CN114377109A

CN114377109A - Nerve-soothing and sleep-aiding composition and preparation method and application thereof

Info

Publication number: CN114377109A
Application number: CN202210054401.XA
Authority: CN
Inventors: 马辉; 朱志铭; 赵大鹏; 韩烁培; 赫彩霞; 李嘉欣
Original assignee: Hebei Yuzhilin Biotechnology Co ltd
Current assignee: Hebei Yuzhilin Biotechnology Co ltd
Priority date: 2022-01-18
Filing date: 2022-01-18
Publication date: 2022-04-22
Anticipated expiration: 2042-01-18
Also published as: CN114377109B

Abstract

The invention relates to a nerve-soothing and sleep-aiding composition which comprises, by mass, 10-30 parts of spina date seed powder, 10-30 parts of lily peptide, 10-15 parts of corn oligopeptide, 3-5 parts of sorbitol, 5-13 parts of gamma-aminobutyric acid, 10-20 parts of passion fruit powder, 0.1-0.3 part of sweetening agent and 1-2.5 parts of sour agent. The nerve-soothing and sleep-aiding composition provided by the invention can adjust the whole sleep process, so that an insomniac can fall asleep quickly, and the people still have full primordial qi after waking up, and do not have a sleeping state.

Description

Nerve-soothing and sleep-aiding composition and preparation method and application thereof

Technical Field

The invention relates to a nerve-soothing and sleep-aiding composition and a preparation method and application thereof, and belongs to the field of nerve-soothing and sleep-aiding compositions.

Background

Insomnia is a healthy predator of human beings, and long-term insomnia can affect normal work and life, easily cause mental asthenia, mental disorder and mental disorder, induce physical diseases such as heart and brain, and cause accidents. The long-term insomnia is also easy to cause the reduction of immunity, so that the aging of the human body is accelerated. Cancer research in the united states investigates have found that sleep has a significant impact on cancer incidence and that insufficient sleep may also induce cancer.

Sleep disorder is a psychological disorder related to psychological factors, which is caused by changes in sleep time and/or sleep quality due to various causes and causes daytime social functions to be affected. Insomnia: or disorders known as falling asleep and maintaining sleep. This is the most common sleep disorder. Insomnia has been identified in three different forms, both with chronic sleep disturbance and complaints of daytime burnout.

First, insomnia due to disorder of falling asleep means difficulty in falling asleep.

② the pillow can keep sleep disorder insomnia and is characterized by frequent night awakening.

③ Final insomnia, early morning waking, and no ability to go to sleep again.

The current medical treatment of insomnia mainly comprises:

1. diazepam (benzodiazepine drugs):

all the medicines with the name suffix of diazepam or the suffix of zolam are all the diazepam medicines.

② drug dependence: including psychological dependence: deep in the heart is eager to take medicine, even if the medicine is not taken, the medicine can be very forceful if the medicine is taken. Somatic dependence: once the medicine is not taken, the original symptoms such as insomnia, dysphoria and the like can reappear, and various somatic symptoms such as palpitation, nausea, sweating and the like can also appear.

2. Third generation hypnotics: such as zolpidem, zopiclone, zaleplon, eszopiclone.

3. Other drugs that improve insomnia: antipsychotic drugs, antidepressant drugs, antihistamine drugs, Chinese patent drugs and the like. The medicine is familiar hypnotic and is also afraid of addiction, and has the advantages of good sedative-hypnotic effect, low price and large side effect, such as dizziness and muscle weakness caused by early waking in the morning, also easily causes the alertness reduction in the daytime, can not be used for driving, and is easy to generate drug dependence after long-term large-scale use.

People also take melatonin for a long time to promote sleep, which actually interferes with normal physiological processes to reduce the secretion of the melatonin, and when the melatonin is stopped, the secretion function of the melatonin cannot be recovered or can only be partially recovered, so that dependence is formed; if melatonin is excessively taken, the concentration of thyroxine and epinephrine in a human body is relatively reduced, so that attention is distracted, the reaction force is weakened, and the sensitivity is reduced.

