CN104623026A - Traditional Chinese medicine preparation for treating ulcerative proctitis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating ulcerative proctitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating ulcerative proctitis. The traditional Chinese medicine preparation is prepared from the following main raw materials in parts by weight: 3-9 parts of cuttlebone, 15-30 parts of cortex dictamni, 10-30 parts of myrrh, 3-9 parts of gallnut, 3-10 parts of bezoar, 5-15 parts of keel, 8-12 parts of indigo naturalis, 10-20 parts of tuckahoe, 10-20 parts of pericarpium papaveris, 5-9 parts of ageratum, 3-6 parts of borneol, 3-15 parts of angelica, 15-40 parts of rhizoma polygoni paleacei, 10-30 parts of hericium erinaceus, 3-9 parts of astragalus membranaceus, 10-20 parts of fructus aurantii immaturus and 6-18 parts of radish. The traditional Chinese medicine preparation has a remarkable effect on ulcerative proctitis and well relieves such symptoms caused by ulcerative proctitis as stomachache, hematochezia, weight reduction, tenesmus, emesis and the like, and locally common medicinal materials are usually selected for the traditional Chinese medicine preparation disclosed by the invention, so that the cost is low and the economical burden of patients is relieved.
Description
Technical field
The invention discloses treatment proctitis ulcerosa Chinese medicine preparation, especially relate to a kind of Chinese medicine preparation for the treatment of proctitis ulcerosa and preparation method thereof, the invention belongs to traditional Chinese medicine field.
Background technology
Chronic nonspecific ulcerative pathological changes is called proctitis ulcerosa when being confined to rectum.Bloody diarrhea is modal early symptom.Other symptoms have stomachache successively, have blood in stool, lose weight, tenesmus, vomiting etc.The cause of disease of proctitis ulcerosa is still failed to understand so far.Genetic factors may have certain status.Psychological factor has critical role in disease progression.Think that the morbidity of inflammatory bowel is the result that allogenic material causes host response, gene and Immunological Effect triple interaction at present.
Clinical manifestation: the initial performance of proctitis ulcerosa can have many forms.Bloody diarrhea is modal early symptom.Other symptoms have stomachache successively, have blood in stool, lose weight, tenesmus, vomiting etc.Main manifestations is arthritis, iridocyclitis, hepatic insufficiency and dermatosis once in a while.Heating is then a uncommon sign relatively, and in Most patients, primary disease shows as chronic, low pernicious, in acute, serious symptom fulminant type in small number of patients (accounting for 15%).These patients are frequent hemafecia, can reach 30 times/day, the high heat of companion, stomachache.Sign is directly related with stadium and clinical manifestation, and patient often loses weight and pale complexion, and when disease activity phase abdomen examination, hypogastric region often has tenderness.May have acute abdomen sign occur together heat and borborygmus minimizing, acute attack or fulminant type case particularly evident.Due to frequent diarrhoea, also can occur that anal skin abrades, strips off, anal fissure or anal fistula.Digital rectal examination sense pain.Rectum shows outward: the inspection of skin, mucosa, tongue, joint and eye is very important.
The Chinese medicine preparation that patent discloses a kind of radiotherapy proctitis of Authorization Notice No. CN 101254276 B (application number 200810054678.2), it is characterized in that being made up of the raw material of following weight ratio, Radix Notoginseng 3-6g, Borneolum Syntheticum 3-6g, Colla Corii Asini 5-10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-30g, Radix Sanguisorbae 15-45g, Radix Et Rhizoma Rhei 6-9g, Herba Agrimoniae 15-30g.The Chinese medicine preparation that patent discloses a kind of radiotherapy proctitis of Authorization Notice No. CN 103356816 B (application number 201310294459.2), is characterized in that: this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Impatientis Chinensis 10-15 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 5-10 part, Herba mazi japonici 12-17 part, Cortex Phellodendri 12-15 part, Herba Euphorbiae Humifusae 7-11 part, Folium Callicarpae Formosanae 13-18 part, Radix Clematidis Henryi 9-16 part, Folium Symplocoris Caudatae 45-50 part, Radix urenae procumbentis 8-15 part, Radix potentillae anserinae 25-28 part, Radix Astragali 20-35 part, Halloysitum Rubrum 20-30 part.
