CN111295372A - 硝羟喹啉前药及其用途 - Google Patents

硝羟喹啉前药及其用途 Download PDF

Info

Publication number
CN111295372A
CN111295372A CN201980004913.1A CN201980004913A CN111295372A CN 111295372 A CN111295372 A CN 111295372A CN 201980004913 A CN201980004913 A CN 201980004913A CN 111295372 A CN111295372 A CN 111295372A
Authority
CN
China
Prior art keywords
alkyl
heterocyclyl
aryl
heteroaryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980004913.1A
Other languages
English (en)
Other versions
CN111295372B (zh
Inventor
邓一军
吴亮
潘柯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANGSU YAHONG MEDICINE SCIENCE & TECHNOLOGY CO LTD
Original Assignee
JIANGSU YAHONG MEDICINE SCIENCE & TECHNOLOGY CO LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JIANGSU YAHONG MEDICINE SCIENCE & TECHNOLOGY CO LTD filed Critical JIANGSU YAHONG MEDICINE SCIENCE & TECHNOLOGY CO LTD
Publication of CN111295372A publication Critical patent/CN111295372A/zh
Application granted granted Critical
Publication of CN111295372B publication Critical patent/CN111295372B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C07D215/34—Carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Abstract

提供硝羟喹啉前药及其用途，具体地，提供式(I)化合物或其药学上可接受的盐、其制备方法、包含其的组合物、及其在制备用于抗感染和抗肿瘤药物中的用途，式(I)中各个基团的定义如说明书中所述。式(I)化合物相对于硝羟喹啉有更好的水溶性、血药浓度或半衰期等药代动力学参数。式(I)化合物可减少给药次数，同时具有在尿路领域以外的其他领域中应用的可能性。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980004913.1A 2018-09-29 2019-09-27 硝羟喹啉前药及其用途 Active CN111295372B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018111483140 2018-09-29
CN201811148314 2018-09-29
PCT/CN2019/108419 WO2020063824A1 (zh) 2018-09-29 2019-09-27 硝羟喹啉前药及其用途

Publications (2)

Publication Number Publication Date
CN111295372A true CN111295372A (zh) 2020-06-16
CN111295372B CN111295372B (zh) 2021-03-09

Family

ID=69953367

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980004913.1A Active CN111295372B (zh) 2018-09-29 2019-09-27 硝羟喹啉前药及其用途

Country Status (11)

Country Link
US (1) US20210363165A1 (zh)
EP (1) EP3858814A4 (zh)
JP (1) JP2022502510A (zh)
KR (1) KR20210070320A (zh)
CN (1) CN111295372B (zh)
AU (1) AU2019351494A1 (zh)
BR (1) BR112021005941A2 (zh)
CA (1) CA3113463A1 (zh)
MX (1) MX2021003724A (zh)
SG (1) SG11202103134TA (zh)
WO (1) WO2020063824A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111646936A (zh) * 2020-06-22 2020-09-11 江苏亚虹医药科技有限公司 芳香醚类化合物的制备方法
CN111773193A (zh) * 2020-07-03 2020-10-16 江苏亚虹医药科技有限公司 含硝羟喹啉赖氨酸盐的药物组合物及其制备方法和用途
CN115427397A (zh) * 2020-03-30 2022-12-02 江苏亚虹医药科技股份有限公司 硝羟喹啉前药的晶型、含其的药物组合物及其制备方法和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112402388A (zh) * 2019-08-05 2021-02-26 江苏亚虹医药科技股份有限公司 一种用于治疗膀胱癌的口服固体制剂及其制备方法
CN111514142B (zh) * 2020-05-29 2021-04-06 江苏亚虹医药科技股份有限公司 含硝羟喹啉前药的药物组合物及其制备方法和应用
CN112745334B (zh) * 2021-02-07 2022-03-25 厦门一先药业有限公司 一种巴洛沙韦及其衍生物的前药、其制备方法和用途
WO2022253159A1 (zh) 2021-05-31 2022-12-08 江苏亚虹医药科技股份有限公司 5-硝基-8-羟基喹啉的应用

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1510067A (fr) * 1966-12-06 1968-01-19 Esters carbamiques dérivés de la quinoléine
GB1168307A (en) * 1967-08-14 1969-10-22 Soc D Etudes Prod Chimique Novel Esters of 5-Nitro-Quinoline
US3828056A (en) * 1972-09-11 1974-08-06 Searle & Co (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)heteroaryloxy ethers
GB1382571A (en) * 1972-08-31 1975-02-05 Roussel Uclaf Quinoline derivatives processes for their preparation and compo sitions incorporating them
DE2728248A1 (de) * 1976-06-24 1978-01-05 Debat Lab Nitroxolinderivate
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
US4472404A (en) * 1982-08-16 1984-09-18 The Dow Chemical Company 8-Quinolinyl carbamates and their use as urinary tract antimicrobials
US4749406A (en) * 1983-10-18 1988-06-07 Ciba-Geigy Corporation Quinoline derivatives and compositions thereof for the protection of cultivated plants
US4829072A (en) * 1986-06-27 1989-05-09 Basf Aktiengesellschaft Quinoline derivatives microbicides containing these compounds, and their use for controlling bacteria and fungi
CN1419450A (zh) * 2000-01-26 2003-05-21 尼科克斯公司 抗微生物药物的硝酸盐
CN101880239A (zh) * 2009-05-08 2010-11-10 北京美倍他药物研究有限公司 丙泊酚的水溶性氨基酸酯衍生物
CN101951914A (zh) * 2005-10-20 2011-01-19 加利福尼亚太平洋医学中心 雄甾酮衍生物及其使用方法
WO2011121366A1 (en) * 2010-04-01 2011-10-06 Respivert Limited Pyrazole p38 map kinase inhibitors
CN102231949A (zh) * 2008-10-01 2011-11-02 陶氏环球技术有限责任公司 杀生物组合物及其使用方法
CN102464631A (zh) * 2010-11-08 2012-05-23 中国科学院上海药物研究所 哌嗪取代的1,3-二取代脲类化合物及哌嗪取代的酰胺类化合物及其制备方法和用途
CN105992759A (zh) * 2013-12-30 2016-10-05 Kt&G生命科学公司 1,2-萘醌的衍生物及其制备方法
WO2017147146A1 (en) * 2016-02-23 2017-08-31 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA883837A (en) * 1971-10-19 Societe D'etudes De Produits Chimiques Furoic esters of 5-nitro quinoline and to methods of preparing them
AU3938893A (en) * 1992-03-27 1993-11-08 Abbott Laboratories Haptens, tracers, immunogens and antibodies for quinoline
CN102239149B (zh) * 2008-10-06 2015-05-13 约翰·霍普金斯大学 喹啉化合物作为血管新生、人类甲硫氨酰氨肽酶、以及sirt1的抑制剂,以及治疗病症的方法
CA3171261A1 (en) * 2020-03-30 2021-10-07 Liang Wu Crystal form of nitroxoline prodrug, pharmaceutical composition containing same, and preparation method therefor and application thereof

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1510067A (fr) * 1966-12-06 1968-01-19 Esters carbamiques dérivés de la quinoléine
GB1168307A (en) * 1967-08-14 1969-10-22 Soc D Etudes Prod Chimique Novel Esters of 5-Nitro-Quinoline
GB1382571A (en) * 1972-08-31 1975-02-05 Roussel Uclaf Quinoline derivatives processes for their preparation and compo sitions incorporating them
US3828056A (en) * 1972-09-11 1974-08-06 Searle & Co (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)heteroaryloxy ethers
DE2728248A1 (de) * 1976-06-24 1978-01-05 Debat Lab Nitroxolinderivate
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
US4472404A (en) * 1982-08-16 1984-09-18 The Dow Chemical Company 8-Quinolinyl carbamates and their use as urinary tract antimicrobials
US4749406A (en) * 1983-10-18 1988-06-07 Ciba-Geigy Corporation Quinoline derivatives and compositions thereof for the protection of cultivated plants
US4829072A (en) * 1986-06-27 1989-05-09 Basf Aktiengesellschaft Quinoline derivatives microbicides containing these compounds, and their use for controlling bacteria and fungi
CN1419450A (zh) * 2000-01-26 2003-05-21 尼科克斯公司 抗微生物药物的硝酸盐
CN101951914A (zh) * 2005-10-20 2011-01-19 加利福尼亚太平洋医学中心 雄甾酮衍生物及其使用方法
CN102231949A (zh) * 2008-10-01 2011-11-02 陶氏环球技术有限责任公司 杀生物组合物及其使用方法
CN101880239A (zh) * 2009-05-08 2010-11-10 北京美倍他药物研究有限公司 丙泊酚的水溶性氨基酸酯衍生物
WO2011121366A1 (en) * 2010-04-01 2011-10-06 Respivert Limited Pyrazole p38 map kinase inhibitors
CN102464631A (zh) * 2010-11-08 2012-05-23 中国科学院上海药物研究所 哌嗪取代的1,3-二取代脲类化合物及哌嗪取代的酰胺类化合物及其制备方法和用途
CN105992759A (zh) * 2013-12-30 2016-10-05 Kt&G生命科学公司 1,2-萘醌的衍生物及其制备方法
WO2017147146A1 (en) * 2016-02-23 2017-08-31 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ACS: "RN 2375195-46-1", 《STN-REG》 *
HUMA BANO ET AL.: "Synthesis, single crystal X‐ray diffraction, Hirshfeld surface and biological activity of quinolone derivatives", 《EUROPEAN JOURNAL OF CHEMISTRY》 *
ORLANDO D. MADOERY ET AL.: "Alkaline Hydrolysis of Quinolyl N,N-Dimethylthiocarbamates", 《J. AGRIC. FOOD CHEM.》 *
SVEN GRASSMANN ET AL.: "Imidazole Derivatives as a Novel Class of Hybrid Compounds with Inhibitory Histamine N-Methyltransferase Potencies and Histamine hH3 Receptor Affinities", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115427397A (zh) * 2020-03-30 2022-12-02 江苏亚虹医药科技股份有限公司 硝羟喹啉前药的晶型、含其的药物组合物及其制备方法和应用
CN115427397B (zh) * 2020-03-30 2024-01-26 江苏亚虹医药科技股份有限公司 硝羟喹啉前药的晶型、含其的药物组合物及其制备方法和应用
CN111646936A (zh) * 2020-06-22 2020-09-11 江苏亚虹医药科技有限公司 芳香醚类化合物的制备方法
WO2021258979A1 (zh) * 2020-06-22 2021-12-30 江苏亚虹医药科技股份有限公司 芳香醚类化合物的制备方法
CN115697970A (zh) * 2020-06-22 2023-02-03 江苏亚虹医药科技股份有限公司 芳香醚类化合物的制备方法
CN111773193A (zh) * 2020-07-03 2020-10-16 江苏亚虹医药科技有限公司 含硝羟喹啉赖氨酸盐的药物组合物及其制备方法和用途

