CN1824020A - Medicine for treating coronary heart disease and preparation method thereof - Google Patents
Medicine for treating coronary heart disease and preparation method thereof Download PDFInfo
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- CN1824020A CN1824020A CNA2005101190911A CN200510119091A CN1824020A CN 1824020 A CN1824020 A CN 1824020A CN A2005101190911 A CNA2005101190911 A CN A2005101190911A CN 200510119091 A CN200510119091 A CN 200510119091A CN 1824020 A CN1824020 A CN 1824020A
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- 239000003814 drug Substances 0.000 title claims abstract description 36
- 208000029078 coronary artery disease Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims description 10
- 229940079593 drug Drugs 0.000 title description 13
- 229920001661 Chitosan Polymers 0.000 claims abstract description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract 3
- 240000007164 Salvia officinalis Species 0.000 claims abstract 2
- 239000000706 filtrate Substances 0.000 claims description 20
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- 235000019634 flavors Nutrition 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 4
- 241000411851 herbal medicine Species 0.000 claims 4
- 244000061520 Angelica archangelica Species 0.000 claims 2
- 241000202807 Glycyrrhiza Species 0.000 claims 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims 2
- 235000001287 Guettarda speciosa Nutrition 0.000 claims 2
- 241000013557 Plantaginaceae Species 0.000 claims 2
- 238000004042 decolorization Methods 0.000 claims 2
- 229940010454 licorice Drugs 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 235000017276 Salvia Nutrition 0.000 claims 1
- 241000304195 Salvia miltiorrhiza Species 0.000 claims 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 1
- 239000008395 clarifying agent Substances 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 10
- 206010003119 arrhythmia Diseases 0.000 abstract description 4
- 230000006793 arrhythmia Effects 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 3
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 206010008479 Chest Pain Diseases 0.000 description 5
- 241000628997 Flos Species 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000031225 myocardial ischemia Diseases 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 4
- 239000012567 medical material Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
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- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
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- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
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- 230000001314 paroxysmal effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
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- 210000001364 upper extremity Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A Chinese medicine for treating coronary heart disease, angina pectoris and arrhythmia is prepared from 5 Chinese-medicinal materials including honeysuckle flower, red sage root, Chinese angelica root, liquorice root, etc through decocting, concentrating to obtain concentrated liquid, dissolving chitosan in acetic acid, adding it to said concentrated liquid while stirring, laying aside, filtering, adding activated carbon, decoloring and concentrating.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of medicine and preparation method for the treatment of coronary heart disease.
Background technology
Coronary heart disease is the formidable enemy of harm humans health, and China is high because of mortality rates such as coronary heart disease every year, the endless misery of bringing for patient and family members.Lack good effect at present, the specific medicament that toxic and side effects is little is cured especially disease such as angina pectoris, arrhythmia of coronary heart disease.
Summary of the invention
The objective of the invention is in order to overcome existing deficiency, and especially disease such as angina pectoris, arrhythmia medicine of a kind of effective treatment coronary heart disease is provided, simultaneously, also disclose a kind of its preparation method.
For achieving the above object, the technical scheme that is provided is;
A kind of medicine for the treatment of coronary heart disease, adopting Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Glycyrrhizae is raw material, makes by the following method:
1. with Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Glycyrrhizae 5 flavor medical materials, decoct with water together 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, the acetic acid with 3% is that solvent is made into 1% chitosan solution, and is standby.
3. with above-mentioned 5 flavor medicinal material extract concentrated solutions, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate after the decolouring of filtrate adding small amount of activated is 1: 1.
The proportion relation of described 5 flavor medical materials is: Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, Radix Glycyrrhizae 50～100g.
Prepare the method for medicine as mentioned above, may further comprise the steps:
1. with Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, 5 kinds of medical materials of Radix Glycyrrhizae 50～100g decoct with water 3 times, decoct 2h, 1.5h and 1h respectively, filter, the merging filtrate and 5 ratios of distinguishing the flavor of Chinese crude drugs and filtrate that are concentrated into are 1: 10, and are standby;
2. the preparation of chitosan clarifier: take by weighing chitosan, it is standby that the acetic acid with 3% is that solvent is made into 1% chitosan solution;
3. with above-mentioned 5 flavor medicinal material extract concentrated solutions, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, the ratio that is concentrated into 5 flavor Chinese crude drugs and filtrate after the decolouring of filtrate adding small amount of activated is 1: 1, promptly.