As can be seen here, Chinese medicine occupies very important status in treatment proctitis, but preparation method is complicated, and great majority are all decoctions, and one is be inconvenient to carry, and two is only for oral administration, and decoction adult takes passable, but child fears hardships, and is not suitable for children taking.
Summary of the invention
Along with the development of Chinese Chinese medicine, in Cure and control proctitis, people gradually appreciate treatment by Chinese herbs proctitis ulcerosa disease therapeutic process and have no side effect, patient bears painful little, the advantage that cost is saved relatively, for the present situation of existing western medical treatment proctitis ulcerosa, an object of the present invention is the Chinese medicine preparation providing treatment proctitis ulcerosa, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine preparation for the treatment of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from: Endoconcha Sepiae 3-9 part, Cortex Dictamni 15-30 part; Myrrha 10-30 part, Galla Chinensis 3-9 part, Calculus Bovis 3-10 part; Os Draconis 5-15 part, Indigo Naturalis 8-12 part, Poria 10-20 part; Pericarpium Papaveris 10-20 part, Herba Pogostemonis 5-9 part, Borneolum Syntheticum 3-6 part; Radix Angelicae Sinensis 3-15 part, Rhizoma Polygoni Paleachi 15-40 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 10-30 part; Radix Astragali 3-9 part, Fructus Aurantii Immaturus 10-20 part, Radix Raphani 6-18 part.
The Chinese medicine preparation for the treatment of proctitis ulcerosa, preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Endoconcha Sepiae 5-9 part, Cortex Dictamni 16-25 part; Myrrha 15-25 part, Galla Chinensis 4-8 part, Calculus Bovis 4-8 part; Os Draconis 8-13 part, Indigo Naturalis 9-11 part, Poria 12-18 part; Pericarpium Papaveris 14-18 part, Herba Pogostemonis 6-8 part, Borneolum Syntheticum 3.5-5 part; Radix Angelicae Sinensis 6-14 part, Rhizoma Polygoni Paleachi 20-38 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-28 part; Radix Astragali 5-7 part, Fructus Aurantii Immaturus 13-18 part, Radix Raphani 10-14 part.
The Chinese medicine preparation for the treatment of proctitis ulcerosa, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Endoconcha Sepiae 8 parts, Cortex Dictamni 20 parts; Myrrha 20 parts, Galla Chinensis 6 parts, Calculus Bovis 5 parts; Os Draconis 10 parts, Indigo Naturalis 10 parts, 15 parts, Poria; Pericarpium Papaveris 15 parts, Herba Pogostemonis 7 parts, Borneolum Syntheticum 4 parts; Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Paleachi 30 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 25 parts; the Radix Astragali 6 parts, Fructus Aurantii Immaturus 15 parts, Radix Raphani 12 parts.
Another object of the present invention is just to provide the preparation method of above-mentioned treatment proctitis ulcerosa.
The preparation method of the Chinese medicine preparation for the treatment of proctitis ulcerosa, step is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1-2 hour, instillation Oleum sesami, again decoct 5 minutes, wait to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris to be placed on food steamer and to steam 10-30 minute, it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds vinegar (preferred rice vinegar), be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 13-16 hour, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 3-8 minute, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 3-5 hour, be placed on food steamer and steam 40-60 minute, be ground into thick liquid with large ferrum spoon, thick liquid dried 10-20 minute, obtains drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, first time adds raw material weight 2-4 water doubly, decoct 20-40 minute, filter, obtain filtrate 1, second time adds filtering residue weight 3-5 water doubly, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the 1-3 water doubly of filtering residue weight for the third time, culture decocts 10-20 minute, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
The preparation method of above-mentioned Chinese medicine preparation, after 1. step decocts with water 1.3-1.8 hour, instillation Oleum sesami, decocts 5 minutes (preferred, after decocting with water 1.5 hours, instillation Oleum sesami, decocts 5 minutes again) again.
The preparation method of above-mentioned Chinese medicine preparation, step 2. stewing 14-15 hour (preferred, stewing 14.5 hours).
The preparation method of above-mentioned Chinese medicine preparation, 2. the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot by step, parch 5-7 minute (preferred, to be placed in rapidly in pot by the Chinese crude drug boiled in a covered pot over a slow fire, parch 6 minutes).
