F；
4) 3) gained extracting solution C is transferred in ginseng Rong D, impregnates 5~10min, squeeze, is separated by solid-liquid separation, obtains extracting solution D and people
Join Rong G；
5) step 2), step 3 and step 4) are an extraction process, and the process of repetition carries out 1-3 times altogether；
6) merge said extracted liquid, obtain total extract, by total extract with 60~200 mesh filter-cloth filterings, be added and account for into filtrate
The sweetener of fresh ginseng weight 0~5%, centrifugation removal of impurities or without centrifugal treating, filtrate is placed in -40~-10 DEG C, and to freeze 4~12 small
Shi Hou is lower than 10% in -30~40 DEG C of dryings to water content, obtains fresh ginseng activity extract, the fresh ginseng activity extract
It needs to select to crushed 8~80 meshes or not pulverize and sieve to get fresh ginseng activated freeze dried powder according to subsequent preparation process；
7) merge above-mentioned ginseng Rong, obtain total ginseng Rong, dry, total ginseng Rong after drying needs to select according to subsequent preparation process
It crushed 8~80 meshes or do not pulverize and sieve to get ginseng Rong's powder.
7. preparation method according to claim 6, which is characterized in that in 6), the sweetener includes sucrose and grape
The mixture of any one or two kinds in sugar.
8. preparation method according to claim 6, which is characterized in that in 7), the drying includes drying, drying in the shade, drying
Dry or freeze-drying.
9. preparation method according to claim 6, which is characterized in that with stirring during the immersion.
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Application publication date: 20190712 |