CN111388541A

CN111388541A - Traditional Chinese medicine composition for acne scars and application thereof

Info

Publication number: CN111388541A
Application number: CN202010314837.9A
Authority: CN
Inventors: 何永超
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-20
Filing date: 2020-04-20
Publication date: 2020-07-10

Abstract

The invention discloses a traditional Chinese medicine composition for treating acne scars, which comprises the following raw materials: 3-15 parts of rheum officinale, 3-10 parts of scutellaria baicalensis, 6-15 parts of fructus forsythiae, 10-15 parts of salvia miltiorrhiza, 3-6 parts of gallnut and 3-10 parts of liquorice. The traditional Chinese medicine composition has the effects of removing blood stasis, eliminating dampness, detoxifying and resolving masses, and is suitable for acne scars caused by damp-heat stasis. The traditional Chinese medicine composition can effectively inhibit the generation of acne scars, has no obvious adverse reaction, and has higher clinical value.

Description

Traditional Chinese medicine composition for acne scars and application thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating acne scars.

Background

Acne is a chronic inflammatory skin disease of hair follicle sebaceous glands, which is better to males and females in adolescence, and the incidence rate of the acne is 8.1 percent according to Chinese population section statistics. However, researches find that more than 95% of people have acnes with different degrees, and 3% -7% of acnes leave scars, which bring great influence on physical and mental health of patients.

In addition, epidemiological studies show that the incidence rate of acne scars in common people is about 1-11%, wherein the incidence rate of patients with mild acne is 26.7%, the incidence rate of patients with moderate acne is 51.3%, and the incidence rate of patients with severe acne is 76.7%, which indicates that the incidence rate of acne scars is positively correlated with the severity of acne, and the incidence rate of acne scars is also correlated with factors such as the recurrence condition of acne. Early prevention is one of the important measures to effectively inhibit acne scarring.

Modern medicine considers that acne scars are formed because anabolism of collagen in the dermis layer is continuously carried out for a long time in the skin injury self-repairing process, the anabolism exceeds the catabolism speed, a large amount of collagen fibers are formed in a long time, or the collagen fibers and the elastic fibers are damaged in the inflammation resolution process, so that the dermis is atrophied. The principle of western medicine treatment is mainly based on the inhibition of collagen fiber formation or the inhibition of dermal atrophy.

Research shows that the Propionibacterium acnes can reduce dermal collagen fibers and further cause scar generation by changing the expression of key genes related to cell proliferation, cytoskeleton formation and cell metabolism in cells, and the transforming growth factors mainly have the functions of regulating cell growth, differentiation, migration and apoptosis and generating various extracellular matrixes including collagen, elastin and fibrin, and the expression of TGF- β is up-regulated in the scar formation process.

The traditional Chinese medicine considers that acne is caused by toxic heat, blood stasis and blood vessel obstruction due to overeating fat and sweet food, dampness and heat transformation assisting, dampness and heat mutual combination, or spleen and stomach injury, dampness generation and phlegm assisting, blood component accumulation for a long time, and skin stagnation due to damp heat and phlegm mutual combination. When acne is squeezed or damaged, stagnation of qi and blood stasis is easily caused, and damp and hot are combined to form the primary stage of acne scars; after qi stagnation and blood stasis, the tendon and vessel tissues of the scar lose the nourishment of qi and blood, so that the deficiency of qi and yin and the blood dryness and spasm of the tendons are caused, and the acne scar is further aggravated. Therefore, the therapeutic principles of removing blood stasis, eliminating dampness, detoxifying and resolving masses are mostly adopted in the early stage of acne scar formation.

The prior patent technology (No. CN103623152B) discloses a pharmaceutical composition for removing acnes, acne marks and acne scars, which comprises 5 Chinese medicinal raw materials such as cordyceps sinensis and the like, and also comprises 4 chemical raw materials, namely tetracycline, chlorpheniramine and metronidazole. According to the current registration or record management method of medicines and cosmetics, the products are difficult to be converted into products for preventing and treating acne scars. In addition, the prior patent technology (application number CN107375437A) discloses an acne-removing traditional Chinese medicine composition, which comprises centella extract, scutellaria extract, vitamin E, clove oil, liquorice extract, sophora flavescens extract, hydrolyzed pearl and borneol, has the effects of clearing heat, promoting diuresis, detoxifying and reducing swelling, and is used for treating acne and pigmentation after acne and resisting acne scar hyperplasia. But is different from the composition (comprising the traditional Chinese medicine raw materials of rhubarb, scutellaria, forsythia, salvia, gallnut and liquorice) and the efficacy (removing blood stasis and dampness, and detoxifying and resolving hard mass).

