CN104940814A - Composition for treating psoriasis and preparation method of composition - Google Patents

Abstract

The invention discloses a composition for treating psoriasis. The composition comprises the following active pharmaceutical ingredients in parts by weight: 20-40 parts of cicada ecdysis, 25-30 parts of cortex dictamni, 15-20 parts of cortex moutan, 20-30 parts of honeysuckle, 20-40 parts of fructus forsythiae, 20-40 parts of radix paeoniae alba, 15-20 parts of liquorice, 15-20 parts of radix saposhnikoviae, 15-20 parts of angelica dahurica, 15-20 parts of notopterygium root, 20-30 parts of linseed, 20-30 parts of grassleaf sweelflag rhizome, 10-20 parts of angelica, 10-20 parts of phellodendron amurense, 15-20 parts of rhizoma curcumae, 20-30 parts of salvia miltiorrhiza and 20-30 parts of figwort. The invention further discloses a preparation method of the composition. The composition provided by the invention has the advantages of good in curative effect, little in toxic and side effect, and low in recurrence rate.

Description

One treats psoriatic composition and method of making the same

Technical field

The present invention relates to a kind of composition and method of making the same, particularly relate to one and treat psoriatic composition and method of making the same.

Background technology

Psoriasis is that a kind of chronic inflammatory skin of the dry squama of recurrent silvery white in lesion erythema is sick, and the cause of disease is not yet clear and definite.Think at present: be that the many factors such as inherited genetic factors and environmental factors interacts the disease caused.Belong to immune-mediated disease, namely the development and change primary disease according to the state of an illness often can be divided into four types: homeliness type, pustular type, joint type and Folium Styracis Suberifoliae type.Men and women, old and young all can fall ill; state of an illness weight is normal relevant with season, diet and extraneous factor; the state of an illness is obstinate; the course of disease time is long, not easily cures, easily recurrence after curing; current doctor trained in Western medicine often adopts vitamins; antibiotics, antitumor class, heavy metal class; immunomodulator or hormone medicine act on neural oral medicine; cutin forming agent, the medicine for external use such as cytotoxic agent, also normal combined with ultraviolet radiation irradiates; the method Comprehensive Treatment primary disease such as photochemistry; but clinical practice proves, described medicine and Therapeutic Method often can produce toxic and side effects, and have many contraindications.

The traditional Chinese medical science is thought: the pathogenesis main manifestations of primary disease is the types such as heat in blood, blood stasis, blood deficiency, for pathogenesis many employings clearing away heat and cooling blood, and nourishing the blood and yin, dampness toxin expelling, blood circulation promoting and blood stasis dispelling, the comprehensive therapy of dispelling wind for relieving itching, has curative effect reliable, can prolonged application, the advantages such as relapse rate is low, and toxic and side effects is little.

Summary of the invention

The object of the present invention is to provide one to treat psoriatic Chinese medicine composition, prove through clinical trial, the erythra that can effectively disappear, alleviate skin lesion, eliminate the symptom such as pruritus.

Present invention also offers a kind of preparation method for the treatment of psoriatic Chinese medicine composition.

One treats psoriatic compositions, comprises the crude drug of following weight portion: Periostracum Cicadae 20 ~ 40 parts, favus skin 25 ~ 30 parts, Cortex Moutan 15 ~ 20 parts, Flos Lonicerae 20 ~ 30 parts, Fructus Forsythiae 20 ~ 40 parts, the Radix Paeoniae Alba 20 ~ 40 parts, 15 ~ 20 parts, Radix Glycyrrhizae, Radix Saposhnikoviae 15 ~ 20 parts, the Radix Angelicae Dahuricae 15 ~ 20 parts, Rhizoma Et Radix Notopterygii 15 ~ 20 parts, Semen Lini 20 ~ 30 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Rhizoma Curcumae 15 ~ 20 parts, Radix Salviae Miltiorrhizae 20 ~ 30 parts, Radix Scrophulariae 20 ~ 30 parts.

