CN111440241A - 一种包含特异性结合ros1的单克隆抗体的癌症试剂盒 - Google Patents
一种包含特异性结合ros1的单克隆抗体的癌症试剂盒 Download PDFInfo
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- CN111440241A CN111440241A CN202010481249.4A CN202010481249A CN111440241A CN 111440241 A CN111440241 A CN 111440241A CN 202010481249 A CN202010481249 A CN 202010481249A CN 111440241 A CN111440241 A CN 111440241A
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07K14/82—Translation products from oncogenes
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
Description
稀释倍数 | OD值 |
500 | 1.936 |
1000 | 1.705 |
2000 | 1.556 |
4000 | 1.407 |
8000 | 1.026 |
16000 | 0.829 |
对照 | 0.093 |
空白对照 | 0.021 |
Claims (6)
Priority Applications (1)
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CN202010481249.4A CN111440241B (zh) | 2020-05-31 | 2020-05-31 | 一种包含特异性结合ros1的单克隆抗体的癌症检测试剂盒 |
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CN202010481249.4A CN111440241B (zh) | 2020-05-31 | 2020-05-31 | 一种包含特异性结合ros1的单克隆抗体的癌症检测试剂盒 |
Publications (2)
Publication Number | Publication Date |
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CN111440241A true CN111440241A (zh) | 2020-07-24 |
CN111440241B CN111440241B (zh) | 2021-01-05 |
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CN202010481249.4A Active CN111440241B (zh) | 2020-05-31 | 2020-05-31 | 一种包含特异性结合ros1的单克隆抗体的癌症检测试剂盒 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113476601A (zh) * | 2021-08-24 | 2021-10-08 | 天津汉青生物科技有限公司 | 干细胞细胞因子联合海藻多糖制备的药物或化妆品 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103858011A (zh) * | 2011-05-23 | 2014-06-11 | 细胞信号科技公司 | 肺癌中的ros激酶 |
CN108997502A (zh) * | 2018-08-09 | 2018-12-14 | 靖江市人民医院 | 鼠抗人ros1蛋白单克隆抗体制备及其免疫组化用途 |
-
2020
- 2020-05-31 CN CN202010481249.4A patent/CN111440241B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103858011A (zh) * | 2011-05-23 | 2014-06-11 | 细胞信号科技公司 | 肺癌中的ros激酶 |
CN106148525A (zh) * | 2011-05-23 | 2016-11-23 | 细胞信号科技公司 | 肺癌中的ros激酶 |
CN108997502A (zh) * | 2018-08-09 | 2018-12-14 | 靖江市人民医院 | 鼠抗人ros1蛋白单克隆抗体制备及其免疫组化用途 |
Non-Patent Citations (1)
Title |
---|
VICTORIA M. RIMKUNAS ET AL.: "Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion", 《CLIN CANCER RES》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113476601A (zh) * | 2021-08-24 | 2021-10-08 | 天津汉青生物科技有限公司 | 干细胞细胞因子联合海藻多糖制备的药物或化妆品 |
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CN111440241B (zh) | 2021-01-05 |
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