CN103520466B

CN103520466B - The Chinese medicine decoction for the treatment of diabetic constipation

Info

Publication number: CN103520466B
Application number: CN201310473812.3A
Authority: CN
Inventors: 马兆强; 张丽香
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-24
Filing date: 2013-09-24
Publication date: 2016-03-30
Anticipated expiration: 2033-09-24
Also published as: CN103520466A

Abstract

The present invention relates to a kind of pharmaceutical formulation field, specifically a kind of Chinese medicine decoction for the treatment of diabetic constipation, its technical characteristic is, raw material composition with parts by weight is: Radix Ophiopogonis 12 ~ 23, Fructus Aurantii Immaturus 12 ~ 22, Semen Trichosanthis 8 ~ 10, the Radix Aucklandiae 12 ~ 16, Radix Et Rhizoma Rhei 4 ~ 6, citron 10 ~ 14, Fructus Aurantii Immaturus 10 ~ 12, Radix Glycyrrhizae 8 ~ 10, Folium Sennae 2 ~ 3, Dens Draconis 4 ~ 6, Ramulus Cinnamomi 12 ~ 16, Rhizoma Chuanxiong 8 ~ 12, above-mentioned 12 taste crude drug are soaked in water by Radix Gentianae 6 ~ 10, filtrate of removing slag after decocting to obtain.Determined curative effect of the present invention, with low cost, have no side effect, be used for the treatment of diabetic constipation.

Description

The Chinese medicine decoction for the treatment of diabetic constipation

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine decoction being used for the treatment of diabetic constipation.

Background technology

As everyone knows, along with the improvement of people living condition, living-pattern preservation, the sickness rate of diabetes and complication raises day by day, diabetic gastrointestinal disease is the common chronic complicating diseases of diabetes, prevalence is 30%-76%, and the constipation most common sympton that is diabetes gastrointestinal disease, account for 60%, its pathogenesis still imperfectly understands, may be due to hyperglycemia and Developmental and Metabolic Disorder, cause neural malnutrition, domination gastrointestinal nerve damage.

Current Western medicine there is no specific treatment ways and means, conventional symptomatic treatment medicine: cisapride sheet, phenolphthalein tablets etc., but the reactions such as some patients has dizziness, distending pain in the head, drowsiness, tongue is numb, abdominal discomfort, arrhythmia, can not tolerate, once the Case report of gynecomasty, galactorrhea, convulsive epilepsy, the extrapyramidal symptoms and frequent micturition was had, limit its clinical practice, the health of the people in serious threat, and quality of life is declined comprehensively.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of determined curative effect, with low cost, the Chinese medicine decoction of the treatment diabetic constipation had no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine decoction for the treatment of diabetic constipation, and its technical characteristic is, raw material composition with parts by weight is: Radix Ophiopogonis 12 ~ 23, Fructus Aurantii Immaturus 12 ~ 22, Semen Trichosanthis 8 ~ 10, the Radix Aucklandiae 12 ~ 16, Radix Et Rhizoma Rhei 4 ~ 6, citron 10 ~ 14, Fructus Aurantii Immaturus 10 ~ 12, Radix Glycyrrhizae 8 ~ 10, Folium Sennae 2 ~ 3, Dens Draconis 4 ~ 6, Ramulus Cinnamomi 12 ~ 16, Rhizoma Chuanxiong 8 ~ 12, Radix Gentianae 6 ~ 10, above-mentioned 12 taste crude drug are soaked in water, filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, determined curative effect, with low cost, have no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopt Radix Ophiopogonis, Fructus Aurantii Immaturus, Semen Trichosanthis, the Radix Aucklandiae, Radix Et Rhizoma Rhei, citron, Fructus Aurantii Immaturus, Radix Glycyrrhizae, Folium Sennae, Dens Draconis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Gentianae is that raw material is prepared from, its component (weight portion) is Radix Ophiopogonis 17, Fructus Aurantii Immaturus 17, Semen Trichosanthis 9, the Radix Aucklandiae 14, Radix Et Rhizoma Rhei 4, citron 12, Fructus Aurantii Immaturus 11, Radix Glycyrrhizae 9, Folium Sennae 2, Dens Draconis 6, Ramulus Cinnamomi 14, Rhizoma Chuanxiong 10, Radix Gentianae 9, get above-mentioned 12 kinds of crude drug gross weights 180 grams mixing, 1 hour is soaked by clean water, water consumption 1200ml, after intense fire is fried open, use slow fire boiling instead, extracting juice 200ml, two decoct the 300ml that adds water, decocting extracting juice 200ml, two decoct mixing, decoct again and be concentrated into 300ml, sterile vacuum is packed, get product preparation.Every day potion divide 2 times oral, each (medicine) being taken before meal 150ml sooner or later.Within 10 days, be a course for the treatment of, each course for the treatment of, every three days, takes three courses for the treatment of of decoction of the present invention continuously.

