CN100336534C - Medicine for treating coronary heart disease and its preparation method - Google Patents
Medicine for treating coronary heart disease and its preparation method Download PDFInfo
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- CN100336534C CN100336534C CNB2005101190911A CN200510119091A CN100336534C CN 100336534 C CN100336534 C CN 100336534C CN B2005101190911 A CNB2005101190911 A CN B2005101190911A CN 200510119091 A CN200510119091 A CN 200510119091A CN 100336534 C CN100336534 C CN 100336534C
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Abstract
The present invention discloses a medicine for treating coronary disease, which is prepared from raw materials of 100 to 300g of honeysuckle flower, 100 to 300g of red sage root, 100 to 200g of Chinese angelica, 100 to 300g of scrophularia root and 50 to 100g of licorice root by the following method: decocting the five kinds of traditional Chinese medicine with water; mixing filter solutions and concentrating the filter solutions to a state in which the proportion of the five kinds of traditional Chinese medicine to the filter solutions is 1 to 10; weighing chitosan and preparing the chitosan into a 1 % chitosan solution by using acetic acid as a solvent; adding 1 % chitosan clarificant of 0.017g/100 ml into the concentrated solution extracted by the five kinds of traditional Chinese medicine when stirring the concentrated solution at a temperature of 60 DEG C to 70 DEG C; settling and filtering the concentrated solution; adding a small amount of active carbon into the filter solution for decolouring, and concentrating the filter solution to a state in which the proportion of the five kinds of traditional Chinese medicine to the filter solution is 1 to 1; then the medicine is obtained. The medicine can effectively treat diseases such as coronary disease, particularly angina pectoris, arrhythmia, etc. Meanwhile, the present invention also discloses a method for preparing the medicine.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of medicine and preparation method for the treatment of coronary heart disease.
Background technology
Coronary heart disease is the formidable enemy of harm humans health, and China is high because of mortality rates such as coronary heart disease every year, the endless misery of bringing for patient and family members.Lack good effect at present, the specific medicament that toxic and side effects is little is cured especially disease such as angina pectoris, arrhythmia of coronary heart disease.
Summary of the invention
The objective of the invention is in order to overcome existing deficiency, and especially disease such as angina pectoris, arrhythmia medicine of a kind of effective treatment coronary heart disease is provided, simultaneously, also disclose a kind of its preparation method.
For achieving the above object, the technical scheme that is provided is;
A kind of medicine for the treatment of coronary heart disease, adopting Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Glycyrrhizae is raw material, makes by the following method:
1. with Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Glycyrrhizae 5 flavor medical materials, decoct with water together 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, the acetic acid with 3% is that solvent is made into 1% chitosan solution, and is standby.
3. with above-mentioned 5 flavor medicinal material extract concentrated solutions, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate after the decolouring of filtrate adding small amount of activated is 1: 1.
The proportion relation of described 5 flavor medical materials is: Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, Radix Glycyrrhizae 50～100g.
Prepare the method for medicine as mentioned above, may further comprise the steps:
1. with Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, 5 kinds of medical materials of Radix Glycyrrhizae 50～100g decoct with water 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, it is standby that the acetic acid with 3% is that solvent is made into 1% chitosan solution;
3. with above-mentioned 5 flavor medicinal material extract concentrated solutions, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate after the decolouring of filtrate adding small amount of activated is 1: 1, promptly.
Medicine of the present invention is a dark red liquid, and it is sweet to distinguish the flavor of, little sweet.
The relative density of medicine of the present invention is not less than 1.2 on inspection.
PH value is 4.0～6.0.
Other meet every regulation relevant under the preparation item
The pharmacological testing of medicine of the present invention:
Medicine of the present invention can obviously prolong isoproterenol and bring out the chmice acute myocardial ischemia airtight anoxia time-to-live, compares with model group, and difference has significance meaning (P＜0.01); Medicine of the present invention can obviously suppress the increase that isoproterenol brings out acute myocardial ischemia mouse cardiac muscle water content; compare with model group; difference has statistical significance (P＜0.05), and medicine of the present invention brings out the chmice acute myocardial ischemia to isoproterenol and has protective effect.
The function of medicine of the present invention with cure mainly: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting QI and nourishing blood, a surname's numbness the chest stuffiness relieving reduces phlegm and activates yang, removing obstruction in the collateral to relieve pain.Be used for the chest pain that qi stagnation and blood stasis type coronary heart disease, angina pectoris, arrhythmia cause, feel suffocated, cardiopalmus is breathed hard, and is weak, diseases such as heart failure.Its usage and consumption: oral, a 10ml～20ml, 2～3 times on the one, be noted that anemia of pregnant woman and the careful usefulness of deficiency of heart-YANG and kidney-YANG type coronary heart disease, the joint sexual life, must guard against annoyed, overwork.Period in a medicine, can be obeyed a small amount of Rhizoma Chuanxiong and drink or drug withdrawal for tea though do not affect the treatment if any borborygmus diarrhoea person, can remove.
The curative effect of medicine of the present invention is described by the typical clinical case:
Case one: the real man of patient Xing Zhen 42 years old went to a doctor on April 11st, 2005.
