CN1485058A - Psoriasis-treating composition - Google Patents
Psoriasis-treating composition Download PDFInfo
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- CN1485058A CN1485058A CNA021309663A CN02130966A CN1485058A CN 1485058 A CN1485058 A CN 1485058A CN A021309663 A CNA021309663 A CN A021309663A CN 02130966 A CN02130966 A CN 02130966A CN 1485058 A CN1485058 A CN 1485058A
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Abstract
The invention relates to a composition for treating psoriasis, comprising essentially cicada skin, dittany bark, root bark of tree peony, honeysuckle flower, capsule of weeping forsythia, white peony root, licorice root, ledebouriella root, dahurian angelica root, notopterygium root, grassleaved sweetflag rhizome, rhizoma zedoariae, salvia miltiorrhizae and scrophularia root.
Description
Technical field
The present invention relates to the psoriatic Chinese medicine composition of a kind of treatment.
Background technology
Psoriasis is a kind of chronic inflammatory disease dermatoses that occurs silvery white dry squama on the erythema of disease damage position repeatedly, and the cause of disease is not bright, thinks at present, is the disease that many-sided factor interactions such as inherited genetic factors and environmental factors cause, belongs to immune-mediated disease.According to change of illness state, primary disease can be divided into homeliness type, pustule type, joint type, four kinds of common types of erythrodermic.Men and women, old and young all can fall ill, and state of an illness weight is normal relevant with season.The state of an illness is obstinate to be difficult for healing, and more easily recurrence of back.At present doctor trained in Western medicine often adopts vitamins, antibiotics, antitumor class, heavy metal class, immunomodulator or agonist, acts on oral medicine such as neural medicine and hormone, cutin form medicine for external use such as agent, cellulotoxic preparation, and often cooperates method synthesis treatment primary disease such as ultraviolet radiation, photochemical method.But clinical practice proves that described medicine and therapy regular meeting produce toxic and side effects, and many contraindications are arranged.
The traditional Chinese medical science thinks that the pathogenesis of primary disease mainly shows as types such as heat in blood, blood stasis, blood deficiency, at pathogenesis, can adopt the comprehensive function of clearing away heat and cooling blood, nourishing the blood and yin, dampness toxin expelling, blood circulation promoting and blood stasis dispelling, dispelling wind for relieving itching, it is reliable to have curative effect, but prolonged application, advantage such as relapse rate is low, side effect is little.
Summary of the invention
The application's purpose just provides the psoriatic Chinese medicine composition of a kind of treatment, proves that through clinical practice the erythra that can disappear effectively alleviates skin lesion, eliminates the pruritus symptom.
The base stock of compositions of the present invention is composed as follows:
Periostracum Cicadae, Cortex Dictamni, Cortex Moutan, Flos Lonicerae, Fructus Forsythiae, the Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, big linum, Rhizoma Acori Graminei, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Radix Scrophulariae
In we, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Dahuricae dispersing wind-cold; Periostracum Cicadae is dispersed wind heat, Cortex Moutan, Flos Lonicerae, Fructus Forsythiae, Cortex Dictamni heat clearing away, removing heat from blood, detoxifcation, and Rhizoma Acori Graminei removing dampness toxin expelling, Radix Salviae Miltiorrhizae, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, is moisturized the Radix Paeoniae Alba, Radix Scrophulariae, Radix Glycyrrhizae nourishing YIN and benefiting blood, and treat psoriasis from many aspects full side.Wherein the Radix Paeoniae Alba has regulating action to cellular immunization, humoral immunization and the cytophagy of body.And inflammatory edema and matter agent arthritis had therapeutical effect, also have analgesia, cooling effect.The Radix Paeoniae Alba is the significant curative effect of a key factor this compositions produces to(for) psoriasis at the synergism of Quan Fangzhong.
By weight, each proportion of raw materials is: Periostracum Cicadae 20-40, Cortex Dictamni 25-30, Cortex Moutan 15-20, Flos Lonicerae 20-30, Fructus Forsythiae 20-40, Radix Paeoniae Alba 20-40, Radix Glycyrrhizae 15-20, Radix Saposhnikoviae 15-20, Radix Angelicae Dahuricae 15-20, Rhizoma Et Radix Notopterygii 15-20, big linum 20-30, Rhizoma Acori Graminei 20-30, Rhizoma Curcumae 15-20, Radix Salviae Miltiorrhizae 20-30, Radix Scrophulariae 20-30
By weight, the optimum ratio of each raw material is: Periostracum Cicadae 30, Cortex Dictamni 30, Cortex Moutan 20, Flos Lonicerae 30, Fructus Forsythiae 30, the Radix Paeoniae Alba 40, Radix Glycyrrhizae 20, Radix Saposhnikoviae 20, the Radix Angelicae Dahuricae 20, Rhizoma Et Radix Notopterygii 15, big linum 30, Rhizoma Acori Graminei 20, Rhizoma Curcumae 20, Radix Salviae Miltiorrhizae 30, Radix Scrophulariae 20
More than be the square substantially of this compositions, add the flavour of a drug of blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, effect such as nourshing Yin and drynsessmoistening prescription on this basis, can strengthen the effect of this compositions, also within the protection domain of this patent.For example, can also add Radix Angelicae Sinensis, Herba Violae, Radix Sophorae Flavescentis etc.