The preparation method of above-mentioned Chinese medicine preparation, 3. step is placed in white vinegar and soaks 3.5-4.5 hour, is placed on food steamer and steams 45-55 minute (preferred, to be placed in white vinegar and to soak 4 hours, be placed on food steamer and steam 50 minutes).
The preparation method of above-mentioned Chinese medicine preparation, 4. first time adds raw material weight 2.5-3.5 water doubly to step, decocts 25-35 minute (preferred, to add the water of raw material weight 3 times for the first time, decoct 30 minutes).
The preparation method of above-mentioned Chinese medicine preparation, step 4. second time adds filtering residue weight 3.5-4.5 water doubly (preferred, second time adds the water of filtering residue weight 4 times).
This Chinese medicine preparation is to proctitis ulcerosa Be very effective, to the stomachache caused by proctitis ulcerosa, have blood in stool, lose weight, tenesmus, the symptom such as vomiting have good mitigation, the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Endoconcha Sepiae: there is astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, effect of removing dampness sore.Be usually used in hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.
Cortex Dictamni: nature and flavor: bitter; Salty; Cold.Gui Jing: spleen channel; Lung meridian; Small intestine meridian; Stomach warp; Urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Cure mainly: the rubella caused by wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.
Myrrha: raw property or lymphatic temperament disease, as raw property arthralgia, sciatica, oral cavity pain, throat aches four kinds of form contrast pains, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria.Hair growing, speckle dispelling disappears trace, and softening the hard mass is except tumor, and except tinea more wound, teeth consolidating is good for gum, removing toxic substances etc.Control alopecia capillary, black spot bruise, verruca plana, various eczema, gingiva is rotten to the corn, and poisonous insect stings wound etc.Leadingly flutter damage, trusted subordinate's blood stasis, traumatics fracture and falls damage, muscles and bones stasis of blood pain, and golden sword damaged, unbearably painful, all with wine throwing drink.
Galla Chinensis: there is pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore.Be usually used in chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.
Calculus Bovis: Calculus Bovis gas delicate fragrance, mildly bitter flavor is then sweet, cool in nature.Can be used for antipyretic, removing toxic substances, arresting convulsion.The disease such as Zhi Gaore coma for oral administration, demented, infantile convulsion, tic, external is controlled laryngopharynx swelling and pain, aphtha carbuncle, is treated toxication.Natural Calculus Bovis is very precious, and international price is higher than gold, and major part uses so-called artificial Calculus Bovis.
Os Draconis: base is former: for mammal in ancient times resembles the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.Composition: Os Draconis, mainly containing calcium carbonate and calcium phosphate, still contain ferrum, potassium, sodium, chlorine, sulfate radical etc.The property of medicine: puckery, sweet, flat.GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquilizing mind, suppressing the hyperactive liver and subsiding YANG, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly cardiopalmus, seized with terror swollen, insomnia, forgetful, infantile convulsion, demented, dizzy, spontaneous sweating, the seminal emission enuresis, bleeding not during menses, chronic diarrhea and dysentery, ulcer does not close up and eczema for a long time.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.
Poria: sweet in the mouth, light, property is put down.Return through GUIXIN, lung, spleen, kidney channel.Effect promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Cure mainly for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Pericarpium Papaveris: have and astringe the lung, astringing intestine to stop diarrhea, effect of pain relieving.Be usually used in chronic cough, chronic diarrhea, proctoptosis, epigastric pain.
Herba Pogostemonis: for dampness taste, distension and fullness in the abdomen, hygropyrexia from the beginning of, vomit, have loose bowels, the disease such as heat-damp in summer, fever with chills, fever with aversion to cold, chest distress.
Borneolum Syntheticum: it can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swells and ache for skin infection, does not hold back after bursting.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Rhizoma Polygoni Paleachi: base is former: be the rhizome of Polygonaceae arsesmart Rhizoma Polygoni Paleachi.Composition: Rhizoma Polygoni Paleachi rhizome is containing Combination tannin.The property of medicine: bitter, acrid, cold.Function cures mainly: dissipating blood stasis stops blooding, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, removing toxic substances, dampness removing.Zhu Zhi WEIJIA is gathered, traumatic injury, traumatic hemorrhage, spits blood, spitting of blood, epistaxis, amenorrhea, metrorrhagia, chronic gastritis, taste-blindness rate, and food stagnation is stagnated, dysentery, enteritis, edema, sore, venom, burn and scald.