This patient, paroxysmal is uncomfortable in chest, pareordia is uncomfortable, breathe hard, dizzy nearly 10 years.Once be diagnosed as " coronary heart disease " over nearly 3 months, chest pain is frequently shown effect, and to left upper extremity radiation, often outbreak when motion is alleviated during rest, with breathing hard, does not once have good then goes to a doctor from obeying multiple Chinese and western drugs.Have a medical check-up: BP 180/110mmHg, the apex first heart sound is low blunt, A
2＞P
2Surplus depletion of YANG gonosome is levied.Electrocardio diagram: inferior myocardial ischemia.Clinical diagnosis: hypertension, coronary heart disease, angina pectoris.Give and Drug therapy of the present invention, 20 milliliters/time, three times/day, took medicine the same day, uncomfortable in chest, breathe hard, chest pain alleviates, and is evident in efficacy, continues treatment, do not have outbreak when moving, the check electrocardiogram recovers normal after taking medicine one month.Follow up a case by regular visits to and do not have recurrence in 4 months.
Case two: patient Jin Chunshan man 60 years old went to a doctor on March 20th, 2005.
This trouble is because of being diagnosed as " hypertension " " coronary heart disease " before 10 years, and repeatedly treat at various big hospital, heavy during fashion, began not have the inducement angina pectoris that takes place frequently night before January, take a favorable turn slightly from clothes " SUXIAO JIUXIN WAN " etc., began before 20 days not only that night angina pectoris attacks but also daytime also take place frequently, sucking first-aid medicines such as " nitroglycerin " recently must not alleviate, and goes to a doctor.Have a medical check-up: BP 160/100mmHg, the apex first heart sound is low blunt, A
2＞P
2Surplus depletion of YANG gonosome is levied.Electrocardio diagram: myocardial ischemia.Clinical diagnosis: hypertension, coronary heart disease, angina pectoris.Give and Drug therapy of the present invention, 20 milliliters/time, three times/day, took medicine the same day, uncomfortable in chest, breathe hard, chest pain alleviates, sb.'s illness took a favorable turn, evident in efficacy, continues treatment, the check electrocardiogram recovers normal after taking medicine one month.Follow up a case by regular visits to and do not have recurrence in 7 months.
Case three: patient Jin Zhen friend man 38 years old went to a doctor on April 1st, 2005.
This is suffered from because of hypertension, precordial fullness was treated 3 years bitterly, and angina pectoris attacks has the squeezing sense behind the breastbone recently, countless from the clothes medicaments for coronary disease, beginning produces effect slightly, and any afterwards medicine is all inoperative, and goes to a doctor, blood pressure 170/100mmHg during prescription on individual diagnosis, pulse 120 times/minute, the electrocardiogram prompting: the ST section moves down, and the T ripple is inverted diagnosis: coronary heart disease, angina pectoris.Give and 20 milliliters/time of Drug therapys of the present invention, three times/day, all other medicines of stopping using, the doing well,improving on the same day of taking medicine,, chest pain uncomfortable in chest through treating disappears, the check electrocardiogram is normal after January.Follow up a case by regular visits to and do not recur today.
The specific embodiment
1. with Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, 5 kinds of medical materials such as Radix Glycyrrhizae 50～100g decoct with water 3 times together, decoct 2h, 1.5h and 1h respectively, filter, merging filtrate and the weight that is concentrated into 5 flavor Chinese crude drugs are 1: 10 with the ratio of filtrate volume, and it is standby to put into the refrigerator and cooled Tibetan then;
2. the preparation of chitosan clarifier takes by weighing chitosan 1g, and it is standby that the acetic acid with 3% is that solvent is made into 1% chitosan solution;
3. with 5 the flavor medicinal material extract concentrated solution, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, add activated carbon decolorizing then, add the 0.1g active carbon in every 100ml filtrate, being concentrated into the 5 flavor weight of Chinese crude drugs and the volume ratio of filtrate is 1: 1, adds 0.2% sodium benzoate again, and promptly the weight that takes by weighing of sodium benzoate is between 0.8～2.4g, last packing 10ml/ props up, and makes 400～1200ml.Embedding, sterilization promptly.The storage of shady and cool place is put in sealing.
Claims (3)
1, a kind of medicine for the treatment of coronary heart disease, adopting Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, Radix Glycyrrhizae 50～100g is crude drug, makes by the following method:
1. with Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Glycyrrhizae 5 flavor Chinese crude drugs, decoct with water together 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, the acetic acid with 3% is that solvent is made into 1% chitosan solution, and is standby;
3. with the concentrated solution of above-mentioned 5 flavor medicinal material extract, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate in the filtrate after the decolouring of adding small amount of activated is 1: 1.
2, prepare the method for medicine according to claim 1, may further comprise the steps:
1. with Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, 5 kinds of medical materials of Radix Glycyrrhizae 50～100g decoct with water 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, the acetic acid with 3% is that solvent is made into 1% chitosan solution, and is standby;
3. with the concentrated solution of above-mentioned 5 flavor medicinal material extract, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate after the decolouring of filtrate adding small amount of activated is 1: 1.
3, the method for preparing medicine according to claim 2 is characterized in that further comprising the steps of: add 0.2% sodium benzoate in the concentrated solution after will decolouring, packing 10ml/ props up, and makes 400～1200ml, the embedding sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101190911A CN100336534C (en) | 2005-12-14 | 2005-12-14 | Medicine for treating coronary heart disease and its preparation method |
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| CNB2005101190911A CN100336534C (en) | 2005-12-14 | 2005-12-14 | Medicine for treating coronary heart disease and its preparation method |
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| CN100336534C true CN100336534C (en) | 2007-09-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109419914A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of Chinese medicine composition |
| CN115227757B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
| CN115337347B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of medicine for treating coronary heart disease |
| CN115337348B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat-accumulation blood vessels |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586562A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Heart strengthening and heart protecting pill |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586562A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Heart strengthening and heart protecting pill |
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