The preparation of compositions method is: after each flavor Chinese medicine is pulverized, sieve with 120 mesh sieves, mix then, make mixed Chinese medicine ripening, sterilization with autoclave, earlier in 10 minutes, be warming up to 110 ℃ rapidly, and insulation 3-5 minute, be cooled to 108 ℃ and be incubated 3-5 minute then, be cooled to 105 ℃ again, be incubated 3-5 minute, be cooled to 100 ℃ and insulation at last, all ripenings, sterilization time is 10-30 minute.Sterilization back packing, every bag 10g.
The effective ingredient that the benefit of step type cooling sterilization is to keep medicine can kill different bacterium spores again.
This compositions also can be made the regular dosage form of pharmaceutics with conventional method, for example adopt the ethanol extraction of water or 50-95%, make soft extract, tablet or electuary according to a conventional method except that after desolvating, or extracting solution makes oral liquid after removing general impurity with water precipitating, precipitate with ethanol mode or stand at low temperature filter type or other usual manners, or incapsulates after the pulverizing medicinal materials.
Extraction described in the preparation method comprises merceration, hot dipping, percolation, reflux.
Clinical efficacy is summed up
One. physical data and Therapeutic Method powder of the present invention, observe the psoriasis vulgaris people in the Characteristic Professional Subjects of Union Hospital outpatient service of Fu Laer base, Qiqihar, be divided into treatment and organize 134 people, matched group 60 people, the treatment group is used powder of the present invention, 10-20g/ time, every day 3 times, taking medicine before meal; Matched group is taken VITAMIN C TABLET 0.2g at every turn, vitamin E soft gelatin capsule 100mg, 1 of vitamin AD soft gelatin capsule, every day 3 times.
Two. the diagnostic criteria skin surface has red pimple, maculopapule, boundary clear, on cover the silvery white squama of multilamellar, be stearic sample gloss after squama scraped off, be called stearic speckle or wax and drip phenomenon, there is shinny thin film to claim the thin film phenomenon under it, visible point-like bleeding behind the removal thin film, the skin lesion form can show as drop shape, coin shape, speckle shape, map shape etc.The skin lesion of different parts has different manifestations: the head skin lesion is that scalp covers thick bits, the hair fasciculation; Facial skin lesion is drop shape or seborrheic dermatitis sample, or is butterfly bluss; The shank skin lesion often is with purple, easily soaks into plumpness, like chronic eczema or neurodermatitis; Palm sole of the foot infringement is the point-like hyperkeratosis, on cover white squama or be well-defined desquamation infringement not of uniform size, normal companion chaps, and can show as dispersivity palm sole of the foot erythema keratinization sample sometimes.The small number of patients skin lesion has on a small quantity and oozes out, and the surface forms dirty brown squama crust.Small number of patients has mucosa infection, shows as the wellability patch of lark and white edge at the buccal mucosa place.
Three. curative effect determinate standard
Recovery from illness: erythra all disappears or only stays the small pieces skin lesion.
Produce effects: more than the deflorescence 50-80%.
Invalid: treatment back skin lesion is not seen and is improved or instead see deterioration.
Tracing study: cured 6 months to 1 year, and do not see that the recidivist was recovery from illness, have erythra person to be recurrence again.
Four. therapeutic outcome:
Cure routine number (%) | Produce effects example number (%) | Invalid routine number (%) | Recur routine number (%) | |
The treatment group | ??70(52.24) | ??64(47.73) | ??0(0) | ??23(17.13) |
Matched group | ??12(20.00) | ??39(65.00) | ??9(15.00) | ??29(48.33) |
The cure rate of two groups of cases and relapse rate are learned processing by statistics, and there is significant difference P>0.05.
Claims (6)
1. the psoriatic compositions of treatment is made by following raw materials in weight portion: Periostracum Cicadae 20-40, Cortex Dictamni 25-30, Cortex Moutan 15-20, Flos Lonicerae 20-30, Fructus Forsythiae 20-40, Radix Paeoniae Alba 20-40, Radix Glycyrrhizae 15-20, Radix Saposhnikoviae 15-20, Radix Angelicae Dahuricae 15-20, Rhizoma Et Radix Notopterygii 15-20, big linum 20-30, Rhizoma Acori Graminei 20-30, Rhizoma Curcumae 15-20, Radix Salviae Miltiorrhizae 20-30, Radix Scrophulariae 20-30 substantially.
