CN106177673A - A kind of medicine for treating thromboangiitis obliterans - Google Patents
A kind of medicine for treating thromboangiitis obliterans Download PDFInfo
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Abstract
The present invention relates to a kind of medicine for treating thromboangiitis obliterans, it is to be prepared from by the raw medicinal material of following weight proportion: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, Folium Mahoniae 7 parts, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts.The present invention uses: Semen Sinapis Albae reduces phlegm by drink, mass dissipating and swelling eliminating；Wild vetch crow wind and heat dispersing, removing toxic substances and promoting subsidence of swelling；Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication；Lin Lan promotes the production of body fluid stomach reinforcing, nourishing YIN and clearing away heat, lung moistening kidney tonifying；Silk flosssilk wadding skin invigorating the liver and kidney, bone and muscle strengthening；RHZOMA SPARGANII removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving；Folium Mahoniae heat clearing away qi-restoratives, dampness is detoxified；The strong muscle of vomiting nut dredging collateral, removing obstruction for relieving pain, subduing swelling and detoxicating；CORTEX ERYTHRINAE expelling wind and removing dampness, channels sootheing and network vessel quickening, killing parasites for relieving itching.All medicines share, and reach effect of heat-clearing and toxic substances removing, disperse blood stasis and dredge collateral, benefiting qi and nourishing blood, blood circulation and channel invigorating.Clinical trial certificate, the present invention can safely and effectively treat thromboangiitis obliterans.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating thromboangiitis obliterans.
Background technology
Thromboangiitis obliterans, has another name called spontaneous gangrene, is in a kind of rare chronic recurrent, small artery and vein
Segmental struvite Progressive symmetric erythrokeratodermia angiopathy, lower limb are common.The skin color and the temperature that show as sick lower limb vein change, lack
Blood, stationary pain, intermittent claudication, pulsation of foot dorsal artery weaken or disappear and migrans Superficial phlebitis, and severe patient has limb
End ulcer and necrosis.The most easily suffer from male adults.Modern medicine there is no unified understanding so far to vasculitic pathogeny,
It is generally believed that it is much the most relevant with sympathetic nerve function disorder and autoimmune response etc..And inhaling relation by marriage is to generally acknowledge the most both at home and abroad
Risk factor.Additionally, cold, humidity, infection, wound etc. can become potential inducement.
Thromboangiitis obliterans belongs to " necrosis " category in Chinese medicine, also referred to as " thromb angintis and thromboarteriosclerosis ", " ten refer to treat coldly ".
Clinical manifestation
Primary disease is more common in person between twenty and fifty, is apt to occur in lower limb.Suffering limb presents momentary or persistence is pale, cyanosis, have scorching hot and twinge,
When sick limb is sagging, color of the leather reddens, and bleaches during upper act, and followed by toes are numb, and Calf muscle pain excites during walking, disappears during rest
Lose；Often there is superficial phlebitis and edema in calf.Find during inspection that pulsation of foot dorsal artery weakens or disappears.Along with the state of an illness is sent out
Exhibition may occur in which intermittent claudication and Raynaud phenomenon, night, the pain increased, toes sharp ache, skin cyanosis, and then toe-end ulcer
Or gangrene and turn black, gradually spread to proximal part.
Drug therapy
1. dextran-40 molecular weight is the dextran intravenous drip of 5000～20000.Prolonged application have hemorrhage can
Can, acute period of expansion and ulcer gangrene, should not be applied with during secondary infection.
2. vasodilation can apply Tolazoline, nicotinic acid, Phenoxybenzamine Hydrochloride etc..
3., when antibiosis have and locally and systemically infects, suitable antibiotic therapy is selected.
4. glucocorticoid to state of an illness acute stage it is contemplated that application, every day oral prednisone or intravenous drip hydrogenation can
Pine.
