ATE460668T1 - Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren - Google Patents

Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren

Info

Publication number
ATE460668T1
ATE460668T1 AT06739883T AT06739883T ATE460668T1 AT E460668 T1 ATE460668 T1 AT E460668T1 AT 06739883 T AT06739883 T AT 06739883T AT 06739883 T AT06739883 T AT 06739883T AT E460668 T1 ATE460668 T1 AT E460668T1
Authority
AT
Austria
Prior art keywords
quantification
breast cancer
vitamin receptors
predicting breast
cellular folate
Prior art date
Application number
AT06739883T
Other languages
English (en)
Inventor
Philip Low
Lynn Hartmann
Christopher Leamon
Phil Ellis
Original Assignee
Purdue Research Foundation
Endocyte Inc
Mayo Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Endocyte Inc, Mayo Foundation filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ATE460668T1 publication Critical patent/ATE460668T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT06739883T 2005-03-30 2006-03-30 Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren ATE460668T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643005P 2005-03-30 2005-03-30
PCT/US2006/011376 WO2006105141A1 (en) 2005-03-30 2006-03-30 Method for cancer prognosis using cellular folate vitamin receptor quantification

Publications (1)

Publication Number Publication Date
ATE460668T1 true ATE460668T1 (de) 2010-03-15

Family

ID=36754569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06739883T ATE460668T1 (de) 2005-03-30 2006-03-30 Verfahren zur prognose von brustkrebs mittels quantifizierung von zellulären folat vitamin rezeptoren

Country Status (10)

Country Link
US (1) US20090081710A1 (de)
EP (2) EP2199796A1 (de)
JP (1) JP2008537778A (de)
CN (1) CN101203759A (de)
AT (1) ATE460668T1 (de)
AU (1) AU2006230219A1 (de)
CA (1) CA2602585A1 (de)
DE (1) DE602006012816D1 (de)
RU (1) RU2007139912A (de)
WO (1) WO2006105141A1 (de)

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ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
CA2484640C (en) 2002-05-15 2012-01-17 Endocyte, Inc. Vitamin-mitomycin conjugates
WO2004069159A2 (en) 2003-01-27 2004-08-19 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
AU2005214331B2 (en) 2004-02-12 2011-09-15 Eisai, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
JP5289935B2 (ja) 2005-03-16 2013-09-11 エンドサイト，インコーポレイテッド プテロイン酸およびその結合体の合成と精製
AU2006241099B2 (en) 2005-04-22 2012-04-19 Eisai, Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
ES2468240T3 (es) 2005-08-19 2014-06-16 Endocyte, Inc. Conjugados de ligando de múltiples fármacos
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN101678124A (zh) 2007-03-14 2010-03-24 恩多塞特公司 结合配体连接的微管溶素递药缀合物
EP3569251A1 (de) 2007-06-25 2019-11-20 Endocyte, Inc. Konjugate mit hydrophilen spacern/linkern
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CA2703491C (en) 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysins and processes for preparing
US20120128587A1 (en) * 2009-07-31 2012-05-24 Endocyte, Inc. Folate-targeted diagnostics and treatment
KR101580713B1 (ko) 2010-02-24 2015-12-29 이뮤노젠 아이엔씨 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도
MX368394B (es) * 2010-11-05 2019-10-01 Eisai Inc Receptor alfa de folato como marcador de diagnostico y pronostico para canceres que expresan receptor alfa de folato.
EA025069B1 (ru) * 2010-11-12 2016-11-30 Эндосайт, Инк. Способ и набор для лечения рака
UA125636C2 (uk) * 2011-04-01 2022-05-11 Іммуноджен, Інк. Способи ідентифікації раку, який може реагувати на анти-folr1 антитіло або анти-folr1 імунокон'югат
LT2731972T (lt) 2011-07-15 2018-03-26 Eisai R&D Management Co., Ltd. Antikūnai prieš foliato receptorius alfa ir jų panaudojimas
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20200079565A (ko) 2012-08-31 2020-07-03 이뮤노젠 아이엔씨 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트
CN102861020A (zh) * 2012-09-25 2013-01-09 上海交通大学医学院附属仁济医院 叶酸在制备预防大肠腺瘤初发药物中的应用
AU2013331440A1 (en) 2012-10-16 2015-04-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
US20140154702A1 (en) * 2012-11-30 2014-06-05 Endocyte, Inc. Methods For Treating Cancer Using Combination Therapies
WO2015031815A2 (en) 2013-08-30 2015-03-05 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
US20150132323A1 (en) * 2013-10-08 2015-05-14 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
EP3574924B1 (de) 2013-11-19 2021-01-06 Purdue Research Foundation Patientenauswahlverfahren für entzündungen
JP6246030B2 (ja) * 2014-03-12 2017-12-13 東芝メディカルシステムズ株式会社 病理染色装置及び病理染色方法
IL257531B2 (en) 2015-09-17 2023-04-01 Immunogen Inc Medicinal compositions containing anti-folr1 immunoconjugates
WO2017218632A1 (en) * 2016-06-14 2017-12-21 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
CN106483282B (zh) * 2016-09-29 2018-08-31 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
WO2018098277A1 (en) 2016-11-23 2018-05-31 Eisai R&D Management Co., Ltd Anti-folate receptor alpha antibodies and uses thereof

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US5989838A (en) * 1992-03-11 1999-11-23 Institute Of Virology, Slovak Academy Of Sciences Immunological methods of detecting MN proteins and MN polypeptides
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5846739A (en) 1995-12-05 1998-12-08 Wisconsin Alumni Research Foundation Immunohistochemical detection assay for carcinoma proliferative status
US6358682B1 (en) 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
AU5697001A (en) * 2000-03-31 2001-10-15 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
ATE451935T1 (de) 2001-09-28 2010-01-15 Purdue Research Foundation Behandlungsverfahren mit liganden- immunogenkonjugaten
AR039429A1 (es) * 2002-04-19 2005-02-16 Endocyte Inc Metodo para aumentar la eliminacion especifica mediada por la respuesta inmune endogena de la poblacion de celulas patogenicas en un animal huesped inmunizado previamente, composicion y combinacion que comprenden un auxiliar th1 y un conjugado hapten-portador de utilidad en el mismo.
CA2484640C (en) 2002-05-15 2012-01-17 Endocyte, Inc. Vitamin-mitomycin conjugates
WO2004069159A2 (en) 2003-01-27 2004-08-19 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates

Also Published As

Publication number Publication date
DE602006012816D1 (de) 2010-04-22
EP1864133A1 (de) 2007-12-12
EP1864133B1 (de) 2010-03-10
US20090081710A1 (en) 2009-03-26
RU2007139912A (ru) 2009-05-10
EP2199796A1 (de) 2010-06-23
JP2008537778A (ja) 2008-09-25
AU2006230219A1 (en) 2006-10-05
WO2006105141A1 (en) 2006-10-05
CN101203759A (zh) 2008-06-18
CA2602585A1 (en) 2006-10-05

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