CN103656405B - Traditional Chinese medicine composition for treating vulvar dystrophy, as well as preparation method and external preparation thereof - Google Patents
Traditional Chinese medicine composition for treating vulvar dystrophy, as well as preparation method and external preparation thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine and discloses a traditional Chinese medicine composition for treating vulvar dystrophy and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following seven traditional Chinese medicinal materials which are used as raw materials: giant knot weed, honeysuckle, golden cypress, cortex moutan, radix stemonae, ligusticum wallichii and borneol. According to the traditional Chinese medicine composition, various traditional Chinese medicinal materials interact and play a synergistic effect; the traditional Chinese medicine composition has the effects of detoxifying, dispersing blood stasis, diminishing inflammation, relieving itching, promoting blood circulation of local tissues, well relieving spasm, improving nutrition of tissues, improving the immunity, reducing inflammatory exudation, resisting hyperplasia and atrophy and stopping cancerization. The traditional Chinese medicine composition has a remarkable effect on treating the vulvar dystrophy, is short in treatment course and quick in effect taking, and ensures that vulvar dystrophy does not relapse after being cured. The used medicinal materials are non-toxic; the traditional Chinese medicine composition has less dependence after long-term use, is low in cost, is suitable for patients suffering from short-term and long-term vulvar dystrophy and has wide market prospect. The preparation method of the traditional Chinese medicine composition is simple and convenient to operate, low in production cost and high in efficiency.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of vulvar dystrophy and preparation method thereof and external preparation.
Background technology
Vulvar dystrophy also makes leukoplakia vulvae (leukoplakia vulvae) comprise that the states such as leucismus in various degree and coarse, atrophy appear in pudendum part skin and mucosa, are called again " vulvar dystrophy ".Pruritus vulvae is the outstanding symptom that first patient feels, especially to attach most importance to night, the degree of pruritus and time, menstruation, weather, food, environment, emotion are relevant, and pruritus is generally intermittent attack, and patient Chang Yinqi itches and scratches and do not stop.Owing to scratching, external genital has many places scratch, redness, due to long-term pruritus result, local generation is burst and swing, chap, fester and secondary infection.So patient often has local scorching hot pain, particularly clitoris, nympha etc. are very sensitive.Skin of vulva mucosa occurs that limitation or diffusivity white become, or hypertrophy plumpness or atrophy attenuation, and the colour of skin is canescence, aubergine or pale red more.Wherein, or see that hypertrophy atrophy mixes, have atrophic type and mix symptom with Accretive Type, its performance has the obvious atrophy of cysthus, and prepuce of clitoris is plump, and keratinization is obvious, and labium majus stricture of vagina is thick, and there is localized thickening ulcer in hypopigmentation.Vulvar dystrophy can betide any age, and in each period of women: there are report in juvenile stage, adolescence, climacteric and geratic period, but the climacteric person of 50 years old front and back is in the majority, and the course of disease is different in size, and elder can reach many decades.Because half carcinoma vulvae patient has leukoplakia vulvae medical history, therefore ill crowd all has great stress and misery.
Vulvar dystrophy is a kind of disease that gynecological clinic is healed compared with refractory.Vulvar dystrophy current diagnosis is easier, and veteran clinician just can diagnose by perusal, but there is no desirable Therapeutic Method.Modern medicine is very advanced abroad, but tackle vulvar dystrophy, still feels simply helpless.The therapeutic scheme Chinese medicine of doctor trained in Western medicine treatment at present mainly comprises: for pudendum hyperplasia of squamous epithelium, adopt glucocorticoid topical therapeutic, as hydrocortisone ointment, Kin White; For lichen sclerosus part, embrocate testosterone propionate and Progesterone, but therapeutic effect is limited, side effect is more.Excision has proved a kind of cruelty and the high therapeutic scheme of relapse rate, at present clinical the last therapeutic scheme when the III later stage, Drug therapy was invalid.More conservative treatment way is such as the sequela such as laser, freezing, sealing are serious, patient is often difficult to accept, due to the shallow top layer of the skin of vulva abundant peripheral nerve that distributes, through laser, the treatment such as freezing, peripheral nerve and blood capillary are damaged, result makes the real malnutrition of skin of vulva and is the progressive atrophy of nerve, and atrophy is irreversible.
