CN101049320A - Buccal tablets of extractive of propolis alcohol - Google Patents
Buccal tablets of extractive of propolis alcohol Download PDFInfo
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- CN101049320A CN101049320A CNA2007100154921A CN200710015492A CN101049320A CN 101049320 A CN101049320 A CN 101049320A CN A2007100154921 A CNA2007100154921 A CN A2007100154921A CN 200710015492 A CN200710015492 A CN 200710015492A CN 101049320 A CN101049320 A CN 101049320A
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Abstract
A buccal lozenge of the alcohol extract of propolis for health-care and preventing and treating disease purpose is prepared from said alcohol extract of propolis (25-35 Wt %) and pharmacologically acceptable carrier.
Description
Technical field
The present invention relates to a kind of buccal tablet, relate in particular to a kind of buccal tablets of extractive of propolis alcohol and preparation method thereof.
Background technology
Propolis is described as " natural plants explosive component treasure-house " by medical expert.Contain tens classes in the propolis, more than 300 kind of natural component, comprising more than 30 kinds of trace element, 20 several amino acids, tens of kinds of aromatics, more than 20 kind of Flavonoid substances that human body is necessary, also have rich organic acid, the rare class material of terpene, vitamin, enzyme, polysaccharide etc. to have the natural component of biologic activity.
Mainly comprise propolis flavone (Propolis Flavonoids) in the pure propolis, propolis lignanoid (PropolisLignin), propolis coumarin (Propolis Coumarins), propolis lactone (Propolis Lactone), propolis anthraquinone (Propolis Anthraguinone), propolis stilbene class (Propolis Stilbene), propolis Saponin (PropolisSaponins), propolis volatile oil (Propolis Oils), propolis organic acid (Propolis Organic acis) and propolis terpenoid nearly thousand kinds of active substance compositions of ten big classes such as (Propolis Terpenoides).The pharmacology and the drug action of known propolis mainly contain: 1. antibacterial action.The propolis tool is wanted the antibacterial and bactericidal action of broad-spectrum, and antibiotics is had obvious synergistic effect; 2. blood circulation promoting and blood stasis dispelling, anti-inflammatory and antalgic, antiulcer action; 3. antioxidation and antifatigue effect; 4. antiviral, protect the liver and improve the gastrointestinal function effect; 5. resisiting influenza virus effect; 6. hypoglycemic activity; 7. vessel softening and effect for reducing blood fat; 8. hypotensive activity; 9. immunostimulant, slow down aging, microcirculation improvement and antitumaous effect; 10. local anesthesia and promotion tissue regeneration effect.In view of described propolis has so many drug action, the research that people have deepened continuously to its expansion, its prospect in clinical practice and health food exploitation is very tempting and wide.But, by retrieval, though, do not see the report of propolis buccal tablet and preparation thereof relevant for many reports of propolis research and development.
Summary of the invention
At the deficiencies in the prior art, the problem to be solved in the present invention provides a kind of buccal tablets of extractive of propolis alcohol and preparation method thereof.
Buccal tablets of extractive of propolis alcohol of the present invention is characterized in that, contains the extractive of propolis alcohol that percentage by weight is 25%-35% and the pharmaceutically acceptable buccal tablet carrier of surplus;
Wherein: described extractive of propolis alcohol is made by following step:
With propolis after freezing under-15 ℃～-25 ℃ conditions, be ground into coarse powder, the dehydrated alcohol that adds 2～4 times of its volumes, 5 ℃～20 ℃ are soaked and stirred 60～84 hours with 10～12 rev/mins rotating speed, filtration or centrifugal, remove sediment, filtrate concentrates and with negative pressure drying under 0.06～0.07Mpa condition, gets thick extractive of propolis alcohol.
Wherein, described extractive of propolis alcohol preferably is prepared from by following method, after propolis-20 is ℃ freezing, be ground into coarse powder, add the dehydrated alcohol of 2～3 times of its volumes, 12 ℃～18 ℃ are soaked and stirred 72～75 hours with 10 rev/mins rotating speed, filtration or centrifugal, remove sediment, filtrate concentrates and with negative pressure drying under the 0.065Mpa condition, gets thick extractive of propolis alcohol.
