CN111467393A - Traditional Chinese medicine composition, pig feed additive and application of pig feed additive in preparation of control agent for porcine reproductive and respiratory syndrome or swine fever - Google Patents
Traditional Chinese medicine composition, pig feed additive and application of pig feed additive in preparation of control agent for porcine reproductive and respiratory syndrome or swine fever Download PDFInfo
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a traditional Chinese medicine composition, a pig feed additive and application thereof in preparing a control agent for porcine reproductive and respiratory syndrome or swine fever. The traditional Chinese medicine composition comprises the following components in parts by mass: 10-50 parts of astragalus membranaceus, 10-30 parts of cortex mori, 5-25 parts of honeysuckle, 5-30 parts of liquorice and 5-25 parts of agastache rugosus. The traditional Chinese medicine composition has a simple formula, adopts common traditional Chinese medicinal materials, is easy to obtain and has low price; the pig feed additive prepared by the traditional Chinese medicine composition has the functions of clearing heat and removing toxicity, and can be used for improving pig immunity and preventing and treating pig respiratory diseases such as porcine reproductive and respiratory syndrome or hog cholera; can improve the production performance of pregnant sows, promote the growth of piglets, ensure the prevention and treatment effect and greatly reduce the prevention and treatment cost.
Description
Technical Field
The invention belongs to the technical field of pig feed additives, and particularly relates to a traditional Chinese medicine composition, a pig feed additive and application thereof in preparation of a control agent for porcine reproductive and respiratory syndrome or swine fever.
Background
The porcine reproductive and respiratory syndrome is caused by porcine reproductive and respiratory syndrome virus infection, the contagious property is strong, and pigs of various ages and breeds can be infected, wherein piglets and pregnant sows with the age of 1 month are the most susceptible pig groups. Once blue-ear disease occurs, piglets and pregnant sows have the highest incidence and have the greatest impact on pig farms.
It is known that the clinical symptoms of porcine reproductive and respiratory syndrome are greatly different under the influence of virus strains, immune states, feeding management factors, environmental conditions and other factors, and can be classified into acute type, chronic type, subclinical type and the like. The chronic porcine reproductive and respiratory syndrome is the main clinical symptom of porcine reproductive and respiratory syndrome virus infection in a large-scale pig farm and mainly shows that: the reproductive performance, the production performance and the immune function of the pregnant sows are reduced, the immunity of piglets is low, and the piglets grow slowly; it is susceptible to secondary infection with other bacterial and viral diseases, and has increased incidence rate of respiratory diseases (such as mycoplasma infection, infectious pleuropneumonia, streptococcosis, eperythrozoonosis) of swinery.
In order to prevent and treat the porcine reproductive and respiratory syndrome, a plurality of traditional Chinese medicine formulas are proposed at present, and the effective components of the traditional Chinese medicine formulas are added into the feed or drinking water of the pigs for administration, so that the porcine reproductive and respiratory syndrome can be conveniently prevented and treated.
For example, the chinese patent application with publication number CN109106792A discloses a compound traditional Chinese medicine preparation for inhibiting blue ear virus and a preparation method thereof, the compound traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of astragalus membranaceus, 5-10 parts of rheum officinale, 10-20 parts of folium isatidis, 5-15 parts of fructus forsythiae, 5-15 parts of fructus gardeniae, 5-15 parts of sweet wormwood, 5-15 parts of honeysuckle, 5-15 parts of radix bupleuri, 5-15 parts of herba houttuyniae and 10-20 parts of folium mori, wherein the sum of the parts by weight of the raw materials is 100 parts.
Also, as disclosed in chinese patent application publication No. CN108030906A, a Chinese medicinal composition for preventing and treating respiratory diseases of swine, a feed and a preparation method thereof are disclosed, the Chinese medicinal composition comprises the following Chinese medicinal components in parts by weight: 5-15 parts of agilawood, 15-35 parts of pinellia ternate, 5-25 parts of coptis chinensis, 5-15 parts of dried orange peel, 5-15 parts of ginger, 5-15 parts of poria cocos and 10-30 parts of bighead atractylodes rhizome.
