JP2020510409A5 - - Google Patents
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- Publication number
- JP2020510409A5 JP2020510409A5 JP2019527561A JP2019527561A JP2020510409A5 JP 2020510409 A5 JP2020510409 A5 JP 2020510409A5 JP 2019527561 A JP2019527561 A JP 2019527561A JP 2019527561 A JP2019527561 A JP 2019527561A JP 2020510409 A5 JP2020510409 A5 JP 2020510409A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- amino acid
- antibody
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 66
- 239000000427 antigen Substances 0.000 claims 64
- 102000036639 antigens Human genes 0.000 claims 64
- 108091007433 antigens Proteins 0.000 claims 64
- 125000003275 alpha amino acid group Chemical group 0.000 claims 58
- 102100035139 Folate receptor alpha Human genes 0.000 claims 36
- 239000000523 sample Substances 0.000 claims 27
- 239000002773 nucleotide Substances 0.000 claims 17
- 125000003729 nucleotide group Chemical group 0.000 claims 17
- 239000012472 biological sample Substances 0.000 claims 13
- 102000006815 folate receptor Human genes 0.000 claims 12
- 108020005243 folate receptor Proteins 0.000 claims 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000007787 solid Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 108010090804 Streptavidin Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 238000004020 luminiscence type Methods 0.000 claims 6
- 229960002685 biotin Drugs 0.000 claims 5
- 235000020958 biotin Nutrition 0.000 claims 5
- 239000011616 biotin Substances 0.000 claims 5
- 238000002965 ELISA Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000000684 flow cytometry Methods 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 238000010166 immunofluorescence Methods 0.000 claims 3
- 238000003364 immunohistochemistry Methods 0.000 claims 3
- 238000001114 immunoprecipitation Methods 0.000 claims 3
- 238000003127 radioimmunoassay Methods 0.000 claims 3
- 238000001262 western blot Methods 0.000 claims 3
- 206010003445 Ascites Diseases 0.000 claims 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000003040 circulating cell Anatomy 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000010451 Folate receptor alpha Human genes 0.000 claims 1
- 108050001931 Folate receptor alpha Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425752P | 2016-11-23 | 2016-11-23 | |
| US62/425,752 | 2016-11-23 | ||
| PCT/US2017/063014 WO2018098277A1 (en) | 2016-11-23 | 2017-11-22 | Anti-folate receptor alpha antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510409A JP2020510409A (ja) | 2020-04-09 |
| JP2020510409A5 true JP2020510409A5 (https=) | 2021-01-14 |
| JP7072571B2 JP7072571B2 (ja) | 2022-05-20 |
Family
ID=60703077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527561A Active JP7072571B2 (ja) | 2016-11-23 | 2017-11-22 | 抗葉酸受容体アルファ抗体およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10822410B2 (https=) |
| EP (1) | EP3544999A1 (https=) |
| JP (1) | JP7072571B2 (https=) |
| WO (1) | WO2018098277A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| US12018069B2 (en) | 2018-06-28 | 2024-06-25 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| CN112955548B (zh) * | 2018-07-09 | 2023-11-24 | 普众发现医药科技(上海)有限公司 | 叶酸受体α特异性抗体 |
| WO2020092474A1 (en) * | 2018-10-31 | 2020-05-07 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| CN114555099A (zh) * | 2019-06-23 | 2022-05-27 | 广东天科雅生物医药科技有限公司 | 抗alpp car-t细胞疗法 |
| WO2021150933A1 (en) * | 2020-01-22 | 2021-07-29 | Michael Watts | Method and system of touring real estate and surveys for the same |
| US20230374140A1 (en) * | 2020-10-09 | 2023-11-23 | Memorial Sloan Kettering Cancer Center | Compositions targeting ndc80/mhc complexes and uses thereof |
| CN117106084B (zh) * | 2021-12-02 | 2024-03-22 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp的单克隆抗体、其抗原结合片段及其应用 |
| CN117700557B (zh) * | 2024-02-05 | 2024-04-30 | 卡秋(江苏)生物科技有限公司 | 一种特异性结合叶酸受体α的抗体或抗原结合片段 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2556027C (en) | 2004-02-12 | 2015-11-24 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
| ATE460668T1 (de) | 2005-03-30 | 2010-03-15 | Purdue Research Foundation | Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren |
| US7754698B2 (en) | 2007-01-09 | 2010-07-13 | Isis Pharmaceuticals, Inc. | Modulation of FR-alpha expression |
| WO2009132081A2 (en) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Monoclonal antibody-based targeting of folate receptors |
| AU2011323124C1 (en) | 2010-11-05 | 2016-09-22 | Eisai Inc. | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
| PL2731972T3 (pl) * | 2011-07-15 | 2018-06-29 | Eisai R&D Management Co., Ltd. | Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania |
| HUE049693T2 (hu) | 2012-08-31 | 2020-10-28 | Immunogen Inc | Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására |
| CN107624071A (zh) * | 2015-04-17 | 2018-01-23 | 诺福泰克公司 | 肺癌治疗方法 |
-
2017
- 2017-11-22 US US15/821,296 patent/US10822410B2/en active Active
- 2017-11-22 EP EP17817451.2A patent/EP3544999A1/en not_active Withdrawn
- 2017-11-22 JP JP2019527561A patent/JP7072571B2/ja active Active
- 2017-11-22 WO PCT/US2017/063014 patent/WO2018098277A1/en not_active Ceased
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