In addition, in patent CN202010091308.7, the insomnia caused by falling asleep is solved by the technical scheme design of calming heart and nourishing blood, clearing intestine and calming stomach and promoting sleep factors. The formula contains lily peptide and lotus seed peptide, and mainly utilizes the principle that the peptide is easy to absorb. In patent CN112205507A, scientific compatibility is carried out according to the traditional Chinese herbal medicine formula theory and the modern pharmaceutical technology principle, and the prepared product has the effects of improving sleep, promoting sleep, soothing nerves and calming the heart. The current patent on the sleep-improving composition is mainly to enable the composition to quickly fall asleep by regulating the heart and inhibiting nervous excitation. The formula mainly aims at the sleep disorder insomnia, but a plurality of people have the phenomena of sleep disorder insomnia maintenance and daytime burnout, and some people can have the symptoms of somnolence, dizziness, hypodynamia and the like after taking the sleep-assisting product.

In view of the shortcomings of the prior art, there is a need to provide a new solution to insomnia.

Disclosure of Invention

The invention aims to overcome the defects in the prior art, provides a nerve-soothing and sleep-aiding composition for regulating the whole sleep process, and also provides a preparation method and application thereof.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

subject of the technology 1

A nerve-soothing and sleep-aiding composition comprises, by mass, 10-30 parts of spina date seed powder, 10-30 parts of lily peptide, 10-15 parts of corn oligopeptide, 3-5 parts of sorbitol, 5-13 parts of gamma-aminobutyric acid, 10-20 parts of passion fruit powder, 0.1-0.3 part of sweetening agent and 1-2.5 parts of sour agent.

As some preferred embodiments of the invention, the nerve-soothing and sleep-aiding composition consists of 10-30 parts by weight of spina date seed powder, 10-30 parts by weight of lily peptide, 10-15 parts by weight of corn oligopeptide, 3-5 parts by weight of sorbitol, 7 parts by weight of gamma-aminobutyric acid, 10-20 parts by weight of passion fruit powder, 0.1-0.3 part by weight of sweetening agent and 1-2.5 parts by weight of sour agent.

As a preferred embodiment of the invention, the nerve-soothing and sleep-aiding composition consists of 15 parts of spina date seed powder, 13 parts of lily peptide, 10 parts of corn oligopeptide, 4 parts of sorbitol, 7 parts of gamma-aminobutyric acid, 17 parts of passion fruit powder, 0.2 part of sweetening agent and 1 part of sour agent in parts by weight.

As a preferred embodiment of the invention, the sweetener is one or more of aspartame, sodium cyclamate or sucralose.

As a preferred embodiment of the present invention, the sour agent includes at least one of citric acid, fruit acid and sorbic acid.

A preparation method of a nerve-soothing and sleep-aiding composition comprises the following steps:

A. preparing components and amounts of a tranquilizing sleep-aiding composition according to claim 1;

B. sieving lily peptide, corn oligopeptide, sorbitol, sweetener and sour agent, and mixing with semen Ziziphi Spinosae powder, gamma-aminobutyric acid and passion fruit powder to obtain mixture;

C. granulating the mixture, oven drying, and packaging to obtain solid beverage or tabletting to obtain candy.

As a preferred embodiment of the invention, the step B screening is specifically 60-100 mesh screening.

As a preferred embodiment of the invention, the drying temperature in the step C is 50-60 ℃, and the moisture content is less than 5%.

Subject matter two

The nerve-soothing and sleep-aiding composition can be applied to preparing functional foods or health-care medicines for soothing nerves and aiding sleep.

As a preferred embodiment of the present invention, the functional food is a solid beverage or a tablet candy.

Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:

the nerve-soothing and sleep-aiding composition provided by the invention can adjust the whole sleep process, so that an insomniac can fall asleep quickly, and the people still have full primordial qi after waking up, and do not have a sleeping state. The invention not only conditions the heart but also focuses on soothing the liver and nourishing the liver, and is not limited to one type of internal organs. The spina date seed enters heart and liver channels, nourishes blood and liver, calms heart and calms nerves; lily enters heart and lung channels, clears fire and nourishes yin, moistens lung and nourishes heart, and the combination of the two can nourish yin, soothe nerves, clear heat and relieve restlessness. The corn oligopeptide contains abundant alanine and leucine, has strong liver protection effect, can regulate liver qi and remove obstruction, nourish the whole body by liver blood, and enable spirit to be calm and fall asleep. The better sleep-aiding effect is achieved by regulating and treating the heart and the liver together. The formula not only has the effect of helping sleep, but also has the effect of reducing blood pressure. The spina date seed contains jujube kernel total glycosides, which can effectively reduce cholesterol contained in serum and improve the content of high-density lipoprotein after entering a body. The spina date seed not only can regulate blood pressure and blood fat, but also has good effects of preventing and treating arteriosclerosis. The corn peptide can inhibit activity of angiotensin converting enzyme, and can be used as competitive inhibitor of angiotensin to relieve vascular tension and reduce blood pressure.