The existing traditional Chinese medicine formulas have more complex components, and some traditional Chinese medicine formulas need more famous and expensive medicinal materials (such as agilawood), so that the prevention and treatment cost of the porcine reproductive and respiratory syndrome is generally higher.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition, a pig feed additive and application of the traditional Chinese medicine composition and the pig feed additive in preparation of a control agent for porcine reproductive and respiratory syndrome or swine fever.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition comprises the following components in parts by weight: 10-50 parts of astragalus membranaceus, 10-30 parts of cortex mori, 5-25 parts of honeysuckle, 5-30 parts of liquorice and 5-25 parts of agastache rugosus.
The traditional Chinese medicine composition has a simple formula, adopts common traditional Chinese medicinal materials, is easy to obtain and has low price; the pig feed additive prepared by the traditional Chinese medicine composition has the functions of clearing heat and removing toxicity, and can be used for improving pig immunity and preventing and treating pig respiratory diseases such as porcine reproductive and respiratory syndrome or hog cholera; can improve the production performance of pregnant sows, promote the growth of piglets, ensure the prevention and treatment effect and greatly reduce the prevention and treatment cost.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 20-30 parts of astragalus membranaceus, 10-20 parts of cortex mori, 15-20 parts of honeysuckle, 15-20 parts of liquorice and 5-10 parts of agastache rugosus.
Or, the traditional Chinese medicine composition comprises the following components in parts by weight: 15-20 parts of astragalus, 20-30 parts of cortex mori, 5-15 parts of honeysuckle, 15-30 parts of liquorice and 10-15 parts of agastache rugosus.
Or, the traditional Chinese medicine composition comprises the following components in parts by weight: 20-45 parts of astragalus membranaceus, 10-15 parts of cortex mori, 5-10 parts of honeysuckle, 5-10 parts of liquorice and 10-25 parts of agastache rugosus.
Therefore, the invention also provides the application of the traditional Chinese medicine composition in preparing the pig feed additive; and a pig feed additive, which is prepared from the traditional Chinese medicine composition; also provides the application of the pig feed additive in preparing a control agent for porcine reproductive and respiratory syndrome or swine fever, a pig immunity enhancer or a piglet growth promoter.
The application of the traditional Chinese medicine composition in preparing the pig feed additive comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and distilling under reduced pressure to obtain agastache rugosus distillate;
the solvent used in the reduced pressure distillation can be water or 5-30% ethanol.
(2) Taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, and cooking;
when in cooking, the surfaces of the four traditional Chinese medicines are moistened and then put into a steam box for cooking for 0.5 to 2 hours; after the cooking is finished, the four cooked traditional Chinese medicines and the cooking liquor are collected simultaneously.
(3) Mixing the four Chinese medicinal materials and their decoction with the herba Agastaches distillate, and heating for 10-60min to obtain water extractive solution;
heating for 10-60min refers to keeping boiling state for 10-60min after boiling.
(4) Concentrating the water extract into an extract, uniformly mixing the extract with auxiliary materials, and granulating to obtain extract granules; the extract particles are the pig feed additive.
Preferably, the auxiliary material can be selected from fatty acids, such as fatty glyceride. When in use, the extract and auxiliary materials are mixed according to the weight ratio of 10: 1-80: 1, and mixing uniformly.
Or, further comprising:
(5) drying all the medicine residues, uniformly mixing the medicine residues with the extract granules, and crushing to obtain the pig feed additive.
After the extract is extracted, the effective medicinal components in the dregs of a decoction are few, but the dregs of a decoction still have utilization value. Therefore, the medicine dregs can be used as the pig feed additive after being crushed.
The invention also provides a pig feed, which comprises a main material and an additive, wherein the additive is the pig feed additive; the additive amount of the pig feed additive in the main material is 2-10 kg/t.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition has a simple formula, adopts common traditional Chinese medicinal materials, is easy to obtain and has low price; the pig feed additive prepared by the traditional Chinese medicine composition has the functions of clearing heat and removing toxicity, and not only can be used for improving the immunity of pigs and preventing and treating porcine respiratory diseases such as porcine reproductive and respiratory syndrome or hog cholera; for the pigs with slight swine fever diseases, under the condition that the pigs still can eat the feed, the increase of the dosage of the pig feed additive is also beneficial to the alleviation and treatment of the swine fever diseases; can also improve the production performance of pregnant sows, promote the growth of piglets, and greatly reduce the prevention and treatment cost while ensuring the prevention and treatment effect.
