CN111343991A - 非炎性病变的治疗 - Google Patents

非炎性病变的治疗 Download PDF

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Publication number
CN111343991A
CN111343991A CN201880048978.1A CN201880048978A CN111343991A CN 111343991 A CN111343991 A CN 111343991A CN 201880048978 A CN201880048978 A CN 201880048978A CN 111343991 A CN111343991 A CN 111343991A
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CN
China
Prior art keywords
methyl
effective amount
therapeutically effective
pharmaceutically acceptable
weeks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880048978.1A
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English (en)
Chinese (zh)
Inventor
D·伯克
A·考尤科夫
V·斯尼基恩
C·施密茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almierre Co ltd
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Almierre Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almierre Co ltd filed Critical Almierre Co ltd
Publication of CN111343991A publication Critical patent/CN111343991A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880048978.1A 2017-07-21 2018-07-20 非炎性病变的治疗 Pending CN111343991A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762535572P 2017-07-21 2017-07-21
US62/535,572 2017-07-21
PCT/IB2018/000938 WO2019016609A1 (en) 2017-07-21 2018-07-20 TREATMENT OF NON-INFLAMMATORY LESIONS

Publications (1)

Publication Number Publication Date
CN111343991A true CN111343991A (zh) 2020-06-26

Family

ID=63713912

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880048978.1A Pending CN111343991A (zh) 2017-07-21 2018-07-20 非炎性病变的治疗

Country Status (13)

Country Link
US (1) US20200222432A1 (https=)
EP (1) EP3654988B1 (https=)
JP (1) JP2020527607A (https=)
KR (1) KR102662461B1 (https=)
CN (1) CN111343991A (https=)
AU (1) AU2018303807B2 (https=)
BR (1) BR112020000968A2 (https=)
CA (1) CA3070663A1 (https=)
ES (1) ES2962380T3 (https=)
IL (1) IL272124A (https=)
MA (1) MA49641A (https=)
MX (1) MX2020000816A (https=)
WO (1) WO2019016609A1 (https=)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080932A1 (en) * 2001-04-05 2002-10-17 Collagenex Pharmaceuticals, Inc. Methods of treating acne
WO2008079363A2 (en) * 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
US20110144003A1 (en) * 2008-05-21 2011-06-16 Galderma Research & Development Maintenance therapy regime/regimen for the treatment of acne
WO2012155146A1 (en) * 2011-05-12 2012-11-15 Paratek Pharmaceuticals, Inc. Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
US20140121188A1 (en) * 2009-10-02 2014-05-01 Foamix Ltd. Compositions for the improved treatment of acne and related disorders
US20150164922A1 (en) * 2012-03-15 2015-06-18 Foamix Pharmaceuticals Ltd. Use of tetracycline compositions for wound treatment and skin restoration
WO2018051102A1 (en) * 2016-09-15 2018-03-22 Antibiotx A/S Combinations comprising dibromopropamidine or diminazene and a tetracycline anti-bacterial agent

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (https=) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US7704959B2 (en) * 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CN102056481A (zh) * 2008-06-05 2011-05-11 陶氏制药科学公司 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂
JP2013500984A (ja) * 2009-07-30 2013-01-10 アラーガン、インコーポレイテッド ダプソンとアダパレンの組み合わせ

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080932A1 (en) * 2001-04-05 2002-10-17 Collagenex Pharmaceuticals, Inc. Methods of treating acne
WO2008079363A2 (en) * 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
US20110144003A1 (en) * 2008-05-21 2011-06-16 Galderma Research & Development Maintenance therapy regime/regimen for the treatment of acne
US20140121188A1 (en) * 2009-10-02 2014-05-01 Foamix Ltd. Compositions for the improved treatment of acne and related disorders
WO2012155146A1 (en) * 2011-05-12 2012-11-15 Paratek Pharmaceuticals, Inc. Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
US20150164922A1 (en) * 2012-03-15 2015-06-18 Foamix Pharmaceuticals Ltd. Use of tetracycline compositions for wound treatment and skin restoration
WO2018051102A1 (en) * 2016-09-15 2018-03-22 Antibiotx A/S Combinations comprising dibromopropamidine or diminazene and a tetracycline anti-bacterial agent

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANGELA MOORE，等: "Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials", 《J DRUGS DERMATOL. 》 *
E GROSSHANS，等: "A comparison of the efficacy and safety of lymecycline and minocycline in patients with moderately severe acne vulgaris", 《EUR J DERMATOL.》 *
JAMES J LEYDEN，等: "Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study", 《J DRUGS DERMATOL. 》 *
佚名: "Double-Blind,Placebo-Controlled Study to Evaluate 3 Doses of P005672 inTreatment of Facial Acne Vulgaris", 《HTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT01628549》 *

Also Published As

Publication number Publication date
AU2018303807B2 (en) 2023-08-24
CA3070663A1 (en) 2019-01-24
IL272124A (en) 2020-03-31
WO2019016609A1 (en) 2019-01-24
KR20200031126A (ko) 2020-03-23
EP3654988A1 (en) 2020-05-27
BR112020000968A2 (pt) 2020-07-14
ES2962380T3 (es) 2024-03-18
AU2018303807A1 (en) 2020-02-13
MA49641A (fr) 2021-06-02
US20200222432A1 (en) 2020-07-16
JP2020527607A (ja) 2020-09-10
MX2020000816A (es) 2020-08-17
KR102662461B1 (ko) 2024-04-30
EP3654988B1 (en) 2023-09-06

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