Vulvar dystrophy belongs to Chinese medicine " pudendal pruritus ", " pain over the perineum " category, how because of dampness-heat of the liver, to make a bet and to invade stain pudendum, or the essence and blood such as blood-deficiency leading to hyperactivity of the liver, the hepatic and renal YIN deficiency, kidney yang deficiency can not moisten and supports due to pudendum.The traditional Chinese medical science is cloudy moss, the erosion of vulva, the erosion of the vulva, pain over the perineum.At present commercially available Chinese patent drugs for treatment vulvar dystrophy is very few, and compatibility is complicated mostly, the course for the treatment of of taking medicine is long, cure rate is low.Therefore, research and development take compatibility Chinese medicine preparation simple, evident in efficacy to treatment vulvar dystrophy significant.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of compatibility is simple, effect is treated vulvar dystrophy significantly Chinese medicine composition and preparation method thereof and external preparation.
For realizing object of the present invention, the present invention adopts following technical scheme:
Treat a Chinese medicine composition for vulvar dystrophy, by the raw material of following weight portion, made:
15～25 parts of 15～25 parts of Cortex Moutans of 25～35 portions of Cortex Phellodendris of 15～25 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
2～7 parts of 5～15 parts of Borneolum Syntheticums of 25～35 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
Preferably, the Chinese medicine composition of described treatment vulvar dystrophy is made by following weight portion raw material:
20 parts of 20 parts of Cortex Moutans of 30 portions of Cortex Phellodendris of 20 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
5 parts of 10 parts of Borneolum Syntheticums of 30 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of vulvar dystrophy, for getting 15～25 weight portion Rhizoma Polygoni Cuspidati, 25～35 weight portion Flos Loniceraes, 15～25 weight portion Cortex Phellodendris, 15～25 weight portion Cortex Moutans, 25～35 weight portion Radixs Stemonae, 5～15 weight portion Rhizoma Chuanxiongs, 2～7 weight portion Borneolum Syntheticums, decoct with water, decocting liquid filters, and filtrate concentrates and get final product.
Preferably, described in decoct with water as decocting with water 2～3 times, each 0.5～1.0 hour, collecting decoction.
The Chinese medicine composition that the present invention also provides above-mentioned preparation method to prepare.
The present invention also provides a kind of Chinese medicine preparation for the treatment of vulvar dystrophy, by Chinese medicine composition and the pharmaceutically acceptable adjuvant of described treatment vulvar dystrophy, is made.
Preferably, it is external preparation.
Preferably, described external preparation is fumigant, lotion or unguentum.
The invention provides a kind of Chinese medicine composition for the treatment of vulvar dystrophy and preparation method thereof.Chinese medicine composition of the present invention is that raw material is prepared from by Rhizoma Polygoni Cuspidati, Flos Lonicerae, Cortex Phellodendri, Cortex Moutan, the Radix Stemonae, Rhizoma Chuanxiong and Borneolum Syntheticum seven taste Chinese crude drugs, in described Chinese medicine composition, each taste Chinese medicine influences each other, synergism, eliminating toxic substances to remove stasis, anti-inflammatory anti-itch, promote local organization blood circulation, play good alleviation spasm simultaneously, improve histotrophic nutrition, improve immunity, reduce inflammatory exudation, anti-hypertrophy, anti-atrophy, stop the effect of canceration, treatment vulvar dystrophy is evident in efficacy, and short treating period, instant effect, does not recur after more.The present invention's medical material used is all nontoxic, and life-time service drug dependence is little, and cheap, and the patient who is applicable to short-term and long-term vulvar dystrophy uses, and has wide market prospect.The preparation method of Chinese medicine composition of the present invention is easy and simple to handle, and production cost is low, and efficiency is high.
The specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition for the treatment of vulvar dystrophy and preparation method thereof and external preparation.Those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Product of the present invention and method are described by preferred embodiment, related personnel obviously can be within not departing from content of the present invention, spirit and scope to product as herein described with method is changed or suitably change and combination, realize and apply the technology of the present invention.