In addition, the introduction of the peptide is another innovation point of the formula. Not limited to the easily absorbable layer of the peptide, but the mechanism of action to aid sleep is elucidated from a cytological point of view. Peptides can repair cells + improve cells + activate cells. Repairing nerve cells, protecting cranial nerves, and regulating balance of nervous system.

Wherein:

wild jujube seed: it enters liver, gallbladder and heart meridians. Nourish heart and tonify liver, calm heart and induce tranquilization, arrest sweating, promote fluid production. Can be used for treating vexation, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid deficiency, and thirst. The spina date seed decoction has better effect of nourishing heart and soothing nerves and is often favored by doctors of all generations, wherein the widely known spina date seed decoction takes the spina date seed as a main medicine and has better effect on insomnia.

Lily peptide: it enters heart and lung meridians. Nourish yin and moisten lung, clear heart and induce tranquilization. Can be used for treating dry cough due to yin deficiency, cough with hemoptysis, vexation, pavor, insomnia, dreaminess, and absentmindedness. The 'tranquilization' of the traditional Chinese medicine theory is matched with the pharmacological action of sedation and hypnosis. Modern pharmacological experimental research shows that the lily can also obviously shorten the sleep latency of an insomnia-causing model animal with sodium pentobarbital and chloroalanine, and the lily has a good sedative and hypnotic effect. The lily peptide is a substance with high activity, high nutrition, small molecules, good water solubility and complete absorption, and has the functions of activating cell activity and reversing aging; repairing denatured cells and scavenging free radicals. Promoting nutrient absorption, discharging metabolic waste, inhibiting cell degeneration, and enhancing immunity.

Corn oligopeptide: the corn oligopeptide has a better protective effect on liver injury at the cellular level and the animal level, and researches show that the corn oligopeptide can reduce the glycolysis level of cells to a certain extent and provide sufficient energy for the cells. In addition, the corn oligopeptide can protect liver stem cells from two aspects of promoting the proliferation of liver oval cells and resisting cell damage. The corn oligopeptide has the effects of inhibiting the activity of angiotensin converting enzyme and relieving the vascular tension, thereby having the effect of reducing blood pressure, but has no side effect on people with normal blood pressure.

Gamma-aminobutyric acid: the gamma-aminobutyric acid is an inhibitory transfer substance of a central nervous system, and can promote vasodilatation through the central nervous system to achieve the effects of soothing the nerves and promoting sleep. Meanwhile, the gamma-aminobutyric acid can effectively improve cerebral blood circulation, increase oxygen supply, promote metabolism of the brain and recover the function and activity of brain cells. The gamma-aminobutyric acid can effectively promote vasodilatation, increase blood flow, increase oxygen supply and promote metabolism, thereby reducing blood pressure. The red yeast rice has the effects of reducing blood fat and blood pressure, wherein the blood fat reducing factor is lovastatin (monacolin-K), and the blood pressure reducing factor is gamma-aminobutyric acid. The effective antihypertensive component of traditional Chinese medicines such as astragalus is reported to be gamma-aminobutyric acid.

Passion fruit powder: the passion fruit powder contains the fragrance of more than 100 fruits such as apples, pineapples, mangoes, bananas and the like, the abundant fragrant phenol components contained in the passion fruit powder have the nerve soothing effect, and insomnia can be prevented by eating the passion fruit powder.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail and fully with reference to the following embodiments.

The examples of the invention were prepared according to the amounts of the components in table 1.

The preparation method of the nerve-soothing and sleep-aiding composition disclosed by the invention in the embodiments 1-4 and the comparative examples 1-5 comprises the following steps:

A. preparing components and using amounts of the nerve-soothing and sleep-aiding composition according to the table 1;

B. sieving Bulbus Lilii peptide, semen Maydis oligopeptide, sorbitol, sweetener and sour agent with 60-100 mesh sieve, and mixing with semen Ziziphi Spinosae powder, gamma-aminobutyric acid, and passion fruit powder in mixer to obtain mixture;

C. taking out the mixture, and granulating by a granulator to obtain wet granules; placing the prepared wet granules in a hot air circulation drying oven, and drying at 55-60 deg.C until the moisture content of the granules is less than 5.0%; and transferring the dried granules into a tabletting machine, adjusting proper machine parameters, and tabletting to obtain 2g of tabletting candies.

