CN111432804A - 冻干的多微粒固体剂型 - Google Patents

冻干的多微粒固体剂型 Download PDF

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Publication number
CN111432804A
CN111432804A CN201880076056.1A CN201880076056A CN111432804A CN 111432804 A CN111432804 A CN 111432804A CN 201880076056 A CN201880076056 A CN 201880076056A CN 111432804 A CN111432804 A CN 111432804A
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CN
China
Prior art keywords
dosage form
solid dosage
microcapsules
multiparticulate solid
multiparticulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880076056.1A
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English (en)
Chinese (zh)
Inventor
玛丽亚·埃本内斯
丹尼斯·卡鲁布克钦
马塞尔·穆宁
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DSM IP Assets BV
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DSM IP Assets BV
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Publication date
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Publication of CN111432804A publication Critical patent/CN111432804A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B7/00—Preservation of fruit or vegetables; Chemical ripening of fruit or vegetables
    • A23B7/02—Dehydrating; Subsequent reconstitution
    • A23B7/024—Freeze-drying, i.e. cryodesiccation or lyophilisation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880076056.1A 2017-11-27 2018-11-22 冻干的多微粒固体剂型 Pending CN111432804A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17203799.6 2017-11-27
EP17203799 2017-11-27
PCT/EP2018/082156 WO2019101832A1 (en) 2017-11-27 2018-11-22 Freeze-dried multiparticulate solid dosage form

Publications (1)

Publication Number Publication Date
CN111432804A true CN111432804A (zh) 2020-07-17

Family

ID=60473407

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880076056.1A Pending CN111432804A (zh) 2017-11-27 2018-11-22 冻干的多微粒固体剂型

Country Status (6)

Country Link
US (1) US20210015753A1 (https=)
EP (1) EP3716953A1 (https=)
JP (1) JP2021504327A (https=)
KR (1) KR20200093608A (https=)
CN (1) CN111432804A (https=)
WO (1) WO2019101832A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118160802A (zh) * 2024-04-01 2024-06-11 青岛安信制果食品有限公司 一种冻干食品及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040228919A1 (en) * 2003-02-28 2004-11-18 Alk-Abello A/S Dosage form having a saccharide matrix
CN1646029A (zh) * 2002-04-11 2005-07-27 加拿大海洋营养保健品有限公司 密封的微胶囊凝聚体及其制备方法
CN1913905A (zh) * 2003-12-24 2007-02-14 弗罗桑公司 益生菌片剂
CN103118662A (zh) * 2010-03-16 2013-05-22 P·R·谢勒科技有限责任公司 制备冻干速溶多相剂型的方法
CN103458709A (zh) * 2011-01-21 2013-12-18 凡赛尔医药股份有限公司 微囊化益生菌物质及其制造方法
CN106455667A (zh) * 2014-05-05 2017-02-22 巴斯夫欧洲公司 脂溶性维生素制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0609265B1 (en) * 1991-10-11 1997-05-28 Abbott Laboratories Unit-of-use reagent composition for specific binding assays
MXPA05009079A (es) * 2003-02-28 2006-05-19 Alk Abello As Forma de dosificacion que tiene una matriz de sacarido.
US20080031949A1 (en) * 2006-07-24 2008-02-07 Cima Labs Inc. High dose orally dissolvable/disintegrable lyophilized dosage form
KR20100047869A (ko) 2007-07-19 2010-05-10 디에스엠 아이피 어셋츠 비.브이. 친유성 헬스 성분의 정제화가능한 배합물
PL2057984T3 (pl) 2007-11-09 2010-05-31 Acino Pharma Ag Tabletki z hydromorfonem o przedłużonym uwalnianiu
EP2606879A1 (en) 2011-12-21 2013-06-26 Hexal AG Multiple unit pellet tablet formulation comprising an opioid
KR102250588B1 (ko) * 2013-07-02 2021-05-12 오스트리아노바 싱가포르 피티이 리미티드 캡슐화 세포의 동결-건조 방법, 동결 건조된 캡슐화 세포, 동결 건조된 캡슐화 세포를 함유하는 조성물, 및 상기 세포 및 조성물의 용도
ES3005432T3 (en) * 2014-08-05 2025-03-14 Advanced Bionutrition Corp Composition comprising hydrophobic biologically active compounds and method for preparing said composition
US20180235899A1 (en) * 2017-02-17 2018-08-23 Privo Technologies, Inc. Particle-based multi-layer therapeutic delivery device and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1646029A (zh) * 2002-04-11 2005-07-27 加拿大海洋营养保健品有限公司 密封的微胶囊凝聚体及其制备方法
US20040228919A1 (en) * 2003-02-28 2004-11-18 Alk-Abello A/S Dosage form having a saccharide matrix
CN1758899A (zh) * 2003-02-28 2006-04-12 阿尔克-阿贝洛有限公司 具有糖基质的剂型
CN1913905A (zh) * 2003-12-24 2007-02-14 弗罗桑公司 益生菌片剂
CN103118662A (zh) * 2010-03-16 2013-05-22 P·R·谢勒科技有限责任公司 制备冻干速溶多相剂型的方法
CN103458709A (zh) * 2011-01-21 2013-12-18 凡赛尔医药股份有限公司 微囊化益生菌物质及其制造方法
CN106455667A (zh) * 2014-05-05 2017-02-22 巴斯夫欧洲公司 脂溶性维生素制剂

Also Published As

Publication number Publication date
US20210015753A1 (en) 2021-01-21
WO2019101832A1 (en) 2019-05-31
JP2021504327A (ja) 2021-02-15
KR20200093608A (ko) 2020-08-05
EP3716953A1 (en) 2020-10-07

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Application publication date: 20200717