Medicine of the present invention is a dark red liquid, and it is sweet to distinguish the flavor of, little sweet.
The relative density of medicine of the present invention is not less than 1.2 on inspection.
PH value is 4.0～6.0.
Other meet every regulation relevant under the preparation item
The pharmacological testing of medicine of the present invention:
Medicine of the present invention can obviously prolong isoproterenol and bring out the chmice acute myocardial ischemia airtight anoxia time-to-live, compares with model group, and difference has significance meaning (P＜0.01); Medicine of the present invention can obviously suppress the increase that isoproterenol brings out acute myocardial ischemia mouse cardiac muscle water content; compare with model group; difference has statistical significance (P＜0.05), and medicine of the present invention brings out the chmice acute myocardial ischemia to isoproterenol and has protective effect.
The function of medicine of the present invention with cure mainly: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting QI and nourishing blood, a surname's numbness the chest stuffiness relieving reduces phlegm and activates yang, removing obstruction in the collateral to relieve pain.Be used for the chest pain that qi stagnation and blood stasis type coronary heart disease, angina pectoris, arrhythmia cause, feel suffocated, cardiopalmus is breathed hard, and is weak, diseases such as heart failure.Its usage and consumption: oral, a 10ml～20ml, 2～3 times on the one, be noted that anemia of pregnant woman and the careful usefulness of deficiency of heart-YANG and kidney-YANG type coronary heart disease, the joint sexual life, must guard against annoyed, overwork.Period in a medicine, can be obeyed a small amount of Rhizoma Chuanxiong and drink or drug withdrawal for tea though do not affect the treatment if any borborygmus diarrhoea person, can remove.
The curative effect of medicine of the present invention is described by the typical clinical case:
Case one: the real man of patient Xing Zhen 42 years old went to a doctor on April 11st, 2005.
This patient, paroxysmal is uncomfortable in chest, pareordia is uncomfortable, breathe hard, dizzy nearly 10 years.Once be diagnosed as " coronary heart disease " over nearly 3 months, chest pain is frequently shown effect, and to left upper extremity radiation, often outbreak when motion is alleviated during rest, with breathing hard, does not once have good then goes to a doctor from obeying multiple Chinese and western drugs.Have a medical check-up: BP 180/110mmHg, the apex first heart sound is low blunt, A
2＞P
2Surplus depletion of YANG gonosome is levied.Electrocardio diagram: inferior myocardial ischemia.Clinical diagnosis: hypertension, coronary heart disease, angina pectoris.Give and Drug therapy of the present invention, 20 milliliters/time, three times/day, took medicine the same day, uncomfortable in chest, breathe hard, chest pain alleviates, and is evident in efficacy, continues treatment, do not have outbreak when moving, the check electrocardiogram recovers normal after taking medicine one month.Follow up a case by regular visits to and do not have recurrence in 4 months.
Case two: patient Jin Chunshan man 60 years old went to a doctor on March 20th, 2005.
This trouble is because of being diagnosed as " hypertension " " coronary heart disease " before 10 years, and repeatedly treat at various big hospital, heavy during fashion, began not have the inducement angina pectoris that takes place frequently night before January, take a favorable turn slightly from clothes " SUXIAO JIUXIN WAN " etc., began before 20 days not only that night angina pectoris attacks but also daytime also take place frequently, sucking first-aid medicines such as " nitroglycerin " recently must not alleviate, and goes to a doctor.Have a medical check-up: BP 160/100mmHg, the apex first heart sound is low blunt, A
2＞P
2Surplus depletion of YANG gonosome is levied.Electrocardio diagram: myocardial ischemia.Clinical diagnosis: hypertension, coronary heart disease, angina pectoris.Give and Drug therapy of the present invention, 20 milliliters/time, three times/day, took medicine the same day, uncomfortable in chest, breathe hard, chest pain alleviates, sb.'s illness took a favorable turn, evident in efficacy, continues treatment, the check electrocardiogram recovers normal after taking medicine one month.Follow up a case by regular visits to and do not have recurrence in 7 months.