For realizing object of the present invention, the present invention adopts following technical scheme:
Treat a Chinese medicine composition for vulvar dystrophy, by the raw material of following weight portion, made:
15～25 parts of 15～25 parts of Cortex Moutans of 25～35 portions of Cortex Phellodendris of 15～25 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
2～7 parts of 5～15 parts of Borneolum Syntheticums of 25～35 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
Traditional Chinese Medicine has the theory of " woman be take liver as congenital ", examines the venation of its liver and follows row, and external genitals is its only way which must be passed, and irritability must not reach by bar, the venation stasis of liver, and external genitals QI and blood is obstructed, and withered mistake hair care is vulvar dystrophy.Modern medicine thinks that the generation of vulvar dystrophy and microcirculation have substantial connection, there is autoimmunity lowly and microcirculation disturbance in vulvar dystrophy site of pathological change, make nutritional labeling can not be transported to each position of skin, melanocyte can not normally be nourished and be affected growth promoter and metabolism, year in and year out, melanin is de-to be lost, thereby local skin decolouring is bleached, and occur that play is itched, atrophy, chap, the disease such as hypertrophy.Traditional Chinese Medicine combines with modern medical theory, and applicant thinks that reconciling patient's spirit feelings will, suitable irritability and QI and blood, raising immunity, improving microcirculation is the key of curing primary disease.Chinese medicine composition of the present invention is for the formed main mechanism of vulvar dystrophy, select Rhizoma Polygoni Cuspidati, Flos Lonicerae, Cortex Phellodendri, Cortex Moutan, the Radix Stemonae, Rhizoma Chuanxiong and Borneolum Syntheticum seven taste Chinese crude drugs to make, eliminating toxic substances to remove stasis, anti-inflammatory anti-itch, promote local organization blood circulation, improve immunity, thereby reach the object for the treatment of vulvar dystrophy.
Wherein, Rhizoma Polygoni Cuspidati latin name Rhizoma Polygoni Cuspidati, is dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.The micro-hardship of Rhizoma Polygoni Cuspidati, be slightly cold, return liver, gallbladder, lung meridian, the effect with heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm, does not Xia the diseases such as, WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus for arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis.
Flos Lonicerae, latin name Lonicera Japonica, have another name called Radix Ophiopogonis, Flos Lonicerae, for the perennial half evergreen winding bejuco of Caprifoliaceae, sweet in the mouth, cold in nature, stem, leaf and Huadu can be used as medicine, and have removing toxic substances, antiinflammatory, virus killing, sterilization, diuresis and antipruritic effect, are used for the treatment of the diseases such as febrile disease due to summer-heat pathogen, dysentery, influenza, furuncle toxic swelling, acute and chronic tonsillitis, periodontitis.
Cortex Phellodendri, latin name Cortex Phellodendri Chinensis, another name Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood Cortex Phellodendri, be the dry bark of rutaceae wampee or Cortex Phellodendri.Cortex Phellodendri nature and flavor, bitter cold, have heat clearing and damp drying, pathogenic fire purging except steaming, an effect of detoxification sore treatment, is used for the treatment of the diseases such as damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity are warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Cortex Moutan, latin name Cortex Moutan Radicis, Chinese medicine name Cortex Moutan, another name moutan root bark, DANGEN, be the dry root bark of ranunculaceae peony, after Paeonia suffruticosa is excavated, scraping root bark, dries and is used as medicine.Cortex Moutan cold nature, bitter in the mouth, pungent, GUIXIN, liver, kidney, lung meridian, the effect with clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, is used for the treatment of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, sends out speckle, tells nosebleed, hot Fu Yin of calentura later stage divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls the disease of flutterring the pain of injury, rheumatism pyretic arthralgia.
The Radix Stemonae, latin name Stemona sessilifolia (Miq.) Miq, has another name called Herba delphinii grandiflori, is the dried root of Stemonaceae plant Radix Stemonae, Radix stemonae japonicae or radix stemonae tuberosae.Radix Stemonae sweet in the mouth, hardship, slightly warm in nature, has the effect of nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing, for oral administration can nourishing the lung to arrest cough, can be used for delousing parasite killing, pudendum Pruritus, tool itching-relieving action outward.
Rhizoma Chuanxiong, latin name Rhizoma Chuanxiong, another name Rhizoma Chuanxiong, is the rhizome of samphire Rhizoma Chuanxiong.Rhizoma Chuanxiong acrid in the mouth, warm in nature, there is the effect of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping, for pain in chest and hypochondrium, rheumatic arthralgia, lump in the abdomen caking, skin infection, swell and ache, fall diseases such as flutterring the pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain.