The Radix Astragali: the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.
Hericium erinaceus (Bull. Ex Fr.) Pers.: base is former: be the sporophore of hedgehog fungus section Hericium fungus Hericium erinaceus (Bull. Ex Fr.) Pers., Hydnum.Composition: containing Hericium erinaceus (Bull. Ex Fr.) Pers. Ketone A, B, C, D, E, F, G, H in Hericium erinaceus, Hericium erinaceus (Bull. Ex Fr.) Pers. alkali etc.Dry sporophore is containing protein, lipid, fiber and glucosan.Also containing sterols: ergosterol etc.Mycelium culture contains Hericium erinaceus (Bull. Ex Fr.) Pers. pyrone A, B etc.The property of medicine: " national Chinese herbal medicine compilation ": " sweet, flat." function cures mainly: strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Cure mainly body void weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
Fructus Aurantii Immaturus: base is former: be the young fruit of Rutaceae citrus plant Citrus aurantium Linn. and variety or Fructus Citri sinensis.Composition: 1. Citrus aurantium Linn.: fruit is mainly containing flavonoid: Hesperidin, neohesperidin, naringin etc.Seed is containing limonin: Fructus Citri ichangensis bitter principle, noisy Milin, deacetylnomilin, limonin etc.2. sweet orange fruit is mainly containing flavonoid: " narirutin, isosakuranetin-7-rutinoside etc.Peel is containing flavonoid: Hesperidin, naringin etc.The property of medicine: bitter, pungent, is slightly cold.Return spleen, stomach, large intestine channel.Function cures mainly: dispelling the stagnated QI removing food stagnancy, reduces phlegm except painful abdominal mass.Cure mainly in stagnating and stop, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, the thoracic obstruction, gastroptosis, uterine prolapse, proctoptosis.
Radix Raphani: base is former: be fresh of Cruciferae Radix Raphani platymiscium Radix Raphani.Composition: root contains glycoside glucosinolate, glucose raphanin, raphanusin.Phenolic acids: P-coumaric acid, caffeic acid, ferulic acid, phenylpyruvic acid, gentisic acid etc.The property of medicine: acrid, sweet, cool; Ripe person is sweet, flat.Return spleen, stomach, lung, large intestine channel.Function cures mainly: help digestion, and the therapeutic method to keep the adverse QI flowing downwards is reduced phlegm, hemostasis.Cure mainly dyspepsia, food stagnation distension, acid regurgitation, regurgitation of food from the stomach, tells food, and hemorrhoidal hamorrhage is had loose bowels, dysentery, constipation, phlegm-heat cough, discomfort in the throat, hemoptysis, and spit blood, epistaxis, has blood in stool, and quenches one's thirst, and drenches worm.Outer treatment skin ulcer abscess, damage congestive edema, scalds and chilblain.
Chinese medicine preparation of the present invention debates the principle of disease treatment based on Chinese medicine.Prepared Chinese medicine preparation is divided into two when using, portion hot water is washed open, put into clean container and be used as enema, another part taken with boiled water, the present invention is more comprehensive to treatment proctitis ulcerosa, affected area administration is more rapid, lasting medicine, alleviates the clinical symptoms such as mucosanguineous feces, diarrhoea, stomachache, tenesmus, anus causalgia pendant pain; Improve the fecal occult blood positive, intestinal mirror mucosa infection and radiation injury; Patients ' life quality can be improved; Relapse rate is low, and curative effect is reliable, and effect is stable, has no side effect, has fabulous therapeutical effect to proctitis ulcerosa, and the present invention is mainly used in the clinical nursing to proctitis ulcerosa patient application, and convenient nursing personnel nurse patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 treats the Chinese medicine preparation of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Endoconcha Sepiae 3 parts, Cortex Dictamni 15 parts; Myrrha 10 parts, Galla Chinensis 3 parts, Calculus Bovis 3 parts; Os Draconis 5 parts, Indigo Naturalis 8 parts, 10 parts, Poria; Pericarpium Papaveris 10 parts, Herba Pogostemonis 5 parts, Borneolum Syntheticum 3 parts; Radix Angelicae Sinensis 3 parts, Rhizoma Polygoni Paleachi 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 10 parts; the Radix Astragali 3 parts, Fructus Aurantii Immaturus 10 parts, Radix Raphani 6 parts.