Therapeutic Principle of the present invention: diabetic constipation belongs to the constipation category that the traditional Chinese medical science is quenched one's thirst in deteriorated case, the scorching blood stasis of deficiency of qi and yin is the important pathogenesis, runs through primary disease all the time.Diabetic constipation be the course of disease with the passing of time, more very, cloudy body fluid deficiency is empty for the scorching blood stasis of deficiency of qi and yin, large intestine not flourish and conduct unable caused by, its pathogenesis is the cloudy body fluid deficiency of gas, dryness of the intestine blood stasis, thus treatment with supplementing QI and nourishing YIN, moisturize purge heat, blood circulation promoting and blood stasis dispelling is for rule.In instant component: Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Radix Et Rhizoma Rhei stasis removing, relieving constipation by purgation, stagnate for Gastrointestinal excess heat, constipation; Stop in Fructus Aurantii Immaturus is stagnant, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis; Semen Trichosanthis enters lung meridian, sweet cold clear and rich, reduces phlegm and purges heat, for controlling the key medicine of heat-phlegm dry phlegm.Enter stomach, large intestine channel, matter profit greasiness, loosening bowel to relieve constipation, controls again dryness of the intestine constipation; The Radix Aucklandiae is used for turbid damp retardance mechanism of qi, and chest and diaphragm painful abdominal mass is vexed, abdominal distention, and vomiting is felt sick, and belch is indigestion and loss of appetite; Citron has effect of activating QI to eliminate phlegm, analgesic antiphlogistic; Heavy thoracic obstruction puerperal abdonimal pain after stopping feeling of fullness distending pain constipation dysentery in Fructus Aurantii Immaturus is stagnant; The Folium Sennae row that is used for purging heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension; Effect of Radix Glycyrrhizae grass has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle skin ulcer; Dens Draconis be ancient times mammal as if the fossil of tooth of class, rhinoceros class, Hippocampal cortex etc., tranquillizing the mind by relieving convulsion, heat clearing away and restlessness relieving.Control infantile convulsion demented, dysphoria with smothery sensation is uneasy, insomnia and dreamful sleep; Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi.Acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.There is relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, effect of activating YANG and prormoting functioning of QI; Rhizoma Chuanxiong is suitable for the various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control wind syndrome of head headache, rheumatic arthralgia etc.; Radix Gentianae nature and flavor are bitter, puckery, Great Cold, nontoxic.Cure mainly cold and heat between bone, frightened pathogenic factor gas, continue wound absolutely, determines the five internal organs, parasite killing poison.All medicines share profit and do not grow greasy, cool and not impairment of YIN, supplementing QI and nourishing YIN, blood stasis dispelling intestine moistening, and make three burnt fluent, constipation is dredged and separates.The present invention has adjustment gastrointestinal function, promotes enterokinesia, constipation relieving symptom, simultaneously can the effect of auxiliary adjustment blood glucose, and clinical practice treatment diabetic constipation obtains good efficacy.

The each raw material of the present invention also can the embodiment that mixes of ratio listed by according to the form below (unit: gram) realize.Its processing technique is identical with embodiment 1.

Below in conjunction with my institute, the clinical preliminary test that namely central hospital of In Shandong Weihai Wendeng City carries out is done further the present invention, is described in detail:

1, case selection: this group 60 example, man 32 example, female 28 example, age 21-64 year, 40 years old mean age, course of disease 2-27, average 10.2 years.

2, Therapeutic Method: early, late twice (medicine) being taken before meal, oral one bag at every turn 10 days is a course for the treatment of, and each course for the treatment of, every three days, takes three courses for the treatment of of the present invention continuously.

3, diagnostic criteria: observe case diabetes diagnostic criterion and all meet the diagnostic criteria that WHO proposed in 1997, and have defecation effort in various degree, constipation with dry stool, the clinical manifestations such as defecation frequency minimizing, get rid of the serious heart, brain, kidney complication, colon, rectum organic disease are got rid of in the barium enema of x line, and Metcalf improves simplification technical measurement Colonic transit time (CTT) and all exceedes upper limits of normal 56 hours.

4, criterion of therapeutical effect: formulate with reference to relevant criterion in " Chinese medical disease Standardization of diagnosis and curative effect " and " new Chinese medicine guideline of clinical investigations (trying) ".Cure: in two days, defecation once, and just matter turns profit, solution just time unobstructed, short-term is without recurrence.Effective: in three days, defecation once, and just matter turns profit, solution just owes smooth.Do not heal: symptom is not improved or even increases the weight of in treatments period recurrence.

5, therapeutic outcome: the present invention treats 60 examples, takes medicine three courses for the treatment of, cures 14 examples, effective 42 examples, invalid 4 examples, cure rate 23%, effective percentage 70%, inefficiency 7%, total effective rate 93%.

Claims

1. treat a Chinese medicine decoction for diabetic constipation, its technical characteristic is: raw material composition with parts by weight is, Radix Ophiopogonis 12 ~ 23, Fructus Aurantii Immaturus 12 ~ 22, Semen Trichosanthis 8 ~ 10, the Radix Aucklandiae 12 ~ 16, Radix Et Rhizoma Rhei 4 ~ 6, citron 10 ~ 14, Fructus Aurantii Immaturus 10 ~ 12, Radix Glycyrrhizae 8 ~ 10, Folium Sennae 2 ~ 3, Dens Draconis 4 ~ 6, Ramulus Cinnamomi 12 ~ 16, Rhizoma Chuanxiong 8 ~ 12, Radix Gentianae 6 ~ 10, above-mentioned 12 taste crude drug are soaked in water, filtrate of removing slag after decocting to obtain.