At present, the prevention and treatment measures aiming at the acne scar mainly comprise laser, radio frequency and medicines (asiaticoside, tretinoin and the like), the laser and the radio frequency are effective means for treating the acne scar, but individual curative effect difference exists, the condition of the acne scar is aggravated due to infection, and the treatment cost price is higher; asiaticoside, tretinoin and other medicines belong to treatment medicines for acne scars, and particularly, tretinoin and other medicines have large adverse reactions. Therefore, for acne scars, products which can be used for early preventive medication to block or inhibit the generation of acne scars and have high safety are urgently needed.

Disclosure of Invention

The invention provides a traditional Chinese medicine composition for early prevention of acne scars, aiming at solving the technical problems.

The purpose of the invention is realized by the following technical scheme:

a traditional Chinese medicine composition for acne scars comprises the following traditional Chinese medicine raw materials in parts by weight: 3-15 parts of rheum officinale, 3-10 parts of scutellaria baicalensis, 6-15 parts of fructus forsythiae, 10-15 parts of salvia miltiorrhiza, 3-6 parts of gallnut and 3-10 parts of liquorice.

The traditional Chinese medicine composition can also be added with one or more of the following traditional Chinese medicine raw materials in parts by weight: 15-30 parts of centella, 9-12 parts of honeysuckle and 6-12 parts of red peony root.

Preferably, the traditional Chinese medicine composition for treating acne scars is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 15 parts of rhubarb, 10 parts of scutellaria baicalensis, 10 parts of fructus forsythiae, 15 parts of centella asiatica, 10 parts of salvia miltiorrhiza, 6 parts of gallnut and 6 parts of liquorice.

Preferably, the traditional Chinese medicine composition for treating acne scars is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 12 parts of rhubarb, 12 parts of scutellaria baicalensis, 10 parts of fructus forsythiae, 20 parts of centella asiatica, 15 parts of salvia miltiorrhiza, 5 parts of gallnut, 9 parts of liquorice and 12 parts of honeysuckle.

Preferably, the traditional Chinese medicine composition for treating acne scars is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 15 parts of rheum officinale, 10 parts of scutellaria baicalensis, 15 parts of fructus forsythiae, 15 parts of centella asiatica, 10 parts of salvia miltiorrhiza, 6 parts of gallnut, 6 parts of liquorice, 12 parts of honeysuckle and 10 parts of red paeony root.

The raw material medicines in the traditional Chinese medicine composition can comprise one or more of the following processed products: the radix et rhizoma Rhei is wine radix et rhizoma Rhei and processed radix et rhizoma Rhei, Scutellariae radix is wine Scutellariae radix, and Saviae Miltiorrhizae radix is wine Saviae Miltiorrhizae radix.

The raw materials of the traditional Chinese medicine composition can comprise one or more of the following extracts: the rhubarb is a rhubarb extract, and each 1 part by weight of the rhubarb extract is equivalent to 4 to 8 parts by weight of the rhubarb; the scutellaria baicalensis is a scutellaria baicalensis extract, and each 1 part by weight of the scutellaria baicalensis extract is equivalent to 2-4 parts by weight of the scutellaria baicalensis; the fructus forsythiae is fructus forsythiae extract, and each 1 part by weight of fructus forsythiae extract is equivalent to 2-8 parts by weight of fructus forsythiae; the centella is a centella extract, and each 1 part by weight of the centella extract is equivalent to 2-4 parts by weight of the centella; the salvia miltiorrhiza is a salvia miltiorrhiza extract, and each 1 part by weight of the salvia miltiorrhiza extract is equivalent to 2-4 parts by weight of the salvia miltiorrhiza; the gallnut is a gallnut extract, and each 1 part by weight of the gallnut extract is equivalent to 3.5-6.5 parts by weight of the gallnut; the liquorice is a liquorice extract, and each 1 part by weight of the liquorice extract is equivalent to 3-5 parts by weight of the liquorice; the honeysuckle is a honeysuckle extract, and each 1 part by weight of the honeysuckle extract is equivalent to 3-4 parts by weight of the honeysuckle; the red peony root is a red peony root extract, and each 1 part by weight of the red peony root extract is equivalent to 3.5-6 parts by weight of the red peony root. The extracts of different traditional Chinese medicine raw materials comprise water extracts prepared by taking water as a solvent and also comprise alcohol extracts prepared by taking 50-80% ethanol as a solvent.