The Chinese medicine preparation for the treatment of proctitis, preparation process is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1 hour, instillation Oleum sesami, decocts 5 minutes again, waits to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris and is placed on food steamer and steams 10 minutes, and it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds rice vinegar, be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 13 hours, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 3 minutes, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 3 hours, be placed on food steamer and steam 40 minutes, be ground into thick liquid with large ferrum spoon, thick liquid dried 10 minutes, obtain drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, add the water of raw material weight 2 times for the first time, decoct 20 minutes, filter, obtain filtrate 1, second time adds filtering residue weight 3-5 water doubly, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the 1-3 water doubly of filtering residue weight for the third time, culture decocts 10 minutes, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
Model case one: Qiu XX, female, 38 years old, Yanzhou, Jining City in Shandong Province personage, the employee of certain company.Symptom: in June, 2013 cervical cancer month after operation, radiation treatment 21 days, stool band pus and blood 3 days, has a small amount of mucus, and companion's diarrhoea watery stool, uses Norfloxacin in treatment of male poor effect.Proctoscopy: see that intestinal wall is congested, swelling is russet, gives to suspend only radiotherapy, goes examination in hospital to be diagnosed as proctitis ulcerosa, suggestion uses gained Chinese medicine preparation of the present invention.
Use and use embodiment 1 gained Chinese medicine preparation, coloclysis also coordinates oral medication 2 days, occurs without hemafecia, Herba Agrimoniae of stopping using, and continue to use this medicine 5 days, clinical symptoms disappears completely, follows up a case by regular visits to and do not recur again after half a year.
Embodiment 2 treats the Chinese medicine preparation of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Endoconcha Sepiae 9 parts, Cortex Dictamni 30 parts; Myrrha 30 parts, Galla Chinensis 9 parts, Calculus Bovis 10 parts; Os Draconis 15 parts, Indigo Naturalis 12 parts, 20 parts, Poria; Pericarpium Papaveris 20 parts, Herba Pogostemonis 9 parts, Borneolum Syntheticum 6 parts; Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Paleachi 40 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 30 parts; the Radix Astragali 9 parts, Fructus Aurantii Immaturus 20 parts, Radix Raphani 18 parts.
The Chinese medicine preparation for the treatment of proctitis, preparation process is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 2 hours, instillation Oleum sesami, decocts 5 minutes again, waits to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris and is placed on food steamer and steams 30 minutes, and it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds rice vinegar, be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 16 hours, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 8 minutes, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 5 hours, be placed on food steamer and steam 60 minutes, be ground into thick liquid with large ferrum spoon, thick liquid dried 20 minutes, obtain drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, add the water of raw material weight 4 times for the first time, decoct 40 minutes, filter, obtain filtrate 1, second time adds the water of filtering residue weight 5 times, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the water of 3 times of filtering residue weight for the third time, culture decocts 20 minutes, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
Model case two: poplar XX, man, 45 years old, Jining of Shandong Province Qufu personage.Symptom: accept radiotherapy in the treatment after operation for cervical carcinoma, 4th week of radiotherapy, there is hemafecia, stomachache, diarrhoea, the malaise symptoms of malaise, goes examination in hospital visible intestinal wall under rectoscope congested, doctor takes hemorrhage and antibiotic medicine treatment, Relapse rate, goes examination in hospital to be diagnosed as proctitis ulcerosa, hears of Chinese medicine preparation curative effect of the present invention fine.
Use and use embodiment 2 gained Chinese medicine preparation, coloclysis oral medication 1 day, malaise symptoms alleviates, and continues to use Chinese medicine preparation of the present invention to treat 7 days, and clinical symptoms disappears completely, follows up a case by regular visits to and do not recur again after half a year.
