CN111329059A - 一种具有胃粘膜保护作用的中药提取物组合物及用途 - Google Patents
一种具有胃粘膜保护作用的中药提取物组合物及用途 Download PDFInfo
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Abstract
本发明公开了一种具有胃粘膜保护作用的中药提取物组合物及用途，具有胃粘膜保护作用的中药提取物组合物，由人参提取物、甘草提取物和山药提取物组成。实验证明，本发明的组合物能够明显保护胃粘膜，预防乙醇对胃粘膜的损伤。本发明的组合物毒副作用低。
Description
技术领域
本发明属于保健食品技术领域，尤其涉及一种具有胃粘膜保护作用的中药提取物组合物及用途。
背景技术
胃是人体的消化器官之一，而胃粘膜是胃的保护伞。胃黏膜具有防止氢离子迅速由胃腔侵入粘膜本身以及防止钠离子从黏膜内迅速向胃腔内弥散的特性。胃黏膜屏障可防止胃腔内的氢离子侵入胃黏膜及胃黏膜内的钠离子扩散入胃腔。但随着生活质量的提高和工作节奏的加快以及饮食不规律，饮酒情况日益增加，应酬饮酒更成为人们工作中不可避免的一部分。由酒精造成的胃黏膜损伤患者正在逐年增加。酒精可破坏胃黏膜屏障，胃腔内的氢离子侵蚀破坏胃黏膜，造成胃黏膜肿胀、出血，引起胃溃疡等疾病。
现代医学对胃黏膜的保护主要包括两方面：一是消除诱因，比如从减少饮酒，改善饮食结构等；二是采用药物。中药制剂由于其历史悠久，效果明显且毒副作用小，日益受到人们的重视。因此，需要为人们提供一种效果持久、长期用药毒副作用低的保护胃粘膜的组合物。
发明内容
本发明的目的是克服现有技术的不足，提供一种具有胃粘膜保护作用的中药提取物组合物。
本发明的第二个目的是提供一种具有胃粘膜保护作用的中药提取物组合物在制备具有胃粘膜保护作用的保健食品中的应用。
本发明的技术方案概述如下：
一种具有胃粘膜保护作用的中药提取物组合物，由人参提取物、甘草提取物和山药提取物组成。
上述组合物，优选地，人参提取物、甘草提取物和山药提取物的重量份依次为：3份、6份和16份。
上述组合物在制备具有胃黏膜保护作用的保健品中的应用。
本发明的优点：
(1)实验证明，本发明的组合物能够明显保护胃粘膜，预防乙醇对胃粘膜的损伤。
(2)本发明的组合物毒副作用低。
附图说明
图1为各组小鼠胃粘膜损伤结果图。
具体实施方式
下面结合具体实施例对本发明作进一步的说明
实施例1
人参提取物的制备：将人参加入10质量倍的体积浓度为70％的乙醇水溶液加热回流提取2小时，共提取3次，合并滤液，浓缩后喷雾干燥得人参提取物粉末，过100目筛备用。
实施例2
甘草提取物的制备：将甘草加入8质量倍的水，加热回流提取2小时，共提取3次，合并滤液，浓缩后喷雾干燥得甘草提取物粉末，过100目筛备用。
实施例3
山药提取物的制备：将山药加入7质量倍的体积浓度为70％的乙醇水溶液加热回流提取1.5小时，再用相当于山药7质量倍的体积浓度30％的乙醇水溶液提取1.5小时，两次提取液合并滤液，浓缩后喷雾干燥得山药提取物粉末，过100目筛备用。
实施例4
一种具有胃粘膜保护作用的中药提取物组合物的制备，称取3Kg人参提取物、6Kg甘草提取物和16Kg山药提取物，混匀，即得。
本发明各组分的药理作用如下：
人参：具有健胃、利尿、调整血压、恢复心脏功能、神经衰弱、祛痰之功效。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克等症。
甘草：具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药之功效。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性等症。
山药：具有补脾养胃，生津益肺，补肾涩精之功效。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴等症。
实施例5
实施例4制备的组合物的胃粘膜保护作用的检测。
(1)实验动物
