CN111393376B - 一种2-氯嘧啶-4-甲酸的合成方法 - Google Patents
一种2-氯嘧啶-4-甲酸的合成方法 Download PDFInfo
- Publication number
- CN111393376B CN111393376B CN202010391225.XA CN202010391225A CN111393376B CN 111393376 B CN111393376 B CN 111393376B CN 202010391225 A CN202010391225 A CN 202010391225A CN 111393376 B CN111393376 B CN 111393376B
- Authority
- CN
- China
- Prior art keywords
- chloropyrimidine
- nickel
- diphenylphosphino
- bis
- formic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010391225.XA CN111393376B (zh) | 2020-05-11 | 2020-05-11 | 一种2-氯嘧啶-4-甲酸的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010391225.XA CN111393376B (zh) | 2020-05-11 | 2020-05-11 | 一种2-氯嘧啶-4-甲酸的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111393376A CN111393376A (zh) | 2020-07-10 |
CN111393376B true CN111393376B (zh) | 2022-05-13 |
Family
ID=71426812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010391225.XA Active CN111393376B (zh) | 2020-05-11 | 2020-05-11 | 一种2-氯嘧啶-4-甲酸的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111393376B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591853A (en) * | 1992-01-24 | 1997-01-07 | Lonza Ltd. | Products of a microbiological process for the production of 2-halo-pyrimidine-4-carboxylic acids |
WO2008016643A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
CN102093149A (zh) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | 一种促进氰基快速水解制备羧酸类化合物的方法 |
CN102227425A (zh) * | 2008-09-26 | 2011-10-26 | 贝林格尔·英格海姆国际有限公司 | 作为ccr1受体拮抗剂的氮杂吲唑化合物 |
CN106083734A (zh) * | 2016-07-28 | 2016-11-09 | 安徽赛迪生物科技有限公司 | 一种制备2‑氯嘧啶‑4甲酸的方法 |
CN110642789A (zh) * | 2019-11-25 | 2020-01-03 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
-
2020
- 2020-05-11 CN CN202010391225.XA patent/CN111393376B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591853A (en) * | 1992-01-24 | 1997-01-07 | Lonza Ltd. | Products of a microbiological process for the production of 2-halo-pyrimidine-4-carboxylic acids |
WO2008016643A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
CN102227425A (zh) * | 2008-09-26 | 2011-10-26 | 贝林格尔·英格海姆国际有限公司 | 作为ccr1受体拮抗剂的氮杂吲唑化合物 |
CN102093149A (zh) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | 一种促进氰基快速水解制备羧酸类化合物的方法 |
CN106083734A (zh) * | 2016-07-28 | 2016-11-09 | 安徽赛迪生物科技有限公司 | 一种制备2‑氯嘧啶‑4甲酸的方法 |
CN110642789A (zh) * | 2019-11-25 | 2020-01-03 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
Non-Patent Citations (2)
Title |
---|
Rapid, Easy Cyanation of Aryl Bromides and Chlorides Using Nickel Salts in Conjunction with Microwave Promotion;Riina K. Arvela等;《Journal of Organic Chemistry》;20031014;第68卷(第23期);9122-9125 * |
过渡金属催化的氰化反应以及芳基化反应研究;张广友;《温州大学硕士学位论文》;20130415;8-12 * |
Also Published As
Publication number | Publication date |
---|---|
CN111393376A (zh) | 2020-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5752256B2 (ja) | 2−メトキシメチル−1,4−ベンゼンジアミンの製造方法 | |
CN102639486B (zh) | 生产n-酰基联苯基丙氨酸的方法 | |
JP2021527703A (ja) | ブリバラセタム中間体、その製造方法及びブリバラセタムの製造方法 | |
CN111763170B (zh) | 氟马替尼中间体的制备方法 | |
JP5791825B2 (ja) | 1−(2−フルオロベンジル)−1H−ピラゾロ[3,4−b]ピリジン−3−ホルムアミジン塩酸塩の合成方法 | |
CN104860923B (zh) | 富马酸沃诺拉赞的制备方法 | |
CN111393376B (zh) | 一种2-氯嘧啶-4-甲酸的合成方法 | |
CN102351790B (zh) | 7-溴-6-氯-4(3h)-喹诺酮的合成方法 | |
CN102659629B (zh) | 化合物及其在制备埃罗替尼中的用途 | |
CN104311540B (zh) | 一种右旋雷贝拉唑钠的合成方法 | |
CN107118215B (zh) | 一种治疗乳腺癌药物瑞博西尼中间体的制备方法 | |
CN107188875B (zh) | 一种取代苯酞类化合物的制备方法及其中间体 | |
CN113336764B (zh) | 一类具有轴手性的联吡啶类配体及其合成方法 | |
CN104529815B (zh) | 合成2,4-二硝基苯氧胺的方法 | |
CN102584695B (zh) | 一种5-甲基烟酸的制备方法 | |
CN113603636A (zh) | 一种Sotorasib中间体的制备方法 | |
CN104326927B (zh) | 一种1-[2-氨基-1-(4-甲氧基苯基)乙基]环己醇硫酸盐的制备方法 | |
CN107011347A (zh) | 一种4‑氯‑7H‑吡咯并[2,3‑d]嘧啶的合成方法 | |
CN103304435B (zh) | 高稳定性高铁螯合能力的螯合剂及其制备方法 | |
CN104672180A (zh) | 一种[(1s)-3-甲基-1-[[(2r)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯的手性制备方法 | |
CN104876861A (zh) | 一种生产2-氯烟酸的方法 | |
CN107827844A (zh) | 一种合成丁内酯衍生物的方法 | |
CN103086962A (zh) | 5-氯-2,4-二羟基吡啶的合成方法 | |
CN109293597B (zh) | 一种非布索坦的制备方法 | |
CN103214380B (zh) | 间羟基-n,n-二乙基苯胺的合成方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 233200 Salt Chemical Industrial Park, Dingyuan County, Chuzhou City, Anhui Province Patentee after: Anhui saidI Biotechnology Co.,Ltd. Address before: 233200 Salt Chemical Industrial Park, Dingyuan County, Chuzhou City, Anhui Province Patentee before: ANHUI SAIDI BIOLOGICAL TECHNOLOGY CO.,LTD. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A synthetic method of 2-chloropyrimidine-4-carboxylic acid Effective date of registration: 20220718 Granted publication date: 20220513 Pledgee: Chuzhou Puhui Financing Guarantee Co.,Ltd. Pledgor: Anhui saidI Biotechnology Co.,Ltd. Registration number: Y2022980010619 |
|
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 233200 Dingyuan Salt Chemical Industrial Park, Chuzhou City, Anhui Province Patentee after: Anhui Peicheng Pharmaceutical Technology Co.,Ltd. Address before: 233200 Salt Chemical Industrial Park, Dingyuan County, Chuzhou City, Anhui Province Patentee before: Anhui saidI Biotechnology Co.,Ltd. |