CA3073956A1 - Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors - Google Patents

Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors Download PDF

Info

Publication number
CA3073956A1
CA3073956A1 CA3073956A CA3073956A CA3073956A1 CA 3073956 A1 CA3073956 A1 CA 3073956A1 CA 3073956 A CA3073956 A CA 3073956A CA 3073956 A CA3073956 A CA 3073956A CA 3073956 A1 CA3073956 A1 CA 3073956A1
Authority
CA
Canada
Prior art keywords
vinyl
pyrimidin
bipyrimidin
isoindoline
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3073956A
Other languages
English (en)
French (fr)
Inventor
An-Hu Li
Dibyendu Dana
Dong Sung Lim
Satishkumar GADHIYA
Dawoon Jung
Prakash Narayan
Quaisar ALI
Swarnalatha PAKA
Itzhak D. Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elicio Therapeutics Inc
Original Assignee
Angion Biomedica Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angion Biomedica Corp filed Critical Angion Biomedica Corp
Publication of CA3073956A1 publication Critical patent/CA3073956A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3073956A 2017-09-03 2018-08-31 Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors Pending CA3073956A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553885P 2017-09-03 2017-09-03
US62/553,885 2017-09-03
PCT/US2018/049225 WO2019046795A1 (en) 2017-09-03 2018-08-31 VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE

Publications (1)

Publication Number Publication Date
CA3073956A1 true CA3073956A1 (en) 2019-03-07

Family

ID=65526110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3073956A Pending CA3073956A1 (en) 2017-09-03 2018-08-31 Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors

Country Status (8)