5. the obvious person of analgesic pain can be selected for various analgesic, or closes or stock with procaine acupoint injection therapy, vein
Periarterial is closed, the most feasible lumbar sympathetic ganglion block or peridural anesthesia etc..
6. treatment by Chinese herbs is started with marrow, whole body therapeutic, makes disease start to take a turn for the better, and human body recovers normal physiological function.
Medical material involved in the present invention all seen from be recorded in " China book on Chinese herbal medicine ".
Summary of the invention
It is desirable to provide a kind of medicine for treating thromboangiitis obliterans, by select suitable medical material and
Its proportioning, reaches safely and effectively to cure the purpose of thromboangiitis obliterans.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine for treating thromboangiitis obliterans, it is characterised in that it is by the crude drug of following weight proportion
Material is prepared from: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, Mahonia fortunei (Lindl.) Fedde
7 parts of leaf, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts.
Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica
It has been recognised by the inventors that the thromboangiitis obliterans cause of disease and diseases caused by exogenous pathogenic factor cold-damp, eating and drinking without temperance, seven emotions cross pole, and prolonged illness deficiency in origin etc. has
Close.Following four can be summarized as about its pathogenesis.Yang-energy is weak, cold blood stasis: prolonged illness spleen kidney yang gas does not fills, and YIN-cold is taken advantage of and attacked
It.Cold coagulation spasm, then the vim and vigour stasis of blood is closed；Cold-damp visitor in passages through which vital energy circulates skin and flesh, then blocks venation, fights in body fluid bone marrow, then injured QI and blood causes
Rong Wei coagulates puckery, it is impossible to moistening foster four ends, acrodynia, necrosis, even come off, the ground person occuping cold is particularly susceptible to suffer from.Turbid damp pents up,
Be hampered venation: visitor's wetland or intemperance of taking food, equal energy product wet wine expectorant for a long time.Damp is deep sticky, and easy damaged yang-energy, checks mechanism of qi,
Hyperamization fortune loses that it is fluent, the most then damp heat-transformation, wet combination of phlegm and heat, also can stasis blocking passages through which vital energy circulates, make blood vessels stagnant and obstructed, then five toes are bad
Extremely.The hepatic and renal YIN deficiency, excessive noxious heat: sexual overstrain, feelings will is unsuccessful, then the loss of kidney water, and fire is the most prosperous mutually, and edema with the liver involved is lost and supported, the most flourish muscle of blood.
Greasy and surfeit flavour, throws off restraint addicted to pungent tobacco and wine, the most damp and the hottest interior life, turns to fire-toxin, stifling internal organs, causes liver and loses muscle extremely, and it is dead that spleen loses meat, and kidney loses bone
Extremely, the disease of necrosis is formed.Asthenia of qi and blood loses, channels stasis blocking: QI-blood circulation whole body, is valued for circulating happy.If the deficiency of vital energy, transport blood incompetent,
Blood deficiency then gas is without being given birth to, and blood vessels intercept not all right, and channels loses it and moistens foster, and four end QI and blood can not be filled and be reached, and the evil coalescence of poison, QI and blood is coagulated
Stagnant, then there is vasculitis, weakness due to chronic disease person is more common.In a word, the major lesions of primary disease is at blood vessels, with the heart, liver,spleen,kidney etc.
Dirty relation is the closest, because of the heart controlling blood vessels, liver governing tendons, the spleen being in charge of the muscles, kidney governing bones.Sick is originally YANG QI deficiency, deficient qi and blood, disease
Be designated as blood stasis, turbid damp, pyretic toxicity stagnate, muscles passages through which vital energy circulates, deteriorated blood slough.If the state of an illness is with the passing of time, podomere is downright bad, and wound surface is not healed, and pus and blood is not
Disconnected, may result in the big wound of QI and blood.Therefore dispelling cold by warming the meridian, promoting blood circulation to remove obstruction in the collateral, clearing away heat-damp and promoting diuresis, blood-activating analgetic are then taked in treatment.
