TWI788484B - 賽佩普斯特（Ｓｅｐｅｔａｐｒｏｓｔ）及Ｒｈｏ激酶抑制劑之組合醫藥 - Google Patents
賽佩普斯特（Ｓｅｐｅｔａｐｒｏｓｔ）及Ｒｈｏ激酶抑制劑之組合醫藥 Download PDFInfo
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- TWI788484B TWI788484B TW107146097A TW107146097A TWI788484B TW I788484 B TWI788484 B TW I788484B TW 107146097 A TW107146097 A TW 107146097A TW 107146097 A TW107146097 A TW 107146097A TW I788484 B TWI788484 B TW I788484B
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- combination
- rho kinase
- glaucoma
- kinase inhibitor
- intraocular pressure
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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| CN111217834B (zh) * | 2020-02-21 | 2021-10-26 | 维眸生物科技（上海）有限公司 | Rock激酶抑制剂的硝基氧衍生物 |
| KR20230051199A (ko) * | 2020-08-13 | 2023-04-17 | 산텐 세이야꾸 가부시키가이샤 | 세페타프로스트를 함유하는 의약 제제 |
| TW202404569A (zh) | 2022-04-22 | 2024-02-01 | 日商參天製藥股份有限公司 | 含有賽佩普斯特(Sepetaprost)之眼科用組合物 |
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| TW201032807A (en) * | 2002-08-29 | 2010-09-16 | Santen Pharmaceutical Co Ltd | Treating agent for glaucoma comprising Rho kinase inhibitor and prostaglandin |
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| US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
| DE3871596T3 (de) | 1987-04-03 | 2000-09-07 | Pharmacia & Upjohn Ab, Stockholm | Anwendung eines Prostaglandins in Mischung mit einem adrenergischen Blocker zur Verminderung des Augen-Innendruckes. |
| ATE289815T1 (de) | 1995-12-21 | 2005-03-15 | Alcon Lab Inc | Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie |
| BR9711154A (pt) | 1996-08-12 | 1999-08-17 | Yoshitomi Pharmaceutical | Agente farmac-utico contendo inibidor cinase rho |
| JP4212149B2 (ja) | 1998-06-11 | 2009-01-21 | 株式会社デ・ウエスタン・セラピテクス研究所 | 医薬 |
| CA2307285C (en) | 1998-08-17 | 2009-03-31 | Senju Pharmaceutical Co., Ltd. | Agent for prophylaxis and treatment of glaucoma |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| JP4342704B2 (ja) | 2000-07-21 | 2009-10-14 | 富士フイルム株式会社 | 液晶分子の配向方法 |
| US20030018079A1 (en) | 2000-11-13 | 2003-01-23 | Richardson Helene | Treatment |
| PE20020958A1 (es) | 2001-03-23 | 2002-11-14 | Bayer Corp | Inhibidores de la rho-quinasa |
| UY27224A1 (es) | 2001-03-23 | 2002-10-31 | Bayer Corp | Inhibidores de la rho-quinasa |
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| JP4017921B2 (ja) | 2002-06-12 | 2007-12-05 | 高砂熱学工業株式会社 | 暖房室内の空気循環装置 |
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| JP4482726B2 (ja) | 2002-08-29 | 2010-06-16 | 参天製薬株式会社 | Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤 |
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| TWI367098B (en) | 2004-12-23 | 2012-07-01 | Kowa Co | Treating agent for glaucoma |
| EP1792622A1 (en) * | 2005-11-11 | 2007-06-06 | GPC Biotech AG | Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues |
| EP2127638A1 (en) * | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| JP2011530511A (ja) * | 2008-08-05 | 2011-12-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療用化合物 |
| JP2010113957A (ja) | 2008-11-06 | 2010-05-20 | Ntt Docomo Inc | コネクタ |
| PT2415763E (pt) | 2009-03-30 | 2016-03-30 | Ube Industries | Composição farmacêutica para tratamento ou prevenção do glaucoma |
| EP3828172A1 (en) | 2009-05-01 | 2021-06-02 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| JP2011013651A (ja) | 2009-07-03 | 2011-01-20 | Mitsumasa Maeda | フレキシブルディスプレイのれん |
| RU2540330C2 (ru) | 2009-07-28 | 2015-02-10 | Оно Фармасьютикал Ко., Лтд. | Бициклическое соединение и его применение для медицинских целей |
| JP5835236B2 (ja) | 2011-01-27 | 2015-12-24 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
| ES2684351T3 (es) * | 2011-02-04 | 2018-10-02 | Kowa Co., Ltd. | Terapia farmacológica para prevenir o tratar glaucoma |
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- 2018-12-20 ES ES24153812T patent/ES3041644T3/es active Active
- 2018-12-20 CA CA3086457A patent/CA3086457A1/en active Pending
- 2018-12-20 JP JP2019560556A patent/JPWO2019124488A1/ja active Pending
- 2018-12-20 EP EP18891292.7A patent/EP3730138B1/en active Active
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2022
- 2022-08-15 US US17/887,854 patent/US12201602B2/en active Active
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2023
- 2023-06-02 JP JP2023091268A patent/JP2023110030A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201032807A (en) * | 2002-08-29 | 2010-09-16 | Santen Pharmaceutical Co Ltd | Treating agent for glaucoma comprising Rho kinase inhibitor and prostaglandin |
Non-Patent Citations (1)
| Title |
|---|
| 期刊 , LJ LU, et al., "Novel pharmacologic candidates for treatment of primary open-angle glaucoma", Yale J Biol Med, 90(1), Mar. 2017: 111~118. * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019124488A1 (ja) | 2019-06-27 |
| EP4338751A2 (en) | 2024-03-20 |
| US11446273B2 (en) | 2022-09-20 |
| TW201927298A (zh) | 2019-07-16 |
| EP3730138A1 (en) | 2020-10-28 |
| EP3730138A4 (en) | 2021-08-25 |
| US20220387372A1 (en) | 2022-12-08 |
| CA3086457A1 (en) | 2019-06-27 |
| US20200316009A1 (en) | 2020-10-08 |
| EP4338751C0 (en) | 2025-09-03 |
| TWI833535B (zh) | 2024-02-21 |
| ES2972934T3 (es) | 2024-06-17 |
| JPWO2019124488A1 (ja) | 2020-12-17 |
| KR20200103042A (ko) | 2020-09-01 |
| ES3041644T3 (en) | 2025-11-13 |
| EP4338751B1 (en) | 2025-09-03 |
| EP4338751A3 (en) | 2024-05-22 |
| EP3730138B1 (en) | 2024-02-14 |
| CN111479568A (zh) | 2020-07-31 |
| KR102792934B1 (ko) | 2025-04-07 |
| US12201602B2 (en) | 2025-01-21 |
| JP2023110030A (ja) | 2023-08-08 |
| TW202320747A (zh) | 2023-06-01 |
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