CN111316103B - 用于预测或诊断肝疾病的组合物 - Google Patents
用于预测或诊断肝疾病的组合物 Download PDFInfo
- Publication number
- CN111316103B CN111316103B CN201880049717.1A CN201880049717A CN111316103B CN 111316103 B CN111316103 B CN 111316103B CN 201880049717 A CN201880049717 A CN 201880049717A CN 111316103 B CN111316103 B CN 111316103B
- Authority
- CN
- China
- Prior art keywords
- differentiation factor
- growth differentiation
- protein
- fibrosis
- liver
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170105714A KR102010652B1 (ko) | 2017-08-21 | 2017-08-21 | 간질환 예측 또는 진단용 조성물 및 이를 이용한 간질환 예측 또는 진단 방법 |
| KR10-2017-0105714 | 2017-08-21 | ||
| PCT/KR2018/009548 WO2019039817A2 (ko) | 2017-08-21 | 2018-08-20 | 간질환 예측 또는 진단용 조성물 및 이를 이용한 간질환 예측 또는 진단 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111316103A CN111316103A (zh) | 2020-06-19 |
| CN111316103B true CN111316103B (zh) | 2023-12-26 |
Family
ID=65439516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880049717.1A Active CN111316103B (zh) | 2017-08-21 | 2018-08-20 | 用于预测或诊断肝疾病的组合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200292553A1 (https=) |
| EP (1) | EP3674710B1 (https=) |
| JP (1) | JP7053783B2 (https=) |
| KR (1) | KR102010652B1 (https=) |
| CN (1) | CN111316103B (https=) |
| WO (1) | WO2019039817A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12372530B2 (en) * | 2017-11-15 | 2025-07-29 | Beth Israel Deaconess Medical Center, Inc. | Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis |
| KR102569644B1 (ko) | 2020-10-30 | 2023-08-23 | 가톨릭대학교 산학협력단 | Gdf15를 유효성분으로 함유하는 면역질환의 예방 및 치료용 조성물 |
| CN113160983A (zh) * | 2021-04-09 | 2021-07-23 | 南京医科大学附属逸夫医院 | 一种代谢相关脂肪性肝病临床预测模型 |
| US20240344134A1 (en) * | 2021-07-26 | 2024-10-17 | Osaka University | Diagnostic marker for hepatic cancer development in chronic hepatic disease |
| WO2023008673A1 (ko) * | 2021-07-30 | 2023-02-02 | 숙명여자대학교산학협력단 | 머신러닝 기반 비알코올성 지방간염 판별용 복합 마커 및 이의 용도 |
| CN115948563A (zh) * | 2023-03-13 | 2023-04-11 | 中国医学科学院北京协和医院 | 蛋白标志物的检测试剂在制备诊断肝癌的产品中的应用 |
| KR20250071598A (ko) | 2023-11-15 | 2025-05-22 | 주식회사 아이도트 | 장내미생물 중 전체 레벨의 데이터를 이용하는 간 질환 진단 시스템 및 방법 |
| KR20250074386A (ko) | 2023-11-20 | 2025-05-27 | 주식회사 아이도트 | 장내 미생물 중 전체 레벨의 데이터를 이용하는 간 질환 진단을 위한 학습 시스템 및 방법 |
| KR20250075910A (ko) | 2023-11-22 | 2025-05-29 | 주식회사 아이도트 | 장내 미생물 중 종 레벨의 데이터를 이용하는 간 질환 진단 시스템 및 방법 |
| KR20250077720A (ko) | 2023-11-24 | 2025-06-02 | 주식회사 아이도트 | 장내 미생물 중 종 레벨의 데이터를 이용하는 간 질환 진단 위한 학습 시스템 및 방법 |
| CN121331222B (zh) * | 2025-12-15 | 2026-03-10 | 北京大学 | 基于蛋白质组的慢性肝脏疾病发病预测的蛋白组合、预测模型及应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105980400A (zh) * | 2013-07-31 | 2016-09-28 | 美国安进公司 | 生长分化因子15(gdf-15)构建体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157235B2 (en) * | 2002-06-17 | 2007-01-02 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| US20070237713A1 (en) * | 2006-04-04 | 2007-10-11 | Fan Rong A | PCan065 Antibody Compositions and Methods of Use |
| EP2209003A1 (en) * | 2009-01-16 | 2010-07-21 | F. Hoffmann-Roche AG | Means and methods for differentiating between fibrosis and cirrhosis |
| EP2211182A1 (en) * | 2009-01-16 | 2010-07-28 | Roche Diagnostics GmbH | Method for the assessment of severity of liver cirrhosis |
| WO2012049874A1 (ja) * | 2010-10-13 | 2012-04-19 | ヒューマン・メタボローム・テクノロジーズ株式会社 | 脂肪性肝疾患を診断するためのバイオマーカー、その測定方法、コンピュータプログラム、および、記憶媒体 |
| HRP20191326T1 (hr) * | 2012-09-26 | 2019-11-01 | Univ Wuerzburg J Maximilians | Monoklonska antitijela za faktor rasta i diferencijacije 15 (gdf-15) |
| ES2924495T3 (es) * | 2016-01-29 | 2022-10-07 | Univ Washington | GDF15 en glaucoma y métodos de uso de este |
| KR102266627B1 (ko) | 2016-03-10 | 2021-06-17 | 엘에스엠트론 주식회사 | 플랫 케이블용 커넥터 |
-
2017
- 2017-08-21 KR KR1020170105714A patent/KR102010652B1/ko active Active
-
2018
- 2018-08-20 EP EP18848723.5A patent/EP3674710B1/en active Active
- 2018-08-20 US US16/630,064 patent/US20200292553A1/en not_active Abandoned
- 2018-08-20 CN CN201880049717.1A patent/CN111316103B/zh active Active
- 2018-08-20 WO PCT/KR2018/009548 patent/WO2019039817A2/ko not_active Ceased
- 2018-08-20 JP JP2020501172A patent/JP7053783B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105980400A (zh) * | 2013-07-31 | 2016-09-28 | 美国安进公司 | 生长分化因子15(gdf-15)构建体 |
Non-Patent Citations (3)
| Title |
|---|
| Association of Serum Level of Growth Differentiation Factor 15 with Liver Cirrhosis and Hepatocellular Carcinoma;Xiuying Liu等;《PLoS ONE》;第10卷(第5期);第1-13页 * |
| Growth Differentiation Factor 15 Predicts Chronic Liver Disease Severity;Eaum Seok Lee等;《Gut and Liver》;第11卷(第2期);第276页 * |
| Significance of growth differentiation factor 15 in chronic HCV patients;Mohab H. Halim等;《Journal of Genetic Engineering and Biotechnology》;第15卷;第403–407页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7053783B2 (ja) | 2022-04-12 |
| EP3674710B1 (en) | 2024-02-28 |
| CN111316103A (zh) | 2020-06-19 |
| WO2019039817A2 (ko) | 2019-02-28 |
| EP3674710A4 (en) | 2020-08-05 |
| JP2020528138A (ja) | 2020-09-17 |
| WO2019039817A9 (ko) | 2019-07-18 |
| EP3674710A2 (en) | 2020-07-01 |
| EP3674710C0 (en) | 2024-02-28 |
| US20200292553A1 (en) | 2020-09-17 |
| WO2019039817A3 (ko) | 2019-06-06 |
| KR20190020581A (ko) | 2019-03-04 |
| KR102010652B1 (ko) | 2019-08-13 |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |