CN111406051A - 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙烯基杂环 - Google Patents

作为rho相关卷曲螺旋激酶(rock)抑制剂的乙烯基杂环 Download PDF

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Publication number
CN111406051A
CN111406051A CN201880056952.1A CN201880056952A CN111406051A CN 111406051 A CN111406051 A CN 111406051A CN 201880056952 A CN201880056952 A CN 201880056952A CN 111406051 A CN111406051 A CN 111406051A
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China
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vinyl
pyridin
isoindoline
bipyrimidinyl
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CN201880056952.1A
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Chinese (zh)
Inventor
李安虎
迪佰恩度·德纳
林东星
萨提什库玛·盖德海亚
郑大云
普拉卡什·纳拉扬
奎萨·阿里
拉沙·帕卡
伊萨克·D·戈德伯格
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Elicio Therapeutics Inc
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Angion Biomedica Corp
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Publication of CN111406051A publication Critical patent/CN111406051A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880056952.1A 2017-09-03 2018-08-31 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙烯基杂环 Pending CN111406051A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553885P 2017-09-03 2017-09-03
US62/553,885 2017-09-03
PCT/US2018/049225 WO2019046795A1 (en) 2017-09-03 2018-08-31 VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE

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CN111406051A true CN111406051A (zh) 2020-07-10

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CN201880056952.1A Pending CN111406051A (zh) 2017-09-03 2018-08-31 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙烯基杂环

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US (1) US11542256B2 (https=)
EP (1) EP3676262A4 (https=)
JP (1) JP2020532551A (https=)
CN (1) CN111406051A (https=)
AU (1) AU2018326785B2 (https=)
CA (1) CA3073956A1 (https=)
IL (1) IL272939A (https=)
WO (1) WO2019046795A1 (https=)

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CA3189725A1 (en) * 2020-07-21 2022-01-27 Angion Biomedica Corp. Inhibitors of rho-associated coiled-coil kinase
KR20250004773A (ko) * 2022-04-20 2025-01-08 상하이 지멍 바이오파마 아이엔씨 Rho 관련 단백질 키나아제 억제제 및 이의 제조와 응용
US12600722B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
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IL272939A (en) 2020-04-30
CA3073956A1 (en) 2019-03-07
JP2020532551A (ja) 2020-11-12
EP3676262A1 (en) 2020-07-08
AU2018326785A1 (en) 2020-04-09
WO2019046795A1 (en) 2019-03-07
US11542256B2 (en) 2023-01-03
AU2018326785B2 (en) 2023-03-02
EP3676262A4 (en) 2021-03-31
US20200231576A1 (en) 2020-07-23

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