CN111479568A - 司培前列素与Rho激酶抑制剂的组合药物 - Google Patents

司培前列素与Rho激酶抑制剂的组合药物 Download PDF

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Publication number
CN111479568A
CN111479568A CN201880081551.1A CN201880081551A CN111479568A CN 111479568 A CN111479568 A CN 111479568A CN 201880081551 A CN201880081551 A CN 201880081551A CN 111479568 A CN111479568 A CN 111479568A
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CN
China
Prior art keywords
speprost
rho kinase
kinase inhibitor
combination
glaucoma
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Pending
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CN201880081551.1A
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English (en)
Chinese (zh)
Inventor
山元誉子
谷口孝纯
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Publication of CN111479568A publication Critical patent/CN111479568A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880081551.1A 2017-12-21 2018-12-20 司培前列素与Rho激酶抑制剂的组合药物 Pending CN111479568A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2017244847 2017-12-21
JP2017-244847 2017-12-21
JP2018180658 2018-09-26
JP2018-180658 2018-09-26
PCT/JP2018/046970 WO2019124488A1 (ja) 2017-12-21 2018-12-20 セペタプロストとＲｈｏキナーゼ阻害剤との組み合わせ医薬

Publications (1)

Publication Number Publication Date
CN111479568A true CN111479568A (zh) 2020-07-31

Family

ID=66993448

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880081551.1A Pending CN111479568A (zh) 2017-12-21 2018-12-20 司培前列素与Rho激酶抑制剂的组合药物

Country Status (9)

Country Link
US (2) US11446273B2 (https=)
EP (2) EP4338751B1 (https=)
JP (2) JPWO2019124488A1 (https=)
KR (1) KR102792934B1 (https=)
CN (1) CN111479568A (https=)
CA (1) CA3086457A1 (https=)
ES (2) ES2972934T3 (https=)
TW (2) TWI788484B (https=)
WO (1) WO2019124488A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019124488A1 (ja) 2017-12-21 2019-06-27 参天製薬株式会社 セペタプロストとＲｈｏキナーゼ阻害剤との組み合わせ医薬
CN111217834B (zh) * 2020-02-21 2021-10-26 维眸生物科技（上海）有限公司 Rock激酶抑制剂的硝基氧衍生物
KR20230051199A (ko) * 2020-08-13 2023-04-17 산텐 세이야꾸 가부시키가이샤 세페타프로스트를 함유하는 의약 제제
TW202404569A (zh) 2022-04-22 2024-02-01 日商參天製藥股份有限公司 含有賽佩普斯特(Sepetaprost)之眼科用組合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1684689A (zh) * 2002-08-29 2005-10-19 参天制药株式会社 由Rho激酶抑制剂和前列腺素类物质构成的青光眼治疗剂
US20110152264A1 (en) * 2008-05-30 2011-06-23 Santen Pharmaceutical Co., Ltd. Method and composition for treating ocular hypertension and glaucoma
US20120122964A1 (en) * 2009-07-28 2012-05-17 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
CN103338772A (zh) * 2011-02-04 2013-10-02 兴和株式会社 用于预防或治疗青光眼的药物疗法

