CN111467256A

CN111467256A - Application of chitosan gel thickener in shower gel

Info

Publication number: CN111467256A
Application number: CN202010286967.6A
Authority: CN
Inventors: 邱元栏
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-13
Filing date: 2020-04-13
Publication date: 2020-07-31

Abstract

The invention relates to an application of a chitosan gel thickener in shower gel, belonging to the field of daily chemical products; the thickener is synthesized by chitosan and 3, 3-dithiodipropionic acid, when in bathing, a part of the thickener is decomposed into chitosan and 3, 3-dithiodipropionic acid in a weak acid environment, and the decomposed chitosan is attached to the skin to have the function of moisturizing; the 3, 3-dithiodipropionic acid is attached to the skin, so that the oil secreted by the skin can be removed, skin metabolites are prevented from blocking pores, and the health of the skin is promoted; the chitosan thickener can wrap chlorophyll which is beneficial to a body and is difficult to dissolve in water, so that the solubility of the chlorophyll in the shower gel is increased, and the skin is protected from being damaged by external ultraviolet rays; the shower gel provided by the invention can balance the water balance of skin microenvironment and inhibit and remove grease secreted by skin, and has the functions of moisturizing and cleaning.

Description

Application of chitosan gel thickener in shower gel

Technical Field

The invention relates to an application of a chitosan gel thickener in shower gel, belonging to the field of daily chemical products.

Technical Field

The shower gel is a washing product prepared from a surfactant and a functional conditioner and used for cleaning and moistening skin. The existing shower gel products mainly play basic cleaning, moisturizing and cooling roles, and although part of shower gel products are declared to have the effects of resisting bacteria, relieving itching and the like, the effects are not ideal enough or gradually weakened along with the prolonging of the storage time.

More surfactants such as fatty alcohol-polyoxyethylene ether sulfate, betaine, fatty acid soap and the like are often added into the existing shower gel product, and various types of surfactants are usually used in combination. The traditional surfactant shower gel mainly comprises fatty alcohol-polyoxyethylene ether sulfate and betaine or fatty acid soap, but the fatty alcohol-polyoxyethylene ether sulfate has the characteristic of strong adsorbability and is easy to cause the feeling of difficult washing for consumers, and the fatty alcohol-polyoxyethylene ether sulfate can generate dioxane by-products in the process and can cause serious irritation to skin and the like; although the fatty acid soap-based body wash has good washability, the body wash has strong alkalinity and strong skin irritation, and is easy to cause dryness, tightness and pruritus after washing. When the content of the surfactant is high, the detergent has a good cleaning effect, but can easily take away normal sebum and other components, and can easily cause adverse reactions such as dryness, red swelling, pruritus and the like after long-term use.

Chitosan is an important component of the dermal matrix, which acts as a connective tissue support and water retention material. Chitosan in the skin and applied externally plays a key role in connective tissue, achieving a fuller, firmer and younger state of the skin.

Chlorophyll is a good natural pigment, has the effects of cooling, detoxifying, moisturizing, resisting radiation and the like, is insoluble in water, is easy to decompose under the conditions of heat, light, oxygen and the like, has high extraction and preparation difficulty, and is easy to deteriorate after being made into bath cream.

Squalane (Squalane): strengthen and repair the epidermis, effectively form the natural protective film, help the balance between skin and sebum. Has strong affinity, can be integrated with the skin lipid membrane of human body, and forms a natural barrier on the skin surface. Can also inhibit the peroxidation of skin lipid, effectively permeate into the skin, promote the proliferation of skin basal cells, and has obvious physiological effects on delaying skin aging, improving and eliminating chloasma. It also has effects in opening skin pore, promoting blood microcirculation, promoting cell metabolism, and repairing damaged cells.

Disclosure of Invention

In order to solve the defects, the invention provides a preparation method of a chitosan gel thickening agent and application of the chitosan gel thickening agent in shower gel.

The invention also aims to provide application of the chitosan gel thickener in shower gel.

The present invention is achieved in the following manner.

The chitosan gel is composed of chitosan and 3, 3-dithiodipropionic acid, and the structural formula of the chitosan gel is shown as a formula (I).

Wherein m is 1-5; wherein n is 10-20.

The structural formula of the chitosan is shown as formula (II):

wherein m is 10-20.

The 3, 3-dithiodipropionic acid of the invention is represented by the formula (III):

the preparation method of the chitosan thickener comprises the following steps:

the preparation method of the compound with the structure shown in the formula (I) comprises the steps of dissolving 5.0-15 g of (II) in 150-400 m L deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 15% of EDC and NHS solution 10-30 m L when the (II) is completely dispersed in water, activating the activated amino to form active amino, then adding 15-45 g of (III), continuing stirring for 8-15 h in ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water (the interception molecular weight of a dialysis bag is 2000-3000) every 4h, and finally carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan gel thickener (I).

The preparation steps of the chitosan thickener are preferably as follows:

8.0-10 g of (II) is dissolved in 150m L deionized water, then the mixture is placed into a water bath kettle at room temperature for magnetic stirring, 15% of EDC and 15-20 m L of NHS solution are added dropwise when the (II) is completely dispersed in water, activated amino is activated into activated amino, then 1.5g of (III) is added, the mixture is continuously stirred for 12-15 h in ice-water bath, after the reaction is finished, the obtained solution (I) is dialyzed for 24h, water is changed every 4h (the intercepted molecular weight of a dialysis bag is 2000), and finally the solution (I) in the dialysis bag is subjected to vacuum freeze drying to obtain the chitosan gel thickening agent.

The shower gel comprises the following components in percentage by weight:

the shower gel is prepared from 16-24 parts of chlorophyll wrapped by a chitosan gel thickener, 60-90 parts of water, 0.4-0.6 part of hydroxyethyl cellulose, 8-15 parts of an N-acyl amino acid surfactant, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer, 0.1-2 parts of antibacterial peptide, 1.8-2.2 parts of GlucamE-20, 0.3-0.5 part of essence and an acid-base regulator NaHCO₃Or K₂CO₃3-5 parts of a skin conditioner and 1.4-2.5 parts of a skin conditioner.

The skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts.

The preparation method of the chlorophyll wrapped by the chitosan gel thickener comprises the following steps: and dispersing chlorophyll in 20-25 parts of water, heating to 55-60 ℃, stirring, and slowly adding the chitosan gel thickener into the water in which the chlorophyll is dispersed to obtain the chlorophyll coated by the chitosan gel thickener.

The preparation method of the chitosan gel thickener in the shower gel comprises the following steps:

1) adding 60-90 parts of water and 0.4-0.6 part of hydroxyethyl cellulose into an emulsifying pot, stirring and heating to 75-80 ℃, homogenizing for 3min, and dissolving the raw materials uniformly to obtain a transparent solution.

2) And then adding 28-32 parts of N-acyl amino acid surfactant, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer and 0.1-2 parts of antibacterial peptide into the solution obtained in the step 1) in sequence, stirring until all the raw materials are dissolved, keeping the temperature for 10min, uniformly stirring, and cooling to 35 ℃.

3) Adding 1.8-2.2 parts of GlucamE E-20, 0.3-0.5 part of essence, an acid-base regulator NaHCO3 or K2CO 33-5 parts and 1.4-2.5 parts of a skin conditioner into the mixed solution obtained in the step 2), slowly dropwise adding 16-24 parts of chlorophyll wrapped by the chitosan gel thickener, observing the viscosity of the shower gel to 6500-7000 mpa · s, filtering and discharging after the shower gel is qualified, and obtaining the shower gel containing the chlorophyll wrapped by the chitosan gel thickener.

Has the advantages that:

the chitosan gel thickener of the invention removes the traditional inorganic salt and chemical synthetic thickener, and selects natural biological agent synthetic thickener; the thickening agent is rich in hydroxyl, carboxyl and amino, and can be rapidly combined with hydrogen and other hydrogen bonds of surfactants and the like in the shower gel to form a similar macromolecular compound after being added into the shower gel, so that the thickening effect is achieved.