The source and the efficacy characteristics of the traditional Chinese medicine raw materials in the composition are as follows:

the rhubarb is the dry root and rhizome of Rheum palmatum Pa matum L, Rheum tanguticum Maxim ex Balf. or Rheum officinale Baill. of Polygonaceae, the nature and taste of the root and rhizome are bitter, cold, spleen, stomach, large intestine, liver and pericardium channels, the functions and main functions are purgation and accumulation, heat clearing and fire purging, blood cooling and detoxification, stasis dispelling and meridian dredging, dampness removing and jaundice abating, excess heat accumulation and stagnation, blood heat hematemesis and epistaxis constipation, conjunctival congestion and swelling, carbuncle and furuncle, intestinal abdominal pain, blood stasis and amenorrhea, postpartum stasis obstruction, traumatic injury, damp heat burn and scald, jaundice and urine red, stranguria and edema, the rhubarb is externally used for clearing heat and heat toxin in upper jiao blood, and swelling of eyes, swollen gum, moderate diarrhea and fire and detoxification, and fire toxin for fire toxin sores.

The Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae. The property and flavor of meridian tropism are bitter and cold. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. The main functions and indications are clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Fructus forsythiae is dried fruit of Vahl, Forsythia subspensa (Thunb.) of Oleaceae. The nature, flavor and meridian tropism are bitter and slightly cold. It enters lung, heart and small intestine meridians. The functions and main indications are clearing away heat and toxic material, reducing swelling and resolving masses and dispelling wind and heat. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early stage epidemic febrile disease, fever, polydipsia, coma, macula, and stranguria caused by heat.

Centella asiatica is a dry whole herb of Centella asiatica (L.) urban Urb, belonging to the family Umbelliferae, and the properties, tastes and channels are bitter, pungent and cold, and the channels of liver, spleen and kidney are involved.

The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia milirhizorrhiza bge. The nature, flavor and meridian tropism are bitter and slightly cold. It enters heart and liver meridians. The functions and main indications are activating blood and dissolving stasis, stimulating the menstrual flow and relieving pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Gallnut is insect gall on leaves of Rhus chinensis Mill, Rhus potaniniiMaxim, Rhus chinensis or Rhus chinensis punjabensis Stew.var.sinica (Diels) Rehd.et Wils. mainly formed by parasitizing the gall aphid Melaphosis chinensis (Bell) Baker. The nature, flavor and meridian tropism are sour, astringent and cold. It enters lung, large intestine and kidney meridians. The actions and indications are astringing lung to reduce fire, astringing intestine to check diarrhea, astringing sweat, stopping bleeding, astringing dampness and healing wound. Can be used for treating chronic cough due to lung deficiency, chronic diarrhea, spontaneous perspiration, night sweat, diabetes, hemafecia, hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, sore, and skin ulcer.

The licorice is dry root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae, and the nature and taste and the channel tropism are sweet, flat, heart, lung, spleen and stomach channels.

Dried flower bud or flower with initial blossom of honeysuckle L, honeysuckle flower and honeysuckle flower of Caprifoliaceae family, nature and taste and meridian tropism are sweet, cold, and the meridian tropism and meridian tropism are lung, heart and stomach.

The red peony root is the dry root of Paeonia lactiflora Pal L or Paeonia veitchii L ynch of Ranunculaceae, the nature and taste and the channel tropism are bitter, the liver channel tropism is slightly cold, the functions and main functions are clearing heat and cooling blood, dissipating blood stasis and relieving pain, and the red blood, the warm toxin and the macula, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrheal, abdominal mass and pain, traumatic injury, carbuncle and sore and ulcer.

The traditional Chinese medicine composition has the effects of removing blood stasis, eliminating dampness, detoxifying and resolving masses. Is suitable for acne scar caused by damp-heat stasis. Rhubarb, radix et rhizoma Rhei, as a monarch drug, has the effects of promoting blood circulation, removing blood stasis, clearing heat, drying dampness and removing toxicity. The radix scutellariae, the fructus forsythiae, the centella, the honeysuckle and the gallnut have the functions of clearing heat and drying dampness, astringing dampness and detoxifying, and assist the monarch drug rhubarb to clear heat, dry dampness and detoxify, the radix salviae miltiorrhizae and the red paeony root have the functions of cooling blood, promoting blood circulation and removing obstruction in channels, and assist the monarch drug rhubarb to promote blood circulation and remove blood stasis, and the seven drugs are. The liquorice is used as a harmonizing medicine and an adjuvant and guiding medicine.