Country Link
US (1) US11542256B2 (https=)
EP (1) EP3676262A4 (https=)
JP (1) JP2020532551A (https=)
CN (1) CN111406051A (https=)
AU (1) AU2018326785B2 (https=)
CA (1) CA3073956A1 (https=)
IL (1) IL272939A (https=)
WO (1) WO2019046795A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11542256B2 (en) 2017-09-03 2023-01-03 Angion Biomedica Corp. Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors
EP4003340A4 (en) * 2019-07-22 2023-09-27 Angion Biomedica Corp. ETHYNYL HETEROCYCLES AS RHO-ASSOCIATED BISPIRAL KINASE (ROCK) INHIBITORS
TW202132285A (zh) * 2019-11-13 2021-09-01 美商愛彼特生物製藥股份有限公司 經取代異吲哚啉基2,2’-聯嘧啶基化合物、其類似物及使用其之方法
CA3189725A1 (en) * 2020-07-21 2022-01-27 Angion Biomedica Corp. Inhibitors of rho-associated coiled-coil kinase
KR20250004773A (ko) * 2022-04-20 2025-01-08 상하이 지멍 바이오파마 아이엔씨 Rho 관련 단백질 키나아제 억제제 및 이의 제조와 응용
US12600722B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
US12600723B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322756A (en) * 1992-07-09 1994-06-21 Xerox Corporation Magnetic fluids and method of preparation
MY134008A (en) * 1999-12-22 2007-11-30 Merck Frosst Canada Inc Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors
EP1490362A2 (en) 2001-03-08 2004-12-29 Millennium Pharmaceuticals, Inc. (homo)piperazine substituted quinolines for inhibiting the phosphorylation of kinases
DE102004039280A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
CR9465A (es) 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
JP5252404B2 (ja) * 2006-08-16 2013-07-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピラジン化合物、その使用及び調製方法
BRPI0717097A2 (pt) * 2006-09-21 2013-11-26 Novartis Ag Derivados de pirrol úteis para o tratamento de doenças mediadas por citocina
US7758972B2 (en) * 2006-09-26 2010-07-20 Semiconductor Energy Laboratory Co., Ltd. Stilbene derivative, light emitting element, light emitting device, and electronic appliance
WO2008054599A2 (en) 2006-09-27 2008-05-08 Surface Logix, Inc. Rho kinase inhibitors
EP2116522B1 (en) * 2007-02-28 2013-09-18 JNC Corporation Pentacyclic liquid crystal compound having cf<sb>2</sb>o bonding group, liquid crystal composition and liquid crystal display
WO2008120810A1 (ja) * 2007-03-29 2008-10-09 Sumitomo Chemical Company, Limited 化合物、光電変換素子及び光電気化学電池
US20120202793A1 (en) 2009-03-09 2012-08-09 Paul Sweetnam Rho kinase inhibitors
US8680116B2 (en) * 2009-07-22 2014-03-25 Merck Sharp & Dohme Corp. Quinolinone PDE2 inhibitors
EP2542528B1 (en) 2010-03-02 2013-06-19 Amakem NV Heterocyclic amides as rock inhibitors
WO2012040499A2 (en) 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
JP5809954B2 (ja) * 2011-12-15 2015-11-11 富士フイルム株式会社 光電変換素子及び色素増感太陽電池
CN113620933A (zh) 2012-10-05 2021-11-09 卡德门企业有限公司 Rho激酶抑制剂
WO2014093773A1 (en) 2012-12-14 2014-06-19 The Brigham And Women's Hospital, Inc. Methods and assays relating to macrophage differentiation
PT2951172T (pt) 2013-01-29 2017-07-12 Redx Pharma Plc Derivados de piridina como inibidores de rock leves
US11311541B2 (en) 2014-04-09 2022-04-26 Kadmon Corporation, Llc Treatment of GVHD
WO2015190467A1 (ja) * 2014-06-11 2015-12-17 富士フイルム株式会社 光電変換素子、色素増感太陽電池、金属錯体色素、色素溶液、およびターピリジン化合物またはそのエステル化物
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
US10011600B2 (en) 2014-09-25 2018-07-03 Araxes Pharma Llc Methods and compositions for inhibition of Ras
WO2016081554A1 (en) 2014-11-18 2016-05-26 Neostem Oncology, Llc Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use
JP2018501276A (ja) 2015-01-09 2018-01-18 ギリアド アポロ， エルエルシー 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法
US9687483B2 (en) 2015-01-26 2017-06-27 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
ES2730112T3 (es) 2015-03-09 2019-11-08 Bristol Myers Squibb Co Lactamas como inhibidores de ROCK
KR20180021741A (ko) 2015-05-29 2018-03-05 에쥐 세라피틱스, 인코포레이티드 시각 손실을 감소시키기 위한 조성물 및 방법
DK3312270T3 (da) 2015-06-16 2020-10-12 Univ Kyoto Fremgangsmåde til fremstilling af plader med høj ydeevne
AU2017246228B2 (en) 2016-04-04 2021-04-15 Chemocentryx, Inc. Soluble C5aR antagonists
JP2019112307A (ja) 2016-04-28 2019-07-11 宇部興産株式会社 置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
SG11201810602YA (en) 2016-06-03 2018-12-28 Chemocentryx Inc Method of treating liver fibrosis
CN107019698A (zh) 2016-08-04 2017-08-08 上海市第十人民医院 Rock2抑制剂在制备炎症性肠病药物中的应用
WO2018052953A1 (en) 2016-09-13 2018-03-22 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
KR101892154B1 (ko) 2017-02-22 2018-08-28 한국과학기술연구원 Ｒｈｏ-연관된 단백질 키나제 저해제를 포함하는 면역 반응 증강용 조성물 및 이를 이용한 방법
CN106916145B (zh) 2017-03-06 2019-06-04 上海应用技术大学 SLx-2119的合成方法
KR20190122806A (ko) 2017-03-13 2019-10-30 장피트 조합 치료요법용 약학 조성물
AU2018234059A1 (en) 2017-03-16 2019-10-31 Takeda Gmbh Treatment of idiopathic pulmonary fibrosis
CN110536682B (zh) 2017-04-18 2023-01-06 基恩菲特公司 依拉非诺或其衍生物与抗nash、抗纤维化或抗胆汁淤积药剂的组合
US11541046B2 (en) 2017-06-30 2023-01-03 Quixgen, Inc. Spirolactone compounds
US11542256B2 (en) 2017-09-03 2023-01-03 Angion Biomedica Corp. Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors
GB201715930D0 (en) 2017-09-30 2017-11-15 Upside Biotechnologies Ltd Cell Culture Medium
GB201715928D0 (en) 2017-09-30 2017-11-15 Auckland Uniservices Ltd Method
KR20200109298A (ko) 2017-10-30 2020-09-22 케모센트릭스, 인크. 면역조절제로서의 중수소화된 화합물
WO2019099457A1 (en) 2017-11-14 2019-05-23 Quixgen, Inc. Benzodioxinone compounds
HRP20241643T1 (hr) 2017-12-06 2025-02-14 Basf As Derivati masnih kiselina za liječenje nealkoholnog steatohepatitisa
MX2020006460A (es) 2017-12-22 2020-11-06 Chemocentryx Inc Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar.
ES2980175T3 (es) 2017-12-22 2024-09-30 Chemocentryx Inc Compuestos anulares fusionados en 6,5 sustituidos con diarilo como inhibidores de C5aR
WO2019195159A1 (en) 2018-04-02 2019-10-10 Chemocentryx, Inc. PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
US20190328721A1 (en) 2018-04-25 2019-10-31 Korea Institute Of Science And Technology Method of activating dendritic cells
CN110200972A (zh) 2019-05-10 2019-09-06 南京市儿童医院 Kd025在制备防治慢性肾纤维化的药物中的用途
EP4003340A4 (en) 2019-07-22 2023-09-27 Angion Biomedica Corp. ETHYNYL HETEROCYCLES AS RHO-ASSOCIATED BISPIRAL KINASE (ROCK) INHIBITORS
CA3189725A1 (en) 2020-07-21 2022-01-27 Angion Biomedica Corp. Inhibitors of rho-associated coiled-coil kinase

Also Published As

Publication number Publication date
IL272939A (en) 2020-04-30
CN111406051A (zh) 2020-07-10
JP2020532551A (ja) 2020-11-12
EP3676262A1 (en) 2020-07-08
AU2018326785A1 (en) 2020-04-09
WO2019046795A1 (en) 2019-03-07
US11542256B2 (en) 2023-01-03
AU2018326785B2 (en) 2023-03-02
EP3676262A4 (en) 2021-03-31
US20200231576A1 (en) 2020-07-23

Similar Documents

Publication Publication Date Title
US11542256B2 (en) Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors
US11504359B2 (en) Antifibrotic compounds and uses thereof
US8513433B2 (en) Small molecule inhibitors of PARP activity
WO2010088000A2 (en) Antifibrotic compounds and uses thereof
AU2003301224C1 (en) Pyrazole derivatives modulators of Hepatocyte Growth Factor (Scatter Factor) activity
AU2003301224B2 (en) Pyrazole derivatives modulators of Hepatocyte Growth Factor (Scatter Factor) activity
CA2767331A1 (en) Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
US11434234B2 (en) Methods and agents for treating disease
US20220281841A1 (en) Ethynylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors
US20230295131A1 (en) Inhibitors of rho-associated coiled-coil kinase
US9597321B2 (en) Antifibrotic compounds and uses thereof
HK40021008A (en) Anti-fibrotic compounds and uses thereof