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US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
DE3871596T3 (de) 1987-04-03 2000-09-07 Pharmacia & Upjohn Ab, Stockholm Anwendung eines Prostaglandins in Mischung mit einem adrenergischen Blocker zur Verminderung des Augen-Innendruckes.
ATE289815T1 (de) 1995-12-21 2005-03-15 Alcon Lab Inc Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie
BR9711154A (pt) 1996-08-12 1999-08-17 Yoshitomi Pharmaceutical Agente farmac-utico contendo inibidor cinase rho
JP4212149B2 (ja) 1998-06-11 2009-01-21 株式会社デ・ウエスタン・セラピテクス研究所 医薬
CA2307285C (en) 1998-08-17 2009-03-31 Senju Pharmaceutical Co., Ltd. Agent for prophylaxis and treatment of glaucoma
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
JP4342704B2 (ja) 2000-07-21 2009-10-14 富士フイルム株式会社 液晶分子の配向方法
US20030018079A1 (en) 2000-11-13 2003-01-23 Richardson Helene Treatment
PE20020958A1 (es) 2001-03-23 2002-11-14 Bayer Corp Inhibidores de la rho-quinasa
UY27224A1 (es) 2001-03-23 2002-10-31 Bayer Corp Inhibidores de la rho-quinasa
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
JP4017921B2 (ja) 2002-06-12 2007-12-05 高砂熱学工業株式会社 暖房室内の空気循環装置
JP4128038B2 (ja) 2002-07-10 2008-07-30 富士フイルム株式会社 電子ペーパー
JP4482726B2 (ja) 2002-08-29 2010-06-16 参天製薬株式会社 Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
AU2003280812A1 (en) 2002-11-18 2004-06-15 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND Beta-BLOCKER
TWI367098B (en) 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
EP1792622A1 (en) * 2005-11-11 2007-06-06 GPC Biotech AG Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues
JP2011530511A (ja) * 2008-08-05 2011-12-22 メルク・シャープ・エンド・ドーム・コーポレイション 治療用化合物
JP2010113957A (ja) 2008-11-06 2010-05-20 Ntt Docomo Inc コネクタ
PT2415763E (pt) 2009-03-30 2016-03-30 Ube Industries Composição farmacêutica para tratamento ou prevenção do glaucoma
EP3828172A1 (en) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
JP2011013651A (ja) 2009-07-03 2011-01-20 Mitsumasa Maeda フレキシブルディスプレイのれん
JP5835236B2 (ja) 2011-01-27 2015-12-24 小野薬品工業株式会社 二環式化合物およびその医薬用途
WO2019124488A1 (ja) 2017-12-21 2019-06-27 参天製薬株式会社 セペタプロストとＲｈｏキナーゼ阻害剤との組み合わせ医薬

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1684689A (zh) * 2002-08-29 2005-10-19 参天制药株式会社 由Rho激酶抑制剂和前列腺素类物质构成的青光眼治疗剂
US20110152264A1 (en) * 2008-05-30 2011-06-23 Santen Pharmaceutical Co., Ltd. Method and composition for treating ocular hypertension and glaucoma
US20120122964A1 (en) * 2009-07-28 2012-05-17 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
CN103338772A (zh) * 2011-02-04 2013-10-02 兴和株式会社 用于预防或治疗青光眼的药物疗法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EYDIE MILLER ELLIS等: "Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study", 《THE BRITISH JOURNAL OF OPHTHALMOLOGY》 *
LOUISE J. LUA，等: "Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma", 《YALE JOURNAL OF BIOLOGY AND MEDICINE》 *

Also Published As

Publication number Publication date
WO2019124488A1 (ja) 2019-06-27
EP4338751A2 (en) 2024-03-20
US11446273B2 (en) 2022-09-20
TW201927298A (zh) 2019-07-16
EP3730138A1 (en) 2020-10-28
EP3730138A4 (en) 2021-08-25
US20220387372A1 (en) 2022-12-08
CA3086457A1 (en) 2019-06-27
US20200316009A1 (en) 2020-10-08
EP4338751C0 (en) 2025-09-03
TWI833535B (zh) 2024-02-21
ES2972934T3 (es) 2024-06-17
JPWO2019124488A1 (ja) 2020-12-17
KR20200103042A (ko) 2020-09-01
ES3041644T3 (en) 2025-11-13
EP4338751B1 (en) 2025-09-03
EP4338751A3 (en) 2024-05-22
EP3730138B1 (en) 2024-02-14
KR102792934B1 (ko) 2025-04-07
US12201602B2 (en) 2025-01-21
JP2023110030A (ja) 2023-08-08
TW202320747A (zh) 2023-06-01
TWI788484B (zh) 2023-01-01

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