Above-mentioned buccal tablets of extractive of propolis alcohol, preferred compatibility mode is: contain the extractive of propolis alcohol that percentage by weight is 27%-32% and the pharmaceutically acceptable buccal tablet carrier of surplus.
Above-mentioned buccal tablets of extractive of propolis alcohol is made by the component of following weight portion: extractive of propolis alcohol 55-65 part, xylitol 40-52 part, sucrose 34-45 part, microcrystalline Cellulose 20-28 part, starch 17-25 part, magnesium stearate 5-7 part, menthol 0.5-1.5 part, citric acid 4.3-6 part, essence sodium 0.2-0.5 part.
Wherein, described buccal tablets of extractive of propolis alcohol is preferably made by the component of following weight portion: 60 parts of extractive of propolis alcohol, 45 parts of xylitol, 40 parts of sucrose, 23 parts of microcrystalline Cellulose, 20 parts of starch, 6 parts of magnesium stearate, 1.0 parts of menthols, 4.7 parts of citric acids, 0.3 part in essence sodium.
Weight portion of the present invention can be the known mass units of field of medicaments such as μ g, mg, g, kg.
The dosage of the buccal tablets of extractive of propolis alcohol that the present invention relates to calculates with the amount that exists in the unit dosage form, and the extractive of propolis alcohol content that the present invention relates in unit dosage form is 20-80mg.
The buccal tablets of extractive of propolis alcohol amount that the adult takes, be 500-1500mg every day, divides and take for 5-8 time.
Buccal tablets of extractive of propolis alcohol provided by the invention is to prepare according to the method that those of ordinary skills know, and its basic preparation method is:
In weight portion, unit is a kilogram, takes by weighing respectively: extractive of propolis alcohol 55-65 part, xylitol 40-52 part, sucrose 34-45 part, microcrystalline Cellulose 20-28 part, starch 17-25 part, magnesium stearate 5-7 part, menthol 0.5-1.5 part, citric acid 4.3-6 part, essence sodium 0.2-0.5 part.
Above-mentioned extractive of propolis alcohol (requiring fineness to reach 400 orders), xylitol, sucrose, microcrystalline Cellulose, starch are mixed, water is evenly moistening, mixture after moistening is sieved and drying, after sieve, granulate adds magnesium stearate, menthol, citric acid, essence sodium, then with this mixture tabletting, every heavy 200mg-250mg, active component extractive of propolis alcohol content is 20-60mg.
Composition and the content of the present invention by the scientific allocation adjuvant, the characteristics that make extractive of propolis alcohol of the present invention have easily to take, mouthfeel are good; Because the extractive of propolis alcohol fineness reaches 400 orders, so the extractive of propolis alcohol among the present invention is in the process of buccal, can directly be absorbed by the through port transmucosal, the loss that has been produced when having avoided nutrition to absorb by organs such as human intestines and stomach and livers has improved the absorption rate of nutrition in the extractive of propolis alcohol.Therefore, buccal tablets of extractive of propolis alcohol of the present invention has important value and contribution to clinical treatment and health care prevention.
The specific embodiment
Embodiment 1:
Buccal tablets of extractive of propolis alcohol:
In weight portion, unit is a kilogram, takes by weighing respectively: 60 parts of extractive of propolis alcohol, 45 parts of xylitol, 40 parts of sucrose, 23 parts of microcrystalline Cellulose, 20 parts of starch, 6 parts of magnesium stearate, 1.0 parts of menthols, 4.7 parts of citric acids, 0.3 part in essence sodium.
Above-mentioned extractive of propolis alcohol (requiring fineness to reach 400 orders), xylitol, sucrose, microcrystalline Cellulose, starch are mixed, water is evenly moistening, mixture after moistening is crossed 16-22 mesh sieve and dry, after sieve, granulate adds magnesium stearate, menthol, citric acid, essence sodium, then with this mixture tabletting, every heavy 250mg, active component extractive of propolis alcohol content is 40mg.
