CN111344008A - 用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法 - Google Patents

用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法 Download PDF

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Publication number
CN111344008A
CN111344008A CN201880073897.7A CN201880073897A CN111344008A CN 111344008 A CN111344008 A CN 111344008A CN 201880073897 A CN201880073897 A CN 201880073897A CN 111344008 A CN111344008 A CN 111344008A
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rsv
protein
composition
rvsv
proteins
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CN201880073897.7A
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Chinese (zh)
Inventor
斯蒂芬·涅维斯克
巴萨瓦拉杰·宾杰瓦达吉
李建荣
马克·皮普尔斯
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Nationwide Childrens Hospital Inc
Ohio State Innovation Foundation
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Nationwide Childrens Hospital Inc
Ohio State Innovation Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18571—Demonstrated in vivo effect
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20271—Demonstrated in vivo effect

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  • Biotechnology (AREA)
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  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880073897.7A 2017-09-15 2018-09-14 用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法 Pending CN111344008A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762559167P 2017-09-15 2017-09-15
US62/559,167 2017-09-15
PCT/US2018/051054 WO2019055768A1 (en) 2017-09-15 2018-09-14 VACCINES AND METHODS OF MAKING AND USING VACCINES FOR THE PREVENTION OF SYNCYTIAL RESPIRATORY VIRUS (RSV) INFECTIONS

Publications (1)

Publication Number Publication Date
CN111344008A true CN111344008A (zh) 2020-06-26

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CN201880073897.7A Pending CN111344008A (zh) 2017-09-15 2018-09-14 用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法

Country Status (8)

Country Link
US (1) US20200276297A1 (https=)
EP (1) EP3681523A4 (https=)
JP (1) JP2020534284A (https=)
KR (1) KR20200096904A (https=)
CN (1) CN111344008A (https=)
AU (1) AU2018331467A1 (https=)
CA (1) CA3075990A1 (https=)
WO (1) WO2019055768A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112226450A (zh) * 2020-08-25 2021-01-15 北京交通大学 一种共表达呼吸道合胞病毒融合前蛋白和黏附糖蛋白的复制缺陷型腺病毒载体疫苗
WO2024235338A1 (zh) * 2023-05-12 2024-11-21 中国科学院微生物研究所 一种呼吸道合胞病毒抗原制备方法和应用
WO2025077200A1 (zh) * 2023-10-12 2025-04-17 中国科学院微生物研究所 一种呼吸道合胞病毒二价抗原制备方法和应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114957407A (zh) 2019-04-02 2022-08-30 赛诺菲 抗原性多聚呼吸道合胞病毒多肽
EP4410969A4 (en) * 2021-09-29 2026-01-21 Sk Bioscience Co Ltd RECOMINED LIVE ATTENUATED RSV VACCINE STRAIN AND ITS PRODUCTION PROCESS
KR102806300B1 (ko) * 2023-01-13 2025-05-14 클립스비엔씨 주식회사 호흡기 신시치아 바이러스 변이체를 포함하는 호흡기 신시치아 바이러스 백신용 융합단백질 및 이의 제조방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224462A (zh) * 1996-07-15 1999-07-28 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒呼吸道合胞病毒疫苗的方法
CN1347458A (zh) * 1999-04-13 2002-05-01 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒负链rna病毒疫苗
US20090162321A1 (en) * 2007-12-20 2009-06-25 Wyeth Methods for packaging propagation-defective vesicular stomatitis virus vectors using a stable cell line that expresses g protein
US20100247621A1 (en) * 2006-11-30 2010-09-30 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Codon modified immunogenic compositions and methods of use
CN102272295A (zh) * 2008-11-05 2011-12-07 默沙东公司 活减毒呼吸道合胞病毒
CN106659777A (zh) * 2014-06-13 2017-05-10 葛兰素史密丝克莱恩生物有限公司 免疫原性组合产品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092548A2 (en) * 2000-06-01 2001-12-06 St. Jude Children's Research Hospital Vaccine and gene therapy vector and methods of use thereof
US20050048030A1 (en) * 2001-09-28 2005-03-03 Raymond Pickles Paramyxoviruses as gene transfer vectors to lung cells
CN1646684B (zh) * 2002-02-21 2010-10-06 免疫医疗疫苗公司 重组副流感病毒表达系统以及包含源自间质肺病毒的异种抗原的疫苗
EP1527087B2 (en) * 2002-07-26 2013-07-17 Her Majesty, The Queen in Right of Canada, as Represented by The Minister of Health Recombinant vesicular stomatitis virus vaccines for viral hemorrhagic fevers
CN1871355B (zh) * 2003-06-09 2011-12-14 惠氏 从cDNA中回收非节段性负链RNA病毒的改进方法
ATE555208T1 (de) * 2003-06-13 2012-05-15 Apath Llc Replikon eines negativsträngigen rna-virus
US8287878B2 (en) * 2004-04-09 2012-10-16 Wyeth Llc Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
WO2009025770A2 (en) * 2007-08-17 2009-02-26 Wyeth A heterologous prime-boost immunization regimen
ES2749381T3 (es) * 2014-03-01 2020-03-20 Univ Texas Vectores víricos Isfahan recombinantes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224462A (zh) * 1996-07-15 1999-07-28 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒呼吸道合胞病毒疫苗的方法
CN1347458A (zh) * 1999-04-13 2002-05-01 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒负链rna病毒疫苗
US20100247621A1 (en) * 2006-11-30 2010-09-30 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Codon modified immunogenic compositions and methods of use
US20090162321A1 (en) * 2007-12-20 2009-06-25 Wyeth Methods for packaging propagation-defective vesicular stomatitis virus vectors using a stable cell line that expresses g protein
CN102272295A (zh) * 2008-11-05 2011-12-07 默沙东公司 活减毒呼吸道合胞病毒
CN106659777A (zh) * 2014-06-13 2017-05-10 葛兰素史密丝克莱恩生物有限公司 免疫原性组合产品

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALEXANDER BUKREYEV等: "The Secreted Form of Respiratory Syncytial Virus G Glycoprotein Helps the Virus Evade Antibody-Mediated Restriction of Replication by Acting as an Antigen Decoy and through Effects on Fc Receptor-Bearing Leukocytes" *
XIANG LIU等: "Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F" *
YUANMEI MA等: "Heat Shock Protein 70 Enhances Mucosal Immunity against Human Norovirus When Coexpressed from a Vesicular Stomatitis Virus Vector" *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112226450A (zh) * 2020-08-25 2021-01-15 北京交通大学 一种共表达呼吸道合胞病毒融合前蛋白和黏附糖蛋白的复制缺陷型腺病毒载体疫苗
WO2024235338A1 (zh) * 2023-05-12 2024-11-21 中国科学院微生物研究所 一种呼吸道合胞病毒抗原制备方法和应用
WO2025077200A1 (zh) * 2023-10-12 2025-04-17 中国科学院微生物研究所 一种呼吸道合胞病毒二价抗原制备方法和应用

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AU2018331467A1 (en) 2020-04-30
EP3681523A4 (en) 2021-12-29
EP3681523A1 (en) 2020-07-22
KR20200096904A (ko) 2020-08-14
CA3075990A1 (en) 2019-03-21
JP2020534284A (ja) 2020-11-26
US20200276297A1 (en) 2020-09-03
WO2019055768A1 (en) 2019-03-21

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