The composition extract is added with proper auxiliary materials required by preparations to prepare medicines or cosmetics, and the preparation forms are granules, capsules, mixtures, tablets, powder, cream, gels, mistura and cream. For example, the composition is added with 6 to 8 times of water or 50 to 80 percent ethanol for extraction twice, each time lasts for 1 to 2 hours, and then the mixture is filtered and concentrated under reduced pressure (the temperature is below 80 ℃, and the vacuum degree is between-0.04 MPa and-0.08 MPa) to prepare dry extract or thick extract; adding starch or dextrin or lactose into the dry extract or the thick extract, and preparing into granules in accordance with pharmacopoeia rules by dry granulation; or adding appropriate amount of water into carbomer 940 and glycerol to make them fully swell, adding triethanolamine and sorbitol, stirring, adding dry extract or soft extract, stirring, and making into gel according with pharmacopoeia.

The invention has the advantages and beneficial effects that:

1. the traditional Chinese medicine composition provided by the invention conforms to the traditional Chinese medicine theory, and has reasonable compatibility and refined formula, and the damp-heat stasis evil formula surrounds acne scars. The raw materials of the composition are all from natural plants, contain no hormone or chemical components, and have no adverse reaction after long-term use.

2. The traditional Chinese medicine composition can effectively block or inhibit the production of acne scars by early prophylactic administration, and avoids the phenomenon that the psychological burden of a patient affects social contact because scars are left due to improper treatment methods; compared with physical treatment methods such as laser radio frequency and the like, the treatment period is shortened, the medical expense of the patient is reduced, and the economic burden of the patient is reduced.

Detailed Description

The following detailed description of the invention, taken in conjunction with specific examples, will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit and scope of the invention.

Example 1: 15 parts of rhubarb, 10 parts of scutellaria baicalensis, 15 parts of fructus forsythiae, 15 parts of salvia miltiorrhiza, 6 parts of gallnut and 10 parts of liquorice.

Example 2: 15 parts of rhubarb, 10 parts of scutellaria baicalensis, 10 parts of fructus forsythiae, 15 parts of centella asiatica, 10 parts of salvia miltiorrhiza, 6 parts of gallnut and 6 parts of liquorice.

Example 3: 10 parts of wine-processed rhubarb, 10 parts of wine-processed scutellaria baicalensis, 10 parts of fructus forsythiae, 15 parts of centella asiatica, 10 parts of wine-processed salvia miltiorrhiza, 6 parts of gallnut, 6 parts of liquorice and 10 parts of honeysuckle.

Example 4: 12 parts of rhubarb, 12 parts of scutellaria baicalensis, 10 parts of fructus forsythiae, 20 parts of centella asiatica, 15 parts of salvia miltiorrhiza, 5 parts of gallnut, 9 parts of liquorice and 12 parts of honeysuckle.

Example 5: 15 parts of cooked rhubarb, 10 parts of scutellaria baicalensis, 15 parts of fructus forsythiae, 15 parts of centella asiatica, 10 parts of salvia miltiorrhiza, 6 parts of gallnut, 6 parts of liquorice, 12 parts of honeysuckle and 10 parts of red paeony root.

The traditional Chinese medicine composition of the embodiment 1 is prepared by weighing the raw materials according to the compatibility proportion of the traditional Chinese medicine composition, adding water for extraction twice, adding 8 times of water for extraction for 1.5 hours for the first time, adding 6 times of water for extraction for 1 hour for the second time, filtering, and concentrating under reduced pressure to obtain an extract with the relative density of 1.25(60 ℃); adding appropriate amount of purified water into carbomer 940 and glycerol to make them fully swell, adding triethanolamine and sorbitol under stirring, adding the above extract, and stirring.

The clinical study of the Chinese medicinal composition for treating acne scars is as follows.

1. General conditions

The patients with moderate and severe facial acne are selected from 40 cases, wherein the age of the patients is between 15 and 34 years, the average age is 26 years, and the course of the disease is between 6 months and 3 years in 26 cases of moderate males and 14 cases of females.

2. Inclusion criteria

(1) Judging whether the nature of the acne lesions belongs to moderate (pustule) and severe (nodule and cyst) according to Chinese acne treatment guidelines (2019 revised edition);

(2) the age is 15-36 years old;

(3) all patients were asked to take no antibiotics or other acne-treating drugs 4 weeks prior to administration, while the oral and topical medications for treating acne and acne scars were discontinued;

(4) the patient voluntarily takes the medicine.

3. Exclusion criteria

(1) Patients with keloid disease constitution and serious liver and kidney insufficiency;

(2) pregnant and lactating women;

(3) patients who have been exposed to sunlight;

(4) patients who cannot insist on medication or cannot follow up on time;

(5) patients with a history of pigmentation abnormalities.