Detailed Description
The technical means of the present invention will be described in further detail below with reference to specific embodiments.
Example 1
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 25 parts of astragalus membranaceus, 15 parts of cortex mori, 18 parts of honeysuckle, 18 parts of liquorice and 8 parts of agastache rugosus.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking water as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1 hour, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 30min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride according to the mass ratio of 30:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 2
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 20 parts of astragalus, 20 parts of white mulberry root-bark, 15 parts of honeysuckle, 20 parts of liquorice and 5 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking water as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, steaming for 0.5 hour, and collecting the steamed four traditional Chinese medicines and a steaming liquid;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 40min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride according to the mass ratio of 10:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 3
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 30 parts of astragalus, 10 parts of cortex mori radicis, 20 parts of honeysuckle, 15 parts of liquorice and 10 parts of agastache rugosus.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking water as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1 hour, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and adding for 50min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride in a mass ratio of 20:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 4
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 17 parts of astragalus, 25 parts of white mulberry root-bark, 10 parts of honeysuckle flower, 22 parts of liquorice and 12 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking water as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1 hour, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and adding for 10min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride in a mass ratio of 60:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 5
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 15 parts of astragalus, 30 parts of white mulberry root-bark, 5 parts of honeysuckle, 30 parts of liquorice and 10 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and distilling under reduced pressure by taking 5% ethanol as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1.5 hours, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 60min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride in a mass ratio of 50:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 6
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 20 parts of astragalus, 20 parts of cortex mori radicis, 15 parts of honeysuckle, 15 parts of liquorice and 15 parts of agastache rugosus.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and distilling under reduced pressure by using 10% ethanol as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1.5 hours, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 45min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride in a mass ratio of 80:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 7
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 35 parts of astragalus, 13 parts of white mulberry root-bark, 7 parts of honeysuckle, 8 parts of liquorice and 16 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking 15% ethanol as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1 hour, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 20min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and the fatty glyceride in a mass ratio of 45:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 8
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 20 parts of astragalus, 15 parts of white mulberry root-bark, 5 parts of honeysuckle, 10 parts of liquorice and 10 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and carrying out reduced pressure distillation by taking water as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, cooking for 1.5 hours, and collecting the four cooked traditional Chinese medicines and cooking liquor;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 35min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and fatty glyceride in a mass ratio of 30:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
Example 9
The embodiment of the invention relates to a feed additive, which is prepared from a traditional Chinese medicine composition with the following components: 45 parts of astragalus, 10 parts of white mulberry root-bark, 10 parts of honeysuckle flower, 5 parts of liquorice and 25 parts of wrinkled gianthyssop herb.
The preparation method comprises the following steps:
(1) taking agastache rugosus according to preset mass parts, and distilling under reduced pressure by using 10% ethanol as a solvent to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, wetting the surfaces of the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice, putting the radix astragali, the cortex mori radicis, the honeysuckle and the liquorice into a steam box, separating water from the steam box, steaming for 2 hours, and collecting the steamed four traditional Chinese medicines and a steaming liquid;
(3) mixing the four Chinese medicinal materials and the decoction with herba Agastaches distillate, and heating for 60min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract and the fatty glyceride in a mass ratio of 40:1, and granulating to obtain extract granules;
(5) drying all the medicine residues, mixing the medicine residues with the extract granules uniformly, and crushing the mixture to be less than 100 mu m to obtain the pig feed additive.
The pig feed additives prepared in examples 1 to 9 were taken to test the control effect of the pig feed additives on porcine reproductive and respiratory syndrome and the influence on the productivity of pregnant sows and the growth and development level of piglets.
