CN111491982B - 作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法 - Google Patents

作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法 Download PDF

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CN111491982B
CN111491982B CN201880080277.6A CN201880080277A CN111491982B CN 111491982 B CN111491982 B CN 111491982B CN 201880080277 A CN201880080277 A CN 201880080277A CN 111491982 B CN111491982 B CN 111491982B
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hyperbranched
nitric oxide
alkyl
group
compound
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CN111491982A (zh
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M·H·舍恩菲施
杨磊
H·金
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University of North Carolina at Chapel Hill
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • C08G83/006—After treatment of hyperbranched macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Dental Prosthetics (AREA)
CN201880080277.6A 2017-11-15 2018-11-14 作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法 Active CN111491982B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762586404P 2017-11-15 2017-11-15
US62/586,404 2017-11-15
US201862737603P 2018-09-27 2018-09-27
US62/737,603 2018-09-27
PCT/US2018/061061 WO2019099525A1 (en) 2017-11-15 2018-11-14 Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto

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CN111491982A CN111491982A (zh) 2020-08-04
CN111491982B true CN111491982B (zh) 2023-04-18

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US (1) US12460050B2 (enExample)
EP (1) EP3710514B1 (enExample)
JP (2) JP2021503029A (enExample)
CN (1) CN111491982B (enExample)
AU (1) AU2018369760B2 (enExample)
CA (1) CA3082130A1 (enExample)
WO (1) WO2019099525A1 (enExample)

Families Citing this family (13)

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US11186681B2 (en) 2016-10-07 2021-11-30 The University Of North Carolina At Chapel Hill S-Nitrosothiol-mediated hyperbranched polyesters
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CN110461338A (zh) 2017-03-28 2019-11-15 北卡罗来纳大学查佩尔希尔分校 作为可生物降解抗菌支架的释放一氧化氮的聚氨基糖苷类和其制备方法
EP3710514B1 (en) 2017-11-15 2023-06-07 The University of North Carolina at Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
EP3762039A4 (en) 2018-03-06 2021-12-22 The University of North Carolina at Chapel Hill NITROGEN OXIDE RELEASING CYCLODEXTRIN AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDINGS AND RELATED PROCEDURES
EP3902841B1 (en) 2018-12-28 2025-01-29 The University of North Carolina at Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
JP7338113B2 (ja) * 2020-04-13 2023-09-05 大成建設株式会社 気体貯蔵放出化合物
EP4167954A4 (en) * 2020-06-18 2024-07-24 Nanometics LLC (D.B.A. Phd Biosciences) CHEMICALLY CROSS-LINKED ELASTOMERS FORMED BY MICHAEL ADDITION AND COMPOSITIONS COMPRISING SUCH ELASTOMERS
CN112023727B (zh) * 2020-08-14 2022-07-12 万华化学集团股份有限公司 一种抗污染抑菌反渗透膜、制备方法及其应用
CN114989265A (zh) * 2022-05-30 2022-09-02 浙江大学 一种具有高效广谱抗细菌、真菌功能的营养型支化结构聚多肽
CN115232318B (zh) * 2022-08-24 2023-12-26 宁波锋成先进能源材料研究院有限公司 一种非离子高分子表面活性剂及其制备方法和应用
CN118772400A (zh) * 2024-06-14 2024-10-15 华东理工大学 一种二醇二氮烯鎓超支化聚合物前驱体的制备方法
CN118955950B (zh) * 2024-07-30 2025-03-14 常熟威怡科技有限公司 一种纤维素抗菌水凝胶的制备方法和应用

Citations (2)

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CN106046382A (zh) * 2016-05-25 2016-10-26 暨南大学 一种装载一氧化氮的阳离子聚合物及其制备方法和应用

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