The present invention treats psoriatic compositions, comprises the crude drug of following weight portion: Periostracum Cicadae 30 parts, favus skin 30 parts, Cortex Moutan 20 parts, Flos Lonicerae 30 parts, Fructus Forsythiae 30 parts, the Radix Paeoniae Alba 40 parts, 20 parts, Radix Glycyrrhizae, Radix Saposhnikoviae 20 parts, the Radix Angelicae Dahuricae 20 parts, Rhizoma Et Radix Notopterygii 15 parts, Semen Lini 30 parts, Rhizoma Acori Graminei 20 parts, Radix Angelicae Sinensis 15 parts, Cortex Phellodendri 15 parts, Rhizoma Curcumae 20 parts, Radix Salviae Miltiorrhizae 30 parts, Radix Scrophulariae 20 parts.

The present invention treats psoriatic compositions, also comprises the crude drug of following weight portion: Radix Notoginseng 10 parts, Herba Violae 20 parts, Radix Isatidis 20 parts.

A kind of preparation method for the treatment of psoriatic compositions, described crude drug clear water is comprised the steps: to clean, remove impurity and dry grinding and sieving, then mix, obtain the crude drug of mix homogeneously, with autoclave by the crude drug ripening after described mixing, sterilizing, obtain the crude drug of sterilizing, by the crude drug of described sterilizing rapid temperature increases to 110 DEG C in ten minutes, then 108 DEG C are cooled to, and preserve 3 ~ 5min and be cooled to 105 DEG C again, insulation 3 ~ 5min, finally be cooled to 100 DEG C, and be incubated, make the whole ripening of described sterilizing crude drug, obtain the crude drug of whole ripening, and then by the crude drug of whole ripening, sterilization time is subpackage after 10 ~ 30min, introduce in clean area.

The present invention treats the preparation method of psoriatic compositions, it is characterized in that, described in employing 120 mesh sieve that sieves sieve.

Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Dahuricae dispersing wind-cold in we, Periostracum Cicadae disperses wind heat, Cortex Moutan, Flos Lonicerae, Fructus Forsythiae, Cortex Phellodendri, favus skin heat clearing away, removing pathogenic heat from blood and toxic substance from the body, Rhizoma Acori Graminei, Cortex Phellodendri, removing dampness toxin expelling, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; The Radix Paeoniae Alba, Radix Scrophulariae, Radix Glycyrrhizae nourishing YIN and benefiting blood, moisturizes; Full side to mediate treatment to psoriasis from many aspects, and wherein the Radix Paeoniae Alba is to Cellular Immunity, and humoral immunization and cytophagy all have conciliation effect, has certain therapeutical effect and analgesia, cooling effect to inflammatory hydrolysis and matter agent arthritis.The Radix Paeoniae Alba in the coordinative role of Quan Fangzhong is: this compositions will produce important function to psoriatic treatment.

The benefit of step type sterilizing is, can keep the effective ingredient of medicine, can kill again different bacterium spores.

This compositions also can make the regular dosage form of pharmaceutics by conventional method, such as: the ethanol extraction adopting water or 70 ~ 95%, make unguentum, tablet or electuary according to a conventional method except after desolventizing, or extracting solution remove general impurity with water precipitating, precipitate with ethanol mode or stand at low temperature filter type or other conventional method after make oral liquid or pulverizing medicinal materials after incapsulate.

Extraction described in preparation method comprises merceration, hot dipping, percolation, reflux etc.

Cortex Phellodendri, returns kidney, urinary bladder channel, mainly plays heat clearing and damp drying, nourishing yin and purging fire, detoxification sore treatment, hyperactivity of fire caused by deficiency of YIN, the effects such as expelling toxin and relieving itching.Cortex Phellodendri and Cortex Moutan, Flos Lonicerae, Fructus Forsythiae, favus skin interact and will play clearing heat and expelling damp, removing pathogenic heat from blood and toxic substance from the body, pathogenic fire purging YIN nourishing, get rid of vivotoxin, and solution sufferer is antipruritic, reaches the effect of getting twice the result with half the effort.

Radix Angelicae Sinensis, returns liver, the heart, spleen channel, mainly plays the effects such as blood circulation promoting and enriching, rheumatism splenalgia, loosening bowel to relieve constipation, cellulitis skin infection, blood deficiency and yellow complexion, asthenia cold abdominalgia, menstruction regulating and pain relieving.Radix Angelicae Sinensis and Flos Carthami, Radix Salviae Miltiorrhizae, Rhizoma Curcumae interact to play and enrich blood, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, except rheumatic arthralgia, regulate meridians, separate constipation blood deficiency.