Case three: patient Jin Zhen friend man 38 years old went to a doctor on April 1st, 2005.
This is suffered from because of hypertension, precordial fullness was treated 3 years bitterly, and angina pectoris attacks has the squeezing sense behind the breastbone recently, countless from the clothes medicaments for coronary disease, beginning produces effect slightly, and any afterwards medicine is all inoperative, and goes to a doctor, blood pressure 170/100mmHg during prescription on individual diagnosis, pulse 120 times/minute, the electrocardiogram prompting: the ST section moves down, and the T ripple is inverted diagnosis: coronary heart disease, angina pectoris.Give and 20 milliliters/time of Drug therapys of the present invention, three times/day, all other medicines of stopping using, the doing well,improving on the same day of taking medicine,, chest pain uncomfortable in chest through treating disappears, the check electrocardiogram is normal after January.Follow up a case by regular visits to and do not recur today.
The specific embodiment
1. with Flos Lonicerae 100～300g, Radix Salviae Miltiorrhizae 100～300g, Radix Angelicae Sinensis 100～200g, Radix Scrophulariae 100～300g, 5 kinds of medical materials such as Radix Glycyrrhizae 50～100g decoct with water 3 times together, decoct 2h, 1.5h and 1h respectively, filter, merging filtrate and the weight that is concentrated into 5 flavor Chinese crude drugs are 1: 10 with the ratio of filtrate volume, and it is standby to put into the refrigerator and cooled Tibetan then;
2. the preparation of chitosan clarifier takes by weighing chitosan 1g, and it is standby that the acetic acid with 3% is that solvent is made into 1% chitosan solution;
3. with 5 the flavor medicinal material extract concentrated solution, add 1% chitosan clarifier down to 0.017g/100ml in 60 ℃～70 ℃ stirrings, static 24 hours, filter, add activated carbon decolorizing then, add the 0.1g active carbon in every 100ml filtrate, being concentrated into the 5 flavor weight of Chinese crude drugs and the volume ratio of filtrate is 1: 1, adds 0.2% sodium benzoate again, and promptly the weight that takes by weighing of sodium benzoate is between 0.8～2.4g, last packing 10ml/ props up, and makes 400～1200ml.Embedding, sterilization promptly.The storage of shady and cool place is put in sealing.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101190911A CN100336534C (en) | 2005-12-14 | 2005-12-14 | Medicine for treating coronary heart disease and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101190911A CN100336534C (en) | 2005-12-14 | 2005-12-14 | Medicine for treating coronary heart disease and its preparation method |
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| Publication Number | Publication Date |
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| CN1824020A true CN1824020A (en) | 2006-08-30 |
| CN100336534C CN100336534C (en) | 2007-09-12 |
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| CNB2005101190911A Expired - Fee Related CN100336534C (en) | 2005-12-14 | 2005-12-14 | Medicine for treating coronary heart disease and its preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109419914A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of Chinese medicine composition |
| CN115227757A (en) * | 2021-08-05 | 2022-10-25 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
| CN115337348A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat accumulation and blood vessels |
| CN115337347A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of medicine for treating coronary heart disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586562A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Heart strengthening and heart protecting pill |
-
2005
- 2005-12-14 CN CNB2005101190911A patent/CN100336534C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109419914A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of Chinese medicine composition |
| CN115227757A (en) * | 2021-08-05 | 2022-10-25 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
| CN115337348A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat accumulation and blood vessels |
| CN115337347A (en) * | 2021-08-05 | 2022-11-15 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of medicine for treating coronary heart disease |
| CN115337347B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of medicine for treating coronary heart disease |
| CN115227757B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Application of traditional Chinese medicine composition in preparation of antihypertensive drugs |
| CN115337348B (en) * | 2021-08-05 | 2023-10-24 | 中国中医药科技发展中心(国家中医药管理局人才交流中心) | Traditional Chinese medicine composition for treating heat-accumulation blood vessels |
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| Publication number | Publication date |
|---|---|
| CN100336534C (en) | 2007-09-12 |
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