TABLE 1

The tablet candies obtained in examples 1 to 4 and comparative examples 1 to 5 were subjected to a sleep-aid test, and the results are shown in Table 2.

1 case collection: 105 patients with insomnia who met the criteria for case screening were collected.

1.1 diagnostic criteria:

the traditional Chinese medicine diagnosis standard is made according to the diagnosis standard about insomnia in the clinical research guiding principles of new traditional Chinese medicines. The sleeping time of the patient is less than 4 hours every day, and the patient is ineffective to take hypnotic drugs; or can fall asleep for 6h after being taken, but the sleep is slight, the patient is easy to wake up and dreamful, the mental state after waking up is poor, the limbs are tired and fatigued, and the duration lasts for more than half a month.

Insomnia diagnosis standards of Chinese Classification and diagnosis standards for mental disorders (H th edition) in China (CCMD-3) were promulgated in 4 months in 2001 as follows:

(1) symptom criteria: insomnia is almost the only symptom, including difficulty in falling asleep, dreaminess, easy waking, early waking, difficulty in falling asleep again after waking, discomfort after waking, or daytime sleepiness; has the advantages of insomnia and extreme attention on insomnia results.

(2) Severity: the discontented sleeping time and quality cause obvious troubles and impaired social functions.

(3) The disease course standard is as follows: firstly, the insomnia latency is prolonged: the time of falling asleep exceeds 30 min; ② disorder of sleep maintenance: the number of awakenings at night is more than 2; the sleep quality is reduced; light sleep and dreaminess; shortening the total sleep time; less than 6 h; residual effect during the day: in the next morning, the patient feels dizziness, lassitude, lethargy and hypodynamia.

(4) Exclusion criteria: and eliminating secondary insomnia caused by physical diseases and mental disorders.

1.2 inclusion criteria:

a. the above diagnostic criteria are met;

b. the age is 18-70 years old, and the nature is not limited;

c. has good compliance and is willing to accept the treatment.

1.3 exclusion criteria:

a. those who do not meet the above diagnostic criteria for insomnia;

b. those that do not meet inclusion criteria;

c. pregnant or lactating women;

d. chronic fatigue, which can be explained by the onset of disease;

e. those with the risk of complicated infection and bleeding;

f. combined with primary diseases of cardiovascular and cerebrovascular diseases, liver, kidney, digestive hematopoietic system and the like, and psychonoses;

g. patients lost visits due to various reasons during follow-up visits, and patients quit themselves due to other random reasons.

In the experiment, 180 volunteers with sleep disorders are divided into 9 groups, 20 in each group, and the preparation products prepared in examples 1-4 and comparative examples 1-5 are respectively eaten in a trial mode, 2 tablets are taken before half sleep every night, and after 2 weeks of continuous taking, the symptoms before test, the taking condition and the taking condition after the test are shown in the following table 2, in the table 2, the volunteers in examples 1-4 respectively take the products prepared in examples 1-4, and the volunteers in comparative examples 1-5 respectively take the products prepared in comparative examples 1-5.

The observation table is filled in detail before and after treatment, and the curative effect is judged after the treatment course is finished. During the test period, other medicines with the function of treating insomnia cannot be used for treatment.

2 criteria for therapeutic efficacy

(1) The clinical cure is as follows: the time for falling asleep is not more than 30 min; recovering normal sleep time or sleep time at night of more than 6 hours, deep sleep, and awakening frequency at night of less than 2 times; refreshing and invigorating.

(2) The effect is shown: the sleep is improved obviously, the sleep time is increased by more than 3 hours, the sleep time is not enough for 6 hours, and the sleep depth is increased.

(3) The method has the following advantages: the symptoms are relieved, and the sleep time is increased by less than 3 hours compared with the prior art.

(4) And (4) invalidation: and insomnia after treatment is not obviously improved or is not aggravated.

