CN111233748A - 合成盐酸替罗非班 - Google Patents
合成盐酸替罗非班 Download PDFInfo
- Publication number
- CN111233748A CN111233748A CN202010156266.0A CN202010156266A CN111233748A CN 111233748 A CN111233748 A CN 111233748A CN 202010156266 A CN202010156266 A CN 202010156266A CN 111233748 A CN111233748 A CN 111233748A
- Authority
- CN
- China
- Prior art keywords
- formula
- oxalyldiamine
- phenyl
- pyridin
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010156266.0A CN111233748B (zh) | 2020-03-09 | 2020-03-09 | 合成盐酸替罗非班 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010156266.0A CN111233748B (zh) | 2020-03-09 | 2020-03-09 | 合成盐酸替罗非班 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111233748A true CN111233748A (zh) | 2020-06-05 |
CN111233748B CN111233748B (zh) | 2022-07-26 |
Family
ID=70878513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010156266.0A Active CN111233748B (zh) | 2020-03-09 | 2020-03-09 | 合成盐酸替罗非班 |
Country Status (1)
Country | Link |
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CN (1) | CN111233748B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112816282A (zh) * | 2020-12-29 | 2021-05-18 | 江苏慧聚药业有限公司 | 一种盐酸替罗非班的有关物质及其制备和检测方法 |
CN115960010A (zh) * | 2022-11-15 | 2023-04-14 | 上海慧聚药业有限公司 | 苯胺类化合物的制备 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102285912A (zh) * | 2011-06-30 | 2011-12-21 | 上海景峰制药有限公司 | N-正丁基磺酰基-o-(4-(4-吡啶基)-丁基)-l-络氨酸烷基酯的制备方法 |
-
2020
- 2020-03-09 CN CN202010156266.0A patent/CN111233748B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102285912A (zh) * | 2011-06-30 | 2011-12-21 | 上海景峰制药有限公司 | N-正丁基磺酰基-o-(4-(4-吡啶基)-丁基)-l-络氨酸烷基酯的制备方法 |
Non-Patent Citations (1)
Title |
---|
CRAIG P. JOHNSTON,ET AL.: "Metallaphotoredox-catalysed sp3-sp3 cross-coupling of carboxylic acids with alkyl halides", 《NATURE》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112816282A (zh) * | 2020-12-29 | 2021-05-18 | 江苏慧聚药业有限公司 | 一种盐酸替罗非班的有关物质及其制备和检测方法 |
CN115960010A (zh) * | 2022-11-15 | 2023-04-14 | 上海慧聚药业有限公司 | 苯胺类化合物的制备 |
Also Published As
Publication number | Publication date |
---|---|
CN111233748B (zh) | 2022-07-26 |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 226123 No. 18, Qinghua Road, Sanchang street, Haimen City, Nantong City, Jiangsu Province Applicant after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 226123 No. 18, Qinghua Road, Sanchang street, Haimen City, Nantong City, Jiangsu Province Applicant before: WISDOM PHARMACEUTICAL Co.,Ltd. |
|
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Applicant after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Applicant before: Jiangsu Huiju Pharmaceutical Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant |