CN111467394A - Traditional Chinese medicine fumigation composition for treating type 2 diabetes and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine fumigation composition for treating type 2 diabetes, which comprises fried rhizoma atractylodis, plantain, siegesbeckia orientalis and pomegranate rind, and also can be added with herba lycopi, poria cocos, mirabilite, sappan wood and the like. The traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, promoting blood circulation, removing blood stasis, removing turbidity and reducing blood sugar, and the fumigation of the traditional Chinese medicine can open the chest and promote blood circulation, so that the medicine can be absorbed through skin and orifices to play a role, and the traditional Chinese medicine composition has a good curative effect on the type 2 diabetes with the main pathogenesis of dampness-turbidity congestion and blood vessel stasis.

Description

Traditional Chinese medicine fumigation composition for treating type 2 diabetes and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine fumigation composition for treating type 2 diabetes, and particularly relates to a traditional Chinese medicine fumigation composition for treating type 2 diabetes and a preparation method thereof.

Background

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic blood glucose level increase, can cause microvascular complications of all systems of the whole body, such as diabetic retinopathy, diabetic nephropathy, cardiovascular complications, peripheral neuropathy, peripheral vasculopathy and the like, has high disability and fatality rate, seriously threatens human health, and causes great burden to social economy. The population of diabetic patients is increasing year by year due to changes in dietary structure and lifestyle of people, and it is estimated that diabetic patients will grow to 6.29 billion worldwide by 2045 years, while China is the country with the largest population of diabetic patients and the incidence and prevalence rates are still rising, so that important prevention and treatment of diabetes is required.

Type 2 diabetes is a metabolic disorder disease with body insulin resistance or relative lack of insulin secretion, and accounts for 90-95% of the general population of diabetes, the current treatment means of type 2 diabetes comprise oral hypoglycemic drugs and insulin injection, the oral hypoglycemic drugs mainly comprise sulfonylureas, glinides, biguanides, α -glucosidase inhibitors, thiazolidinediones, DPP-4 inhibitor G L P-1 receptor agonists and the like, and the drugs can effectively control blood sugar, but have gastrointestinal discomfort, cause hypoglycemia and other adverse reactions.

Diabetes belongs to the field of diabetes in traditional Chinese medicine, traditional Chinese medicine has a long history and obvious curative effect on type 2 diabetes, and modern pharmacological studies show that many traditional Chinese medicines have the effect of reducing blood sugar. Traditional Chinese medicine fumigation is also called as traditional Chinese medicine vapor transdermal therapy, can enable the medicine to be directly absorbed through skin, orifices and acupoints, and has dual effects of fumigation thermotherapy and medicine therapy. The heat generated during fumigation can release the bowels, promote skin blood circulation and organism metabolism, and promote drug penetration without irritation to gastrointestinal tract. Has good effect on patients with type 2 diabetes mellitus with symptoms of excessive damp-heat and vein stasis.

Disclosure of Invention

In order to solve the problems, the invention provides a traditional Chinese medicine fumigation composition and a preparation method thereof, wherein the traditional Chinese medicine fumigation composition is used for treating type 2 diabetes.

The traditional Chinese medicine composition preferably comprises the following traditional Chinese medicine components: parched rhizoma Atractylodis, herba plantaginis, Siegesbeckiae herba, and pericarpium Granati.

Preferably, the traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia orientalis and 15 to 30 parts of pomegranate rind.

As a preferred embodiment, the traditional Chinese medicine composition preferably comprises, based on parts by weight: 15 parts of fried rhizoma atractylodis, 15 parts of plantain, 15 parts of herba siegesbeckiae and 15 parts of pomegranate rind.

Preferably, the traditional Chinese medicine composition is characterized by also comprising the following components: herba Lycopi and lignum sappan.

Preferably, for the patients with numbness and pain of limbs, the traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia, 15 to 30 parts of pomegranate rind, 15 to 30 parts of herba lycopi and 15 to 30 parts of sappan wood.

Preferably, for patients with frequent micturition and loose stool, the traditional Chinese medicine composition preferably further comprises the following components: poria cocos (Schw.) wolf. Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia orientalis, 15 to 30 parts of pomegranate rind and 15 to 30 parts of tuckahoe.

Preferably, for people with yellow tongue fur and constipation, the traditional Chinese medicine composition preferably further comprises the following components: mirabilite. Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain herb, 15 to 30 parts of siegesbeckia orientalis, 15 to 30 parts of pomegranate rind and 15 to 30 parts of mirabilite.

The action and efficacy of each component are as follows.

Rhizoma atractylodis: pungent, bitter and warm in property, entering spleen, stomach and liver meridians. Has effects of eliminating dampness, invigorating spleen, dispelling pathogenic wind, dispelling cold, and improving eyesight. Can be used for treating abdominal distention, diarrhea, common cold due to wind-cold, dim eyesight, edema, and loempe due to damp obstruction of middle warmer. Research shows that the rhizoma atractylodis has the effects of reducing blood sugar, reducing blood pressure, regulating gastrointestinal functions, resisting ulcer, resisting bacteria, diminishing inflammation, promoting urination and the like.

Plantain herb: sweet in nature and cold in flavor, it enters liver, kidney, lung and small intestine meridians. Has effects of clearing heat, promoting diuresis, treating stranguria, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm, and can be used for treating stranguria due to heat, pain, edema, fullness, summer-heat, dampness, diarrhea, conjunctival congestion, swelling and pain, phlegm heat, cough, etc. Pharmacological research shows that the medicine has the functions of reducing blood sugar, reducing blood fat, promoting urination, promoting defecation, regulating immunity, resisting oxidation and the like.

Herba siegesbeckiae: pungent, bitter and cold herbs enter liver and kidney meridians. Has effects of dispelling pathogenic wind and removing dampness, benefiting articulation, improving eyesight and removing toxic substance, and can be used for treating rheumatalgia, myasthenia of tendons and bones, soreness of waist and knees, rheumatism, eczema, hemiplegia, etc. Modern pharmacological research shows that the extract has the functions of reducing blood sugar, resisting inflammation, relieving pain, protecting blood vessel, resisting thrombus, resisting bacteria, resisting allergy, etc.

Pomegranate rind: sour in flavor and warm in nature, it enters large intestine meridian. Has effects in relieving diarrhea with astringents, astringing to stop bleeding, and killing parasite. It can be used for treating chronic diarrhea, dysentery, hematochezia, rectocele, metrorrhagia, leukorrhagia, abdominal pain due to parasitic infestation, etc. Modern pharmacological research shows that the extract has the functions of reducing blood sugar, resisting bacteria, resisting virus, resisting oxidation, resisting tumor, resisting peptic ulcer and the like.

Herba lycopi: bitter and pungent with slight warm property enter liver and spleen meridians. Has effects in promoting blood circulation, regulating menstruation, dispelling blood stasis, removing carbuncle, inducing diuresis, and relieving swelling. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, skin sore, carbuncle, toxic swelling, edema, and ascites. Pharmacological research shows that the decoction has the functions of improving microcirculation, resisting blood coagulation, relieving pain, tranquilizing, resisting bacteria, resisting virus, resisting cancer, protecting liver, etc.

Sappan wood: sweet, salty and neutral, enter heart, liver and spleen meridians. Has effects of promoting blood circulation, removing blood stasis, relieving swelling and pain. Can be used for treating traumatic injury, amenorrhea, dysmenorrhea, blood stasis, swelling and pain, chest and abdomen pricking pain, and superficial infection. Pharmacological research shows that the chemical components contained in the Chinese medicinal composition have the effects of resisting inflammation, resisting tumor, suppressing immunity, resisting bacteria, resisting virus, resisting oxidation, protecting blood vessels, calming and the like.

Tuckahoe, poria cocos: sweet, bland and neutral, enter heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, regulating stomach function, calming heart, and tranquilizing mind. It is suitable for patients with anorexia, loose stool, edema, oliguria, phlegm and fluid retention, dizziness, palpitation, pavor, and insomnia due to spleen deficiency and excessive dampness. Pharmacological research shows that the effective components have the functions of reducing blood sugar, promoting urination, resisting inflammation, regulating immunity, tranquilizing, protecting liver, etc.

Mirabilite: salty, bitter and cold in property, it enters stomach and large intestine meridians. Has effects of clearing heat, relaxing bowels, moistening dryness, softening hard mass, clearing heat and relieving swelling. It is suitable for abdominal distention and pain, constipation, and intestinal abscess with swelling and pain due to excessive heat accumulation in stomach and intestine, and can be used for treating acute mastitis, aphtha, conjunctival congestion, swelling and pain, etc. The research shows that it has the functions of purgation, resisting tumor, resisting inflammation and benefiting gallbladder.

Type 2 diabetes belongs to the category of diabetes in traditional Chinese medicine, and clinically, the symptoms of dry mouth, polydipsia, polyphagia, hunger, lassitude and hypodynamia, frequent micturition, sweetness and the like can be seen, and the causes are mainly caused by insufficient innate endowment, deficiency of matrix yin, fatness and mellowness of food or emotional disorder. The diabetes is different from the upper, middle and lower ones, the stomach is the sea of food, mainly receiving the rotten food, and the spleen is the acquired root, mainly transporting and transforming, and transporting the body fluids to the stomach, and the spleen and stomach are in the middle energizer and in the upper and lower traffic, which is closely related to the occurrence of diabetes. Deficient innate endowment, deficient constitutional yin, the spleen and stomach are easily damaged by dry heat, the stomach fire is exuberant, and the spleen yin is deficient, so that the patients have thirst, polydipsia, polyphagia and hyperphagia; food tends to damage spleen and stomach due to fat, sweet and thick taste, phlegm-dampness, weakness of spleen and stomach, dysfunction of transportation and transformation, water-dampness retention, frequent urination, sweet taste and loose stool due to the injection of food essence into urine. Long-term mental stress or depression, emotional discomfort, liver-qi stagnation, or exhaustion of heart, struggle and desire to reinforce the mind, leading to long-term fire formation, intense heat in the interior, burning yin and fluid, and impairment of qi and yin, manifested as dry mouth, polydipsia, lassitude, hypodynamia and constipation. Internal heat due to yin deficiency consuming body fluids can cause blood vessel loss, blood circulation disorder, and stagnation of vessels and collaterals, which can lead to numbness and pain of limbs. The disease of diabetes is based on yin deficiency and dryness-heat, and because yin and yang are mutually used, yin and yang are damaged after long-term disease, so that yin and yang are both deficient, qi and yin are damaged, qi and blood of viscera are not smooth to move, dampness and turbidity can be caused to stop internally, phlegm and turbidity stasis and blood can obstruct veins, so for the patients with long-term damage and pathological changes caused by diet, the attention is paid to clear heat, promote diuresis, dispel turbidity, activate blood, dissipate blood stasis and dredge collaterals.

Spleen deficiency can lead to water-dampness retention, which is apt to produce phlegm-turbidity, while rhizoma atractylodis is pungent and warm, and is the monarch drug for spleen, stomach and liver meridians, invigorating stomach and spleen, drying dampness and removing arthralgia. Long-term retention of damp pathogen is apt to transform into damp-heat, which may cause the symptoms of dysuria, burning sensation and stabbing pain, arthralgia, soreness and weakness of waist and knees, etc. The plantain herb is sweet and cold, clears heat and promotes diuresis, and induces diuresis for treating stranguria; the herba siegesbeckiae is pungent and cold, can dispel wind and dampness, can promote joint movement, can help rhizoma atractylodis to promote diuresis and remove turbid pathogen, can eliminate phlegm and improve eyesight, and can prevent other diseases, and the herba siegesbeckiae and the rhizoma atractylodis are used as ministerial medicaments. The turbid-dampness stays in the intestines, the clear-turbid-dampness of the small intestine is indistinguishable, and the conduction function of the large intestine is disordered, so that the stool is thin and soft, or even loose and undiluted. Pomegranate rind is sour in taste and warm in nature, has the effect of relieving diarrhea with astringents, and is used as an adjuvant drug. The leaf tianshi proposes 'long-term disease entering collaterals', when treating blood and activating blood circulation firstly, while water damp phlegm is a tangible evil, and obstruction of the channels can cause unsmooth circulation of qi and blood, and qi stagnation and blood stasis can cause obstruction of collaterals, with symptoms of numbness, pain and coldness of limbs, thus herba lycopi and sappan wood are used for activating blood and dissolving stasis, and activating collaterals and relieving pain. For diarrhea due to spleen deficiency with excessive dampness, add Fu Ling to strengthen the actions of cang Zhu to strengthen spleen and dry dampness, harmonize stomach and induce tranquilization. For constipation, it is added Natrii sulfas for purging heat, relaxing bowels, moistening dryness and softening hard masses, because damp turbidity, blood stasis and heat transformation due to long-term stagnation or yin deficiency with internal heat consume body fluids and cause constipation. Modern pharmacological studies show that rhizoma atractylodis, plantain, herba siegesbeckiae, pomegranate rind and poria all have the function of reducing blood sugar. After the decoction is carried out, the traditional Chinese medicine is fumigated, so that the medicine can be directly absorbed through skin and orifices, has the functions of clearing heat and promoting diuresis, promoting blood circulation and removing blood stasis, and removing turbidity and reducing blood sugar, and is mainly used for treating diabetes caused by dampness and turbidity accumulation and blood vessel stasis.