Embodiment 2:
Buccal tablets of extractive of propolis alcohol:
In weight portion, unit is a kilogram, takes by weighing respectively: 55 parts of extractive of propolis alcohol, 40 parts of xylitol, 34 parts of sucrose, 20 parts of microcrystalline Cellulose, 17 parts of starch, 5 parts of magnesium stearate, 0.5 part of menthol, 4.3 parts of citric acids, 0.2 part in essence sodium.
Above-mentioned extractive of propolis alcohol (requiring fineness to reach 400 orders), xylitol, sucrose, microcrystalline Cellulose, starch are mixed, water is evenly moistening, mixture after moistening is crossed 16-22 mesh sieve and dry, after sieve, granulate adds magnesium stearate, menthol, citric acid, essence sodium, then with this mixture tabletting, every heavy 200mg, active component extractive of propolis alcohol content is 20mg.
Embodiment 3:
Buccal tablets of extractive of propolis alcohol:
In weight portion, unit is a kilogram, takes by weighing respectively: 65 parts of extractive of propolis alcohol, 52 parts of xylitol, 45 parts of sucrose, 28 parts of microcrystalline Cellulose, 25 parts of starch, 7 parts of magnesium stearate, 1.5 parts of menthols, 6 parts of citric acids, 0.5 part in essence sodium.
Above-mentioned extractive of propolis alcohol (requiring fineness to reach 400 orders), xylitol, sucrose, microcrystalline Cellulose, starch are mixed, water is evenly moistening, mixture after moistening is crossed 16-22 mesh sieve and dry, after sieve, granulate adds magnesium stearate, menthol, citric acid, essence sodium, then with this mixture tabletting, every heavy 250mg, active component extractive of propolis alcohol content is 60mg.
Embodiment 4:
The extractive of propolis alcohol preparation:
Get propolis 500g ,-20 ℃ freezing after, be ground into coarse powder, add dehydrated alcohol 1000ml, sealing, 15 ℃ are soaked and stirred 3500 rev/mins of centrifugal precipitations of going 72 hours with 10 rev/mins rotating speed, filtrate backflow concentrates, and with negative pressure drying under the 0.065Mpa condition, gets thick extractive of propolis alcohol.
Embodiment 5:
The extractive of propolis alcohol preparation:
Get propolis ,-25 ℃ freezing after, be ground into coarse powder, the dehydrated alcohol that adds 3 times of its volumes, 20 ℃ are soaked and stirred 200 order net filtrations 84 hours with 12 rev/mins rotating speed, remove sediment, the filtrate routine concentrates and with negative pressure drying under the 0.07Mpa condition, gets thick extractive of propolis alcohol.
Claims (5)
1. a buccal tablets of extractive of propolis alcohol is characterized in that, contains the extractive of propolis alcohol that percentage by weight is 25%-35% and the pharmaceutically acceptable buccal tablet carrier of surplus;
Wherein: described extractive of propolis alcohol is made by following step:
With propolis after freezing under-15 ℃～-25 ℃ conditions, be ground into coarse powder, the dehydrated alcohol that adds 2～4 times of its volumes, 5 ℃～20 ℃ are soaked and stirred 60～84 hours with 10～12 rev/mins rotating speed, filtration or centrifugal, remove sediment, filtrate concentrates and with negative pressure drying under 0.06～0.07Mpa condition, gets thick extractive of propolis alcohol.
2. buccal tablets of extractive of propolis alcohol as claimed in claim 1, it is characterized in that, described extractive of propolis alcohol is prepared from by following method, after propolis-20 is ℃ freezing, is ground into coarse powder, the dehydrated alcohol that adds 2～3 times of its volumes, 12 ℃～18 ℃ are soaked and stirred 72～75 hours with 10 rev/mins rotating speed, filter or centrifugal, remove sediment, filtrate concentrates and with negative pressure drying under the 0.065Mpa condition, gets thick extractive of propolis alcohol.
3. buccal tablets of extractive of propolis alcohol as claimed in claim 1 is characterized in that, contains the extractive of propolis alcohol that percentage by weight is 27%-32% and the pharmaceutically acceptable buccal tablet carrier of surplus.