Borneolum Syntheticum, has another name called Borneolum Syntheticum, Flos Mume brain, natural Broneolum Syntheticum, borneol, is the crystallization obtaining in the resin of Borneolum Syntheticum and volatile oil.Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian, there is the effects such as the loose poison of the refreshment of having one's ideas straightened out, heat clearing away, improving acuity of vision and removing nebula, be used for the treatment of calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer and hoodwink the disease such as key, sore throat is deaf, aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium clearly.
Rhizoma Polygoni Cuspidati described in the present invention, Flos Lonicerae, Cortex Phellodendri, Cortex Moutan, the Radix Stemonae, Rhizoma Chuanxiong and Borneolum Syntheticum are well known to a person skilled in the art, can by commercial sources buy from a medical store obtain or by disclosed method cultivation in prior art, gathering obtains, its specification meets country or industry standard.Medical material used is all nontoxic simultaneously, and long-term taking drug dependence is little, and cheap, is applicable to ordinary consumer and uses.
As preferably, Chinese medicine composition of the present invention, by following weight portion raw material, made:
20 parts of 20 parts of Cortex Moutans of 30 portions of Cortex Phellodendris of 20 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
5 parts of 10 parts of Borneolum Syntheticums of 30 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
The present invention also provides the preparation method of described Chinese medicine composition, for getting 15～25 weight portion Rhizoma Polygoni Cuspidati, 25～35 weight portion Flos Loniceraes, 15～25 weight portion Cortex Phellodendris, 15～25 weight portion Cortex Moutans, 25～35 weight portion Radixs Stemonae, 5～15 weight portion Rhizoma Chuanxiongs, decoct with water, decocting liquid filters, and filtrate is mixed and get final product with 2～7 weight portion Borneolum Syntheticum.
In certain embodiments, the preparation method of Chinese medicine composition of the present invention, for getting 20 weight portion Rhizoma Polygoni Cuspidati, 30 weight portion Flos Loniceraes, 20 weight portion Cortex Phellodendris, 20 weight portion Cortex Moutans, the 30 weight portion Radixs Stemonae, 10 weight portion Rhizoma Chuanxiongs, decoct with water, decocting liquid filters, and filtrate is mixed and get final product with 5 weight portion Borneolum Syntheticum.
Further, decoct with water as decocting with water 2～3 times described in preparation method of the present invention, each 0.5～1.0 hour, collecting decoction.
Wherein, described in while decocting with water, the addition of described water is 7～10 times of medical material gross weight, the medical material of every 1 weight portion adds water 7～10 weight portions.
The Chinese medicine composition that the present invention also provides above-mentioned preparation method to prepare.
Further, the present invention also provides the clinical preparation of described Chinese medicine composition.Those skilled in the art can add Chinese medicine composition of the present invention according to different patients' demand that to prepare different dosage form be required various pharmaceutically conventional adjuvants, as solvent, polymer matrix, aluminium hydroxide, vaseline, glycerol, gelatin etc., with conventional method of Chinese medicinal, through the acceptable adjuvant pharmaceutically that adds that conventional machining is direct or indirect, make common dosage forms.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is external preparation.
Further, described external preparation is preferably fumigant, lotion or unguentum, is easy to use, through focus, and arrive meridians, internal organs by human body skin, Yu cave, and treating both the principal and secondary aspects of a disease, antipruritic rapidly, with strong points, curative effect is obvious.Wherein said unguentum can be ointment and plaster.
Using dosage and the using method of the clinical preparation of Chinese medicine composition of the present invention depend on factors, comprise patient's age, body weight, sex, natural health situation, nutriture, activity intensity, service time, metabolic rate, the course of disease order of severity and the diagnosis and treatment doctor's of compound subjective judgment.Those skilled in the art can easily determine using dosage and the using method of the clinical preparation of Chinese medicine composition according to above-mentioned factor.
The present invention is through clinical observation on the therapeutic effect, and in the cloudy underfed patient of 240 exceptions, treatment group is used Chinese medicine composition ointment of the present invention about 7 days, to have obvious effect, after 1 course for the treatment of, 6 examples of fully recovering, effective 97 examples, effective 17 examples, invalid 0 example, aobvious rate reaches 86%, and total effective rate reaches 100%; Matched group: recovery from illness 0 example, effective 43 examples, effective 71 examples, invalid 6 examples, aobvious rate reaches 36%, and total effective rate reaches 95%.Two groups of obvious effective rates relatively have significant difference (P<0.05).The Chinese medicine composition that shows tool treatment vulvar dystrophy of the present invention is evident in efficacy.In treated patient, do not have detail to occur untoward reaction, show that Chinese medicine composition of the present invention and described Chinese medicine composition clinical preparation are nontoxic to human-body safety.