Embodiment 3 treats the Chinese medicine preparation of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Endoconcha Sepiae 5 parts, Cortex Dictamni 16 parts; Myrrha 15 parts, Galla Chinensis 4 parts, Calculus Bovis 4 parts; Os Draconis 8 parts, Indigo Naturalis 9 parts, 12 parts, Poria; Pericarpium Papaveris 14 parts, Herba Pogostemonis 6 parts, Borneolum Syntheticum 3.5 parts; Radix Angelicae Sinensis 6 parts, Rhizoma Polygoni Paleachi 20-38 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 15 parts; the Radix Astragali 5 parts, Fructus Aurantii Immaturus 13 parts, Radix Raphani 10 parts.
The Chinese medicine preparation for the treatment of proctitis, preparation process is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1.3 hours, instillation Oleum sesami, again decoct 5 minutes, wait to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris to be placed on food steamer and to steam 15 minutes, it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds rice vinegar, be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 14 hours, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 5 minutes, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 3.5 hours, be placed on food steamer and steam 45 minutes, be ground into thick liquid with large ferrum spoon, thick liquid dried 13 minutes, obtain drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, add the water of raw material weight 2.5 times for the first time, decoct 25 minutes, filter, obtain filtrate 1, second time adds the water of filtering residue weight 3.5 times, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the water of 1.5 times of filtering residue weight for the third time, culture decocts 13 minutes, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
Embodiment 4 treats the Chinese medicine preparation of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Endoconcha Sepiae 9 parts, Cortex Dictamni 25 parts; Myrrha 25 parts, Galla Chinensis 8 parts, Calculus Bovis 8 parts; Os Draconis 13 parts, Indigo Naturalis 11 parts, 18 parts, Poria; Pericarpium Papaveris 18 parts, Herba Pogostemonis 8 parts, Borneolum Syntheticum 5 parts; Radix Angelicae Sinensis 14 parts, Rhizoma Polygoni Paleachi 38 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 28 parts; the Radix Astragali 7 parts, Fructus Aurantii Immaturus 18 parts, Radix Raphani 14 parts.
The Chinese medicine preparation for the treatment of proctitis, preparation process is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1.8 hours, instillation Oleum sesami, again decoct 5 minutes, wait to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris to be placed on food steamer and to steam 25 minutes, it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds rice vinegar, be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 15 hours, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 7 minutes, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 4.5 hours, be placed on food steamer and steam 55 minutes, be ground into thick liquid with large ferrum spoon, thick liquid dried 18 minutes, obtain drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, add the water of raw material weight 3.5 times for the first time, decoct 35 minutes, filter, obtain filtrate 1, second time adds the water of filtering residue weight 4.5 times, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the water of 2.5 times of filtering residue weight for the third time, culture decocts 18 minutes, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
Embodiment 5 treats the Chinese medicine preparation of proctitis ulcerosa, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Endoconcha Sepiae 8 parts, Cortex Dictamni 20 parts; Myrrha 20 parts, Galla Chinensis 6 parts, Calculus Bovis 5 parts; Os Draconis 10 parts, Indigo Naturalis 10 parts, 15 parts, Poria; Pericarpium Papaveris 15 parts, Herba Pogostemonis 7 parts, Borneolum Syntheticum 4 parts; Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Paleachi 30 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 25 parts; the Radix Astragali 6 parts, Fructus Aurantii Immaturus 15 parts, Radix Raphani 12 parts.
The Chinese medicine preparation for the treatment of proctitis, preparation process is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1.5 hours, instillation Oleum sesami, again decoct 5 minutes, wait to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris to be placed on food steamer and to steam 20 minutes, it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds rice vinegar, be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 14.5 hours, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 6 minutes, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 4 hours, be placed on food steamer and steam 50 minutes, be ground into thick liquid with large ferrum spoon, thick liquid dried 15 minutes, obtain drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, add the water of raw material weight 3 times for the first time, decoct 30 minutes, filter, obtain filtrate 1, second time adds the water of filtering residue weight 4 times, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the water of 2 times of filtering residue weight for the third time, culture decocts 15 minutes, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
Experimental example: 1, selection of clinical: in order to verify the effect of Chinese medicine composition of the present invention, we have extracted 400 patients and have carried out the experiment of medicine, are equally divided into two groups, experimental group and matched group.
2, inclusion criteria: through being diagnosed as proctitis ulcerosa patient, has proctitis ulcerosa clinical symptoms one or more.