选用昆明种雄性小鼠，22g～25g，每组7只。
(2)仪器与试剂
无水乙醇、质量浓度为0.5％羟甲基纤维素钠水溶液、质量浓度为1％甲醛水溶液、解剖器械。
(3)实验方案
35只昆明种雄性小鼠，随机分为5组，每组7只，苦味酸标记：分别为空白对照组、模型组、给药组1、给药组2、给药组3。
表1不同组别的供试品
各给药组按上表进行给药，每只小鼠给药0.1mL/10g，连续灌胃给药7天，每天1次。
空白组和模型组给予相同量的质量浓度为0.5％羟甲基纤维素钠水溶液，造模前禁食24h。末次给药30min后，除空白组外，每只小鼠灌胃给予无水乙醇0.13mL/10g，1h后即建立起小鼠急性胃黏膜损伤模型，取材，观察实验组对大剂量无水乙醇造成的急性胃黏膜损伤的作用。小鼠脱颈椎处死，解剖，结扎幽门、贲门，剪下胃体，注入1％甲醛溶液0.3mL，并于该甲醛溶液中浸泡30min后，取出组织，沿胃大弯剪开，生理盐水冲洗胃内容物，平铺组织，观察胃黏膜损伤情况。
(4)实验结果
1)临床观察结果
实验期间，对各组小鼠进行临床观察，各组小鼠体型、被毛、皮肤、粪便、步态、精神、呼吸等均未见异常，体重、摄食量均无统计学差异。
2)各组小鼠胃粘膜损伤结果，见图1。
小鼠灌胃给予大剂量无水乙醇1h后，小鼠出现胃黏膜损伤现象。肉眼观察。
空白组小鼠胃部未见明显异常。
模型组小鼠胃部损伤较严重，出现黏膜充血水肿、出血及糜烂。
而给药组可见明显胃部保护作用。较于模型组，给药组胃组织中条状损伤减少，出血斑点较少，其中给药组3效果要优于给药组1和2。从实验结果可看出，该组合物对小鼠的胃粘膜具有保护作用。
按常规方法将本发明的组合物制备成颗粒剂，片剂，胶囊剂，散剂，用于制备胃粘膜保护保健食品。用于缓解人饮酒后导致的胃粘膜损伤。
Claims (3)
1.一种具有胃粘膜保护作用的中药提取物组合物，其特征在于由人参提取物、甘草提取物和山药提取物组成。
2.根据权利要求1所述组合物，其特征在于所述人参提取物、甘草提取物和山药提取物的重量份依次为：3份、6份和16份。
3.权利要求1或2所述组合物在制备具有胃黏膜保护作用的保健品中的应用。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003206238A (ja) * | 2001-11-06 | 2003-07-22 | Rohto Pharmaceut Co Ltd | 医薬組成物 |
| CN102293936A (zh) * | 2011-09-14 | 2011-12-28 | 四川万安石斛产业开发有限公司 | 一种保护胃粘膜的药物组合物或保健食品组合物及制备方法 |
| CN106109823A (zh) * | 2016-07-13 | 2016-11-16 | 天津大学 | 一种具有胃粘膜保护功能的组合物及制剂 |
| CN110301641A (zh) * | 2019-07-25 | 2019-10-08 | 兰州大学 | 一种辅助保护胃黏膜的保健食品 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003206238A (ja) * | 2001-11-06 | 2003-07-22 | Rohto Pharmaceut Co Ltd | 医薬組成物 |
| CN102293936A (zh) * | 2011-09-14 | 2011-12-28 | 四川万安石斛产业开发有限公司 | 一种保护胃粘膜的药物组合物或保健食品组合物及制备方法 |
| CN106109823A (zh) * | 2016-07-13 | 2016-11-16 | 天津大学 | 一种具有胃粘膜保护功能的组合物及制剂 |
| CN110301641A (zh) * | 2019-07-25 | 2019-10-08 | 兰州大学 | 一种辅助保护胃黏膜的保健食品 |
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