The chitosan gel thickener is stable under the condition of weak alkalinity, after an acid-base regulator is added, the gel thickener can stably exist in a weak alkaline environment (pH value is 7-7.5), when a user takes a bath, in a weak acid environment of tap water, a part of the gel thickener is decomposed into chitosan and 3, 3-dithiodipropionic acid under the weak acid environment (pH value is 6.5-7.0), wherein the chitosan can capture moisture under the microenvironment of the surface of the skin on the surface of the skin, and the effect of moisturizing the skin is achieved; the 3, 3-dithiodipropionic acid can enhance the decomposition and removal of fatty acid secreted by epidermal cells of the skin, achieve the effect of cleaning the skin for a long time and reduce the generation of peculiar smell. A part of the chitosan gel thickening agent can be retained on the skin surface to form a protective film, so that the excessive water loss on the skin surface is further prevented.

The following will clearly and completely describe the technical scheme of the embodiment of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1 preparation of Chitosan thickener 1

The preparation method of the compound with the structure shown in the formula (I) comprises the steps of dissolving 5.0g of (II) in 200m L deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 15% of EDC and NHS solution 10m L when the (II) is completely dispersed in water, activating amino to be active amino, then adding 15g of (III), continuing stirring for 8-10 h in an ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the interception molecular weight of a dialysis bag is 2000-3000), and finally carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan gel thickener (I).

The structural formula of the chitosan gel thickener is shown as a formula (I).

Wherein m is 1-5. Wherein n is 10-20.

Example 2 preparation of Chitosan thickener 2

Dissolving 10g of (II) in 450m L deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 15% of EDC and NHS solution 15m L when (II) is completely dispersed in water, activating amino to obtain active amino, then adding 30g of (III), continuing stirring for 12-14 h in an ice-water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the molecular weight cut-off of a dialysis bag is 2000-3000), and finally, carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan gel thickener (I).

Example 3 preparation of chlorophyll encapsulated by Chitosan gel thickener

The preparation method of chlorophyll wrapped by the chitosan gel thickener comprises the following steps: and dispersing chlorophyll in 20-25 parts of water, heating to 55-60 ℃, stirring, and slowly adding the chitosan gel thickener into the water in which the chlorophyll is dispersed to obtain the chlorophyll coated by the chitosan gel thickener.

Example 4 Chitosan gel thickener in shower gel preparation 1

3) Adding 1.8-2.2 parts of GlucamE-20, 0.3-0.5 part of essence and an acid-base regulator NaHCO into the mixed solution obtained in the step 2)₃Or K₂CO₃3-5 parts of a skin conditioner and 1.4-2.5 parts of a chitosan gel thickener, slowly dripping 16-24 parts of chlorophyll wrapped by the chitosan gel thickener, observing the viscosity of the shower gel to be 6500-7000 mpa · s, filtering and discharging after the shower gel is qualified, and thus obtaining the shower gel containing the chlorophyll wrapped by the chitosan gel thickener.

Example 5 Chitosan gel thickener in shower gel preparation 2

1) Adding 70-80 parts of water and 0.5-0.6 part of hydroxyethyl cellulose into an emulsifying pot, stirring and heating to 75-80 ℃, homogenizing for 3min, and dissolving the raw materials uniformly to obtain a transparent solution.

2) And then, sequentially adding 29-30 parts of N-acyl amino acid surfactant, 4-6 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1.5-0.2 part of citric acid, 0.15-2 parts of carbomer and 0.1-2 parts of antibacterial peptide into the solution obtained in the step 1), stirring until all the raw materials are dissolved, keeping the temperature for 10min, uniformly stirring, and cooling to 35 ℃.

3) Adding 1.9-2.1 parts of GlucamE-20, 0.3-0.4 part of essence and acid-base regulator NaHCO into the mixed solution obtained in the step 2)₃Or K₂CO₃3-5 parts of a skin conditioner and 1.8-2.0 parts of a chitosan gel thickener, slowly dripping 18-21 parts of chlorophyll wrapped by the chitosan gel thickener, observing the viscosity of the shower gel to be 6500-7000 mpa · s, filtering and discharging after the shower gel is qualified, and thus obtaining the shower gel containing the chlorophyll wrapped by the chitosan gel thickener.