3, Therapeutic Method: be divided into two when prepared Chinese medicine preparation uses, portion hot water is washed open, puts into clean container and is used as enema, another part taken with boiled water.
4, curative effect situation criterion: 1, cure.After using medicine, malaise symptoms disappears completely; 2, effective.After using medicine, malaise symptoms alleviates or partial disappearance; 3, invalid.After using medicine, malaise symptoms is unchanged.We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis have been carried out to data.
Specific experiment result is as following table:
Table 1:
Prove through clinical trial, use Chinese medicine preparation of the present invention compared with the means of western medical treatment proctitis ulcerosa, control recurrence rate after healing low, treatment means is more comprehensive thoroughly, have no side effect between the operating period, while treatment proctitis ulcerosa, the clinical symptoms such as hemafecia, diarrhoea, stomachache, tenesmus, anus causalgia pendant pain brought by proctitis can be alleviated.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 99%, is Chinese medicine preparation conventional in clinical care.
Claims (10)
1. treat the Chinese medicine preparation of proctitis ulcerosa, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Endoconcha Sepiae 3-9 part, Cortex Dictamni 15-30 part; Myrrha 10-30 part, Galla Chinensis 3-9 part, Calculus Bovis 3-10 part; Os Draconis 5-15 part, Indigo Naturalis 8-12 part, Poria 10-20 part; Pericarpium Papaveris 10-20 part, Herba Pogostemonis 5-9 part, Borneolum Syntheticum 3-6 part; Radix Angelicae Sinensis 3-15 part, Rhizoma Polygoni Paleachi 15-40 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 10-30 part; Radix Astragali 3-9 part, Fructus Aurantii Immaturus 10-20 part, Radix Raphani 6-18 part.
2. the Chinese medicine preparation for the treatment of proctitis ulcerosa according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Endoconcha Sepiae 5-9 part, Cortex Dictamni 16-25 part; Myrrha 15-25 part, Galla Chinensis 4-8 part, Calculus Bovis 4-8 part; Os Draconis 8-13 part, Indigo Naturalis 9-11 part, Poria 12-18 part; Pericarpium Papaveris 14-18 part, Herba Pogostemonis 6-8 part, Borneolum Syntheticum 3.5-5 part; Radix Angelicae Sinensis 6-14 part, Rhizoma Polygoni Paleachi 20-38 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-28 part; Radix Astragali 5-7 part, Fructus Aurantii Immaturus 13-18 part, Radix Raphani 10-14 part.
3. the Chinese medicine preparation for the treatment of proctitis ulcerosa according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Endoconcha Sepiae 8 parts, Cortex Dictamni 20 parts; Myrrha 20 parts, Galla Chinensis 6 parts, Calculus Bovis 5 parts; Os Draconis 10 parts, Indigo Naturalis 10 parts, 15 parts, Poria; Pericarpium Papaveris 15 parts, Herba Pogostemonis 7 parts, Borneolum Syntheticum 4 parts; Radix Angelicae Sinensis 12 parts, Rhizoma Polygoni Paleachi 30 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 25 parts; the Radix Astragali 6 parts, Fructus Aurantii Immaturus 15 parts, Radix Raphani 12 parts.