The analysis test of the prevention and treatment effect is carried out in a certain pig farm in the Shanghai between 2019-2020, 860 sows are kept in the farm, 9 test groups ① - ⑨ and 1 control group are randomly selected for the sows, 36 sows/group of the test groups and 33 control groups are selected for the sows, wherein after the sows are bred, the pig feed added with the pig feed additive prepared in the examples 1-9 is correspondingly used in the whole process of the test groups ① - ⑨, the adding amount of the pig feed additive is 33kg per ton and the immunization of the porcine reproductive and respiratory syndrome vaccine is not carried out, the porcine reproductive and respiratory syndrome vaccine is inoculated to the sows of the control groups after the breeding, but no additive is added to the pig feed, other components in the pig feed are the same as the test groups, and the test is completed until the piglets are weaned.
After the test is finished, the number of live pigs born by each test group and each control group, the number of weaned live piglets after the weaning and the weight of weaned piglets are counted and compared, and the counting and comparing results are shown in table 1.
TABLE 1
As can be seen from Table 1, compared with the control group, the sows in each test group have good productivity, sufficient milk after farrowing, good growth vigor of the suckling piglets and larger average body weight average of the piglets after slaughtering although the sows are not inoculated with the blue-ear disease vaccine.
Taking a test group ① as an example, after sows in the test group are fed with the pig feed additive prepared in the example 1, the average number of pigs per litter is 0.9 more than that of live pigs produced in a control group, 0.34 more live pigs are bred, 1.24 live piglets are added in total, 2.7 piglets can be bred by using the feed additive, calculated according to the production of 2.2 piglets of one sow in the whole year, 1350 pigs can be produced in one year by one breeding sow, the economic income is increased by 81 ten thousand yuan by calculating the net profit of one pig, calculated by about 1 ton of feed used by one sow in the whole year, 3kg of Lanwenbike is required to be added in total, the production cost is increased by about 450 yuan, the total cost is increased by 22.5 yuan, the income of one sow in 500 farrow can be increased by 58 yuan in year, and if 2000 yuan of the profit of one pig in the current pigsty can be analyzed, and the income of hundreds of million yuan can be increased.
An experiment is carried out by selecting one pig herd with the risk of swine fever epidemic situation, selecting 600 pigs, randomly dividing the pigs into three test groups and a control group according to the principle that the proportion of the day age, the weight, the health condition and the sex is the same, wherein each group comprises 150 pigs, ① of the test group is fed with the pig feed added with the feed additive prepared in the embodiment 1 (the addition amount is 3kg per ton) continuously for 60 days, ② of the test group is fed with the pig feed added with the feed additive prepared in the embodiment 4 (the addition amount is 3kg per ton) continuously for 60 days, ③ of the test group is fed with the pig feed added with the feed additive prepared in the embodiment 7 (the addition amount is 3kg per ton) continuously for 60 days, and the control group is fed with the pig feed not added with the feed additive prepared in the embodiment 1 continuously for 60 days and is injected with oxytetracycline to treat the sick pigs.
The daily health care of the experimental group and the control group is carried out according to the same pig farm feeding scheme, the pig plague incidence conditions of the experimental group and the control group are counted after 60 days, and the statistical results are shown in table 2.
TABLE 2
As can be seen from the table 2, after the feed additive provided by the invention is fed, the number of diseased pigs is greatly reduced, and the feed additive provided by the invention has a good prevention and treatment effect on swine fever.
Claims (10)
1. A traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 10-50 parts of astragalus membranaceus, 10-30 parts of cortex mori, 5-25 parts of honeysuckle, 5-30 parts of liquorice and 5-25 parts of agastache rugosus.
2. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 20-30 parts of astragalus membranaceus, 10-20 parts of cortex mori, 15-20 parts of honeysuckle, 15-20 parts of liquorice and 5-10 parts of agastache rugosus.
3. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 15-20 parts of astragalus, 20-30 parts of cortex mori, 5-15 parts of honeysuckle, 15-30 parts of liquorice and 10-15 parts of agastache rugosus.
4. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 20-45 parts of astragalus membranaceus, 10-15 parts of cortex mori, 5-10 parts of honeysuckle, 5-10 parts of liquorice and 10-25 parts of agastache rugosus.
5. The use of a Chinese medicinal composition as claimed in any one of claims 1-4 in the preparation of a pig feed additive.
6. The application of the traditional Chinese medicine composition of claim 5 in preparing a pig feed additive, which is characterized by comprising the following steps:
(1) taking agastache rugosus according to preset mass parts, and distilling under reduced pressure to obtain agastache rugosus distillate;
(2) taking radix astragali, cortex mori radicis, honeysuckle and liquorice according to preset mass parts, and cooking;
(3) mixing the four Chinese medicinal materials and their decoction with the herba Agastaches distillate, and heating for 10-60min to obtain water extractive solution;
(4) concentrating the water extract into an extract, uniformly mixing the extract with auxiliary materials, and granulating to obtain extract granules; the extract particles are the pig feed additive.
7. The use of the Chinese medicinal composition of claim 5 in the preparation of a pig feed additive for preventing and treating porcine reproductive and respiratory syndrome, further comprising:
(5) drying all the medicine residues, uniformly mixing the medicine residues with the extract granules, and crushing to obtain the pig feed additive.
8. A pig feed additive, which is characterized by being prepared from the traditional Chinese medicine composition of any one of claims 1 to 4.
9. A pig feed, comprising main materials and additives, wherein the additives are the pig feed additive according to claim 8; the additive amount of the pig feed additive in the main material is 2-10 kg/t.
10. Use of the pig feed additive according to claim 8 for the preparation of a control agent for porcine reproductive and respiratory syndrome or swine fever, a pig immunity enhancer or a piglet growth promoter.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112868929A (en) * | 2021-01-13 | 2021-06-01 | 江西正邦动物保健品有限公司 | Pig additive containing saccharicterpenin and preparation method and application thereof |
| CN114344402A (en) * | 2022-03-02 | 2022-04-15 | 广东天山药业有限公司 | A Chinese medicinal composition for preventing and treating porcine reproductive and respiratory syndrome and its preparation method |
| CN115581740A (en) * | 2022-10-20 | 2023-01-10 | 河南大德广动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316094A (en) * | 2012-03-20 | 2013-09-25 | 董根荣 | Micropowder preparation of traditional Chinese veterinary medicine for improving immunity and preparation method thereof |
| CN105396060A (en) * | 2015-12-09 | 2016-03-16 | 马凯 | Drug for treatment of bronchial asthma |
| CN106615660A (en) * | 2016-12-30 | 2017-05-10 | 中悦民安（北京）科技发展有限公司 | Premix feed capable of preventing and curing porcine reproductive and respiratory syndrome (PRRS) of pregnant sows, and preparation method of premix feed |
-
2020
- 2020-05-26 CN CN202010454508.4A patent/CN111467393A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316094A (en) * | 2012-03-20 | 2013-09-25 | 董根荣 | Micropowder preparation of traditional Chinese veterinary medicine for improving immunity and preparation method thereof |
| CN105396060A (en) * | 2015-12-09 | 2016-03-16 | 马凯 | Drug for treatment of bronchial asthma |
| CN106615660A (en) * | 2016-12-30 | 2017-05-10 | 中悦民安（北京）科技发展有限公司 | Premix feed capable of preventing and curing porcine reproductive and respiratory syndrome (PRRS) of pregnant sows, and preparation method of premix feed |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112868929A (en) * | 2021-01-13 | 2021-06-01 | 江西正邦动物保健品有限公司 | Pig additive containing saccharicterpenin and preparation method and application thereof |
| CN114344402A (en) * | 2022-03-02 | 2022-04-15 | 广东天山药业有限公司 | A Chinese medicinal composition for preventing and treating porcine reproductive and respiratory syndrome and its preparation method |
| CN114344402B (en) * | 2022-03-02 | 2023-05-16 | 广东天山药业有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN115581740A (en) * | 2022-10-20 | 2023-01-10 | 河南大德广动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN115581740B (en) * | 2022-10-20 | 2023-09-19 | 河南大德广动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
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