Flos Carthami, GUIXIN, Liver Channel, Flos Carthami and Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Scrophulariae, Radix Glycyrrhizae interact and will play good therapeutic effect, and obvious effective rate, cure rate are all significantly improved, and reduce relapse rate simultaneously.

Detailed description of the invention

Embodiment 1

One treats psoriatic compositions, and described compositions comprises the crude drug of following weight portion: Periostracum Cicadae 20, favus skin 25, Cortex Moutan 20, Flos Lonicerae 20, Fructus Forsythiae 40, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 15, Radix Saposhnikoviae 20, the Radix Angelicae Dahuricae 15, Rhizoma Et Radix Notopterygii 20, Semen Lini 20, Rhizoma Acori Graminei 30, Radix Angelicae Sinensis 10, Cortex Phellodendri 20, Rhizoma Curcumae 20, Radix Salviae Miltiorrhizae 20, Radix Scrophulariae 20.

Embodiment 2

One treats psoriatic compositions, and described compositions comprises the crude drug of following weight portion: Periostracum Cicadae 40, favus skin 30, Cortex Moutan 15, Flos Lonicerae 30, Fructus Forsythiae 20, the Radix Paeoniae Alba 40, Radix Glycyrrhizae 20, Radix Saposhnikoviae 15, the Radix Angelicae Dahuricae 20, Rhizoma Et Radix Notopterygii 15, Semen Lini 30, Rhizoma Acori Graminei 20, Radix Angelicae Sinensis 10, Cortex Phellodendri 20, Rhizoma Curcumae 15, Radix Salviae Miltiorrhizae 30, Radix Scrophulariae 30.

Embodiment 3

One treats psoriatic compositions, and described compositions comprises the crude drug of following weight portion: Periostracum Cicadae 30, favus skin 30, Cortex Moutan 20, Flos Lonicerae 30, Fructus Forsythiae 30, the Radix Paeoniae Alba 40, Radix Glycyrrhizae 20, Radix Saposhnikoviae 20, the Radix Angelicae Dahuricae 20, Rhizoma Et Radix Notopterygii 15, Semen Lini 30, Rhizoma Acori Graminei 20, Radix Angelicae Sinensis 15, Cortex Phellodendri 15, Rhizoma Curcumae 20, Radix Salviae Miltiorrhizae 30, Radix Scrophulariae 20, Radix Notoginseng 10, Herba Violae 20, Radix Isatidis 20.

Embodiment 4

A kind of preparation method for the treatment of psoriatic compositions, described crude drug clear water is comprised the steps: to clean, remove after impurity dries pulverizing and use 120 mesh sieve, then mix, obtain the crude drug of mix homogeneously, with autoclave by the crude drug ripening after described mixing, sterilizing, obtain the crude drug of sterilizing, by the crude drug of described sterilizing rapid temperature increases to 110 DEG C in ten minutes, then 108 DEG C are cooled to, and preserve 3 ~ 5min and be cooled to 105 DEG C again, insulation 3 ~ 5min, finally be cooled to 100 DEG C, and be incubated, make the whole ripening of described sterilizing crude drug, obtain the crude drug of whole ripening, and then by the crude drug of whole ripening, sterilization time is subpackage after 10 ~ 30min, introduce in clean area.

Therapeutic effect contrasts:

Physical data and Therapeutic Method: observe psoriasis vulgaris people with powder of the present invention in the Characteristic Professional Subjects of Union Hospital outpatient service of Fu Laer base, Qiqihaer City, be divided into treatment group 134 people, matched group 60 people, treatment group uses the powder of the present embodiment; 10 ~ 20g/ time, every day 3 times, taking medicine before meal; Matched group each serving using vitamin C 0.2g, vitamin E soft capsules 100mg, vitamin AD soft gelatin capsule every day three times, oral.