Also Published As

Publication number Publication date
US20210363165A1 (en) 2021-11-25
EP3858814A1 (en) 2021-08-04
WO2020063824A1 (zh) 2020-04-02
JP2022502510A (ja) 2022-01-11
BR112021005941A2 (pt) 2021-06-29
AU2019351494A1 (en) 2021-05-20
CA3113463A1 (en) 2020-04-02
SG11202103134TA (en) 2021-04-29
KR20210070320A (ko) 2021-06-14
MX2021003724A (es) 2021-05-14
CN111295372B (zh) 2021-03-09
EP3858814A4 (en) 2022-10-05

Similar Documents

Publication Publication Date Title
CN111295372B (zh) 硝羟喹啉前药及其用途
JP6947644B2 (ja) 重水素化ケノデオキシコール酸誘導体およびこの化合物を含む薬物組成物
CN108135912B (zh) 孕甾醇及其使用方法
TWI676628B (zh) 抑制ｍｃｌ－１蛋白之化合物
WO2021027911A1 (zh) 新型螺环类K-Ras G12C抑制剂
EP3483142A1 (en) Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
EP3816163A1 (en) Cell necrosis inhibitor, preparation method therefor and use thereof
EP3653625B1 (en) Fused ring derivative having mgat-2 inhibitory activity
TW202220985A (zh) 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
WO2019205979A1 (zh) 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途
WO2023280280A1 (zh) 作为KRas G12D抑制剂的稠环化合物
CN113754654A (zh) 咪唑并吡啶类化合物及其用途
TW202321218A (zh) Shp2抑制劑、包含其的藥物組合物及其用途
RU2753036C1 (ru) Производное триптолида, способ его получения и применение
KR910008799B1 (ko) 에피포도필로톡신 배당체의 4'-아실 유도체
WO2019149089A1 (zh) 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途
CN113698390B (zh) 用作ret激酶抑制剂的化合物及其应用
TW202130619A (zh) 硝羥喹啉前藥及其用途
WO2021033766A1 (ja) ビタミンｄ活性を有するリトコール酸誘導体
KR20230170693A (ko) Metap-2 억제제, 약제학적 조성물 및 이의 치료 방법
WO2023141852A1 (zh) Cdk2抑制剂及其制备方法和用途
KR20000075717A (ko) 퀴녹살린디온
TW202408505A (zh) 雙官能基化合物及包含該雙官能基化合物之醫藥組成物，及其用於製備治療雄激素受體相關疾病之藥物的用途
WO2002096921A1 (fr) Nouveau derive glucose induisant l'apoptose, procede de production et utilisation comme medicament
CN115884776A (zh) 杂环大环化合物及其医药用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Room 1009, building D, phase II, new drug creation base, No.1 Yaocheng Avenue, Taizhou City, Jiangsu Province, 225316

Applicant after: Jiangsu Yahong Pharmaceutical Technology Co.,Ltd.

Address before: Room 1009, building D, phase II, new drug creation base, No.1 Yaocheng Avenue, Taizhou City, Jiangsu Province, 225316

Applicant before: JIANGSU YAHONG MEDICINE SCIENCE & TECHNOLOGY Co.,Ltd.

CB02 Change of applicant information
GR01 Patent grant
GR01 Patent grant