Example 6 moisturizing Effect and whitening test

(1) The test method comprises the following steps: 80 healthy volunteer subjects were selected, with the age between 25-55 years. All subjects were randomly divided into 2 test groups of 40 persons each, test 1 and comparative 1 groups, respectively, wherein test 1 group used the body wash prepared from the formulation of example 6, respectively, and comparative 1 group used a commercially available body wash, respectively. Subjects in all test groups bathe every night. During the trial period, the sun is prevented from being exposed to the sun, and other bathing products are forbidden. After 1 month of continuous use, all subjects were tested and recorded for their moisturizing and whitening effect.

(2) Evaluation criteria for Effect

The whitening effect of the skin care product is evaluated by using the change rate of the skin melanin content and the brightness, and the specific method comprises ① the skin melanin content, analyzing the change condition of the melanin content of the facial skin of a subject by using a Japanese Meinengda CD-2600 spectrophotometer, collecting reflected light vertical to the surface of the skin by adopting a L ab color system, wherein b & lt & gt in measurement parameters reflects the color change range from yellow to blue (the value change range is +60 yellow to-60 blue), is positively correlated with the skin melanin content, and is related to the reflection of yellow light by melanin, before the test is started, the melanin content of the skin of each subject is detected and recorded, and after 1 month of the test, the melanin of the skin of each subject is detected again and recorded.

The skin melanin reduction rate was calculated using the following formula:

melanin reduction rate (pre-test value-post-test value)/pre-test value × 100%.

② the skin brightness is better when the skin brightness is measured by a skin test system (VISIA), the brighter the skin is, the higher the skin brightness is, and the darker the skin is, the brightness of the skin of each subject is detected and recorded before the test is started, the brightness of the skin of each subject is detected again after 1 month of the test, and the record is recorded, the change rate of the brightness of the skin is calculated by the following formula, namely the brightness change rate is (value after the test-value before the test)/value before the test is × 100%, the higher the brightness increase rate is, and the better the whitening effect is.

The results are shown in Table 1

Table 1 test results of moisturizing effect of bath according to the present invention

Group of	The average water content is increased%	Average melanin reduction%	The average brightness is increased%
				Test 1 group	23.9	15.6	10
Comparative 1 group	12.1	5.4	3.7

The results show that after the volunteer subjects in the test 1 group respectively use the bath foam prepared by the formula in example 5, the average skin dryness of the skin is obviously reduced, no white skin on the skin appears in autumn and winter, the average brightness increase rate of the skin is as high as about 10%, the whitening is improved by about 15.6%, and the moisture is improved by 23.9% on average; is obviously better than the use condition of the volunteer subjects in the comparative group 1. The results show that the components of the bath foam formula provided by the invention are mutually coordinated and enhanced, and the optimal moisturizing and whitening effects are exerted together.

EXAMPLE 7 preparation of Chitosan thickener

The preparation method of the compound with the structure shown in the formula (I) comprises the steps of dissolving 10g of (II) in 300m L deionized water, then placing the mixture into a water bath kettle at room temperature for magnetic stirring, dropwise adding 15% of EDC and NHS solution 20-30 m L when the (II) is completely dispersed in water, activating amino to be active amino, then adding 35g of the (III), continuing stirring for 8-15 h in ice water bath, dialyzing the obtained solution (I) for 24h after the reaction is finished, changing water every 4h (the interception molecular weight of a dialysis bag is 2000-3000), and finally carrying out vacuum freeze drying on the solution (I) in the dialysis bag to obtain the chitosan gel thickener (I).

Claims

1. The application of the chitosan gel thickener in the shower gel is characterized in that: the chitosan gel is composed of chitosan and 3, 3-dithiodipropionic acid, and the structural formula is shown as a formula (I);

the shower gel is prepared by coagulating chitosan16-24 parts of glue thickener-coated chlorophyll, 60-90 parts of water, 0.4-0.6 part of hydroxyethyl cellulose, 8-15 parts of N-acyl amino acid surfactant, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer, 0.1-2 parts of antibacterial peptide, 1.8-2.2 parts of GlucamE-20, 0.3-0.5 part of essence and acid-base regulator NaHCO₃Or K₂CO₃3-5 parts of a skin conditioner and 1.4-2.5 parts of a skin conditioner;

the skin conditioner is a compound of hydrolyzed sericin, olive oil PEG-7 esters, panthenol and plant extracts;

the preparation method of the chlorophyll wrapped by the chitosan gel thickener comprises the following steps: dispersing chlorophyll in 20-25 parts of water, heating to 55-60 ℃, stirring, and slowly adding a chitosan gel thickener into the water in which the chlorophyll is dispersed to obtain chlorophyll coated by the chitosan gel thickener;

the preparation method of the shower gel comprises the following steps:

1) adding 60-90 parts of water and 0.4-0.6 part of hydroxyethyl cellulose into an emulsifying pot, stirring and heating to 75-80 ℃, homogenizing for 3min, and dissolving the raw materials into a transparent solution uniformly;

2) sequentially adding 28-32 parts of N-acyl amino acid surfactant, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer and 0.1-2 parts of antibacterial peptide into the solution obtained in the step 1), stirring until all raw materials are dissolved, keeping the temperature for 10min, uniformly stirring, and cooling to 35 ℃;

2. The application of the chitosan gel thickener in the shower gel as claimed in claim 1, wherein the proportion of the shower gel is preferably as follows:

18-22 parts of chlorophyll and 70-90 parts of water, 0.4-0.6 part of hydroxyethyl cellulose, 10-12 parts of N-acyl amino acid surfactant, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer, 0.1-2 parts of antibacterial peptide, 1.8-2.2 parts of GlucamE-20, 0.3-0.5 part of essence and acid-base regulator NaHCO₃Or K₂CO₃3-5 parts of a skin conditioner.

3. The application of the chitosan gel thickener in the shower gel as claimed in claim 1, wherein the preparation method of the shower gel is preferably as follows:

1) adding 40-70 parts of water and 0.4-0.6 part of hydroxyethyl cellulose into an emulsifying pot, stirring and heating to 75-80 ℃, homogenizing for 3min, and dissolving the raw materials into a transparent solution uniformly;

2) sequentially adding 28-32 parts of N-acyl amino acid surfactant, 2-8 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.1-0.25 part of citric acid, 0.3-1.5 parts of carbomer and 0.3-2 parts of antibacterial peptide into the solution obtained in the step 1), stirring until all raw materials are dissolved, keeping the temperature for 10min, uniformly stirring, and cooling to 35 ℃;

3) adding 1.8-2.2 parts of GlucamE-20, 0.3-0.5 part of essence and an acid-base regulator NaHCO into the mixed solution obtained in the step 2)₃Or K₂CO₃3-5 parts, slowly dripping 16-24 parts of chlorophyll wrapped by the chitosan gel thickener, observing the viscosity of the shower gel to be 6500-7000 mpa, and filtering and discharging after the shower gel is qualified to obtain the shower gel containing the chlorophyll wrapped by the chitosan gel thickener.

4. The application of the chitosan gel thickener in the shower gel as claimed in claim 1, wherein the preparation method of the shower gel is further preferably as follows:

1) adding 60-65 parts of water and 0.5-0.6 part of hydroxyethyl cellulose into an emulsifying pot, stirring and heating to 75-80 ℃, homogenizing for 3min, and dissolving the raw materials into a transparent solution uniformly;

2) sequentially adding 28-30 parts of N-acyl amino acid surfactant, 6-8 parts of sodium cocoyl glycinate, 1-2 parts of Squalane (Squalane), 0.15-0.2 part of citric acid, 0.5-1 part of carbomer and 0.8-1.5 parts of antibacterial peptide into the solution obtained in the step 1), stirring until all raw materials are dissolved, keeping the temperature for 10min, uniformly stirring, and cooling to 35 ℃;

3) adding 1.8-2.0 parts of GlucamE-20, 0.4-0.5 part of essence and acid-base regulator NaHCO into the mixed solution obtained in the step 2)₃Or K₂CO₃3-5 parts, slowly adding 18-20 parts of chlorophyll wrapped by the chitosan gel thickener dropwise, observing the viscosity of the shower gel to be 6500-7000 mpa, and filtering and discharging after the shower gel is qualified to obtain the shower gel containing the chlorophyll wrapped by the chitosan gel thickener.

5. The application of the chitosan gel thickener in the shower gel is characterized in that: the shower gel is used for protecting skin from being wet.

6. The application of the chitosan gel thickener in the shower gel is characterized in that: the shower gel can be used for inhibiting oil secreted by skin.