4. buccal tablets of extractive of propolis alcohol as claimed in claim 1, it is characterized in that described buccal tablets of extractive of propolis alcohol is made by the component of following weight portion: extractive of propolis alcohol 55-65 part, xylitol 40-52 part, sucrose 34-45 part, microcrystalline Cellulose 20-28 part, starch 17-25 part, magnesium stearate 5-7 part, menthol 0.5-1.5 part, citric acid 4.3-6 part, essence sodium 0.2-0.5 part.
5. buccal tablets of extractive of propolis alcohol as claimed in claim 4, it is characterized in that described buccal tablets of extractive of propolis alcohol is made by the component of following weight portion: 60 parts of extractive of propolis alcohol, 45 parts of xylitol, 40 parts of sucrose, 23 parts of microcrystalline Cellulose, 20 parts of starch, 6 parts of magnesium stearate, 1.0 parts of menthols, 4.7 parts of citric acids, 0.3 part in essence sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710015492A CN101049320B (en) | 2007-05-11 | 2007-05-11 | Buccal tablets of extractive of propolis alcohol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710015492A CN101049320B (en) | 2007-05-11 | 2007-05-11 | Buccal tablets of extractive of propolis alcohol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101049320A true CN101049320A (en) | 2007-10-10 |
| CN101049320B CN101049320B (en) | 2010-05-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710015492A Expired - Fee Related CN101049320B (en) | 2007-05-11 | 2007-05-11 | Buccal tablets of extractive of propolis alcohol |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078337A (en) * | 2011-01-14 | 2011-06-01 | 哈药集团密山蜂业有限公司 | Propolis natural reduction extraction process method |
| CN101411417B (en) * | 2008-11-24 | 2012-09-05 | 南京老山药业股份有限公司 | Propolis chawing pieces and processing technique |
| CN103494050A (en) * | 2013-09-26 | 2014-01-08 | 张路扬 | Novel formula and production technology of propolis tablet product |
| CN108159081A (en) * | 2017-12-28 | 2018-06-15 | 浙江金童生物科技有限公司 | A kind of propolis buccal tablet and preparation method thereof |
| CN111407820A (en) * | 2020-02-28 | 2020-07-14 | 浙江金童生物科技有限公司 | Sugar-free buccal tablet and preparation method thereof |
| CN111493302A (en) * | 2020-03-31 | 2020-08-07 | 浙江金童生物科技有限公司 | Propolis pollen royal jelly tablet and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052619C (en) * | 1995-03-07 | 2000-05-24 | 徐静兰 | Natural royal jelly tablet |
| CN1480202A (en) * | 2003-06-27 | 2004-03-10 | 中国农业科学院蜜蜂研究所 | Propolis drop pills and its preparing method |
| CN1274684C (en) * | 2003-11-21 | 2006-09-13 | 长春中医学院 | Bee glue flavone extract preparation method, pharmaceutical preparation and its new medical uses |
-
2007
- 2007-05-11 CN CN200710015492A patent/CN101049320B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411417B (en) * | 2008-11-24 | 2012-09-05 | 南京老山药业股份有限公司 | Propolis chawing pieces and processing technique |
| CN102078337A (en) * | 2011-01-14 | 2011-06-01 | 哈药集团密山蜂业有限公司 | Propolis natural reduction extraction process method |
| CN103494050A (en) * | 2013-09-26 | 2014-01-08 | 张路扬 | Novel formula and production technology of propolis tablet product |
| CN108159081A (en) * | 2017-12-28 | 2018-06-15 | 浙江金童生物科技有限公司 | A kind of propolis buccal tablet and preparation method thereof |
| CN111407820A (en) * | 2020-02-28 | 2020-07-14 | 浙江金童生物科技有限公司 | Sugar-free buccal tablet and preparation method thereof |
| CN111493302A (en) * | 2020-03-31 | 2020-08-07 | 浙江金童生物科技有限公司 | Propolis pollen royal jelly tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101049320B (en) | 2010-05-19 |
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Granted publication date: 20100519 Termination date: 20130511 |