Another object of the present invention is to provide a method for preparing a herbal fumigation composition for treating type 2 diabetes, comprising the steps of:

(1) weighing the traditional Chinese medicine components according to the weight ratio;

(2) mixing the traditional Chinese medicine components, placing the mixture into a container, and adding water to soak the mixture for 30 minutes;

(3) decocting in water for 30 minutes to obtain 400ml decoction;

(4) filtering the liquid medicine, putting the liquid medicine into a medicine placing opening of a fumigating machine for fumigating, wherein the fumigating temperature is 40-45 ℃, and the fumigating time is 15-20 min.

The invention also provides application of the traditional Chinese medicine fumigation composition in preparing a medicine for treating type 2 diabetes.

Detailed Description

The present invention will be described in further detail with reference to the following examples, which are not intended to limit the invention thereto.

Example 1

15g of fried rhizoma atractylodis, 15g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi, 15g of sappan wood and 15g of tuckahoe.

Mixing the raw materials, placing in an earthen pot, adding water, soaking for 30 minutes, decocting for 30 minutes again to obtain 400ml of liquid medicine, filtering the liquid medicine, and putting into a medicine placing opening of a fumigation machine for fumigation. And (3) use guidance: every 2 days, the fumigation time is 15-20 min, the fumigation temperature is 40-45 ℃, and 8 weeks are a course of treatment.

Example 2

20 g of fried rhizoma atractylodis, 20 g of plantain, 20 g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi, 15g of sappan wood and 15g of mirabilite.

The preparation and administration method is as in example 1.

Example 3

25 g of fried rhizoma atractylodis, 20 g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 20 g of herba lycopi and 20 g of sappan wood.

The preparation and administration method is as in example 1.

Example 4

25 g of fried rhizoma atractylodis, 25 g of plantain, 20 g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi and 20 g of tuckahoe.

The preparation and administration method is as in example 1.

Example 5

25 g of fried rhizoma atractylodis, 25 g of plantain, 25 g of herba siegesbeckiae, 25 g of pomegranate rind and 20 g of mirabilite.

The preparation and administration method is as in example 1.

Example 6

30 g of fried rhizoma atractylodis, 30 g of plantain, 15g of herba siegesbeckiae, 20 g of pomegranate bark and 15g of tuckahoe.

The preparation and administration method is as in example 1.

Example 7

20 g of fried rhizoma atractylodis, 25 g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi and 20 g of sappan wood.

The preparation and administration method is as in example 1.

Example 8

30 g of fried rhizoma atractylodis, 30 g of plantain, 30 g of herba siegesbeckiae, 30 g of pomegranate bark and 15g of sappan wood.

The preparation and administration method is as in example 1.

Example 9

25 g of fried rhizoma atractylodis, 25 g of plantain, 20 g of herba siegesbeckiae, 20 g of pomegranate rind and 20 g of herba lycopi.

The preparation and administration method is as in example 1.

Example 10

20 g of fried rhizoma atractylodis, 15g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi, 15g of sappan wood, 15g of tuckahoe and 15g of mirabilite.

Example 11

18 g of fried rhizoma atractylodis, 18 g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 18 g of herba lycopi and 20 g of tuckahoe.

Example 12

25 g of fried rhizoma atractylodis, 25 g of plantain, 25 g of herba siegesbeckiae, 25 g of pomegranate rind, 30 g of herba lycopi and 30 g of sappan wood.

Example 13

20 g of fried rhizoma atractylodis, 15g of plantain, 15g of herba siegesbeckiae, 25 g of pomegranate rind, 25 g of sappan wood and 25 g of tuckahoe.

Example 14

30 g of fried rhizoma atractylodis, 25 g of plantain, 25 g of herba siegesbeckiae, 25 g of pomegranate rind, 25 g of herba lycopi and 20 g of mirabilite.

Example 15

25 g of fried rhizoma atractylodis, 25 g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 20 g of herba lycopi, 20 g of sappan wood, 25 g of tuckahoe and 20 g of mirabilite.