4. Method of treatment

The facial skin with acne is cleaned, the gel prepared from the traditional Chinese medicine composition is uniformly applied to the surface of the acne, the acne is gently massaged for 1-2 min, the dosage is determined according to the area of the acne, the gel is applied for 1 time in the morning and at night every day, 4 weeks are 1 treatment course, the curative effect is evaluated at the end of each treatment course, and the maximum treatment course is 4 treatment courses.

5. The therapeutic effect evaluation index is determined according to data before and after the course of treatment and patient self-evaluation. And (3) healing: the skin lesions are faded by more than 80 percent, the itch and the tightening feeling are avoided, the hardness, the elasticity and the color are basically consistent with those of the surrounding skin, the new skin is flat, and the patient is satisfied; the effect is shown: 60% -80% of skin damage is repaired, itch and tightening feeling are basically absent, hardness, elasticity and color are close to those of surrounding skin, the new skin is relatively flat, and patients are satisfied; and (4) invalidation: the skin damage is reduced or subsided by less than 60 percent, the skin has itching and tightening feeling, the hardness, the elasticity and the color are obviously different from those of the surrounding skin, the new skin is uneven, and the patient is not satisfied. The total effective rate is recovery + obvious effect.

6. The results of the study on the curative effect results are shown in table 1, 25 patients (62.5%) are cured in 40 patients, 14 patients (35%) are effective, 1 patient (2.5%) is ineffective, and the total effective rate is 97.5%.

TABLE 140 the results of different patients after different courses of treatment

7. After 40 patients are treated by different courses of treatment (treatment period: 4 courses at most, 4 weeks in each course), no obvious adverse reactions such as skin irritation, skin discomfort burning, dryness, scaling, redness and swelling and the like are observed.

Claims

1. A traditional Chinese medicine composition for acne scars is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 3-15 parts of rheum officinale, 3-10 parts of scutellaria baicalensis, 6-15 parts of fructus forsythiae, 10-15 parts of salvia miltiorrhiza, 3-6 parts of gallnut and 3-10 parts of liquorice.

2. The traditional Chinese medicine composition according to claim 1, wherein one or more of the following traditional Chinese medicine raw materials in parts by weight can be added into the traditional Chinese medicine composition: 15-30 parts of centella, 9-12 parts of honeysuckle and 6-12 parts of red peony root.

3. The traditional Chinese medicine composition according to claims 1 to 2, wherein the traditional Chinese medicine raw materials may comprise one or more of the following processed products: the radix et rhizoma Rhei is wine radix et rhizoma Rhei and processed radix et rhizoma Rhei, Scutellariae radix is wine Scutellariae radix, and Saviae Miltiorrhizae radix is wine Saviae Miltiorrhizae radix.

4. The composition as claimed in claims 1 to 3, wherein the Chinese herbal materials may comprise one or more of the following extracts: the rhubarb is a rhubarb extract, and each 1 part by weight of the rhubarb extract is equivalent to 4 to 8 parts by weight of the rhubarb; the scutellaria baicalensis is a scutellaria baicalensis extract, and each 1 part by weight of the scutellaria baicalensis extract is equivalent to 2-4 parts by weight of the scutellaria baicalensis; the fructus forsythiae is fructus forsythiae extract, and each 1 part by weight of fructus forsythiae extract is equivalent to 2-8 parts by weight of fructus forsythiae; the centella is a centella extract, and each 1 part by weight of the centella extract is equivalent to 2-4 parts by weight of the centella; the salvia miltiorrhiza is a salvia miltiorrhiza extract, and each 1 part by weight of the salvia miltiorrhiza extract is equivalent to 2-4 parts by weight of the salvia miltiorrhiza; the gallnut is a gallnut extract, and each 1 part by weight of the gallnut extract is equivalent to 3.5-6.5 parts by weight of the gallnut; the liquorice is a liquorice extract, and each 1 part by weight of the liquorice extract is equivalent to 3-5 parts by weight of the liquorice; the honeysuckle is a honeysuckle extract, and each 1 part by weight of the honeysuckle extract is equivalent to 3-4 parts by weight of the honeysuckle; the red peony root is a red peony root extract, and each 1 part by weight of the red peony root extract is equivalent to 3.5-6 parts by weight of the red peony root. The extracts of different traditional Chinese medicine raw materials comprise water extracts prepared by taking water as a solvent and alcohol extracts prepared by taking 50-80% ethanol as a solvent.

5. The traditional Chinese medicine composition according to any one of claims 1 to 4, wherein the composition is prepared into a medicine or a cosmetic by adding proper auxiliary materials required by the preparation, and the dosage form is granules, capsules, mixtures, tablets, powder, cream, gels, mistura and creams.