4. the preparation method of the Chinese medicine preparation of the treatment proctitis ulcerosa according to any one of claim 1-3, is characterized in that: step is as follows:
1. Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris are placed in clean container, after decocting with water 1-2 hour, instillation Oleum sesami, again decoct 5 minutes, wait to decoct well-done Endoconcha Sepiae, Os Draconis and Pericarpium Papaveris to be placed on food steamer and to steam 10-30 minute, it is crisp to take out parch, and it is stand-by to grind to form smalls;
2. Cortex Dictamni, Myrrha, Galla Chinensis and Calculus Bovis are cleaned, drain away the water, be cut into silk, be placed in crock, pot burnt heat, adds vinegar (preferred rice vinegar), be heated to add white sugar when steam is blown out, with ferrum spoon white sugar be stirred to and melt completely, be poured in crock while hot, cover lid, stewing 13-16 hour, gets the hot pot dryouied, add mixed oil, when hot pot surrounding has blue or green cigarette to emerge, the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot, parch 3-8 minute, it is stand-by to grind to form smalls;
3. Radix Raphani peeling is cleaned, be cut into block, be placed in white vinegar and soak 3-5 hour, be placed on food steamer and steam 40-60 minute, be ground into thick liquid with large ferrum spoon, thick liquid dried 10-20 minute, obtains drying object;
4. by Poria, Herba Pogostemonis, Borneolum Syntheticum, Radix Angelicae Sinensis, Rhizoma Polygoni Paleachi, Hericium erinaceus (Bull. Ex Fr.) Pers., the Radix Astragali and Fructus Aurantii Immaturus are together placed in marmite, decoct three times, first time adds raw material weight 2-4 water doubly, decoct 20-40 minute, filter, obtain filtrate 1, second time adds filtering residue weight 3-5 water doubly, intense fire is fried open, turn slow fire boiling 1 hour, filter, obtain filtrate 2, add the 1-3 water doubly of filtering residue weight for the third time, culture decocts 10-20 minute, filter, obtain filtrate 3, three times filtrates merge decoction again 10 minutes, add step (1)-(3) gained crude drug and Indigo Naturalis, abundant stirring and decocting, when filtrate is concentrated into 1/2 of original volume, cease fire, bottle and get final product.
5. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: after 1. step decocts with water 1.3-1.8 hour, instillation Oleum sesami, again decoct 5 minutes (preferably, after decocting with water 1.5 hours, instillation Oleum sesami, decocts 5 minutes again).
6. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: step 2. stewing 14-15 hour (preferred, stewing 14.5 hours).
7. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: 2. the Chinese crude drug boiled in a covered pot over a slow fire is placed in rapidly in pot by step, parch 5-7 minute (preferred, to be placed in rapidly in pot by the Chinese crude drug boiled in a covered pot over a slow fire, parch 6 minutes).
8. the preparation method of Chinese medicine preparation according to claim 4, it is characterized in that: 3. step is placed in white vinegar and soaks 3.5-4.5 hour, be placed on food steamer and steam 45-55 minute (preferred, to be placed in white vinegar and to soak 4 hours, be placed on food steamer and steam 50 minutes).
9. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: 4. first time adds raw material weight 2.5-3.5 water doubly to step, decocts 25-35 minute (preferred, to add the water of raw material weight 3 times for the first time, decoct 30 minutes).
10. the preparation method of Chinese medicine preparation according to claim 4, is characterized in that: step 4. second time adds filtering residue weight 3.5-4.5 water doubly (preferred, second time adds the water of filtering residue weight 4 times).
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| CN105031501A (en) * | 2015-09-06 | 2015-11-11 | 张梅娟 | Composition for treating ulcerative colitis and preparing method thereof |
| CN105169198A (en) * | 2015-09-06 | 2015-12-23 | 李双玲 | Nutritive medicinal preparation for preventing colorectal cancer and preparation method thereof |
| EP3662891A4 (en) * | 2017-08-01 | 2021-08-04 | CK Biotech | Composition for preventing hair loss or promoting hair growth |
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| CN101011534A (en) * | 2007-02-02 | 2007-08-08 | 南京中医药大学 | Chinese medicine preparation for treating ulcerative proctitis and its preparation process |
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| CN1785389A (en) * | 2005-11-18 | 2006-06-14 | 李胜利 | Preparation method of Chinese medicine for treating ulcero proctitis |
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Cited By (4)
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| CN105031501A (en) * | 2015-09-06 | 2015-11-11 | 张梅娟 | Composition for treating ulcerative colitis and preparing method thereof |
| CN105169198A (en) * | 2015-09-06 | 2015-12-23 | 李双玲 | Nutritive medicinal preparation for preventing colorectal cancer and preparation method thereof |
| EP3662891A4 (en) * | 2017-08-01 | 2021-08-04 | CK Biotech | Composition for preventing hair loss or promoting hair growth |
| US11154566B2 (en) | 2017-08-01 | 2021-10-26 | Ck Biotech | Composition for preventing hair loss or promoting hair growth |
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Denomination of invention: Traditional Chinese medicine preparations and their preparation methods for treating ulcerative proctitis Effective date of registration: 20231231 Granted publication date: 20180112 Pledgee: Bank of China Limited by Share Ltd. Zhangpu branch Pledgor: TONGYITANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980075812 |