Cases of disease

Case 1

For a certain orchid, a woman in the age of 67 years is treated due to 'numbness of both lower limbs and cooling for more than 2 months', the disease is acceptable, the epigastric and abdominal distension is uncomfortable, the stool is thin and loose, no obvious dry mouth, polydipsia and polyuria exist, in the past 10 years of type 2 diabetes mellitus, 0.5g of metformin is orally taken, 80mg of gliclazide tablets are orally taken, 2 times a day, the blood sugar is not well controlled, 12.8 mmol/L of fasting blood sugar and 17 mmol/L of postprandial blood sugar are checked, the traditional Chinese medicine fumigation composition is prepared by decocting 15g of fried rhizoma atractylodis, 15g of plantain, 15g of herba siegesbeckiae, 15g of pomegranate rind, 15g of herba lycopi, 15g of sappan wood and 15g of poria cocos with water to 400ml of liquid medicine, the liquid medicine is filtered and then put into a medicine placing port of a fumigation machine for fumigation, the fumigation is carried out once every 2 days, the fumigation time is 20min each time, the fumigation temperature is 42 ℃, 8 weeks, the 8.0 mmol/L of fasting blood sugar is rechecked.

Case 2

For a male in age of 58, the male is diagnosed with symptoms of debilitation, frequent micturition, burning, dry stool, soreness and weakness of waist and knees and sleep improvement due to 'dry mouth, polydipsia and polyuria for more than 1 month', the existing type 2 diabetes mellitus is orally taken at present, 0.5g of metformin and 50mg of acarbose are checked for 3 times per day, 9.7 mmol/L of fasting blood sugar and 15.6 mmol/L of postprandial blood sugar, the traditional Chinese medicine fumigation composition is prepared by decocting 15g of fried rhizoma atractylodis, 15g of plantain herb, 15g of siegesbeckia herb, 15g of pomegranate rind, 15g of herba lycopi, 15g of sappan wood and 15g of mirabilite with water to 400ml of liquid medicine, the liquid medicine is filtered and put into a medicine placing port of a fumigation machine for fumigation, the fumigation is carried out once every 2 days, the fumigation time is 20min each time, the fumigation temperature is 42 ℃, the fasting blood sugar is checked again after 8 weeks, the 7.8 mmol/L of the fasting blood sugar is checked.

The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It should be noted that, for a person skilled in the art, several modifications and refinements can be made without departing from the basic principle of the invention, and these modifications and refinements are also considered to be within the protective scope of the invention.

Claims (7)

1. The traditional Chinese medicine composition for treating type 2 diabetes by fumigation is characterized by comprising the following traditional Chinese medicine components: parched rhizoma Atractylodis, herba plantaginis, Siegesbeckiae herba, and pericarpium Granati.

2. The traditional Chinese medicine composition according to claim 1, which comprises, on a weight basis: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia orientalis and 15 to 30 parts of pomegranate rind; preferably comprises 15 parts of fried rhizoma atractylodis, 15 parts of plantain, 15 parts of herba siegesbeckiae and 15 parts of pomegranate rind.

3. The traditional Chinese medicine composition according to claim 1 or 2, wherein the traditional Chinese medicine composition further comprises, based on parts by weight: herba Lycopi and lignum sappan; preferably, the traditional Chinese medicine composition further comprises the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia, 15 to 30 parts of pomegranate rind, 15 to 30 parts of herba lycopi and 15 to 30 parts of sappan wood.

4. The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition further comprises, based on parts by weight: poria cocos (wolf) wolf; preferably, the traditional Chinese medicine composition further comprises the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia, 15 to 30 parts of pomegranate rind, 15 to 30 parts of herba lycopi, 15 to 30 parts of sappan wood and 15 to 30 parts of tuckahoe.

5. The traditional Chinese medicine composition according to any one of claims 1 to 4, wherein the traditional Chinese medicine composition further comprises, based on parts by weight: mirabilite; preferably, the traditional Chinese medicine composition further comprises the following components in parts by weight: 15 to 30 parts of fried rhizoma atractylodis, 15 to 30 parts of plantain, 15 to 30 parts of siegesbeckia, 15 to 30 parts of pomegranate rind, 15 to 30 parts of herba lycopi, 15 to 30 parts of sappan wood, 15 to 30 parts of tuckahoe and 15 to 30 parts of mirabilite.

6. The use of the Chinese medicinal composition according to claims 1-5 in the preparation of a medicament for the treatment of type 2 diabetes.

7. A method for preparing the Chinese medicinal composition according to claims 1-5, which is characterized by comprising the following steps:

(1) weighing the traditional Chinese medicine components according to the weight ratio;

(2) mixing the traditional Chinese medicine components, placing the mixture into a container, and adding water to soak the mixture for 30 minutes;

(3) decocting in water for 30 minutes to obtain 400ml decoction;

(4) filtering the liquid medicine, putting the liquid medicine into a medicine placing opening of a fumigating machine for fumigating, wherein the fumigating temperature is 40-45 ℃, and the fumigating time is 15-20 min.