The present invention uses: Semen Sinapis Albae reduces phlegm by drink, mass dissipating and swelling eliminating；Wild vetch crow wind and heat dispersing, removing toxic substances and promoting subsidence of swelling；Cortex Phellodendri heat clearing away is dry
Wet, eliminating fire and detoxication；Lin Lan promotes the production of body fluid stomach reinforcing, nourishing YIN and clearing away heat, lung moistening kidney tonifying；Silk flosssilk wadding skin invigorating the liver and kidney, bone and muscle strengthening；RHZOMA SPARGANII removing blood stasis row
Gas, removing food stagnancy pain relieving；Folium Mahoniae heat clearing away qi-restoratives, dampness is detoxified；The strong muscle of vomiting nut dredging collateral, removing obstruction for relieving pain, subduing swelling and detoxicating；Erythrina indica
Skin expelling wind and removing dampness, channels sootheing and network vessel quickening, killing parasites for relieving itching.All medicines share, and reach heat-clearing and toxic substances removing, disperse blood stasis and dredge collateral, benefiting qi and nourishing blood, blood circulation and channel invigorating
Effect.
Below in conjunction with clinical laboratory data beneficial effects of the present invention is described:
1, physical data
Inventor collects 63 example Patients With Thromboangitis Obliterans between in October ,-2014 in August, 2012 altogether.It is randomly divided into: treatment
Organize 32 examples, matched group 31 example.Male 28 examples of wherein treatment group, female 4 example, age 18～44 years old, the course of disease 1 month～2 years；Matched group man
28 examples, female 3 example, between age 19～43 years old, the course of disease 1 month～3 years.The data such as two groups of sexes, age, courses of disease are poor without significance
Different, there is comparability.
Diagnostic criteria
1. this sick almost all occurs 20～40 years old male.
2. patient have more lower limb Progressive symmetric erythrokeratodermia intermittent limping and chronic ischemic symptom (numb, be afraid of cold, pain, pale, become silted up
Blood) etc. performance.
3. 40%～50% has shallow table unresolved superficial phlebitis history of attack and sign, and beating of suffering limb arteriolar weakens or disappear
Lose.
4. patient has smoking history, the overwhelming majority to have by cold-damp (damp) history.
5. need to make angiography and impedance type rheography, ultrasonic doppler etc. to check.
1. inclusive criteria meets diagnostic criteria；2. the age 18～50 years old；3. compliance is good；Sign informed consent the most voluntarily
Book.
Exclusion standard 1. gestation, women breast-feeding their children；2. suffer from severe cardiac, lung, liver, renal disease patient；3. spiritedness system
System disease, it is impossible to partner treatment person；4. through the patient of other drug treatment after morbidity.
2, Therapeutic Method
Treatment group is administered orally the capsule that the present invention prepares according to specific embodiment 3, three times a day.Treat 2 months.
Matched group is administered orally beraprost sodium sheet, each 40 μ g, three times a day.Treat 2 months.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
1. recovery from illness: cardinal symptom disappears, and wound heals completely, suffering limb disturbance of blood circulation is alleviated or is obviously improved, and resumes work
Without recurrence in 1 year, walking speed 100～120m/min, and walking about more than 1500m can be continued without discomfort person；
The most effective: clinical symptom relief, limbs wound surface is close to healing or reduces, and distal limb blood circulation and rheography slightly change
Kind, walking speed 100～120m/min, can walk about 300m；
The most invalid: symptom and sign continue to add severe one without progressive or the state of an illness.
3.2 treatment statistical results are shown in Table 1.
1 liang of table group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) | Obvious adverse reaction example |
| Treatment group | 32 | 14 | 16 | 2 | 94% | 0 |
| Matched group | 31 | 9 | 16 | 6 | 81% | 0 |
Visible, thromboangiitis obliterans can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: Semen Sinapis Albae 6 grams, wild vetch crow 6 grams, Cortex Phellodendri 6 grams, Lin Lan 10 grams, silk flosssilk wadding skin 10 grams, RHZOMA SPARGANII 7 grams, Folium Mahoniae
7 grams, vomiting nut 1 gram, CORTEX ERYTHRINAE 9 grams；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, mistake
Filter；Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of adult normal.
For treating thromboangiitis obliterans.Oral, the most once.
Embodiment 2
Weigh: Semen Sinapis Albae 6 grams, wild vetch crow 6 grams, Cortex Phellodendri 6 grams, Lin Lan 10 grams, silk flosssilk wadding skin 10 grams, RHZOMA SPARGANII 7 grams, Folium Mahoniae
7 grams, vomiting nut 1 gram, CORTEX ERYTHRINAE 9 grams；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours,
Filter；Merging filtrate, concentrates, and is dried, and packaging must meet the powder of one day consumption of adult normal.
For treating thromboangiitis obliterans.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Weigh: Semen Sinapis Albae 6 grams, wild vetch crow 6 grams, Cortex Phellodendri 6 grams, Lin Lan 10 grams, silk flosssilk wadding skin 10 grams, RHZOMA SPARGANII 7 grams, Folium Mahoniae
7 grams, vomiting nut 1 gram, CORTEX ERYTHRINAE 9 grams；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, be dried,
Load capsule shells, the capsule of one day consumption of adult normal must be met.
For treating thromboangiitis obliterans.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. the medicine being used for treating thromboangiitis obliterans, it is characterised in that it is by the raw material of following weight proportion
Medical material is prepared from: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, ten big merits
7 parts of labor leaf, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts.
2. the medicine for treating thromboangiitis obliterans as claimed in claim 1, it is characterised in that its preparation method
For: weigh: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, Folium Mahoniae 7
Part, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, mistake
Filter；Merging filtrate, is concentrated into 120 parts, obtains decoct；Above-mentioned part each means weight portion.
3. the medicine for treating thromboangiitis obliterans as claimed in claim 1, it is characterised in that its preparation method
For: weigh: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, Folium Mahoniae 7
Part, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, mistake
Filter；Merging filtrate, concentrates, and is dried, and packaging obtains powder；Above-mentioned part each means weight portion.
4. the medicine for treating thromboangiitis obliterans as claimed in claim 1, it is characterised in that its preparation method
For: weigh: Semen Sinapis Albae 6 parts, wild vetch crow 6 parts, Cortex Phellodendri 6 parts, Lin Lan 10 parts, silk flosssilk wadding skin 10 parts, RHZOMA SPARGANII 7 parts, Folium Mahoniae 7
Part, vomiting nut 1 part, CORTEX ERYTHRINAE 9 parts；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, be dried,
Load capsule shells, obtain capsule；Above-mentioned part each means weight portion.
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| CN201610716674.0A CN106177673A (en) | 2016-08-25 | 2016-08-25 | A kind of medicine for treating thromboangiitis obliterans |
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| CN201610716674.0A CN106177673A (en) | 2016-08-25 | 2016-08-25 | A kind of medicine for treating thromboangiitis obliterans |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496715A (en) * | 2017-09-28 | 2017-12-22 | 南阳市中心医院 | Treat Chinese medicine composition of Buerger's disease and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011493A (en) * | 2007-01-16 | 2007-08-08 | 李丰举 | Angiitis granule and its preparation method |
-
2016
- 2016-08-25 CN CN201610716674.0A patent/CN106177673A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011493A (en) * | 2007-01-16 | 2007-08-08 | 李丰举 | Angiitis granule and its preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496715A (en) * | 2017-09-28 | 2017-12-22 | 南阳市中心医院 | Treat Chinese medicine composition of Buerger's disease and preparation method thereof |
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Application publication date: 20161207 |
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| WD01 | Invention patent application deemed withdrawn after publication |