The invention provides a kind of Chinese medicine composition for the treatment of vulvar dystrophy and preparation method thereof.Chinese medicine composition of the present invention is that raw material is prepared from by Rhizoma Polygoni Cuspidati, Flos Lonicerae, Cortex Phellodendri, Cortex Moutan, the Radix Stemonae, Rhizoma Chuanxiong and Borneolum Syntheticum seven taste Chinese crude drugs, in described Chinese medicine composition, each taste Chinese medicine influences each other, synergism, eliminating toxic substances to remove stasis, anti-inflammatory anti-itch, promote local organization blood circulation, play good alleviation spasm simultaneously, improve histotrophic nutrition, improve immunity, reduce inflammatory exudation, anti-hypertrophy, anti-atrophy, stop the effect of canceration, treatment vulvar dystrophy is evident in efficacy, and short treating period, instant effect, does not recur after more.The present invention's medical material used is all nontoxic, and life-time service drug dependence is little, and cheap, and the patient who is applicable to short-term and long-term vulvar dystrophy uses, and has wide market prospect.The preparation method of Chinese medicine composition of the present invention is easy and simple to handle, and production cost is low, and efficiency is high.
In order further to understand the present invention, below in conjunction with embodiment, the present invention is described in detail.
Embodiment 1: the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
Described Chinese medicine composition is to be made by following crude drug: Rhizoma Polygoni Cuspidati 15g, Flos Lonicerae 35g, Cortex Phellodendri 15g, Cortex Moutan 25g, Radix Stemonae 25g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 2g.
Preparation method is after above-mentioned medicine except Borneolum Syntheticum washs respectively, dries, pulverizes, and the decocting that mixing by weight ratio at normal temperatures adds 7 times of weight boils 2 times, each 1 hour, and collecting decoction, decocting liquid filters, and filtrate is mixed with Borneolum Syntheticum and be get final product.
Embodiment 2: the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
Described Chinese medicine composition is to be made by following crude drug: Rhizoma Polygoni Cuspidati 25g, Flos Lonicerae 25g, Cortex Phellodendri 25g, Cortex Moutan 15g, Radix Stemonae 35g, Rhizoma Chuanxiong 5g, Borneolum Syntheticum 7g.
Preparation method is after above-mentioned medicine except Borneolum Syntheticum washs respectively, dries, pulverizes, and the decocting that mixing by weight ratio at normal temperatures adds 10 times of weight boils 3 times, each 1 hour, and collecting decoction, decocting liquid filters, and filtrate is mixed with Borneolum Syntheticum and be get final product.
Embodiment 3: the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
Described Chinese medicine composition is to be made by following crude drug: Rhizoma Polygoni Cuspidati 20g, Flos Lonicerae 30g, Cortex Phellodendri 20g, Cortex Moutan 20g, Radix Stemonae 30g, Rhizoma Chuanxiong 10g, Borneolum Syntheticum 5g.
Preparation method is after above-mentioned medicine except Borneolum Syntheticum washs respectively, dries, pulverizes, and the decocting that mixing by weight ratio at normal temperatures adds 8 times of weight boils 3 times, each 0.5 hour, and collecting decoction, decocting liquid filters, and filtrate is mixed with Borneolum Syntheticum and be get final product.
Embodiment 4: the fumigant of the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
The Chinese medicine composition of getting embodiment 1 gained mixes the herbal fumigation agent that makes treatment vulvar dystrophy of the present invention according to a conventional method with conventional adjuvant.
Embodiment 5: the lotion of the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
The Chinese medicine composition of getting embodiment 3 gained mixes with conventional adjuvant the Chinese medicine lotion that makes treatment vulvar dystrophy of the present invention according to a conventional method.
Embodiment 6: the ointment of the Chinese medicine composition for the treatment of vulvar dystrophy of the present invention
The Chinese medicine composition of getting embodiment 2 gained mixes with conventional adjuvant the Chinese medicine ointment that makes treatment vulvar dystrophy of the present invention according to a conventional method.