TABLE 2

Group of	Cure (%)	Effect showing example (%)	Effective example (%)	Ineffective example (%)
					Example 1	5(25％)	10(50％)	5(25％)	0(0％)
Example 2	5(25％)	11(55％)	4(20％)	0(0％)
					Example 3	8(40％)	10(50％)	2(10％)	0(0％)
Example 4	8(40％)	11(55％)	1(5％)	0(0％)
					Comparative example 1	1(5％)	7(35％)	10(50％)	2(10％)
Comparative example 2	1(5％)	6(30％)	11(55％)	2(10％)
					Comparative example 3	1(5％)	8(40％)	10(50％)	3(15％)
Comparative example 4	3(15％)	8(40％)	8(40％)	1(5％)
					Comparative example 5	3(15％)	6(30％)	10(50％)	1(5％)

For the non-effective cases of comparative examples 1-5, i.e. the patients with no significant improvement or adverse increase in insomnia after treatment, the volunteers of this group continuously took the products prepared in comparative examples 1-5 for 2-8 weeks, respectively, and the results of the change in symptoms in the volunteer group are shown in Table 3.

TABLE 3

The effects of the present invention will be described below by taking example 4 as an example only.

Sedative effect on mice

1.1 Experimental materials

Clean-grade Kunming mice, weighing 18-22g, half each male and half, and all groups of mice are fed in cages and freely eat drinking water.

1.2, grouping and administration

120 healthy Kunming mice were randomly divided into a blank control group, an example 4 group, a comparative example 1 group, a comparative example 2 group, a comparative example 3 group and a gamma-aminobutyric acid group 6 group, and each group had 20 mice. Each group was given 4 g/kg. d of the confectioneries prepared in example 4, comparative example 1, comparative example 2 and comparative example 3^-1The γ -aminobutyric acid group was administered with γ -aminobutyric acid at the same dose as in example 4, and the blank control group was administered with physiological saline at the same volume as in example 4, and the administration was performed by gavage once a day for 3 consecutive days. Mice were placed in an activity box for 3 minutes before dosing, and the number of spontaneous activity in each group of animals for 3 minutes was recorded, and the mean value was taken as the pre-dose normal value. The rate of inhibition of activity was measured 1 hour after the last administration, and = (mean of activity in blank group-mean of administration group)/mean of blank group × 100%.

1.3 results

The results are shown in Table 4.

TABLE 4 comparative data for post-dose sedation test in groups of mice

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. The nerve-soothing and sleep-aiding composition is characterized by comprising, by mass, 10-30 parts of spina date seed powder, 10-30 parts of lily peptide, 10-15 parts of corn oligopeptide, 3-5 parts of sorbitol, 5-13 parts of gamma-aminobutyric acid, 10-20 parts of passion fruit powder, 0.1-0.3 part of sweetening agent and 1-2.5 parts of sour agent.

2. The composition for soothing nerves and aiding sleep as claimed in claim 1, which is characterized by comprising, by mass, 10-30 parts of spina date seed powder, 10-30 parts of lily peptide, 10-15 parts of corn oligopeptide, 3-5 parts of sorbitol, 7 parts of gamma-aminobutyric acid, 10-20 parts of passion fruit powder, 0.1-0.3 part of sweetening agent and 1-2.5 parts of sour agent.

3. The composition for soothing nerves and aiding sleep as claimed in claim 1, which is characterized by consisting of 15 parts by weight of spina date seed powder, 13 parts by weight of lily peptide, 10 parts by weight of corn oligopeptide, 4 parts by weight of sorbitol, 7 parts by weight of gamma-aminobutyric acid, 17 parts by weight of passion fruit powder, 0.2 part by weight of sweetening agent and 1 part by weight of sour agent.

4. A composition for soothing nerves and aiding sleep as claimed in claim 1, wherein the sweetener is one or more of aspartame, sodium cyclamate or sucralose.

5. A composition for soothing nerves and aiding sleep as claimed in claim 1, wherein the sour agent comprises one or more of citric acid, fruit acid and sorbic acid.

6. A method of preparing a composition for soothing the nerves and aiding sleep according to claim 1, comprising the steps of:

7. The method for preparing a composition for soothing nerves and aiding sleep according to claim 6, wherein the sieving in the step B is performed by a 60-100 mesh sieve.

8. The method for preparing a composition for soothing nerves and improving sleep as claimed in claim 6, wherein the temperature for drying in step C is 50-60 deg.C, and the moisture content is less than 5%.

9. The use of the composition for tranquilizing mind and improving sleep according to claim 1 in the preparation of a functional food or health care medicine for tranquilizing mind and improving sleep.

10. The use according to claim 9, wherein the functional food is a solid beverage or a tabletted candy.