Diagnostic criteria: skin surface has red papules, maculopapule, boundary clear, on cover multilamellar silvery white squama, in stearic sample gloss after squama is scraped off, be called that stearic speckle or wax drip phenomenon, shinny Pu thin film is had to claim film phenomenon under it, visible point-like bleeding after removing thin film, skin lesion form is a drop-wise, coin shape, speckle shape, map shape etc., the skin lesion of different parts has different manifestations, head skin lesion is that scalp covers thick bits, scalp fasciculation, face skin lesion is some drop-wise, face skin lesion is seborrheic dermatitis sample, or in butterfly bluss, shank skin lesion is often with purple, plump in infiltrating, like chronic rash or neurodermatitis, the infringement of the palm sole of the foot is point-like hyperkeratosis, on cover white squama or sized by the well-defined desquamation infringement that differs, normal with crowfoot cracks, sometimes dispersivity palm sole of the foot erythema keratinization sample can be shown as, small number of patients skin lesion has and oozes out on a small quantity, surface forms dirty brown squama crust, small number of patients has mucosa infection, the wellability speckle (sheet) of lark and white edge is shown as at buccal mucosa place

Three, criterion is treated

Recovery from illness: erythra all disappears or only stays small pieces skin lesion.

Effective: deflorescence more than 50 ~ 80

Invalid: after treatment, skin lesion has no and improves or instead see deterioration

Treatment group 70

Contrast effect is as shown in table 1

Table 1 therapeutic effect contrast table

Above-described embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determines.

Claims (5)

1. the psoriatic compositions for the treatment of, it is characterized in that, described compositions comprises the crude drug of following weight portion: Periostracum Cicadae 20 ~ 40 parts, favus skin 25 ~ 30 parts, Cortex Moutan 15 ~ 20 parts, Flos Lonicerae 20 ~ 30 parts, Fructus Forsythiae 20 ~ 40 parts, the Radix Paeoniae Alba 20 ~ 40 parts, 15 ~ 20 parts, Radix Glycyrrhizae, Radix Saposhnikoviae 15 ~ 20 parts, the Radix Angelicae Dahuricae 15 ~ 20 parts, Rhizoma Et Radix Notopterygii 15 ~ 20 parts, Semen Lini 20 ~ 30 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Rhizoma Curcumae 15 ~ 20 parts, Radix Salviae Miltiorrhizae 20 ~ 30 parts, Radix Scrophulariae 20 ~ 30 parts.

2. treat psoriatic compositions according to claim 1, it is characterized in that, described compositions comprises the crude drug of following weight portion: Periostracum Cicadae 30 parts, favus skin 30 parts, Cortex Moutan 20 parts, Flos Lonicerae 30 parts, Fructus Forsythiae 30 parts, the Radix Paeoniae Alba 40 parts, 20 parts, Radix Glycyrrhizae, Radix Saposhnikoviae 20 parts, the Radix Angelicae Dahuricae 20 parts, Rhizoma Et Radix Notopterygii 15 parts, Semen Lini 30 parts, Rhizoma Acori Graminei 20 parts, Radix Angelicae Sinensis 15 parts, Cortex Phellodendri 15 parts, Rhizoma Curcumae 20 parts, Radix Salviae Miltiorrhizae 30 parts, Radix Scrophulariae 20 parts.

3. treat psoriatic compositions according to claim 2, it is characterized in that, described compositions also comprises the crude drug of following weight portion: Radix Notoginseng 10 parts, Herba Violae 20 parts, Radix Isatidis 20 parts.

4. described in a claim 1 or 2 or 3, treat the preparation method of psoriatic compositions, it is characterized in that, described crude drug clear water is cleaned, remove impurity and dry grinding and sieving, then mix, obtain the crude drug of mix homogeneously, with autoclave by the crude drug ripening after described mixing, sterilizing, obtain the crude drug of sterilizing, by the crude drug of described sterilizing rapid temperature increases to 110 DEG C in ten minutes, then 108 DEG C are cooled to, and preserve 3 ~ 5min and be cooled to 105 DEG C again, insulation 3 ~ 5min, finally be cooled to 100 DEG C, and be incubated, make the whole ripening of described sterilizing crude drug, obtain the crude drug of whole ripening, and then by the crude drug of whole ripening, sterilization time is subpackage after 10 ~ 30min, introduce in clean area.

5. treat the preparation method of psoriatic compositions according to claim 4, it is characterized in that, described in employing 120 mesh sieve that sieves sieve.