Embodiment 7: the observation of curative effect of Chinese medicine composition of the present invention
Choose at random the patient that 240 examples are vulvar dystrophy.Patient diagnosis canonical reference < < new Chinese medicine guideline of clinical investigations (1998) > > is foundation, and with reference to seven editions teaching material < < obstetrics and gynecology > > of national higher medical institution.Patient is divided into two groups at random, treatment group 120 examples, wherein age 18-30 year 10 examples; 31-40 year 25 examples; 41-50 year 48 examples; 51-60 year 37 examples.Matched group 120 examples, age 18-30 year 10 examples; 31-40 year 28 examples; 41-50 year 37 examples; 51-60 year 45 examples.The course of disease is the shortest 6 months, the longest 25 years.
Therapeutic Method: treatment group is used the ointment of Chinese medicine composition of the present invention sooner or later, stops other western medicines in treatment during treatment.Matched group adopts Kin White part to embrocate sooner or later, stops other western medicines in treatment during treatment.More than divide into groups 1 month is a course for the treatment of.
Parameters for observation on effect: 1) disease damage degree and scope; 2) ulceration of chapping; 3) pruritus; 4) pain.Be divided into light, in, severe, with scoring respectively before and after treatment.One month course for the treatment of.
Curative effect determinate standard: draft following level Four with reference to < < new Chinese medicine guideline of clinical investigations > >: recovery from illness: symptom, sign, disease integration therapeutic index N >=95%, a not recurrence in month after drug withdrawal; Effective: symptom, sign, disease integration therapeutic index N >=70% ,≤95%; Effective: symptom, sign, disease integration therapeutic index N >=30% ,≤70%; Invalid: symptom, sign, disease integration therapeutic index N < 30%.
Statistical method: adopt SPPS17.0 statistics software, measurement data adopts t check, and enumeration data adopts X2 check, the p < 0.05 of take has statistical significance as difference.
Result: in the cloudy underfed patient of 240 exceptions, treatment group is taken Chinese medicinal composition granules of the present invention after 1 course for the treatment of, recovery from illness 6 examples, effective 97 examples, effective 17 examples, invalid 0 example, aobvious rate reaches 86%, and total effective rate reaches 100%; Matched group: recovery from illness 0 example, effective 43 examples, effective 71 examples, invalid 6 examples, aobvious rate reaches 36%, and total effective rate reaches 95%.Two groups of obvious effective rates relatively have significant difference (P<0.05).All do not find obvious adverse reaction for two groups.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.
Claims (8)
1. a Chinese medicine composition for the treatment of vulvar dystrophy, is characterized in that, by the raw material of following weight portion, is made:
15～25 parts of 15～25 parts of Cortex Moutans of 25～35 portions of Cortex Phellodendris of 15～25 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
2～7 parts of 5～15 parts of Borneolum Syntheticums of 25～35 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
2. Chinese medicine composition according to claim 1, is characterized in that, by following weight portion raw material, is made:
20 parts of 20 parts of Cortex Moutans of 30 portions of Cortex Phellodendris of 20 parts of Flos Loniceraes of Rhizoma Polygoni Cuspidati
5 parts of 10 parts of Borneolum Syntheticums of 30 parts of Rhizoma Chuanxiongs of the Radix Stemonae.
3. a preparation method for the treatment of the Chinese medicine composition of vulvar dystrophy, it is characterized in that, getting 15～25 weight portion Rhizoma Polygoni Cuspidati, 25～35 weight portion Flos Loniceraes, 15～25 weight portion Cortex Phellodendris, 15～25 weight portion Cortex Moutans, 25～35 weight portion Radixs Stemonae, 5～15 weight portion Rhizoma Chuanxiongs decocts with water, decocting liquid filters, and filtrate is mixed and get final product with 2～7 weight portion Borneolum Syntheticum.
4. preparation method according to claim 3, is characterized in that, described in decoct with water as decocting with water 2～3 times, each 0.5～1.0 hour, collecting decoction.
5. the Chinese medicine composition that described in claim 3 or 4 prepared by preparation method.
6. a Chinese medicine preparation for the treatment of vulvar dystrophy, is characterized in that, by Chinese medicine composition and pharmaceutically acceptable adjuvant described in claim 1,2 or 5, is made.
7. clinical preparation according to claim 6, is characterized in that, it is external preparation.
8. clinical preparation according to claim 7, is characterized in that, described external preparation is fumigant, lotion or unguentum.
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|---|---|
| CN103656405A (en) | 2014-03-26 |
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