2. compositions according to claim 1 is characterized in that the weight portion proportioning of described raw material is: Periostracum Cicadae 30, Cortex Dictamni 30, Cortex Moutan 20, Flos Lonicerae 30, Fructus Forsythiae 30, the Radix Paeoniae Alba 40, Radix Glycyrrhizae 20, Radix Saposhnikoviae 20, the Radix Angelicae Dahuricae 20, Rhizoma Et Radix Notopterygii 15, big linum 30, Rhizoma Acori Graminei 20, Rhizoma Curcumae 20, Radix Salviae Miltiorrhizae 30, Radix Scrophulariae 20.
3. compositions according to claim 1 and 2 is characterized in that it can being to be prepared into conventional dosage form for oral administration with conventional method.
4. preparation claim 1 or 2 described method for compositions is characterized in that may further comprise the steps: after each flavor raw material pulverizing, sieve with 120 mesh sieves, mix then, make mixed raw material ripening, sterilization with autoclave, in 10 minutes, be warming up to 110 ℃ rapidly earlier, and be incubated 3-5 minute, be cooled to 108 ℃ and be incubated 3-5 minute then, be cooled to 105 ℃ again, be incubated 3-5 minute, be cooled to 100 ℃ and insulation at last, all ripenings, sterilization time are sterilization back packing in 10-30 minute.
5. prepare claim 1 or 2 described method for compositions, it is characterized in that may further comprise the steps: with raw material with water or ethanol extraction, extracting solution is made oral liquid, soft extract after removing general impurity with water precipitating, precipitate with ethanol mode or stand at low temperature filter type or other usual manners.
6. according to the preparation method of claim 5, it is characterized in that: extracting solution is removed impurity or without the remove impurity process, is added conventional adjuvant and make electuary or tablet.
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CNB021309663A CN1267146C (en) | 2002-09-23 | 2002-09-23 | Psoriasis-treating composition |
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CNB021309663A CN1267146C (en) | 2002-09-23 | 2002-09-23 | Psoriasis-treating composition |
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CN1267146C CN1267146C (en) | 2006-08-02 |
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Cited By (7)
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US6921547B2 (en) * | 2003-09-04 | 2005-07-26 | Ren-Rong Chen | Externally applied medicine for baby's hernia |
CN100368004C (en) * | 2004-09-10 | 2008-02-13 | 申国宁 | Chinese medicinal composition for treating psoriasis, its preparation and quality control |
CN100394961C (en) * | 2005-12-29 | 2008-06-18 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal nutritive product for preventing and treating psoriasis and its manufacturing method |
CN100522137C (en) * | 2007-02-16 | 2009-08-05 | 遵义医学院附属医院 | Cream for treating psoriasis and its preparing process |
CN102228613A (en) * | 2011-05-31 | 2011-11-02 | 渠淑敏 | Chinese patent medicine for treating tinea capitis |
CN103272131A (en) * | 2012-07-07 | 2013-09-04 | 苗洁清 | Preparation method of mouth cleaning care medicine in perioperative period |
CN104940814A (en) * | 2015-06-10 | 2015-09-30 | 姜洁 | Composition for treating psoriasis and preparation method of composition |
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US8428086B2 (en) | 2006-01-05 | 2013-04-23 | Lg Electronics Inc. | Transmitting data in a mobile communication system |
KR101211807B1 (en) | 2006-01-05 | 2012-12-12 | 엘지전자 주식회사 | Method for managing synchronization state for mobile terminal in mobile communication system |
US8493854B2 (en) | 2006-02-07 | 2013-07-23 | Lg Electronics Inc. | Method for avoiding collision using identifier in mobile network |
KR101387475B1 (en) | 2006-03-22 | 2014-04-22 | 엘지전자 주식회사 | method of processing data in mobile communication system having a plurality of network entities |
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2002
- 2002-09-23 CN CNB021309663A patent/CN1267146C/en not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6921547B2 (en) * | 2003-09-04 | 2005-07-26 | Ren-Rong Chen | Externally applied medicine for baby's hernia |
CN100368004C (en) * | 2004-09-10 | 2008-02-13 | 申国宁 | Chinese medicinal composition for treating psoriasis, its preparation and quality control |
CN100394961C (en) * | 2005-12-29 | 2008-06-18 | 颜怀伟 | Medicine and food dual purpose Chinese medicinal nutritive product for preventing and treating psoriasis and its manufacturing method |
CN100522137C (en) * | 2007-02-16 | 2009-08-05 | 遵义医学院附属医院 | Cream for treating psoriasis and its preparing process |
CN102228613A (en) * | 2011-05-31 | 2011-11-02 | 渠淑敏 | Chinese patent medicine for treating tinea capitis |
CN102228613B (en) * | 2011-05-31 | 2012-11-14 | 渠淑敏 | Chinese patent medicine for treating tinea capitis |
CN103272131A (en) * | 2012-07-07 | 2013-09-04 | 苗洁清 | Preparation method of mouth cleaning care medicine in perioperative period |
CN104940814A (en) * | 2015-06-10 | 2015-09-30 | 姜洁 | Composition for treating psoriasis and preparation method of composition |
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